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This study identifies the optimal combination of active and passive thermoplastic materials for producing multi-material programmable 3D structures. These structures can undergo shape changes with varying radii of curvature over time when exposed to hot water. The research focuses on examining the thermal, thermomechanical, and mechanical properties of active (PLA) and passive (PRO-PLA, ABS, and TPU) materials. It also includes the experimental determination of the radius of curvature of the programmed 3D structures. The pairing of active PLA with passive PRO-PLA was found to be the most effective for creating complex programmable 3D structures capable of two-sided transformation. This efficacy is attributed to the adequate apparent shear strength, significant differences in thermomechanical shrinkage between the two materials, identical printing parameters for both materials, and the lowest bending storage modulus of PRO-PLA among the passive materials within the activation temperature range. Multi-material 3D printing has also proven to be a suitable method for producing programmable 3D structures for practical applications such as phone stands, phone cases, door hangers, etc. It facilitates the programming of the active material and ensures the dimensional stability of the passive components of programmable 3D structures during thermal activation.
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The work reports the proposed development of the laminated carbon fiber-reinforced polymer composites (CFRP), at a uniaxial angle as a primary bend clamp material assembly of the offshore gas lift pipelines. Generally, the clamps are utilized to repair the defect of the metallic pipelines due to their practical and mechanical strength. The existing bend clamp model poses challenges especially when applied to the J-tube bending side due to mechanical buckling and corrosion. This study evaluates the effect of laminated CFRP subjected to uniform uniaxial and in-plane compression on API 5 L X52. Several tests, including tensile, bend, and impact tests, are chosen to assess the effect of multiple and thick carbon layers to improve the clamp's mechanical properties. Scanning electronic microscope (SEM) intends to reveal the surface characterization of carbon fiber clamp. The result shows that laminated carbon fiber increases the durability and mechanical properties of the bend clamp for two weeks. The tensile test result shows that the uniaxial orientation has the highest tensile strength of about 2000N and is affected by the strong interfacial bond between the fiber and metal layers. The high impact energy of 2242 ± 0.001 J of the same orientation shows the stability of the clamp under unprecedented dynamic load and enhances the safety. The SEM result at uniaxial shows the resistance towards fracture has increased and was initiated from the air pocket in the composite.
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INTRODUCTION: The pharmaceutical industry is gradually changing batch-wise manufacturing processes to continuous manufacturing processes, due to the advantages it has to offer. The final product quality and process efficiency of continuous manufacturing processes is among others impacted by the properties of the raw materials. Existing knowledge on the role of raw material properties in batch processing is however not directly transferable to continuous processes, due to the inherent differences between batch and continuous processes. AREAS COVERED: A review is performed to evaluate the role of excipient properties for different unit operations used in continuous manufacturing processes. Unit operations that will be discussed include feeding, blending, granulation, final blending, and compression. EXPERT OPINION: Although the potency of continuous manufacturing is widely recognized, full utilization still requires a number of challenges to be addressed effectively. An expert opinion will be provided that discusses those challenges and potential solutions to overcome those challenges. The provided overview can serve as a framework for the pharmaceutical industry to push ahead process optimization and formulation development for continuous manufacturing processes.
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Química Farmacêutica , Composição de Medicamentos , Indústria Farmacêutica , Excipientes , Pós , Comprimidos , Excipientes/química , Química Farmacêutica/métodos , Composição de Medicamentos/métodos , Humanos , Tecnologia Farmacêutica/métodos , Preparações Farmacêuticas/químicaRESUMO
The gold standard for diagnosing viruses such as the Hepatitis B Virus has remained largely unchanged, relying on conventional methods involving extraction, purification, and polymerase chain reaction (PCR). This approach is hindered by limited availability, as it is time-consuming and requires highly trained personnel. Moreover, it suffers from low recovery rates of the nucleic acid molecules for samples with low copy numbers. To address the challenges of complex instrumentation and low recovery rate of DNA, a drying process coupled with thermal treatment of whole blood is employed, resulting in the creation of a dried blood matrix characterized by a porous structure with a high surface-to-volume ratio where it also inactivates the amplification inhibitors present in whole blood. Drawing on insights from Brunauer-Emmett-Teller (BET)- Barrett-Joyner-Halenda (BJH) analysis, scanning electron microscopy (SEM), and fluorescence recovery after photobleaching (FRAP), detection assay is devised for HBV, as a demonstration, from whole blood with high recovery of DNA and simplified instrumentation achieving a limit of detection (LOD) of 10 IU mL-1. This assay can be completed in <1.5 h using a simple heater, can be applied to other DNA viruses, and is expected to be suitable for point-of-care, especially in low-resource settings.
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In recent years, attention to the realization and characterization of wetsuits for scuba diving and other sea sports or activities has increased. The research has aimed to establish reliable and standardized measurement methods to objectively assess wetsuit quality, particularly focusing on their mechanical and thermal properties. In this work, we describe and compare two different measurement methods for the characterization of neoprene wetsuit thermal resistivity. The first method follows the existing regulations in the field, while the second one, which we are originally proposing in this paper, offers an alternative yet accurate way based on a simplified experimental set-up and easier measurements. In both cases, the wetsuit sample under testing was shaped in the form of a cylindrical sleeve of proper dimensions and wrapped around a phantom containing water at a higher temperature and surrounded by water at a lower temperature. The wetsuit's cylindrical surface allows heat flow from the warmer water on the inside to the colder water on the outside through the wetsuit area. In the first case, a thermal steady state was achieved, with constant heat flow from the phantom to the exterior. This was obtained with a power balance between two homogenous quantities. Electrically supplied thermal heating within the phantom was used to balance the thermal energy naturally flowing through the wetsuit's surface. In this first case, a stable and fixed temperature difference was obtained between the inner and the outer surfaces of the wetsuit sample. In the second case, a thermal transient was analyzed during the cooling process of the phantom, and the thermal time constant was measured, providing the sample thermal resistance once the phantom thermal capacity was known. In both cases and methods, the heat flow and thermal resistance of other elements than the wetsuit must be evaluated and compensated for if they are not negligible. Finally, the thermal resistivity per unit area of the wetsuit material was obtained with the product of the wetsuit sample's thermal resistance and the wetsuit area. The measurements, conducted until now by immersing the phantom in a free surface tank, show that both methods-under stationary and under transient temperature conditions-were valid to assess the wetsuit's thermal resistivity. The stationary method somehow provided better accuracy while involving less well-known parameters but at the expense of a more complicated experimental set-up and additional energy consumption. The transitory method, on the other hand, is quite easy to implement and, after careful characterization of the phantom's parameters, it provided similar results to the stationary one. An uncertainty budget was evaluated for both methods, and they did provide highly compatible measurement results, with resistivity values of 0.104(9) m2·K/W (stationary method) and 0.095(9) K·m2/W (transient method) for the same wetsuit sample under testing, which is also consistent with the values in the literature. We finally propose that the novel method is a valid alternative for characterization of the thermal insulation properties of a scuba diving wetsuit.
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This work evaluates the electrical, optical and thermal properties of Sn-doped GexSi1-xOy thin films for use as microbolometer sensing materials. The films were prepared using a combination of a radio frequency (RF) magnetron and direct current (DC) sputtering using a Kurt J Leskar Proline PVD-75 series sputtering machine. Thin films were deposited in an O2+Ar environment at a chamber pressure of 4 mTorr. The thicknesses of the thin films were varied between 300 nm-1.2 µm by varying the deposition time. The morphology and microstructure of thin films were investigated by atomic force microscope (AFM) imaging and X-ray diffraction (XRD), while the atomic composition was determined using the energy dispersive spectroscopy (EDS) function of a scanning electron microscope. The thin film with an atomic composition of Ge0.45Si0.05Sn0.15O0.35 was found to be amorphous. We used the Arrhenius relationship to determine the activation energy as well as temperature coefficient of resistance of the thin films, which were found to be 0.2529 eV and -3.26%/K, respectively. The noise voltage power spectral density (PSD) of the film was analyzed using a Primarius-9812DX noise analyzer using frequencies ranging from 2 Hz to 10 kHz. The noise voltage PSD of the film was found to be 1.76 × 10-11 V2/Hz and 2.78 × 10-14 V2/Hz at 2 Hz and 1KHz frequencies, respectively. The optical constants were determined using the ellipsometry reflection data of samples using an RC2 and infrared (IR) VASE Mark-II ellipsometer from J A Woollam. Absorption, transmission and reflection data for a wavelength range of 900 nm-5000 nm were also determined. We also determined the optical constant values such as the real and imaginary parts of refractive index (n and k, respectively) and real and imaginary part of permittivity (ε1 and ε2, respectively) for wavelength ranges between 193 nm to 35 µm. An optical band gap of 1.03 eV was determined from absorption data and using Tauc's equation. In addition, the thermal conductivity of the film was analyzed using a Linseis thin film analyzer employing the 3ω method. The thermal conductivity of a 780 nm thick film was found to be 0.38 Wm-1K-1 at 300 K. From the data, the Ge-Si-Sn-O alloy was found to be a promising material for use as a sensing material for microbolometers.
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Considering that global awareness for sustainable development has risen to face environmental damages, different building materials have been considered from a mechanical perspective. In this sense, considering the richness of South America regarding its woods, the Guayacan and the Ecuadorian oak timbers have not been previously characterized. The present research has performed mechanical, thermal, and moisture content characterizations to acknowledge the benefits of considering these materials for the building industries. In this sense, Guayacan has been shown to have lower thermal conductivity, making it ideal for thermal insulation; the oak from Manabi showed the best compressive strength; while the oak from El Oro stands with the best tensile strength; and the oak from Loja showed the best modulus of elasticity. On the other hand, all the materials were compared by multicriteria decision methods to select the best, by using the COPRAS method driven by the objective entropy-weighted method, showing that the oak from Loja is the best choice considering the advantage that presents with the modulus of elasticity. In this sense, it is concluded that regarding the mechanical properties, there is not much difference for the compression, bending, and tensile strength; nevertheless, for the modulus of elasticity the oak from Loja stands out, making it a factor to be considered in the selection of a wood for building applications that is corroborated through multicriteria decision methods.
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The second harmonic generation (SHG) technique offers a quantitative damage parameter known as the acoustic nonlinearity parameter (ß) capable of detecting the change in the inherent material nonlinearity. However, current SHG methods, in particular, those used for measuring ß in construction materials, have an unresolved issue in their application due to limited sample sizes. The restricted sample dimensions lead to the generation of boundary-reflected waves, which hinder the selective detection of propagating waves and thus the precise evaluation of material nonlinearity through ß. Furthermore, the use of large samples limits the compatibility of the SHG method with other characterization modalities, such as mechanical tests, X-ray diffraction, and computerized tomography. To address this issue, this paper introduces a new SHG method that is based on the use of nonlinear standing waves - the dominant longitudinal standing waves in a forced-free configuration. The corrections for phase delay and attenuation effect of each reflected wave are made, enabling accurate measurements of ß in thin samples with no requirement in the thickness-wavelength ratio. The measured ß is then employed to quantify the microstructural modification in cement paste induced by thermal damage, validating the proposed method as a promising tool for quantifying microstructural changes in materials.
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Principal component analysis (PCA) and partial least squares regression (PLS) were combined in this study to identify key material descriptors determining tabletability in direct compression and roller compaction. An extensive material library including 119 material descriptors and tablet tensile strengths of 44 powders and roller compacted materials with varying drug loads was generated to systematically elucidate the impact of different material descriptors, raw API and filler properties as well as process route on tabletability. A PCA model was created which highlighted correlations between different powder descriptors and respective characterization methods and, thus, can enable reduction of analyses to save resources to a certain extent. Subsequently, PLS models were established to identify key material attributes for tabletability such as density and particle size but also surface energy, work of cohesion and wall friction, which were for the first time demonstrated by PLS as highly relevant for tabletability in roller compaction and direct compression. Further, PLS based on extensive material characterization enabled the prediction of tabletability of materials unknown to the model. Thus, this study highlighted how PCA and PLS are useful tools to elucidate the correlations between powder and tabletability, which will enable more robust prediction of manufacturability in formulation development.
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Pós , Análise de Componente Principal , Comprimidos , Resistência à Tração , Comprimidos/química , Análise dos Mínimos Quadrados , Pós/química , Excipientes/química , Tamanho da Partícula , Composição de Medicamentos/métodosRESUMO
Terahertz time-domain spectroscopy (THz-TDS) is an emerging optical technique that has potential applications in the characterization of (bio)materials. However, the complicated extraction of optical parameters from multi-layered and optically thin samples is a barrier towards its acceptance by applied scientists. Therefore, the aim of this work is to provide a straightforward approach for the extraction of the THz absorption coefficient and index of refraction profiles of aqueous thin films in a window-sample-window configuration, which is ubiquitous in many laboratories (i.e., sample in a cuvette). A numerical approach-based methodology that accounts for multiple layers, Fabry-Pérot effect, and sample thickness is elaborated which involves an optical interference model based on a tri-layer structure and a simple thickness estimation technique. This method was validated on water samples where a good agreement was found with the THz optical parameters of water reported in the literature, while the use of a commercial software resulted in erroneous optical parameters estimates when used without due regard to its limitations. A case study was then performed to demonstrate the ability of the proposed method to characterize agarose hydrogels with varying degree of sulfation. It was demonstrated that THz-TDS can provide insight into the hydration state of the agarose hydrogels, including the relative number of the hydrogen bonds between the hydroxyl moieties of water and the polysaccharide network which is perturbed by the presence of sulfate. The trend in the index of refraction profiles suggested microstructural differences between the agarose hydrogels, which were confirmed by visualizing the agarose network morphology using cryo-SEM imaging.
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Materials for heat sinks in automotive heat dissipation systems must demonstrate both high thermal conductivity and stress resistance during assembly. This research proposes a composite material, comprised of thermally conductive ceramic fillers and matrix resins, as a suitable option for such application. The strategy for designing this material interface is directed with Hansen solubility parameters (HSP). A composite material featuring a honeycomb-like structure made of poly(methyl methacrylate) (PMMA) and boron nitride (BN) particles was successfully fabricated through press molding. This yielded a continuous BN network exhibiting high thermal conductivity and moderate mechanical strength. The HSP evaluation led to the suggestion of introducing highly polar functional groups into the matrix resin to enhance the affinity between PMMA resin and BN fillers. In line with this recommendation, a nitrile (CN) groupâa highly polar groupâwas introduced to PMMA (CN-PMMA), significantly enhancing the composite's maximum bending stress without noticeably degrading other properties. Surface HSP evaluation through contact angle measurements revealed an "interface enrichment effect", with the CN groups concentrating at the resin-filler interface and effectively interacting with the surface functional groups on the BN particles, which resulted in an increase in the maximum bending stress. These findings emphasize the advantage of employing HSP methodologies in designing high-performance composite materials.
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The knowledge of the mechanical behavior of a 3D-printed material is fundamental for the 3D printing outbreaking technology to be considered for a range of applications. In this framework, the significance, reliability, and accuracy of the information obtained by testing material coupons assumes a pivotal role. The present work focuses on an evaluation of the static mechanical properties and failure modes of a 3D-printed short carbon fiber-reinforced polyamide in relation to the specimen's unique meso-structural morphology and water content. Within the manufacturing limitations of a commercially available printer, specimens of dedicated combinations of geometry and printing patterns were specifically conceived and tested. The specimens' meso-structure morphologies were investigated by micro-computed tomography. The material failure mechanisms were inferred from an analysis of the specimens' fracture surfaces and failure morphologies. The outcomes of the present analysis indicate that each test specimen retained proper mechanical properties, thereby suggesting that they should be accurately designed to deliver representative information of the underlying material beads or of their deposition layout. Suggestions on the adoption of preferred test specimens for evaluating specific material properties were proposed.
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PURPOSE: In this work, we define a signal detection based metrology to characterize the separability of two different multi-dimensional signals in spectral CT acquisitions. METHOD: Signal response was modelled as a random process with a deterministic signal and stochastic noise component. A linear Hotelling observer was used to estimate a scalar test statistic distribution that predicts the likelihood of an intensity value belonging to a signal. Two distributions were estimated for two materials of interest and used to derive two metrics separability: a separability index (s') and the area under the curve of the test statistic distributions. Experimental and simulated data of photon-counting CT scanners were used to evaluate each metric. Experimentally, vials of iodine and gadolinium (2, 4, 8 mg/mL) were scanned at multiple tube voltages, tube currents and energy thresholds. Additionally, a simulated dataset with low tube current (10-150 mAs) and material concentrations (0.25-4 mg/mL) was generated. RESULTS: Experimental data showed that conditions favorable for low noise and expression of k-edge signal produced the highest separability. Material concentration had the greatest impact on separability. The simulated data showed that under more difficult separation conditions, difference in material concentration still had the greatest impact on separability. CONCLUSION: The results demonstrate the utility of a task specific metrology to measure the overlap in signal between different materials in spectral CT. Using experimental and simulated data, the separability index was shown to describe the relationship between image formation factors and the signal responses of material.
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Tomografia Computadorizada por Raios X , Iodo , Razão Sinal-Ruído , Processamento de Imagem Assistida por Computador/métodos , Gadolínio/química , Imagens de FantasmasRESUMO
Efflux pumps are active transporters, which allow the cell to remove toxic substances from within the cell including antibiotics and photosensitizer complexes. Efflux pump inhibitors (EPIs), chemicals that prevent the passage of molecules through efflux pumps, play a crucial role in antimicrobial effectiveness against pathogen. In this work, we studied the effect of EPI, namely, reserpine, on photodeactivation rate of pathogens when used with Ag NPs and methylene blue (MB). Our results show that using reserpine led to a higher deactivation rate than Ag NPs and MB alone. The mechanism of this observation was investigated with singlet oxygen generation amount. Additionally, different sizes of Ag NPs were tested with reserpine. Molecular docking calculation shows that reserpine had higher affinity toward AcrB than MB. The improvement in bacterial deactivation rate is attributed to blockage of the AcrAB-TolC efflux pump preventing the removal of MB rather than enhanced singlet oxygen production. These results suggest that using reserpine with nanoparticles and photosynthesize is a promising approach in photodynamic therapy.
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Nanopartículas Metálicas , Azul de Metileno , Simulação de Acoplamento Molecular , Fotoquimioterapia , Fármacos Fotossensibilizantes , Reserpina , Prata , Oxigênio Singlete , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/farmacologia , Azul de Metileno/farmacologia , Prata/farmacologia , Prata/química , Reserpina/farmacologia , Nanopartículas Metálicas/química , Oxigênio Singlete/metabolismo , Escherichia coli/efeitos dos fármacosRESUMO
Scanning micrο X-ray fluorescence (µ-XRF) and multispectral imaging (MSI) were applied to study philately stamps, selected for their small size and intricate structures. The µ-XRF measurements were accomplished using the M6 Jetstream Bruker scanner under optimized conditions for spatial resolution, while the MSI measurements were performed employing the XpeCAM-X02 camera. The datasets were acquired asynchronously. Elemental distribution maps can be extracted from the µ-XRF dataset, while chemical distribution maps can be obtained from the analysis of the multispectral dataset. The objective of the present work is the fusion of the datasets from the two spectral imaging modalities. An algorithmic co-registration of the two datasets is applied as a first step, aiming to align the multispectral and µ-XRF images and to adapt to the pixel sizes, as small as a few tens of micrometers. The dataset fusion is accomplished by applying k-means clustering of the multispectral dataset, attributing a representative spectrum to each pixel, and defining the multispectral clusters. Subsequently, the µ-XRF dataset within a specific multispectral cluster is analyzed by evaluating the mean XRF spectrum and performing k-means sub-clustering of the µ-XRF dataset, allowing the differentiation of areas with variable elemental composition within the multispectral cluster. The data fusion approach proves its validity and strength in the context of philately stamps. We demonstrate that the fusion of two spectral imaging modalities enhances their analytical capabilities significantly. The spectral analysis of pixels within clusters can provide more information than analyzing the same pixels as part of the entire dataset.
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Research on biomaterials typically starts with cytocompatibility evaluation, using the ISO 10993-5 standard as a reference that relies on extract tests to determine whether the material is safe (cell metabolic activity should exceed 70 %). However, the generalized approach within the standard may not accurately reflect the material's behavior in direct contact with cells, raising concerns about its effectiveness. Calcium phosphates (CaPs) are a group of materials that, despite being highly biocompatible and promoting bone formation, still exhibit inconsistencies in basic cytotoxicity evaluations. Hence, in order to test the cytocompatibility dependence on different experimental setups and material-cell interactions, we used amorphous calcium phosphate, α-tricalcium phosphate, hydroxyapatite, and octacalcium phosphate (0.1 mg/mL to 5 mg/mL) with core cell lines of bone microenvironment: mesenchymal stem cells, osteoblast-like and endothelial cells. All materials have been characterized for their physicochemical properties before and after cellular contact and once in vitro assays were finalized, groups identified as 'cytotoxic' were further analyzed using a modified Annexin V apoptosis assay to accurately determine cell death. The obtained results showed that indirect contact following ISO standards had no sensitivity of tested cells to the materials, but direct contact tests at physiological concentrations revealed decreased metabolic activity and viability. In summary, our findings offer valuable guidelines for handling biomaterials, especially in powder form, to better evaluate their biological properties and avoid false negatives commonly associated with the traditional standard approach.
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Materiais Biocompatíveis , Fosfatos de Cálcio , Durapatita , Teste de Materiais , Células-Tronco Mesenquimais , Osteoblastos , Fosfatos de Cálcio/química , Materiais Biocompatíveis/toxicidade , Materiais Biocompatíveis/farmacologia , Humanos , Teste de Materiais/métodos , Teste de Materiais/normas , Células-Tronco Mesenquimais/efeitos dos fármacos , Osteoblastos/efeitos dos fármacos , Osteoblastos/metabolismo , Sobrevivência Celular/efeitos dos fármacos , Apoptose/efeitos dos fármacos , Linhagem Celular , Células Endoteliais/efeitos dos fármacos , Células Endoteliais/metabolismo , AnimaisRESUMO
Film-coated tablets as solid oral dosage forms are a well-accepted way of administering drugs but are not without specific challenges during manufacturing. One relevant criterion of the final product is the visual integrity and therewith, the absence of cosmetic optical defects such as edge chipping. The aim of the present study was to examine the origin of those edge chipping defects, which were observed during commercial manufacturing of film-coated tablets, and to provide recommendations for process optimization to reduce the defect occurrence. The unraveling of the herein described phenomenon necessitated an interplay of in-depth material characterization, discrete element modeling (DEM) as well as an in-house developed optical measurement system for the automated quantification of tablet defects. As a result of this investigation, the automatic unloading step after the tablet coating process was identified as the most critical step for the occurrence of chipping defects and a replacement by manual unloading was proposed to reduce the defect propensity. The recommended optimization was subsequently confirmed in several manufacturing runs and a reduction of defect propensity by a factor of 5 was observed, highlighting the relevance and the impact of the performed thorough investigation.
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Indústrias , Comprimidos , Composição de MedicamentosRESUMO
This paper proposes a novel engineering approach to control molten metals at high temperatures considering the industrial environment of such materials. To reduce analysis time and cost, in-line analysis techniques are more advantageous as they provide real-time information about melt composition. For this reason, recent research works focus on the development of new devices based on LIBS (Laser Induced Breakdown Spectroscopy). These devices allowed for analyzing impurities inside molten metals with great performance. However, improvements related to the immersion probe conception are still required. Indeed, the previous design used bubbling inside the melt, leading to spatial instabilities of the surface analyzed by LIBS. The solution presented here is mechanical stirring by innovative rotary blades which will be a part of an immersion LIBS probe. Their rotation will generate a representative, renewed, and stable surface that will be targeted by spectroscopic techniques in general and particularly by LIBS laser for molten metal monitoring at high temperatures. This solution was validated using experimental tests based on particle imaging velocimetry (PIV) in water at room temperature and then applied to silicon melt at high temperatures. To do so, it was necessary to design a system that allows the introduction of the blade in the melt and controls its rotation.
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Osteoderms (ODs) are mineralized tissue embedded within the skin and are particularly common in reptiles. They are generally thought to form a protective layer between the soft tissues of the animal and potential external threats, although other functions have been proposed. The aim of this study was to characterize OD variation across the lizard body. Adults of three lizard species were chosen for this study. After whole body CT scanning of each lizard, single ODs were extracted from 10 different anatomical regions, CT scanned, and characterized using sectioning and nanoindentation. Morphological analysis and material characterization revealed considerable diversity in OD structure across the species investigated. The scincid Tiliqua gigas was the only studied species in which ODs had a similar external morphology across the head and body. Greater osteoderm diversity was found in the gerrhosaurid Broadleysaurus major and the scincid Tribolonotus novaeguineae. Dense capping tissue, like that reported for Heloderma, was found in only one of the three species examined, B. major. Osteoderm structure can be surprisingly complex and variable, both among related taxa, and across the body of individual animals. This raises many questions about OD function but also about the genetic and developmental factors controlling OD shape.
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This study critically reviews the key aspects of nanoparticles and their impact on molten salts (MSs) for thermal energy storage (TES) in concentrated solar power (CSP). It then conducts a comprehensive analysis of MS nanofluids, focusing on identifying the best combinations of salts and nanoparticles to increase the specific heat capacity (SHC) efficiently. Various methods and approaches for the synthesis of these nanofluids are explained. The article presents different experimental techniques used to characterize nanofluids, including measuring the SHC and thermal conductivity and analyzing particle dispersion. It also discusses the challenges associated with characterizing these nanofluids. The study aims to investigate the underlying mechanisms behind the observed increase in SHC in MS nanofluids. Finally, it summarizes potential areas for future research, highlighting crucial domains for further investigation and advancement.