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2.
Pediatr Emerg Care ; 39(12): 902-906, 2023 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-37968113

RESUMO

OBJECTIVE: This study aimed to describe a single-center experience of pediatric drowning and to investigate risk factors associated with the development of pediatric multiple-organ dysfunction syndrome (MODS) after drowning events. METHODS: A single-center retrospective case-control study was performed at a tertiary children's hospital examining patients aged 1 month to 25 years who were admitted to the pediatric intensive care unit after a drowning event. The study period was June 2016 to June 2021. Patients who developed MODS at day 1 of intensive care admission were compared with those who did not. RESULTS: A total of 48 patients with a median age of 2.3 years were included. Twenty-nine (60%) had MODS at 24 hours. Those with MODS at 24 hours were more likely to require cardiopulmonary resuscitation (CPR), required longer duration of CPR, and had longer submersion times; otherwise, there were no differences in baseline characteristics. Those who developed MODS at 24 hours had longer lengths of stays, longer lengths of mechanical ventilation, and higher mortality. Multiple admission parameters were evaluated based on MODS-free survival at 24 hours. On univariable analysis, patients without MODS-free survival at 24 hours had higher rates of CPR, higher blood glucose on admission, higher illness severity scores, higher lactates, and lower Glasgow Coma Scale scores. A multivariable model was constructed using risk factors at presentation that were significant on univariable analysis; blood glucose greater than 200 mg/dL was associated with decreased odds of MODS-free survival at 24 hours after controlling for CPR administration of greater than 5 minutes and body temperature. CONCLUSIONS: Development of MODS in pediatric drowning is associated with worse patient outcomes. Hyperglycemia was identified as a potentially modifiable risk factor for the development of MODS at 24 hours and could serve as a useful prognostic parameter in this unique patient population.


Assuntos
Afogamento , Insuficiência de Múltiplos Órgãos , Humanos , Criança , Pré-Escolar , Insuficiência de Múltiplos Órgãos/epidemiologia , Insuficiência de Múltiplos Órgãos/etiologia , Estudos Retrospectivos , Estudos de Casos e Controles , Afogamento/etiologia , Glicemia , Fatores de Risco
3.
Turk J Ophthalmol ; 53(3): 136-141, 2023 06 21.
Artigo em Inglês | MEDLINE | ID: mdl-37345286

RESUMO

Objectives: Microbial keratitis can cause significant visual morbidity and is a common reason for presentation to eye casualty clinics. Contact lens wear and poor contact lens hygiene significantly increase the risk of corneal infection. This study aimed to determine the level of contact lens hygiene awareness amongst contact lens wearers attending our service and determining whether contact lens type and hygiene attitude are related to severity of disease. Materials and Methods: This prospective questionnaire-based study included 50 consecutive patients attending the eye casualty clinic of a tertiary referral center. Visual acuity was assessed at presentation and 2 weeks after diagnosis. Patients were divided into subgroups according to contact lens type (monthly, bi-weekly, daily, and extended day and night wear) and risk group (low, medium, and high) depending on their contact lens hygiene practices. Results: Thirty-four women and 16 men were included in this study. Twenty-four patients used monthly disposable contact lenses, 16 used daily disposable contact lenses, 6 were using bi-weekly replacement lenses, and 4 patients were using extended wear (day and night) contact lenses. Twenty-five patients were diagnosed with corneal ulcer, 23 of which had some degree of poor contact lens hygiene. Best corrected visual acuity (BCVA) significantly improved after treatment. Mean BCVA was 0.24 LogMAR before treatment and 0.09 LogMAR after treatment (p<0.05). Conclusion: Our study highlights the need to improve contact lens hygiene awareness and influence hygiene practices. Patients with the poorest contact lens hygiene had slower visual recovery and a higher prevalence of corneal ulcer. Contact lens hygiene advice needs to be clear and reinforced over time.


Assuntos
Lentes de Contato , Úlcera da Córnea , Afogamento , Ceratite , Masculino , Humanos , Feminino , Úlcera da Córnea/epidemiologia , Úlcera da Córnea/etiologia , Estudos Prospectivos , Afogamento/etiologia
4.
Med Arch ; 76(1): 49-54, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35422567

RESUMO

Background: According to the World Health Organization (WHO), drowning is globally considered as one of the leading causes of injury related deaths. Defined as the process of experiencing respiratory impairment from submersion in a liquid medium. Drowning is a public health concern in Jordan. This study aimed to investigate drowning incident data from the Forensic Medicine Teaching Centre in the North of Jordan for the purpose of defining high risk groups and circumstances around drowning fatalities which suffered an attention deficit. Objective: The study aims to describe the rate of fatal drowning in North of Jordan and to properly understand the risk factors associated with it. Methods: The present study is retrospective, based on investigating 2808 autopsy reports and selecting only 85 drowning related death reports conducted through a 5 year period (2015-2019) in the Forensic Medicine Teaching Centre which serves Northern Jordan including Irbid, Jarash, Ajloun, and Al-Mafraq. The statistical analysis of fatal drowning cases included the following risk variables: Age, gender, month, year, nationality, address, alcohol and drug consumption. Results: 15 variables were consistent and analyzed across the database of this study. The high risk groups and patterns were identified and the majority of fatal drowning cases were related to males (80.4%). Age group from (2 to 27 years of age were included in the high-risk groups with (88.2%) of all cases. Specifically, the age 2 had the highest occurring frequency. While (17.6%) of drowning fatalities occurred in August. Alcohol and drugs had no significant impact on increasing drowning rates. The dominant manner of death among all cases was accidental (95.3%). Fatal drowning rates were decreasing throughout the years of (2015-2019). Conclusion: Defining drowning high risk groups and its epidemiology helps to overcome this preventable cause of death. The current study highlights the necessity for the need of further interventions to be actively fixed into policies and educational programs and emphasize safety precautions during water activities and to improve the dataset collection for better planning of prevention strategies.


Assuntos
Afogamento , Adolescente , Adulto , Criança , Pré-Escolar , Afogamento/epidemiologia , Afogamento/etiologia , Afogamento/prevenção & controle , Etanol , Humanos , Jordânia/epidemiologia , Masculino , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
5.
J Safety Res ; 77: 99-104, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34092332

RESUMO

BACKGROUND: Land motor traffic crash (LMTC) -related drownings are an overlooked and preventable cause of injury death. The aim of this study was to analyze the profile of water-related LMTCs involving passenger cars and leading to drowning and fatal injuries in Finland, 1972 through 2015. MATERIALS AND METHODS: The database of the Finnish Crash Data Institute (FCDI) that gathers detailed information on fatal traffic accidents provided records on all LMTCs leading to drowning during the study period and, from 2002 to 2015, on all water-related LMTCs, regardless of the cause of death. For each crash, we considered variables on circumstances, vehicle, and fatality profiles. RESULTS: During the study period, the FCDI investigated 225 water-related LMTCs resulting in 285 fatalities. The majority of crashes involved passenger cars (124), and the cause of death was mostly drowning (167). Only 61 (36.5%) fatalities suffered some-generally mild-injuries. The crashes frequently occurred during fall or summer (63.7%), in a river or ditch (60.5%), and resulted in complete vehicle's submersion (53.7 %). Half of the crashes occurred in adverse weather conditions and in over 40% of the cases, the driver had exceeded the speed limit. Among drivers, 77 (68.8%) tested positive for alcohol (mean BAC 1.8%). CONCLUSION: Multidisciplinary investigations of LMTCs have a much higher potential than do exclusive police and medico-legal investigations. The risk factors of water-related LMTCs are similar to those of other traffic crashes. However, generally the fatal event in water-related LMTC is not the crash itself, but drowning. The paucity of severe physical injuries suggests that victims' functional capacity is usually preserved during vehicle submersion. Practical Applications: In water-related LMTCs, expansion of safety measures is warranted from general traffic-injury prevention to prevention of drowning, including development of safety features for submerged vehicles and simple self-rescue protocols to escape from a sinking vehicle.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Afogamento/epidemiologia , Imersão/efeitos adversos , Acidentes de Trânsito/mortalidade , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Bases de Dados Factuais , Afogamento/etiologia , Afogamento/mortalidade , Feminino , Finlândia/epidemiologia , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Adulto Jovem
6.
Am J Forensic Med Pathol ; 42(3): 275-277, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-33346983

RESUMO

ABSTRACT: In swimming pools, malfunctions in the pool water drainage system can result with severe injuries, or even death, and mostly children are affected by these accidents. In this case report, the death scene and postmortem examination findings of a 12-year-old girl, who was trapped by her feet in the pool water drainage system, are reported. The external examination revealed ecchymotic areas with abrasions on both lower legs and both feet, suggesting suction of both feet through the uncovered pool drainage system opening. To prevent such accidents, safety practices related to the water circulation system should be developed in swimming pools and similar areas; children should be supervised at all times; and emergency medical teams, as well as lifeguards, should be available for immediate intervention.


Assuntos
Acidentes , Afogamento/etiologia , Piscinas , Criança , Feminino , Humanos , Sucção
7.
BMC Public Health ; 20(1): 1553, 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-33059656

RESUMO

BACKGROUND: Accidental drowning of children under five is a serious problem in China. The present study analyzed data on environmental and sociodemographic factors and on primary caregivers of drowned children to understand factors that may contribute to this problem. METHODS: The present study collected information on 563 cases of drowning in children under five from October 1, 2015, to September 30, 2016, in 334 sampling districts in China. Primary caregivers were interviewed individually using the Drowning Mortality among Children under 5 Questionnaire. RESULTS: Most drowned children under 5 years old were boys, and 71.6% lived within 100 m of a body of water. The drownings primarily occurred in ponds, canals, rivers, and wells, and over 90% of these water bodies had no safety measures. There were 28.1% of primary caregivers who did not provide full-time care for the children, and 83.1% of them had no knowledge of first aid skills for drowning. CONCLUSION: Encouraging kindergarten enrollment and providing safety education for children may reduce drowning in children under 5 years of age. Public water body protection measures should be strengthened to prevent children from drowning. Encouraging primary caregivers to care full-time for the children and learning first aid skills for drowning may also help reduce fatalities.


Assuntos
Cuidadores/estatística & dados numéricos , Afogamento/etiologia , Cuidadores/psicologia , Pré-Escolar , China/epidemiologia , Afogamento/mortalidade , Afogamento/prevenção & controle , Meio Ambiente , Feminino , Primeiros Socorros/psicologia , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Lactente , Masculino , Fatores de Risco , Fatores Socioeconômicos , Inquéritos e Questionários , Água/efeitos adversos
8.
Respir Res ; 21(1): 232, 2020 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-32907551

RESUMO

BACKGROUND: Ferroptosis is a new type of nonapoptotic cell death model that was closely related to reactive oxygen species (ROS) accumulation. Seawater drowning-induced acute lung injury (ALI) which is caused by severe oxidative stress injury, has been a major cause of accidental death worldwide. The latest evidences indicate nuclear factor (erythroid-derived 2)-like 2 (Nrf2) suppress ferroptosis and maintain cellular redox balance. Here, we test the hypothesis that activation of Nrf2 pathway attenuates seawater drowning-induced ALI via inhibiting ferroptosis. METHODS: we performed studies using Nrf2-specific agonist (dimethyl fumarate), Nrf2 inhibitor (ML385), Nrf2-knockout mice and ferroptosis inhibitor (Ferrostatin-1) to investigate the potential roles of Nrf2 on seawater drowning-induced ALI and the underlying mechanisms. RESULTS: Our data shows that Nrf2 activator dimethyl fumarate could increase cell viability, reduced the levels of intracellular ROS and lipid ROS, prevented glutathione depletion and lipid peroxide accumulation, increased FTH1 and GPX4 mRNA expression, and maintained mitochondrial membrane potential in MLE-12 cells. However, ML385 promoted cell death and lipid ROS production in MLE-12 cells. Furthermore, the lung injury became more aggravated in the Nrf2-knockout mice than that in WT mice after seawater drowning. CONCLUSIONS: These results suggested that Nrf2 can inhibit ferroptosis and therefore alleviate ALI induced by seawater drowning. The effectiveness of ferroptosis inhibition by Nrf2 provides a novel therapeutic target for seawater drowning-induced ALI.


Assuntos
Lesão Pulmonar Aguda/metabolismo , Afogamento/metabolismo , Ferroptose/fisiologia , Fator 2 Relacionado a NF-E2/metabolismo , Água do Mar/efeitos adversos , Lesão Pulmonar Aguda/etiologia , Lesão Pulmonar Aguda/prevenção & controle , Animais , Linhagem Celular , Afogamento/etiologia , Afogamento/prevenção & controle , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Mucosa Respiratória/metabolismo
9.
Leg Med (Tokyo) ; 47: 101783, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32919339

RESUMO

A study was undertaken of all drowning deaths that occurred over a 30-year period from 1988 to 2017 in the urban section of the River Torrens, Adelaide, South Australia, an augmented waterway that runs through the central business district. Autopsy records from Forensic Science South Australia (FSSA) were reviewed. There were 34 drownings (0-5 cases/yr) with 28 males and 6 females (M;F = 4.6:1), with an age range for males of 18-76yrs (mean 42.0; SD 18.0) and for females of 20-84yrs (mean 69.3; SD 24.5). There were 15 (44%) accidents, 11 (32%) suicides, 1 (3%) homicide and 7 (21%) undetermined. Of the 22 cases during or after 1994 with complete toxicology reports, 10 (45%) had a blood alcohol concentration (BAC) of greater than 0.05% (g/100 mL) with an illicit substance detected in 4 (18%) cases: (MDMA (3,4-methylenedioxymethamphetamine), methylamphetamine and THC (delta-9-tetrahydrocannabinol) acid). The presence of various therapeutic drugs was also detected in 10 cases (45%) including temazepam, fluoxetine, diazepam, olanzapine, amitriptyline, carbamazepine, codeine, citalopram and valproate. Although the numbers of cases were not high, the urban portion of the River Torrens had a much higher number of drowning events per kilometre compared to other inland waterways in South Australia such as the Murray River. This is most likely due to the vulnerability that exists for intoxicated individuals in the city from falls into the water and to the availability of the river as a means of suicide to members of the adjacent urban population.


Assuntos
Afogamento/epidemiologia , Ciências Forenses , Rios , População Urbana/estatística & dados numéricos , Acidentes/estatística & dados numéricos , Adolescente , Adulto , Austrália/epidemiologia , Afogamento/etiologia , Feminino , Homicídio/estatística & dados numéricos , Humanos , Drogas Ilícitas/sangue , Masculino , Pessoa de Meia-Idade , Psicotrópicos/sangue , Detecção do Abuso de Substâncias , Suicídio/estatística & dados numéricos , Fatores de Tempo , Adulto Jovem
10.
Wilderness Environ Med ; 31(1): 11-15, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32057630

RESUMO

INTRODUCTION: Most recreational whitewater fatalities are caused by fixed underwater entrapment or by "flush drowning," an obscure term frequently associated with high-volume rivers, continuous rapids, cold water, and a lack of prolonged underwater entrapment. Although entrapment drowning is typically associated with submersion hypoxia, flush drownings likely involve diverse mechanisms of death; as such, a concise definition is elusive. This said, certain risk factors may be predictively associated with flush drownings. We attempt to further characterize causes of fatal river accidents and possible effects of water temperature on injury pattern. METHODS: We reviewed river mortality data collected from the American Whitewater Association accident database comparing fatal whitewater accident trends in the Rocky Mountain region versus the Southeastern United States. We limited data from the Southeast to the months of June through August to create a warm water cohort. We then divided lethal accidents into flush drowning, entrapment submersion, or miscellaneous events, defining each category in specific terms. RESULTS: Flush drownings were more common in the Rocky Mountains than in the Southeast subgroup and involved older victims on average than entrapment drowning or miscellaneous events. Entrapment drownings were common in both regions, primarily occurring at fallen trees or rock formations. CONCLUSIONS: Flush drownings appear to occur more frequently in older persons. Although hypothetical, the relative increase in flush drowning in the Rocky Mountains might partly be the result of colder water temperatures. If the cause of flush drowning is better understood, safety in whitewater recreation may be improved.


Assuntos
Afogamento/classificação , Rios , Movimentos da Água , Esportes Aquáticos/estatística & dados numéricos , Afogamento/etiologia , Afogamento/mortalidade , Humanos , Fatores de Risco , Terminologia como Assunto , Estados Unidos/epidemiologia
11.
J Safety Res ; 70: 117-125, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31847986

RESUMO

OBJECTIVE: Recreational boating is a popular pastime in many high income countries, and is a leading activity prior to drowning. This study reports on unintentional fatal drowning associated with boating-related incidents in Australia. METHODS: A total population, retrospective, cross sectional design examined all boating-related unintentional drowning deaths between July 1, 2005 and June 30, 2015. Variables examined included age, sex, location of drowning incident, vessel type, activity, presence of alcohol/drugs, and lifejacket wear. Relative risk (with a 95% confidence interval) was calculated using fatal drowning rates per 100,000 population and rates per 100,000 registered vessels. Chi square analysis and non-parametric tests for significance were applied. Statistical significance was deemed p < .05. RESULTS: A total of 415 people drowned while boating during the study period, 91.8% male and 35.7% aged between 25 and 44 years. Men were 10 times more likely to drown when boating than females (RR = 10.64 CI:7.55-14.97). Over one-quarter (28.7%) of incidents involved alcohol, in 30.6% drugs were identified (31.3% were illegal) and 90.4% were not wearing a lifejacket. Children were more at risk of drowning on a houseboat than adults (RR = 7.13; CI:1.61-31.61). Females were more likely to drown than males when using a personal watercraft (RR = 10.53; CI:2.75-40.33). CONCLUSION: Boaters may be taking unnecessary risks by disregarding safety regulations, such as not wearing lifejackets and substance use (such as alcohol and illegal drugs). Boating in remote locations presents a high risk of drowning. While safety regulations are in place, enforcement and behavior change remain challenges. Practical application: Findings support recommendations for increased enforcement of alcohol-related regulations and introducing drug-testing for boaters. Consistency of boating safety regulations, especially around lifejacket wear, is recommended to influence behavior change. The effectiveness of current lifejacket regulations need to be critically evaluated in the context of increasing wear rates for adults and children.


Assuntos
Afogamento/epidemiologia , Esportes Aquáticos/legislação & jurisprudência , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Austrália/epidemiologia , Criança , Pré-Escolar , Estudos Transversais , Afogamento/etiologia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
12.
Wilderness Environ Med ; 30(3): 321-327, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31178366

RESUMO

Sudden death during whitewater recreation often occurs through understandable mechanisms such as underwater entrapment or trauma, but poorly defined events are common, particularly in colder water. These uncharacterized tragedies are frequently called flush drownings by whitewater enthusiasts. We believe the condition referred to as cold water immersion syndrome may be responsible for some of these deaths. Given this assumption, the physiologic alterations contributing to cold water immersion syndrome are reviewed with an emphasis on those factors pertinent to flush drowning.


Assuntos
Temperatura Baixa/efeitos adversos , Afogamento/mortalidade , Hipotermia/mortalidade , Imersão/efeitos adversos , Esportes Aquáticos , Afogamento/etiologia , Afogamento/fisiopatologia , Humanos , Hipotermia/etiologia , Hipotermia/fisiopatologia , Imersão/fisiopatologia , Síndrome
13.
J Safety Res ; 69: 69-73, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31235237

RESUMO

INTRODUCTION: Bathing is the most problematic activity of daily living for aging adults, and the ability to perform it is influenced by physical capabilities that decrease with age. Drowning is an under-documented event related to bathing for older adults. This study investigates the circumstances of these tragedies, to prevent them. METHODS: Census of 2005-2014 bathtub drownings in the province of Quebec (Canada) involving victims aged 65+. Coroner's reports were analyzed using a grid based on factors previously associated with bath-related drownings in literature, iteratively modified. RESULTS: Among the 92 bathtub drowning victims inventoried, 42% were aged 65+. The average age of older victims is 79 (65-97, ±9 years). Main probable cause of drowning is a cardiac problem, although only 19% of victims had a medical history of heart disease. Most victims were alone in their apartment or residence when drowning occurred. Risky periods appear to be springtime, Sundays, and evenings. Despite expectations, relevant information about the physical environment is very scarce. CONCLUSIONS: At least 39 Quebecers, aged 65+, drowned in their bathtubs over a 10-year period. More older adults than children are victims of bathtub drownings in community-dwellings. It seems that bathing may induce heart distress, leading to an appreciable number of drownings. PRACTICAL IMPLICATIONS: Since cardiac health problems are present in these deplorable events, promoting access to safety devices in the environment (emergency button, grab bars) and modified personal hygiene habits (bathing chair, showering) might be potential ways to prevent drowning and improve safety in older adults while they perform their personal hygiene, an essential activity for health and human dignity.


Assuntos
Banhos/efeitos adversos , Afogamento/etiologia , Planejamento Ambiental , Segurança , Idoso , Idoso de 80 Anos ou mais , Canadá , Censos , Afogamento/prevenção & controle , Feminino , Serviços de Saúde para Idosos , Cardiopatias/complicações , Habitação , Humanos , Masculino , Equipamentos de Proteção , Quebeque , Tecnologia Assistiva
14.
BMC Public Health ; 19(1): 599, 2019 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-31101032

RESUMO

BACKGROUND: Drowning is a leading cause of accidental death in children under 14 years of age in Guangdong, China. We developed a statistical model to classify the risk of drowning among children based on the risk factors. METHODS: A multiple-stage cluster random sampling was employed to select the students in Grades 3 to 9 in two townships in Qingyuan, Guangdong. Questionnaire was a self-reported measure consisting of general information, knowledge, attitudes and activities. A univariate logistic regression model was used to preliminarily select the independent variables at a P value of 0.1 for multivariable model. Three-quarters of the participants were randomly selected as a training sample to establish the model, and the remaining were treated as a testing sample to validate the model. RESULTS: A total of 8390 children were included in this study, about 12.18% (1013) experienced drowning during the past one year. In the univariate logistic regression model, introvert personality, unclear distributions of water areas on the way to school, and bad relationships with their classmates and families were positively associated with drowning. However, females, older age and lower swimming skills were negatively associated with drowning. After employing the prediction model with these factors to estimate drowning risk of the students in the testing samples, the results of Hosmer-Lemeshow tests showed non-significant differences between the predictive results and actual risk (χ2 = 5.97, P = 0.65). CONCLUSIONS: Male, younger children, higher swimming skills, bad relationship with their classmates and families, introvert personality and unclear distributions of water areas on the way to school were important risk factors of non-fatal drowning among children. The prediction model based on these variables has an acceptable predictive ability.


Assuntos
Afogamento/etiologia , Modelos Estatísticos , Medição de Risco/métodos , Estudantes/estatística & dados numéricos , Adolescente , Criança , Pré-Escolar , China , Análise por Conglomerados , Feminino , Humanos , Modelos Logísticos , Masculino , Análise Multivariada , Fatores de Risco , Instituições Acadêmicas , Autorrelato , Natação
15.
Environ Health Prev Med ; 24(1): 31, 2019 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-31084599

RESUMO

In Japan, because the most common site of drowning among patients with epilepsy is the bathtub, showering is generally recommended as an alternative to bathing. We herein report a case involving a female patient with epilepsy who drowned while showering. She had been diagnosed with epilepsy approximately 25 years previously, and her condition had progressed to refractory epilepsy. Carbamazepine, levetiracetam, lamotrigine, clobazam, and perampanel were prescribed daily. One day while showering, the patient was found lying with her face immersed in water that had accumulated on the floor of the bathtub. A forensic autopsy revealed water in the stomach, trachea, and proximal regions of both lung bronchi as well as white and red foam on the pharynx and larynx. A total of 1.9 µg/mL of lamotrigine, 0.14 µg/mL of carbamazepine, and 0.069 µg/mL of perampanel were detected in the patient's blood. The patient's cause of death was determined to be drowning due to an epileptic seizure. Although the patient was prescribed five types of antiepileptic medication, only three were detected in her blood. The current case demonstrates that drowning can occur while showering, suggesting that it is unsafe for patients with medication nonadherence. To prevent unintentional deaths in the bathroom, we recommend that patients with epilepsy maintain high adherence to all prescriptions and are supervised by a family member, even when showering. The current case is the first autopsy report of a patient with epilepsy who drowned while showering.


Assuntos
Afogamento/etiologia , Afogamento/patologia , Epilepsia Resistente a Medicamentos/patologia , Adulto , Anticonvulsivantes/sangue , Anticonvulsivantes/uso terapêutico , Autopsia , Epilepsia Resistente a Medicamentos/tratamento farmacológico , Feminino , Humanos , Japão , Adesão à Medicação
17.
Inj Prev ; 25(5): 392-399, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-29875291

RESUMO

INTRODUCTION: Globally, rivers are a common drowning location. In Australia, rivers are the leading location for fatal drowning. Limited information exists on exposure and impact on river drowning risk. METHODS: Australian unintentional fatal river drowning data (sourced from coronial records) and nationally representative survey data on river visitation were used to estimate river drowning risk based on exposure for adults (18 years and older). Differences in river drowning rates per 100 000 (population and exposed population) were examined by sex, age group, activity prior to drowning, alcohol presence and watercraft usage. RESULTS: Between 1 January 2014 and 31 December 2016, 151 people drowned in Australian rivers; 86% male and 40% aged 18-34 years. Of survey respondents, 73% had visited a river within the last 12 months. After adjusting for exposure: males were 7.6 times more likely to drown at rivers; female drowning rate increased by 50% (0.06-0.09 per 100 000); males aged 75+ years and females aged 55-74 years were at highest risk of river drowning; and swimming and recreating pose a high risk to both males and females. After adjusting for exposure, males were more likely to drown with alcohol present (RR=8.5; 95% CI 2.6 to 27.4) and in a watercraft-related incident (RR=25.5; 95% CI 3.5 to 186.9). CONCLUSIONS: Calculating exposure for river drowning is challenging due to diverse usage, time spent and number of visits. While males were more likely to drown, the differences between males and females narrow after adjusting for exposure. This is an important factor to consider when designing and implementing drowning prevention strategies to effectively target those at risk.


Assuntos
Afogamento/etiologia , Afogamento/prevenção & controle , Rios , Adulto , Distribuição por Idade , Idoso , Austrália/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recreação , Fatores de Risco , Distribuição por Sexo , Natação/estatística & dados numéricos , Adulto Jovem
18.
Acta Paediatr ; 108(4): 731-739, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30252948

RESUMO

AIM: Our aim was to improve our understanding of the contextual factors contributing to child drowning in rural West Bengal, India. METHODS: This 2017 study used interviews, focus groups and observations and the participants included community leaders, household heads, parents and children aged 7-17 years from three remote villages. They included adults and children who had been directly affected by the loss of family members or friends. RESULTS: We conducted 19 in-depth interviews, six focus groups and three informal observations in public locations where people were exposed to water. The area contained a high number of natural open areas of water, which increased the drowning risk. Participants reported that children frequently played unsupervised near potentially hazardous water, as their parents worked long hours and there was a lack of safe recreational spaces. Suggested approaches to reducing the drowning risk included parental education to improve child supervision and establishing village committees to effectively communicate the drowning risks to local government. Low-cost, community-based approaches to improving child water safety need to be developed. CONCLUSION: Drowning was clearly a complex issue in rural West Bengal, with a significant impact on children and their families. Community-based approaches are clearly needed.


Assuntos
Afogamento/prevenção & controle , Conhecimentos, Atitudes e Prática em Saúde , Adolescente , Adulto , Criança , Afogamento/etiologia , Feminino , Humanos , Índia , Masculino , Pessoa de Meia-Idade , População Rural
19.
Inj Prev ; 25(5): 459-471, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-30514722

RESUMO

BACKGROUND: The WHO advocates a 7-step process to enable countries to develop and implement drowning prevention strategies. We sought to assess, using existing data sources, the drowning situation in Tanzania as a first step in this process. METHODS: We searched for data on causes of death in Tanzania by reviewing existing literature and global datasets and by in-country networking. Authors and institutions were then contacted to request aggregate data on drowning mortality. Site-specific drowning estimates were combined using a random effects meta-analytic approach. We also tested for evidence of variations in drowning estimates by sex and by age group. RESULTS: We acquired partial or complete information on drowning deaths for 13 data sources. We found strong evidence for substantial variations between study sites (p<0.001). Combining population-based data, we estimated an average of 5.1 drowning deaths per 100 000 persons per year (95% CI 3.8 to 6.3). The proportions of deaths due to drowning were 0.72% (95% CI 0.55 to 0.88) and 0.94% (95% CI 0.09 to 1.78) combining population-based data and hospital-based data, respectively. Males were at greater risk than females, while both under-five children and adults aged 45 years or more were at greater risk than those aged 5-44 years. CONCLUSION: Our estimates of drowning burden are broadly in line with the 2016 Global Burden of Disease and the 2015 WHO Global Health Estimates. While this exercise was useful in raising the burden of drowning in Tanzania with policy makers, planning drowning prevention strategies in this country will require a better understanding of which subpopulations are at high risk.


Assuntos
Afogamento/mortalidade , Adolescente , Adulto , Distribuição por Idade , Idoso , Causas de Morte , Criança , Pré-Escolar , Afogamento/etiologia , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Distribuição por Sexo , Tanzânia/epidemiologia , Adulto Jovem
20.
J Appl Physiol (1985) ; 125(4): 1128-1130, 2018 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-30070612

RESUMO

The advent of artificial ventilation was largely sparked by the popular belief that drowning and other causes of asphyxia could induce death-like states known as suspended animation. While the mystical nature of such states befuddled some physicians into the early 1900s, an English medical student by the name of Edmund Goodwyn (1756-1829) published a thesis in 1786, which demonstrated that suspended animation was simply the physical manifestation of extreme hypoxia. Goodwyn's work advanced one of the earliest arguments in favor of artificial ventilation for the treatment of asphyxia over alternative resuscitation measures like heat and exsanguination. In addition, Goodwyn's remarkable dissertation contains the first account of a reflex known as diving bradycardia, and possibly the first vehement refutation of claims by his contemporaries that pulmonary circulation stopped during exhalation. While miscellaneous aspects of his thesis have occasionally been mentioned by a few medical historians, the overall visionary nature of his work has yet to be recognized. This article attempts to accomplish this goal and to provide a first biographical glimpse of a man whose scientific career appears to have ended prematurely, perhaps because of his profound aversion to controversy.


Assuntos
Fisiologia/história , Respiração Artificial/história , Animais , Afogamento/etiologia , História do Século XVIII , História do Século XIX , Humanos , Circulação Pulmonar , Respiração
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