Ratiometric singlet oxygen self-detecting and oxygen self-supplying nanosensor for real-time photodynamic therapy feedback and therapeutic effect enhancement.

Integration of singlet oxygen (1O2) detection that provides necessary therapeutic feedback into nanotheranostics for hypoxic tumor photodynamic therapy (PDT) is desirable but still challenging. Herein, we report a nanosensor (denominated PAPD) by combining dual-channel ratiometric sensing and oxygen-augmenting strategies, which synergistically realizes real-time 1O2 self-detection, O2 self-supply and enhanced phototherapy. PAPD nanosensor is constructed by encapsulating anthracene-based 1O2 sensitive fluorophore (DPA) into porphyrin metal-organic frameworks (PCN-224), decorating gold nanoparticles (AuNPs) as nanoenzymes, and coating polyethylene glycol thiol (PEG-SH) by the Au-S bond. PCN-224 serves as 1O2 reference fluorescence (FL) agent and photosensitizer. Once PCN-224-induced 1O2 is synthesized, the dual-channel ratiometric FL signal of PAPD actualizes sensitive, accurate and dynamic 1O2 visualization and gives real-time therapeutic information correlated with the therapeutic progression. Additionally, the catalase-like activity of PAPD possesses in situ O2 production via intracellular H2O2 decomposition and accelerates 1O2 yields for amplifying the tumor cell killing efficiency. Moreover, the ratiometric 1O2 self-detection affords the capacity to evaluate the O2 self-supplying effect in tumor 4T1 cells. Consequently, the rational-designed nanosensor PAPD provides a paradigm for real-time therapeutic evaluation and precise hypoxic tumor treatment clinically.

A Self-Detecting and Self-Cleaning Biomimetic Porous Metal-Based Hydrogel for Oil/Water Separation.

Porous materials with super-wetting surfaces (superhydrophilic/underwater superoleophobic) are ideal for oil/water separation. However, the inability to monitor the pollution degree and self-cleaning during the separation process limits their application in industrial production. In this study, a porous metal-based hydrogel is proposed, inspired by the porous structure of wood. Porous copper foam with nano-Cu(OH)2 is used as the skeleton, and its surface is coated with a polyvinyl alcohol, tannic acid, and multiwalled carbon nanotube cross-linked hydrogel coating. The hydrogel has superhydrophilicity and excellent oil/water separation efficiency (>99%) and can adapt to various environments. This approach can also realize hydrogel pollution degree self-detection according to the change in the electrical signal generated during the oil/water separation process, and the hydrogel can also be recovered by soaking to realize self-cleaning. This study will provide new insights into the application of oil/water separation materials in practical industrial manufacturing.

Educating Parents Improves Their Ability to Recognize Adolescent Idiopathic Scoliosis: A Diagnostic Accuracy Study.

(1) In countries where scoliosis screening programs ended, the responsibility for detection shifted from healthcare professionals to parents. Since recognizing scoliosis is difficult for parents, more patients are presenting late. Increased awareness of scoliosis may favor earlier detection. This study examines the effect of educating parents to recognize scoliosis. (2) In this cross-sectional study a consecutive group of parents completed a digital assessment. They had to complete two identical series of fourteen cases (eight with scoliosis and six without). Each case displayed two photographs of the child's back; one in standing position and one during forward-bending. Based on visual inspection, parents had to indicate if the child had to be referred to a physician. After assessing the first series, information was given on how to detect scoliosis. Subsequently, parents assessed the second series of cases. Sensitivity and specificity were calculated before and after education. (3) A total of 100 parents completed the assessment. The sensitivity to detect scoliosis was slightly but significantly higher after education (68.8% versus 74.0%; p = 0.002), while specificity was not (74.0% versus 74.8%; p = 0.457). (4) This study showed that educating parents improved their ability to recognize scoliosis without increasing the false positive referral rate. Although written instructions can bridge the gap with professional screening programs, the overall sensitivity in this study remained low. Therefore, education can improve the awareness and ability to detect scoliosis, but will not replace screening by professionals.

A Thermoelectric MEMS Microwave Power Sensor with Inline Self-Detection Function.

In this paper, the design, fabrication and measurement of a thermoelectric MEMS microwave power sensor with the terminal load inline self-detection function is proposed. The structure of the sensor mainly includes a coplanar waveguide, a thermopile, two terminal load resistors and two calibration resistors. In order to realize the inline self-detection function, the load and calibration resistors are designed to form a voltage divider circuit. The fabrication of this sensor is compatible with the GaAs MMIC technology. The on-chip performance is tested by using a microwave experimental platform. The measured reflection loss is less than -10 dB at 0.1-10 GHz. When the bias voltage is not applied, the sensitivity of the sensor is 47.39 µV/mW@5 GHz and 32.58 µV/mW@10 GHz, respectively, and when the bias voltage is applied, the sensitivity is 47.50 µV/mW@5 GHz and 32.73 µV/mW@10 GHz, respectively. The difference between the two cases is less than 0.5% at the same frequency, which indicates that whether or not to apply the bias voltage has little effect on the sensitivity. In addition, when the calibration resistance is increased from 50 to 100 Ω, the current flowing through the load resistance is decreased under the same bias voltage. Therefore, the DC power consumed on the load resistance will be significantly reduced. This makes the measured and theoretical results show better agreement, thus verifying the validity of the design.

Psychometric Assessment of an Online Self-Test Measuring Risky Eating Behavior, Depression, Social Anxiety, and Self-Injury in Mexican Adolescents.

The objective of this study was to evaluate the validity and reliability of OTESSED, an online test for the self-detection and prevention of risk factors for eating disorders and related problems, such as depression, social anxiety, and self-injury, in samples of male and female adolescents. Participants formed a non-probability sample of N = 577 high school students. The mean ages of boys and girls were the same (Mage = 15.61; SD = 0.73). Among the main results, scales of depression, self-injury, social anxiety, and risky eating behavior (REB) with construct validity (CFA) were obtained. The first two showed the same structure (two factors per sex), with an appropriate reliability omega value (0.92), and a similar percentage of explained variance (≥50). The REB scale presented two factors for boys and three for girls, with an appropriate omega value (0.88) and explained variance percentage (0.56). The instrument validation process was completed, meeting the discriminant validity criterion for each scale of the OTESSED.

Online Test of Risk Self-Detection of Eating Disorders.

This study's central aim was to examine the effectiveness of an online test of the Risk Self-Detection of Eating Disorders through the evaluation of (1) its psychometric properties, the significant probability of predicting risk eating behavior and the correct classification of membership to the risk or non-risk group and (2) the ability to measure users' risk self-awareness through a group of statements and explore the expected responses through frequency analysis of the content provided by the users. The non-probability sample was comprised of n = 541 women aged 15 to 25 (M = 18.3; SD = 2.4). The instrument showed good psychometric properties, a structure of three predictive risk factors, and proper effect sizes (R2 = 0.67-0.69). Among the most critical findings were high percentages of correct classification (94-97%) and expected responses (61%). The logistic regression analysis showed that the risk of presenting eating disorders was higher if the participants smoked, consumed alcohol, had sexual experiences before the age of 15, and if those sexual experiences were non-consensual. Evidence is presented about the promising results of the online data collection method and its potential benefits.

Espinalioma de lengua: informe de un caso clínico / Tongue spinalioma. clinical case report

Objetivos: concientizar sobre la importancia de la consulta estomatológica y educar en la autodetección de lesiones facultativamente cancerizables. Caso clínico: paciente con antecedentes traumáticos locales de larga data, producidos por piezas dentarias con bordes filosos, obturaciones desbordantes y el consumo de tabaco, factores predisponentes e incidentes en el desencadenamiento de la lesión neoplásica. Conclusión: el caso presentado pone en evidencia las deficientes medidas de prevención primaria y la falta de acciones conducentes a la práctica de autoevaluaciones orales periódicas.

Aim: To raise awareness about the importance of pathology consultation and patient education in self detection of potentially cancerous lesions. Clinical case: We report the case of a patient with along history of local traumatisms generated by tooth lesions with sharp edges, over contoured restorations and tobacco consumption, all of which are considered risk factors in the generation of neoplasic processes. Conclusion: The case that is reported shows lack of useof primary preventive and self detections conducts that could prevent the development of cancerous lesions.

Un estudio preliminar de una prueba de autodetección a distancia. Riesgo en trastornos alimentarios / A preliminary study of an online self-detection test. Risk in eating disorders

El objetivo de este estudio fue evaluar la utilidad de una prueba de autodetección de riesgo en trastornos alimentarios a distancia (PARTAD), desde una perspectiva cuantitativa, determinando su validez predictiva y poder de clasificación y una cualitativa, analizando el contenido de las opiniones y sugerencias de las usuarias. De la muestra total (n = 3,501) 3,059 eran adolescentes (13-19 años) y jóvenes (20-35 años); 394 mujeres adultas (36-50 años); y 48 adultas maduras (51-60 años). Se construyó un instrumento de 30 ítems dicotómicos y de opción múltiple y se agregaron 2 preguntas abiertas con propósitos de retroalimentación para mejorarlo y para la evaluación cualitativa. El análisis discriminante arrojó una función con fuerte poder discriminatorio entre grupos, con alto y bajo riesgo en trastornos alimentarios, que explica hasta el 88% de la varianza y el 100% de clasificación correcta. También se obtuvo un 23% de comentarios (706), el análisis y clasificación de sus contenidos mostraron los efectos esperados. Los resultados permiten responder afirmativamente en relación con la utilidad del PARTAD.

The aim of this study was to evaluate the usefulness of an Online Test of Self-Detection in Risk for Eating Disorder (OTSDRED) from a quantitative perspective (determining its predictive validity and classification power) and from a qualitative one (analyzing the opinions and suggestions of users). From the total sample (N = 3501) of women, 3059 were adolescents (13- 19 years), youth (20-35 years); 394 adult (36-50 years); and 48 mature adult (51-60 years). An instrument of 30 dichotomous items and multiple choice was built. Two open questions with feedback for improvement purposes and for the qualitative assessment were added. The Discriminant Analysis yielded strong discriminatory power function between groups with high and low risk for eating disorders, explaining up to 88% of the variance and 100% of correct classification. With regard to the qualitative perspective a 23% of comments (706) were obtained; the analysis and classification of its contents showed the expected effects. The results from the quantitative and qualitative analysis allowed affirmative answer regarding the usefulness of OTSDRED.