Extraction of Bioactive Compounds from the Fruits of Jambolan (Syzygium cumini (L.)) Using Alternative Solvents.

This work demonstrates the effectiveness of using alternative solvents to obtain jambolan extracts with a high content of bioactive compounds compared to conventional organic solvents, being the first study to evaluate the best ecological solvent alternative for Syzygium cumini (L.) Skeels. Five alternative solvents were used for extraction: water at 25 °C (W25), water at 50 °C (W50), water at 75 °C (W75), water with citric acid at 2.4% (CA2), and water with citric acid at 9.6% (CA9) in comparison with three conventional solvents: ethanol (EtOH), water with ethanol at 50% (WE), and water with methanol at 50% (WM). A protocol was then established for the extraction and concentration of samples obtained with these solvents. The highest content of total phenolic compounds (TPCs) in the extracts was obtained with the solvent W75 (1347.27 mg GAE/100 g), while in the concentrates it was the solvents EtOH (3823.03 mg GAE/100 g) and WM (4019.39 mg GAE/100 g). Total monomeric anthocyanins (TMAs) increased by 209.31% and 179.95% in extractions with CA2 and CA9, respectively, compared to pulp (35.57 mg eq c-3-g/100 g), demonstrating that they are the most efficient alternative solvents in this extraction. The levels of bioactive compounds and antioxidant activity varied according to the solvents used. Delphinidin 3,5-diglucoside, cyanidin 3,5-diglucoside, delphinidin 3-glucoside, petunidin 3,5-diglucoside, cyanidin 3-glucoside, peonidin 3,5-diglucoside, malvidin 3,5-diglucoside, petunidin 3-glucoside, and malvidin 3-glucoside were identified in most of the samples by UPLC-MS/MS. This study suggests that a simple procedure using alternative solvents can be used as an environmentally friendly strategy to achieve efficient extraction of bioactive compounds in jambolan.

Encrucijadas de la virtualidad. Niñeces y adolescencias en tiempos de incertidumbre y violencias / Crossroads of virtuality. children and adolescences in times of uncertainties and violence / Carrefour de la virtualité. les enfants et les adolescents en temps d'incertitudes et de violence / Encruzilhadas da virtualidade. infância e adolescência em tempos de incertezas e violências

Entre otros efectos, la pandemia produjo en niños y adolescentes un uso casi abusivo de las pantallas, como modo de conectarse con el mundo. Y mientras algunos las utilizaron para sostener redes afectivas, otros se encerraron en ellas y se aislaron del mundo, resultándoles después muy difícil el regreso. Estamos viendo ahora los efectos de esos tiempos de apego a la virtualidad y de ausencia de contacto con pares, tanto en la primera infancia, como en la edad escolar y en la adolescencia. Así, nos encontramos con un recrudecimiento de un modo de ubicarse por parte de los adultos frente a niñas, niños y adolescentes en el que no se toma en cuenta la lógica infantil, no se los escucha y no se toma en cuenta su sufrimiento. Esto lleva a que se supongan pandemias de TEA (Trastorno de Espectro Autista) y de TDAH (Trastorno por déficit de atención con hiperactividad).Los profesionales psi tenemos una enorme responsabilidad en esta época. Somos artífices de futuro. Es decir, podemos cambiar destinos de niñas, niños y adolescentes si entendemos que trabajar con ellos, en el ámbito que fuera, supone un posicionamiento que implica una representación del otro como ser humano, como sujeto merecedor de intercambios simbólicos AU

Among other effects, the pandemic led children and adolescents to an almost abusive use of screens as a way to connect with the world. While some used them to maintain affective relationships, others closed themselves off and isolated from the world, making it very difficult for them to return to in-person relationships afterward. We are now witnessing the effects of those times of attachment to virtuality and lack of contact with peers, both in early childhood, school-age and adolescence. Thus, we find an upsurge of a way for adults to position themselves in relation to children and adolescents, where the child's logic is not considered, they are not heard, and their psychological suffering is not taken into account. This leads to the assumption of pandemics of ASD (Autism Spectrum Disorder) and ADHD (Attention Deficit Hyperactivity Disorder). Psychologists have a huge responsibility in this era. We are architects of the future. That is, we can change the destinies of children and adolescents if we understand that working with them in any context involves a positioning that implies a representation of the other as a human being, as a subject deserving of symbolic exchanges AU

Entre autres effets, la pandémie a produit une utilisation presque abusive des écrans chez les enfants et les adolescents, comme moyen de se connecter avec le monde. Et tandis que certains les utilisaient pour entretenir des réseaux émotionnels, d'autres s'enfermaient et s'isolaient du monde, ce qui rendait très difficile leur retour ultérieur. Nous constatons aujourd'hui les effets de ces périodes d'attachement à la virtualité et d'absence de contact avec les pairs, tant dans la petite enfance qu'à l'âge scolaire et à l'adolescence.Ainsi, on constate une aggravation d'une manière de positionner les adultes envers les filles, les garçons et les adolescents dans laquelle la logique des enfants n'est pas prise en compte, ils ne sont pas écoutés et leurs souffrances ne sont pas prises encompte. Cela conduit à de supposées pandémies de TSA (trouble du spectre autistique) et de TDAH (trouble du déficit de l'attention avec hyperactivité). Nous, les professionnels du psi, avons une énorme responsabilité en cette période. Nous sommes les architectes du futur. Autrement dit, nous pouvons changer le destin des filles, des garçons et des adolescents si nous comprenons que travailler avec eux, quel que soit le domaine, implique un positionnement qui implique une représentation de l'autre comme être humain, comme sujet digne d'échanges symboliques AU

Entre outros efeitos, a pandemia levou crianças e adolescentes a um uso quase abusivo das telas como forma de se conectar com o mundo. Enquanto alguns as utilizavam para manter redes afetivas, outros se fecharam nelas e se isolaram do mundo, tornando difícil o retorno a relações presenciais. Estamos agora testemunhando os efeitos desses tempos de apego à virtualidade e falta de contato com os pares, tanto na primeira infância quanto na idade escolar e na adolescência. Assim, nos deparamos com o recrudescimento de uma forma de posicionamento por parte dos adultos em relação a crianças e adolescentes, em que a lógica infantil não é considerada, eles não são ouvidos, e seu sofrimento psicológico não é levado em conta. Issoleva à suposição de pandemias de Transtorno do Espectro Autista (TEA) e Transtorno do Déficit de Atenção/Hiperatividade (TDAH).Os profissionais da psicologia têm uma enorme responsabilidade nesta época. Somos arquitetos do futuro. Ou seja, podemos mudar os destinos das crianças e adolescentes se compreendermos que trabalhar com e qualquer contexto envolve um posicionamento que implica uma representação do outro como ser humano, como sujeito merecedor de trocas simbólicas AU

Fish Protein Hydrolysates: Bioactive Properties, Encapsulation and New Technologies for Enhancing Peptides Bioavailability.

Fish protein hydrolysates (FPHs) can be obtained from substrates such as fish muscle, skin, and wastes and assign value to these fish by-products. Proteolytic enzymes catalyze the hydrolysis of these fish substrates' peptide bonds resulting in smaller peptides that present several bioactive properties. Hydrolysates' bioactive properties are a function of the fish species used as the substrate, the enzyme selectivity or specificity, pH and temperature applied in the reaction, etc. Furthermore, many pre-treatment methods are being applied to fish protein substrates to improve their enzyme susceptibility and increase the number of smaller bioactive peptides. This review addresses the production of FPHs and the main bioactive properties evaluated recently in the literature and emphasizes the substrate treatments by high-pressure processing, microwave, ultrasound, and thermal treatments to achieve better bioactivity making essential amino acids more available in peptides. The bioactive properties most found in FPHs were antioxidants, antimicrobials, anticancer, and antihypertensive. These bioactivities may vary depending on the conditions of hydrolysis, fish species, and fractionation and isolation of specific peptides.New technologies for the treatment of by-products can reduce process losses and achieve better results by cleavage of proteins. Conversely, encapsulation and film utilization can improve bioactivity, bioavailability, and controlled release when applied to foods, resulting in improved health.

Telesupervision in Psychotherapy: A Bibliometric and Systematic Review.

(1) Background: This systematic review supported by a bibliometric analysis identified quantitative and qualitative empirical studies that allowed us to respond to the objective of identifying and discussing the scope and limitations of the clinical-psychotherapeutic supervision in virtual modality or telesupervision. (2) Methods: The articles were selected according to the Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and the eligibility criteria proposed by the PICOS strategy (population, interventions, comparators, outcomes, and study design) based on 396 records of scientifically identified articles in the Journal Citation Report databases of the Web of Science. (3) Results: The literature review stages allowed the selection of three articles, which were added three others that were already included in a previous review, to enrich the analysis and discussion. The results of the present review highlighted aspects of nonverbal communication, alliance, comfort, preference, trust, and construction of professional identity, among others, both considering only the telesupervision format and comparing it with traditional face-to-face supervision. (4) Conclusions: The contributions that these results are providing to the understanding of the scope and limitations of the practice of telesupervision are discussed, also considering its interference in the construction of the professional identity of supervisors and supervisees.

Desafios atuais e futuros do uso da medicina de precisão no acesso ao diagnóstico e tratamento de câncer no Brasil / Current and future challenges of the use of precision medicine in cancer diagnosis and treatment in Brazil / Desafíos actuales y futuros del uso de la medicina de precisión en el acceso al diagnóstico y tratamiento del cáncer en Brasil

Este artigo busca refletir, cultural e eticamente, sobre os desafios atuais e futuros da incorporação de novas biotecnologias de diagnóstico e tratamento de câncer no Brasil, bem como seu impacto no acesso e no controle do câncer no país. Para tanto, esta pesquisa parte da problematização da literatura sobre o tema e dos resultados de um estudo, que realizou uma websurvey com especialistas médicos dos setores público e privado brasileiros, associados às dez sociedades oncológicas mais representativas do país, atuantes nas áreas da clínica, cirurgia, radioterapia, patologia e diagnóstico. A discussão do estudo desenvolve-se em torno de três eixos temáticos: conhecimento e expectativas sobre o advento das novas tecnologias para o diagnóstico e tratamento do câncer; considerações estruturais e éticas envolvidas no uso atual e futuro das novas tecnologias; e possíveis cenários associados ao uso e aplicação das novas tecnologias para o diagnóstico e tratamento do câncer. Foram suscitadas algumas questões: novos paradigmas tecnológicos beneficiarão todos os usuários do Sistema Único de Saúde (SUS) ou serão privilégios de poucos? Diminuirão as discrepâncias em termos de oferta de distribuição de serviços, de recursos tecnológicos e de acesso ao diagnóstico e tratamento do câncer? Como diversos segmentos da sociedade poderão participar e influir nesse processo? Que tipos de cenários poderão ainda compor esse quadro? Visando contribuir com o planejamento da atenção ao câncer no Brasil, o artigo finaliza propondo o desenvolvimento de futuras ações a partir de cinco dimensões estratégicas: dimensão econômica; dimensão científica, de inovação e tecnológica; dimensão estrutural; dimensão cultural; e dimensão reguladora.

This study seeks to culturally and ethically reflect on the current and future challenges of incorporating new biotechnologies to diagnose and treat cancer in Brazil and assess their impact on cancer control. To this end, this study begins by problematizing the literature on the subject and the results of a study that conducted a web survey with medical specialists from the Brazilian public and private sectors; the latter associated with the ten most representative cancer societies in the country, working in clinical practice, surgery, radiotherapy, pathology, and diagnosis. We discussed this study around three thematic axes: knowledge and expectations on the advent of new technologies to diagnose and treat cancer; structural and ethical considerations in the current and future use of new technologies; and possible scenarios associated with the use and application of new technologies to diagnose and treat cancer. We have raised some questions: will new technological paradigms benefit all Brazilian Unified National Health System (SUS) users, or will they be the privileges of the few? Will they reduce discrepancies regarding the distribution of technological services and resources and cancer diagnosis and treatment? How can different segments of society participate and influence this process? What scenarios can still compose this picture? Aiming to contribute to planning the future of cancer care in Brazil, this study proposes the development of future actions from five strategic dimensions: economy; science, innovation and technology; structure; culture; and regulation.

Este artículo busca reflexionar, cultural y éticamente, sobre los desafíos actuales y futuros de la incorporación de nuevas biotecnologías para el diagnóstico y tratamiento del cáncer en Brasil, así como su impacto en el acceso y control del cáncer en el país. Para ello, parte de la problematización de la literatura sobre el tema y de los resultados de un estudio que realizó una encuesta web con médicos especialistas de los sectores público y privado brasileños asociados a las diez sociedades oncológicas más representativas del país y actuantes en las áreas de clínica, cirugía, radioterapia, patología y diagnóstico. La discusión del estudio se desarrolla en torno a tres ejes temáticos: conocimiento y expectativas sobre el advenimiento de las nuevas tecnologías para el diagnóstico y tratamiento del cáncer; consideraciones estructurales y éticas involucradas en el uso actual y futuro de las nuevas tecnologías; posibles escenarios asociados al uso y aplicación de nuevas tecnologías para el diagnóstico y tratamiento del cáncer. Se han suscitado algunas cuestiones: ¿Los nuevos paradigmas tecnológicos beneficiarán a todos los usuarios del Sistema Único de Salud (SUS) o serán privilegios de unos pocos? ¿Reducirán las discrepancias en la oferta de distribución de servicios y recursos tecnológicos y en el acceso al diagnóstico y tratamiento del cáncer? ¿Cómo los diferentes segmentos de la sociedad podrán participar e influir en este proceso? ¿Qué clase de escenarios todavía podrán componer esta imagen? Con el objetivo de contribuir a la planificación futura de la atención del cáncer en Brasil, el artículo concluye con una propuesta para el desarrollo de acciones futuras desde cinco dimensiones estratégicas: económica; científica, de innovación y tecnología; estructural; cultural; y reguladora.

Exergames como conteúdo estratégico na educação física escolar / Exergames as strategic content in school physical education

O objetivo do trabalho foi analisar a influência da utilização dos exergames como parte integrante no conteúdo da Educação Física Escolar na coordenação motora dos estudantes. Três grupos experimentais (GE) participaram das 18 intervenções com exergames, jogos em quadra, ou aulas alternadas, respectivamente, enquanto o grupo controle (GC) seguiu com as aulas regulares de Educação Física. Testes de coordenação motora foram aplicados antes e após as intervenções. Os dados foram analisados através de medidas de tendências centrais, com comparações entre grupos (Kruskal-Wallis) e, para cada grupo, comparações entre momentos (Wilcoxon para amostras pareadas) e cálculo do tamanho do efeito. Não houve diferença significativa entre GC e GE, mas houve grande efeito para todos os grupos experimentais, principalmente no de exergames, em quase todas as habilidades. O uso dos exergames no contexto escolar pode promover uma ampliação do repertório motor da criança e o aperfeiçoamento de algumas habilidades de maneira lúdica, o que geralmente não ocorre em aulas de educação física sem organização do conteúdo.

The aim of this study was to analyze the influence of the use of exergames as part of scholar physical education on the student's motor coordination. Three experimental groups (GE) took part in 18 intervention classes either with exergames only, general games in the court only, or alternating exergames and games in the court, while the control group (GC) kept attending the regular physical education classes. Motor coordination tests were conducted before and after the period of the interventions. Data were analyzed by means of central trend measures, with comparisons between groups (Kruskal-Wallis) and, for each group, between moments (pair-wise Wilcoxon) and effect size. No difference was found between GC and GE, but the intervention led to large effects in the three experimental groups, mainly in the exergames group, in which the effect was large in almost all skills assessed. The use of exergames in a school context can promote an expansion of the child's motor repertoire and the improvement of some skills in a playful way, what usually does not occur in physical education classes without content organization.

Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Consensus on genetically modified cells. VII. Present and future of technologies for production of CAR cell therapies.

Chimeric Antigen Receptor T (CAR-T) cells are certainly an important therapy for patients with relapsed and/or refractory hematologic malignancies. Currently, there are five CAR-T cell products approved by the FDA but several research groups and/or biopharmaceutical companies are encouraged to develop new products based on CAR cells using T or other cell types. Production of CAR cells requires intensive work from the basic, pre-clinical to translational levels, aiming to overcome technical difficulties and failure in the production. At least five key common steps are needed for the manipulation of T-lymphocytes (or other cells), such as: cell type selection, activation, gene delivery, cell expansion and final product formulation. However, reproducible manufacturing of high-quality clinical-grade CAR cell products is still required to apply this technology to a greater number of patients. This chapter will discuss the present and future development of new CAR designs that are safer and more effective to improve this therapy, achieving more selective killing of malignant cells and less toxicity to be applied in the clinical setting.

Pneumococcal Vaccines: Past Findings, Present Work, and Future Strategies.

The importance of Streptococcus pneumoniae has been well established. These bacteria can colonize infants and adults without symptoms, but in some cases can spread, invade other tissues and cause disease with high morbidity and mortality. The development of pneumococcal conjugate vaccines (PCV) caused an enormous impact in invasive pneumococcal disease and protected unvaccinated people by herd effect. However, serotype replacement is a well-known phenomenon that has occurred after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) and has also been reported for other PCVs. Therefore, it is possible that serotype replacement will continue to occur even with higher valence formulations, but the development of serotype-independent vaccines might overcome this problem. Alternative vaccines are under development in order to improve cost effectiveness, either using proteins or the pneumococcal whole cell. These approaches can be used as a stand-alone strategy or together with polysaccharide vaccines. Looking ahead, the next generation of pneumococcal vaccines can be impacted by the new technologies recently approved for human use, such as mRNA vaccines and viral vectors. In this paper, we will review the advantages and disadvantages of the addition of new polysaccharides in the current PCVs, mainly for low- and middle-income countries, and we will also address future perspectives.

THE FUTURE OF TECHNOLOGY AND ROBOTICS IN SURGERY.

In the past three decades, several technologies designed for other purposes, have been applied in surgery to provide more precision to the surgical procedures and better outcomes. In surgery, innovation requires evidence before widespread implementation of novelties and a continuous quality improvement process to assess benefits and risks. Robotics in surgery has been widely implemented, but in some cases, there are many doubts regarding its clinical benefit and cost utility. The future of surgery lies in the fulfillment of four main conditions: safety, access, efficiency, and efficacy. Innovation and technology should help to accomplish these conditions, but it must not be the center of surgical practice. We present here our perspective on the main issues related to technology and robotics focusing on evidence-based surgery.

Hospital Investment Decisions in Healthcare 4.0 Technologies: Scoping Review and Framework for Exploring Challenges, Trends, and Research Directions.

BACKGROUND: Alternative approaches to analyzing and evaluating health care investments in state-of-the-art technologies are being increasingly discussed in the literature, especially with the advent of Healthcare 4.0 (H4.0) technologies or eHealth. Such investments generally involve computer hardware and software that deal with the storage, retrieval, sharing, and use of health care information, data, and knowledge for communication and decision-making. Besides, the use of these technologies significantly increases when addressed in bundles. However, a structured and holistic approach to analyzing investments in H4.0 technologies is not available in the literature. OBJECTIVE: This study aims to analyze previous research related to the evaluation of H4.0 technologies in hospitals and characterize the most common investment approaches used. We propose a framework that organizes the research associated with hospitals' H4.0 technology investment decisions and suggest five main research directions on the topic. METHODS: To achieve our goal, we followed the standard procedure for scoping reviews. We performed a search in the Crossref, PubMed, Scopus, and Web of Science databases with the keywords investment, health, industry 4.0, investment, health technology assessment, healthcare 4.0, and smart in the title, abstract, and keywords of research papers. We retrieved 5701 publications from all the databases. After removing papers published before 2011 as well as duplicates and performing further screening, we were left with 244 articles, from which 33 were selected after in-depth analysis to compose the final publication portfolio. RESULTS: Our findings show the multidisciplinary nature of the research related to evaluating hospital investments in H4.0 technologies. We found that the most common investment approaches focused on cost analysis, single technology, and single decision-maker involvement, which dominate bundle analysis, H4.0 technology value considerations, and multiple decision-maker involvement. CONCLUSIONS: Some of our findings were unexpected, given the interrelated nature of H4.0 technologies and their multidimensional impact. Owing to the absence of a more holistic approach to H4.0 technology investment decisions, we identified five promising research directions for the topic: development of economic valuation methodologies tailored for H4.0 technologies; accounting for technology interrelations in the form of bundles; accounting for uncertainties in the process of evaluating such technologies; integration of administrative, medical, and patient perspectives into the evaluation process; and balancing and handling complexity in the decision-making process.

Safe Introduction of New Technologies and Techniques in Minimally Invasive Colorectal Surgery.

In the past 20 years, colorectal surgery has experienced important advances as a result of new technologies that have increasingly transformed conventional open surgery into maximal usage of minimally invasive approaches. While many tools are being developed to change the way that operations are being performed, quality must not suffer. We describe here some of the aspects to pursue to achieve optimal and safe outcomes while utilizing minimally invasive techniques such as robotic surgery, transanal total mesorectal excision, as well as the role of immunofluorescence.

Pneumococcal vaccines: past findings, present work, and future strategies

The importance of Streptococcus pneumoniae has been well established. These bacteria can colonize infants and adults without symptoms, but in some cases can spread, invade other tissues and cause disease with high morbidity and mortality. The development of pneumococcal conjugate vaccines (PCV) caused an enormous impact in invasive pneumococcal disease and protected unvaccinated people by herd effect. However, serotype replacement is a well-known phenomenon that has occurred after the introduction of the 7-valent pneumococcal conjugate vaccine (PCV7) and has also been reported for other PCVs. Therefore, it is possible that serotype replacement will continue to occur even with higher valence formulations, but the development of serotype-independent vaccines might overcome this problem. Alternative vaccines are under development in order to improve cost effectiveness, either using proteins or the pneumococcal whole cell. These approaches can be used as a stand-alone strategy or together with polysaccharide vaccines. Looking ahead, the next generation of pneumococcal vaccines can be impacted by the new technologies recently approved for human use, such as mRNA vaccines and viral vectors. In this paper, we will review the advantages and disadvantages of the addition of new polysaccharides in the current PCVs, mainly for low- and middle-income countries, and we will also address future perspectives.

Fundamentos teóricos para un estudio sobre la ludopatía / Theoretical foundations for a study on compulsive gambling

RESUMEN El presente texto hace referencia al uso de las nuevas tecnologías entre los adolescentes y jóvenes y al modo en que a nivel mundial llega a convertirse en una conducta adictiva, debido a su empleo inadecuado en esta población. Su objetivo está dirigido a fundamentar los elementos epistemológicos sobre la ludopatía para su atención. Se incursiona en cuestiones inherentes a las adicciones, la drogadicción y en particular sobre la ludopatía y sus consecuencias en los sujetos comprendidos entre las edades mencionadas. Este artículo constituye una salida del proyecto de investigación Sistema de estrategias educativas para la prevención de conductas adictivas en los adolescentes del área de salud Tula Aguilera, el cual gestiona el Centro para el Desarrollo de las Ciencias Sociales y Humanísticas en Salud, de la Universidad de Ciencias Médicas de Camagüey. El tipo de estudio es de carácter Investigación Desarrollo y se ejecutó en el período comprendido entre enero de 2017 y febrero de 2020.

ABSTRACT The present text makes reference to the use of the new technologies among the adolescents and young and to the way in that its inadequate employment at world level in the people, ends up becoming an addictive behavior. Their objective is directed to base the elements epistemológicos of the treatment of the ludopatía, from the school activity. This article constitutes an exit of the project of investigation System of educational strategies for the prevention of addictive behaviors in the adolescents of the area of health Tula Aerie, which negotiates the Center for the Development of the Social and Humanistic Sciences in Health, of the University of Medical Sciences of Camagüey. The study type is of character Investigation Development and it was executed in the period understood between January of 2017 and February of 2020.

Novas perspectivas para reabilitação de dentes tratados endodonticamente / Novel perspectives for the rehabilitation of endodontically treated teeth

Vários fatores podem influenciar o desempenho clínico de dentes com tratamento endodôntico (DTE). Além disso diversas são as opções restauradoras indicadas em respeito a este cenário, em especial com o notório avanço de novas técnicas e tecnologias para uso clínico. Dentre estas corriqueiramente envolvem-se o uso de restaurações diretas (confeccionadas com resina composta), pinos metálicos ou de fibra de vidro, pinos pré-fabricados ou fresados, assim como restaurações indiretas compostas de coroas cerâmicas, inlays, onlays ou endocrowns; sempre com o foco na reabilitação funcional e estética do caso em tela. Neste trabalho, através de uma revisão narrativa, foram expostos conceitos relativos às modalidades restauradores que se advêm do uso de novas tecnologias na reabilitação de dentes tratados endodonticamente(AU)

Several factors may influence the clinical performance of endodontically treated teeth (ETT). In addition, there are several restorative options indicated regarding this scenario, especially with the notable advance of new techniques and technologies for clinical use. These routinely involve the use of direct restorations (made of composite resin), metal or fiberglass posts, prefabricated or milled posts, as also indirect restorations composed of ceramic crowns, inlays, onlays or endocrown; always focusing on functional and aesthetic rehabilitation of the case in hand. In this study, through a narrative review, concepts related to the restorative modalities that were introduced with the use of new technologies in the rehabilitation of endodontically treated teeth were discussed(AU)

Impacto de las nuevas tecnologías en la endoscopía diagnóstica y terapéutica / Impact of new technologies in diagnostic and therapeutic endoscopy

El desarrollo y aplicación de la tecnología en la medicina ha creado dilemas éticos para los galenos, al tener que definir hasta qué punto es ético someter a un paciente a una técnica quirúrgica o un procedimiento endoscópico que presente una alta incidencia de complicaciones cuando pueden existir otros con mejores resultados. En este trabajo se analizan los efectos beneficiosos y nocivos de los adelantes tecnológicos para las ciencias médicas, de ahí que el objetivo fue identificar la influencia de la revolución científico técnica en el desarrollo de la cirugía endoscópica endoluminal. Se analiza cómo el médico debe mantener un equilibrio entre la ciencia y la ética, que le permita, además de ser acertado en el diagnóstico y el tratamiento, ser más humano y comprensivo con sus pacientes. Se concluye que la revolución científica técnica de hoy, que integra conocimientos y experiencia, ha dado solidez al cómo hacer y por qué. Sin embargo, los recursos en ocasiones pueden ser limitados. Ello significa que no siempre se puede realizar todo lo que es técnicamente factible. Las buenas prácticas médicas deben acompañar a todos los galenos a sabiendas de que es la vida de un ser humano que ha confiado en sus capacidades intelectuales y buen poder de decisión(AU)

The development and application of technology in medicine has created ethical dilemmas for physicians to define to what extent it is ethical to subject a patient to a surgical technique or an endoscopic procedure that presents a high incidence of complications when there may be others with best results. In this work the beneficial and harmful effects of the technological advancements for the Medical Sciences are analyzed, for that reason the objective of the same one was to identify the influence of the Technical Scientific Revolution in the development of the Endoluminal Endoscopic Surgery. It is analyzed how the doctor must maintain a balance between science and ethics, which allows him, in addition to being successful in diagnosis and treatment, to be more human and understanding with his patients. It is concluded that the technical scientific revolution of today, which integrates knowledge and experience, has given solidity to how to do and why. However, resources can sometimes be limited. This means that everything that is technically feasible cannot always be done. Good medical practices should accompany all physicians knowing that it is the life of a human being who has relied on their intellectual abilities and good decision-making power(AU)

A 'feasibility space' as a goal to be achieved in the development of new technologies for converting renewable energies.

This method article proposes the establishment of a feasibility space as an objective to be achieved during the development of new technologies to convert energy from renewable resources. The feasibility space can also be a reference when designing an energy system based on renewable resources. The feasibility space is a set of parameter values for the design stage that define the economic and technical feasibility of an energy system or a new technology, which must be satisfied when the energy system comes into operation or when the new technology for converting power goes into operation. The study of possible feasibility spaces allows characterizing energy systems or new technologies as attractive investments, or on the other hand, as unfeasible ventures.-The method proposes to establish a goal to achieve during the development of technologies for energy conversion.-The method provides a benchmark for both the stages of design and development of generation systems and new technologies.-The feasibility space constitutes a planning tool for power systems based on renewable resources of any size.

Soledad social en ancianos hospitalizados en el servicio de Geriatría. Hospital "Comandante Faustino Pérez" / Social loneliness in elder people hospitalized in the Geriatrics service. Clinical Surgical Hospital "Comandante Faustino Pérez"

RESUMEN Introducción: la soledad social se define como la experiencia subjetiva de insatisfacción frente a la sociedad en la que se vive; en términos de estilos de vida, de valores y de uso de nuevas tecnologías, entre otros aspectos. Objetivo: caracterizar la soledad social en los adultos mayores hospitalizados. Materiales y método: se realizó un estudio observacional, descriptivo, transversal en pacientes que ingresaron en el servicio de Geriatría del Hospital Clínico Quirúrgico "Comandante Faustino Pérez", provincia Matanzas, desde octubre 2015 - 2016. El universo estuvo constituido por 212 pacientes que vivían en compañía y no padecían de demencia, confusión mental ni enfermedades graves. Para la recogida de la información se aplicó al universo de estudio la Escala ESTE II de soledad social, validada a nivel nacional e internacional para identificar el nivel de soledad social. Se utilizaron métodos de estadística descriptiva. Los resultados se presentaron en tablas. Resultados: alto nivel de soledad social en los ancianos estudiados, en el grupo atareo de 60-70 años, sin pareja, de bajo nivel de escolaridad y con enfermedades crónicas. Insuficiente percepción de apoyo y participación social, así como un limitado uso de las nuevas tecnologías. Conclusiones: predominó alto nivel de sentimiento de soledad en los ancianos, asociado a insuficiente percepción de apoyo y participación social, más un bajo acceso a las nuevas tecnologías (AU).

ABSTRACT Introduction: social loneliness is defined as the subjective experience of dissatisfaction toward society in which one lives, in terms of lifestyles, values ​​and use of new technologies among others. Objective: to characterize social loneliness in hospitalized elder adults. Material and Method: a cross-sectional, observational, descriptive, study was conducted in patients admitted to the Geriatrics Service of the Clinical Surgical Hospital "Comandante Faustino Pérez", province of Matanzas, in the period October 2015 - 2016. The universe was formed by 212 patients who lived accompanied and did not suffer from dementia, mental confusion nor serious illnesses. For collecting the information of the studied universe, the authors used the ESTE II Scale of social loneliness validated at national and international level to identify the level of social loneliness. Descriptive statistical methods were used and the results were shown in tables. Results: high level of social loneliness in studied elder people of the 60-70 years-old group, without a partner, with a low level of scholarship and with chronic diseases. They had an insufficient perception of support and social participation, as well as made a limited use of the new technologies. Conclusions: a high level of the loneliness feeling predominated in elder people, associated to an insufficient perception of support and social participation, plus a low access to the new technologies (AU).

[The technological tools of the diagnosis and treatment of attention deficit disorder and hyperactivity]. / Herramientas tecnológicas del diagnóstico y tratamiento del trastorno por déficit de atención e hiperactividad.

Attention deficit disorder and hyperactivity (ADHD) is the main reason for consultation in most Pediatric Neurology units in Spain. The new technologies also associate benefits for both patients and professionals and the health system itself, which makes its rational implementation essential. Genetics, neuroimaging or virtual reality, for example, are clear exponents of the results that can be achieved by optimizing traditional processes. The different technologies that we collect in this article are fully operational and have thousands of experience in patients. The incorporation of them to the usual clinical practice is in our hands.

El trastorno por déficit de atención e hiperactividad (TDAH) es el principal motivo de consulta en la mayoría de las unidades de Neurología Pediátrica en España. Las nuevas tecnologías asocian además beneficios tanto para los pacientes como para los profesionales y el propio sistema sanitario. Se hace imprescindible su implementación racional. La genética, la neuroimagen o la realidad virtual por ejemplo, son claros exponentes de los resultados que se pueden conseguir al optimizar los procesos tradicionales. Las diferentes tecnologías que recogemos en este artículo están completamente operativas y cuentan con miles de pacientes de experiencia. La incorporación de las mismas a la práctica clínica habitual está en nuestras manos.

Herramientas tecnológicas del diagnóstico y tratamiento del trastorno por déficit de atención e hiperactividad / The technological tools of the diagnosis and treatment of attention deficit disorder and hyperactivity

El trastorno por déficit de atención e hiperactividad (TDAH) es el principal motivo de consulta en la mayoría de las unidades de Neurología Pediátrica en España. Las nuevas tecnologías asocian además beneficios tanto para los pacientes como para los profesionales y el propio sistema sanitario. Se hace imprescindible su implementación racional. La genética, la neuroimagen o la realidad virtual por ejemplo, son claros exponentes de los resultados que se pueden conseguir al optimizar los procesos tradicionales. Las diferentes tecnologías que recogemos en este artículo están completamente operativas y cuentan con miles de pacientes de experiencia. La incorporación de las mismas a la práctica clínica habitual está en nuestras manos.

Attention deficit disorder and hyperactivity (ADHD) is the main reason for consultation in most Pediatric Neurology units in Spain. The new technologies also associate benefits for both patients and professionals and the health system itself, which makes its rational implementation essential. Genetics, neuroimaging or virtual reality, for example, are clear exponents of the results that can be achieved by optimizing traditional processes. The different technologies that we collect in this article are fully operational and have thousands of experience in patients. The incorporation of them to the usual clinical practice is in our hands.

Advances in spirometry testing for lung function analysis.

Introduction: Spirometry, the most common lung function test, is used to evaluate individuals with respiratory complaints or known respiratory disease. However, its underutilization and the misinterpretation of its parameters are causes for concern. Areas covered: This review describes new spirometry-derived metrics, new reference equations, recent recommendations for presentation of results, recent spirometry-based prevalence studies, and technological advances in spirometry equipment. Expert opinion: The underutilization of spirometry can be overcome by increasing access to portable, hand-held, and user-friendly spirometers, together with strategies that increase awareness of the importance of spirometry. New metrics derived from spirometry, together with traditional spirometric criteria, can identify individuals with structural lung disease and respiratory morbidity. Some problems with the reference equations were solved by the Global Lung Function Initiative (GLI), which covers a wider age range and more ethnic groups and provides limits of normality using the z-score. Despite these advantages, the GLI equations lack data from large populations (especially those from Africa, South Asia, and Latin America) and greater representation of older people. Another disadvantage attributed to the GLI is the lack of predicted values for peak expiratory flow and other airflows, limiting the interpretation of the maximal expiratory flow-volume curve.