Laparoscopic gastrectomy versus open gastrectomy for gastric cancer in patients among octogenarians: a meta-analysis.

PURPOSE: Currently, there is no consensus regarding whether super-elderly (aged > 80 years) patients are suitable candidates for laparoscopic surgery. This study aimed to analyse the short-term outcomes and oncological prognosis of laparoscopic gastrectomy in super-elderly patients with gastric cancer (GC). METHODS: Following PRISMA and AMSTAR-2 guidelines, we searched the Web of Science, Embase, Cochrane Library, and Pubmed databases from inception until May 2024 and performed a meta-analysis. All published studies exploring the surgical outcomes and oncological prognosis of laparoscopic versus open gastrectomy in super-elderly patients with GC were reviewed. Statistical analyses were performed using RevMan 5.3. RESULTS: A total of 1,085 studies were retrieved, eight of which were included in the meta-analysis, comprising 807 patients > 80 years of age with GC. The meta-analysis showed that compared with open gastrectomy, patients with GC > 80 years old who underwent laparoscopic gastrectomy had a longer operative time (weighted mean difference [WMD] = 30.48, p < 0.001), less intraoperative blood loss (WMD = -166.96, P < 0.001), shorter postoperative exhaust time (WMD =-0.83, p < 0.001), shorter length of stay (WMD = -0.78, p < 0.001), fewer overall complications (Odds ratio [OR] = 0.54, p = 0.003), higher 5-year overall survival rate (OR = 1.66, p = 0.03) and disease-specific survival rate (OR = 3.23, p < 0.001). Furthermore, laparoscopic gastrectomy did not significantly affect the number of lymph node dissections, the rate of D2 radical gastrectomy, major postoperative complications, or postoperative pneumonia. CONCLUSIONS: Compared to open gastrectomy, patients with GC aged > 80 years who underwent laparoscopic gastrectomy may have better short-term outcomes. Age should not be a contraindication for minimally invasive surgery.

Robotic versus laparoscopic gastrectomy for gastric cancer: A Western propensity score matched analysis.

BACKGROUND: Robot-assisted gastrectomy (RG) has been shown to be safe and feasible in the treatment of gastric cancer (GC). However, it is unclear whether RG is equivalent to laparoscopic gastrectomy (LG), especially in the Western world. Our objective was to compare the outcomes of RG and LG in GC patients. METHODS: We reviewed all gastric adenocarcinoma patients who underwent curative gastrectomy by minimally invasive approach in our institution from 2009 to 2022. Propensity score matching (PSM) analysis was conducted to reduce selection bias. DaVinci Si platform was used for RG. RESULTS: A total of 156 patients were eligible for inclusion (48 RG and 108 LG). Total gastrectomy was performed in 21.3% and 25% of cases in LG and RG, respectively. The frequency of stage pTNM II/III was 48.1%, and 54.2% in the LG and RG groups (p = 0.488). After PSM, 48 patients were matched in each group. LG and RG had a similar number of dissected lymph nodes (p = 0.759), operative time (p = 0.421), and hospital stay (p = 0.353). Blood loss was lower in the RG group (p = 0.042). The major postoperative complications rate was 16.7% for LG and 6.2% for RG (p = 0.109). The 30-day mortality rate was 2.1% and 0% for LG and RG, respectively (p = 1.0). There was no significant difference between the LG and RG groups for disease-free survival (79.6% vs. 61.2%, respectively; p = 0.155) and overall survival (75.9% vs. 65.7%, respectively; p = 0.422). CONCLUSION: RG had similar surgical and long-term outcomes compared to LG, with less blood loss observed in RG.

Laparoscopic gastrectomy for early and advanced gastric cancer in a western center: a propensity score-matched analysis.

The employment of laparoscopic gastrectomy (LG) in the management of gastric cancer (GC) is increasing. Despite recent results from randomized trials, its effectiveness and oncological results in different scenarios remain controversial, especially in western centers. The aim of this study was to compare the short-term outcomes and survival of LG with open gastrectomy (OG) for GC. We reviewed all GC patients who underwent curative gastrectomy from a prospective database. Propensity score-matched (PSM) analysis including 10 variables was conducted to reduce patient selection bias using a 1:1 case-control match. A total of 530 GC were eligible for inclusion (438 OG and 92 LG). Older age, lower hemoglobin levels, total gastrectomy, larger tumor size, greater depth of tumor invasion and advanced pTNM stage was more frequent in the OG group. After PMS analysis, 92 patients were matched in each group. All variables assigned in the score were well matched. LG group had a slightly higher number of retrieved lymph nodes (42.3 vs 37.6), however, without reaching statistical significance (p = 0.072). No differences were recorded about the frequency of major postoperative complications (POC) and mortality rates between OG and LG groups (12% vs 15.2%, p = 0.519, respectively). In survival analysis, after matching, there was no difference in survival between the two groups. Multivariate analysis showed that only ASA and pN stage were independent factor associated with survival after PSM. In conclusion, laparoscopic gastrectomy was a safe and effective surgical technique for gastric cancer, with short-term and oncological outcomes comparable to open surgery.

Resultados tempranos en pacientes con cáncer gástrico sometidos a gastrectomía laparoscópica con intención curativa / Early results in gastric cancer patients undergoing laparoscopic gastrectomy with curative intent

Introducción. El manejo de pacientes con cáncer gástrico está determinado por el estadio preoperatorio y requiere de una estrategia multidisciplinaria. La cirugía radical, especialmente en pacientes con estadios tempranos, es potencialmente curativa. El abordaje por vía laparoscópica ofrece ventajas sobre la vía abierta, sin embargo, en nuestro medio no hay información en cuanto a resultados oncológicos y posoperatorios tempranos. Métodos. Estudio retrospectivo, descriptivo, de tipo transversal, en pacientes con cáncer gástrico llevados a gastrectomía laparoscópica con intención curativa, entre el 2014 y el 2019, en tres instituciones de la ciudad de Medellín. Se analizaron los datos demográficos, los resultados posoperatorios y oncológicos a corto plazo. Resultados. Se incluyeron 75 pacientes sometidos a gastrectomía laparoscópica. La mediana de edad fue de 64 años y el estadio más frecuente fue el III. La gastrectomía fue subtotal en 50 pacientes (66,7 %) y total en 25 pacientes (33,3 %). Se hizo disección linfática D2 en 73 pacientes (97,3 %) con una mediana en el recuento ganglionar de 27. La tasa de resección R0 fue de 97,3 %. La mediana de estancia hospitalaria fue de seis días. La tasa de complicaciones mayores fue del 20 % y la mortalidad a 90 días fue del 4 %. Discusión. La calidad oncológica de la gastrectomía laparoscópica fue adecuada y cumple con las recomendaciones de las guías internacionales. Si bien la morbilidad sigue siendo alta, tiene una tasa de sobrevida del 96 % a 90 días.

Introduction. The management of patients with gastric cancer is determined by the preoperative stage and requires a multidisciplinary strategy. Radical surgery, especially in patients with early stages, is potentially curative. The laparoscopic approach offers advantages over the open approach, however, in our setting there is no information regarding oncological and early postoperative results.Methods. Retrospective, descriptive, cross-sectional study in patients with gastric cancer who underwent laparoscopic gastrectomy with curative intent, between 2014 and 2019, in three institutions in the city of Medellín. Demographic data, postoperative and short-term oncological results were analyzed.Results. Seventy-five patients undergoing laparoscopic gastrectomy were included. The median age was 64 years and the most frequent stage was III. Gastrectomy was subtotal in 50 patients (66.7%) and total in 25 patients (33.3%). D2 lymphatic dissection was performed in 73 patients (97.3%) with a median lymph node count of 27. The R0 resection rate was 97.3%. The median hospital stay was six days. The major complication rate was 20% and the 90-day mortality was 4%.Discussion. The oncological quality of the laparoscopic gastrectomy was adequate and complies with the recommendations of international guidelines. Although morbidity remains high, it has a 96% survival rate at 90 days

Two-dimensional versus three-dimensional laparoscopic gastrectomy in surgical efficacy for gastric cancer: a systematic review and meta-analysis.

BACKGROUND: The surgical efficacy of three-dimensional (3D) and two-dimensional (2D) laparoscopic gastrectomy for gastric cancer remains controversial. A meta-analysis with all eligible studies was conducted to explore the surgical efficacy of 2D versus 3D laparoscopic gastrectomy for gastric cancer. METHODS: A systematic search was performed. The weighted mean difference (WMD) or odds risk (OR) of patients with 2D or 3D laparoscopic gastrectomy were used to calculate surgical efficacy of 3D and 2D laparoscopic gastrectomy for gastric cancer. RESULTS: Ten studies involving 1478 patients who underwent 2D or 3D laparoscopic gastrectomy were identified. Three-dimensional laparoscopic gastrectomy decreases operation time (WMD: - 16.517, 95% CI - 25.550 to - 7.484, P = 0.000), intraoperative blood loss (WMD: - 21.060, 95% CI - 32.209 to - 9.911, P = 0.000) and number of retrieved lymph nodes (WMD: 3.699, 95% CI 1.838-5.560, P = 0.000) compared with 2D laparoscopic surgery. However, no differences in time to first postoperative flatus (WMD: - 0.119, 95% CI - 0.330 to - 0.092, P = 0.269), perioperative complications (OR: 0.901, 95% CI 0.649-1.251, P = 0.534), or hospital stay (WMD: - 0.624, 95% CI - 1.983 to 0.735, P = 0.368) were noted between 3D and 2D laparoscopic gastrectomy for gastric cancer. CONCLUSION: 3D laparoscopic gastrectomy decreases the operation time, intraoperative blood loss, and numbers of retrieved lymph nodes compared with 2D laparoscopic gastrectomy for gastric cancer.

Minimally invasive gastrectomy for gastric cancer: A national perspective on oncologic outcomes and overall survival.

BACKGROUND: Minimally invasive (MI) gastrectomy has become increasingly common as a resection technique for gastric cancer; however, data are limited regarding peri-operative morbidity, oncologic outcomes and long-term survival, particularly in the Western patient population. STUDY DESIGN: The 2010-2012 National Cancer Data Base was queried for adult patients who underwent gastrectomy for localized, intestinal-type gastric adenocarcinoma. Patients were classified by surgical approach (MI vs. open gastrectomy) on an intent-to-treat basis. Groups were propensity score matched using a 1:1 nearest neighbor algorithm, and outcomes were compared. Survival was estimated using the Kaplan-Meier method. RESULTS: Among 5420 patients, 1423 (26%) underwent MI gastrectomy. Following adjustment with propensity matching, all baseline characteristics were highly similar between 1175 patients in each treatment group. Between propensity-matched groups, MI gastrectomy patients had similar rates of margin-negative resections (91 vs. 90%, p = 0.447), median lymph node harvest (16 vs. 15, p = 0.104), and utilization of adjuvant therapies (28 vs. 28%, p = 0.748). MI gastrectomy was associated with shorter hospital stay (8 vs. 9 days, p < 0.001) without an increase in unplanned readmissions (7 vs. 6%, p = 0.456) or 30-day mortality (2 vs. 3%, p = 0.655). There was no difference in 3-year overall survival (50 vs. 55%, p = 0.359). CONCLUSIONS: On a national level, MI gastrectomy for gastric cancer appears to be associated with similar perioperative and long-term outcomes compared to the traditional open approach. While prospective studies remain essential, these data provide greater equipoise for ongoing trials and institutional efforts to further implement and evaluate this technique.

Minimally invasive surgery for gastric cancer: time to change the paradigm / Cirurgia minimamente invasiva no câncer gástrico: tempo de mudar o paradigma

ABSTRACT Introduction: Minimally invasive surgery widely used to treat benign disorders of the digestive system, has become the focus of intense study in recent years in the field of surgical oncology. Since then, the experience with this kind of approach has grown, aiming to provide the same oncological outcomes and survival to conventional surgery. Regarding gastric cancer, surgery is still considered the only curative treatment, considering the extent of resection and lymphadenectomy performed. Conventional surgery remains the main modality performed worldwide. Notwithstanding, the role of the minimally invasive access is yet to be clarified. Objective: To evaluate and summarize the current status of minimally invasive resection of gastric cancer. Methods: A literature review was performed using Medline/PubMed, Cochrane Library and SciELO with the following headings: gastric cancer, minimally invasive surgery, robotic gastrectomy, laparoscopic gastrectomy, stomach cancer. The language used for the research was English. Results: 28 articles were considered, including randomized controlled trials, meta-analyzes, prospective and retrospective cohort studies. Conclusion: Minimally invasive gastrectomy may be considered as a technical option in the treatment of early gastric cancer. As for advanced cancer, recent studies have demonstrated the safety and feasibility of the laparoscopic approach. Robotic gastrectomy will probably improve outcomes obtained with laparoscopy. However, high cost is still a barrier to its use on a large scale.

RESUMO Introdução: A cirurgia minimamente invasiva amplamente usada para tratar doenças benignas do aparelho digestivo, tornou-se o foco de intenso estudo nos últimos anos no campo da oncologia cirúrgica. Desde então, a experiência com este tipo de abordagem tem crescido, com o objetivo de fornecer os mesmos resultados oncológicos e sobrevivência à cirurgia convencional. Em relação ao câncer gástrico, o tratamento cirúrgico ainda é considerado o único tratamento curativo, considerando a extensão da ressecção e linfadenectomia realizada. A gastrectomia convencional continua a ser a principal modalidade realizada em todo o mundo. Não obstante, o papel do acesso minimamente invasivo tem ainda de ser esclarecido. Objetivo: Avaliar e resumir o estado atual da ressecção minimamente invasiva do câncer gástrico. Método: Foi realizada revisão da literatura utilizando as bases Medline/PubMed, Cochrane Library e SciELO com os seguintes descritores: câncer gástrico, cirurgia minimamente invasiva, gastrectomia robótica, gastrectomia laparoscópica, neoplasia de estômago. A língua usada para a pesquisa foi o inglês. Resultados: Foram considerados para elaboração desta revisão 28 artigos, entre eles ensaios clínicos randomizados, metanálises, estudos coorte prospectivos e retrospectivos. Conclusão: A gastrectomia minimamente invasiva é opção técnica no tratamento do câncer gástrico precoce. Quanto ao câncer avançado, estudos recentes têm demonstrado a segurança e a viabilidade do acesso videolaparoscópico. A gastrectomia robótica provavelmente melhorará os resultados obtidos com a laparoscopia. Porém, o alto custo ainda é impedimento para sua utilização em larga escala.

Comparison of laparoscopic total gastrectomy and laparotomic total gastrectomy for gastric cancer / Comparação entre a gastrectomia total laparoscópica e a gastrectomia total laparotômica para o câncer gástrico

BACKGROUND: The use of laparoscopy for the treatment of gastric cancer suffered some resistance among surgeons around the world, gaining strength in the past decade. However, its oncological safety and technical feasibility remain controversial. AIM: To describe the results from the clinical and anatomopathological point of view in the comparative evaluation between the surgical videolaparoscopic and laparotomic treatments of total gastrectomy with linphadenectomy at D2, resection R0. METHOD: Retrospective analyses and comparison data from patients submitted to total gastrectomy with D2 linphadenectomy at a sole institution. The data of 111 patients showed that 64 (57,7%) have been submitted to laparotomic gastrectomy and 47 (42,3%) to gastrectomy entirely performed through videolaparoscopy. All variables related to the surgery, post-operative follow-up and anatomopathologic findings have been evaluated. RESULTS: Among the studied variables, videolaparoscopy has shown a shorter surgical time and a more premature period for the introduction of oral and enteral nourishment than the open surgery. As to the amount of dissected limph nodes, there has been a significant difference towards laparotomy with p=0,014, but the average dissected limph nodes in both groups exceed 25 nodes as recommended by the JAGC. Was not found a significant difference between the studied groups as to age, ASA, type of surgery, need for blood transfusion, stage of the disease, Bormann classification, degree of differentiation, damage of the margins, further complications and death. CONCLUSION: The total gastrectomy with D2 lymphadenectomy performed by laparoscopy presented the same benefits known of laparotomy and with the advantages already established of minimally invasive surgery. It was done with less surgical time, less time for re-introduction of the oral and enteral diets and lower hospitalization time compared to laparotomy, without increasing postoperative ...

RACIONAL: A utilização da videolaparoscopia para o tratamento das neoplasia gástricas sofreu certa resistência entre os cirurgiões ao redor do mundo, ganhando força na década passada. Porém, sua segurança oncológica e viabilidade técnica continuam controversas. OBJETIVO: Demonstrar os resultados do ponto de vista clínico e anatomopatológico na avaliação comparativa entre o tratamento cirúrgico videolaparoscópico e laparotômico da gastrectomia total com linfadenectomia a D2, ressecção R0. MÉTODOS: Estudo retrospectivo dos dados dos prontuários dos pacientes submetidos à gastrectomia total com lindadenectomia a D2, em uma única instituição. Dos 111 prontuários, 64 (57,7%) foram submetidos à gastrectomia laparotômica e 47 (42,3%) à gastrectomia totalmente vídeolaparoscópica. Foram avaliadas variáveis relacionadas ao ato cirúrgico, a evolução pós-operatória e a achados anatomopatológicos. RESULTADOS: A técnica videolaparoscópica demonstrou tempo cirúrgico menor e período para re-introdução alimentar oral e enteral mais precoce que a operação laparotômica. Quanto ao número de linfonodos dissecados, houve diferença significante a favor da laparotômica (p=0,014); porém, a média de linfonodos dissecados em ambos os grupos ultrapassou os 25 preconizados pela JAGC. Não foi encontrada diferença significante entre os grupos estudados no que diz respeito à idade, gênero, ASA, tipo de operação, necessidade de hemotransfusão, estadiamento, classificação de Bormann, grau de diferenciação, comprometimento de margens, complicações e óbito. CONCLUSÕES: A gastrectomia total com linfadenectomia a D2 realizada por videolaparoscopia apresenta os mesmos benefícios conhecidos da cirurgia laparotômica e com as vantagens já estabelecidas da cirurgia minimamente invasiva. Ela apresentou menor tempo cirúrgico, menor tempo para a re-introdução das dietas oral e enteral e tempo de alta menor em relação à laparotômica, sem aumentar as complicações pós-operatórias. .