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1.
Stud Hist Philos Sci ; 92: 239-248, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-35219525

RESUMO

Physical theories, for the most part, should be understood as modelling isolated subsystems of a larger universe; doing so, among other benefits, greatly clarifies the interpretation of the dynamical symmetries of those theories. I provide a detailed framework for analysing the subsystem structure of physical theories and applying it to the interpretation of their symmetries: the core concept is subsystem recursivity, whereby interpretative conclusions about a sector of a theory can be deduced from considering subsystems of other models of the same theory. I illustrate the framework by extensive examples from nonrelativistic particle mechanics, and in particular from Newtonian theories of gravity. A sequel to the paper will apply the framework to the local and global symmetries of classical field theory.

2.
Artigo em Inglês | MEDLINE | ID: mdl-31960585

RESUMO

Viruses are highly ordered supramolecular complexes that have evolved to propagate by hijacking the host cell's machinery. Although viruses are very diverse, spreading through cells of all kingdoms of life, they share common functions and properties. Next to the general interest in virology, fundamental viral mechanisms are of growing importance in other disciplines such as biomedicine and (bio)nanotechnology. However, in order to optimally make use of viruses and virus-like particles, for instance as vehicle for targeted drug delivery or as building blocks in electronics, it is essential to understand their basic chemical and physical properties and characteristics. In this context, the number of studies addressing the mechanisms governing viral properties and processes has recently grown drastically. This review summarizes a specific part of these scientific achievements, particularly addressing physical virology approaches aimed to understand the self-assembly of viruses and the mechanical properties of viral particles. Using a physicochemical perspective, we have focused on fundamental studies providing an overview of the molecular basis governing these key aspects of viral systems. This article is categorized under: Biology-Inspired Nanomaterials > Protein and Virus-Based Structures Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.


Assuntos
Vírion/fisiologia , Montagem de Vírus/fisiologia , Vírus/metabolismo , Fenômenos Biomecânicos , Genoma Viral , Humanos , Vírus/genética
3.
Materials (Basel) ; 10(11)2017 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-29120402

RESUMO

Thermally-assisted compaction of granular materials is of keen interest in many engineering applications. A proper estimation of the material behavior of compacted granular materials is contingent upon the knowledge of microstructure formation, which is highly dependent on the bulk material properties and processing conditions, during the deformation stage. Originating from the pair interactions between particles, the macroscopic properties are obtained using various homogenization techniques and postulating continuum constitutive laws. While pioneers in this field have laid fundamental groundwork regarding effective medium descriptions, there exists a discrepancy between discrete and continuum level solutions. In our previous work, we elaborated a Particle Mechanics Approach (PMA) that integrates thermal contact and Hertzian deformation models to understand the thermo-mechanically-coupled consolidation problem. We also considered the analogous problem from the perspective of the conventional Continuum Mechanics Approach (CMA). In this study, following the multi-scale modeling framework, we propose an effective thermal expansion coefficient for the thermally-assisted compaction of granular materials.

4.
Annu Rev Chem Biomol Eng ; 5: 203-28, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24655134

RESUMO

Suspensions of non-Brownian particles are commonly encountered in applications in a large number of industries. These suspensions exhibit nonlinear flow behavior, even in Newtonian suspending fluids under conditions where inertial effects can be ignored and linearity would normally be expected. We review the observed rheological behavior, emphasizing concentrated suspensions of spheres in Newtonian fluids, and we examine both particle-level and continuum approaches to describing the nonlinear behavior. Particle-particle nonhydrodynamic interactions appear to be important in concentrated suspensions. Continuum descriptions are not yet adequate to describe the observed behavior.


Assuntos
Algoritmos , Modelos Químicos , Reologia , Suspensões/química , Simulação por Computador , Tamanho da Partícula , Viscosidade
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