RESUMO
Drugs are a rare cause of immune hemolytic anemia, but an investigation for a drug antibody may be warranted if a patient has definitive evidence of immune hemolysis, other more common causes of hemolysis have been excluded, and there is a good temporal relationship between the administration of a drug and the hemolytic event. Drug antibodies are either drug-dependent (require drug to be in the test system) or drug-independent (reactive without drug present in the test). Drug-dependent antibodies are investigated by testing drug-treated red blood cells (RBCs) or by testing RBCs in the presence of a solution of drug. Drug-independent antibodies are serologically indistinct from idiopathic warm autoantibodies and cannot be defined or excluded by serologic testing. Nonimmunologic protein adsorption, caused by some drugs, is independent of antibody production but may also cause immune hemolytic anemia. Serologic methods for testing for drug antibodies are presented, and observations from more than 30 years of this laboratory's experience are discussed.
Assuntos
Anemia Hemolítica Autoimune/induzido quimicamente , Complexo Antígeno-Anticorpo/sangue , Autoanticorpos/sangue , Adsorção , Anemia Hemolítica Autoimune/diagnóstico , Anemia Hemolítica Autoimune/história , Anemia Hemolítica Autoimune/imunologia , Antibacterianos/efeitos adversos , Antineoplásicos/efeitos adversos , Proteínas Sanguíneas/química , Proteínas Sanguíneas/imunologia , Células Cultivadas , Teste de Coombs , Eritrócitos/efeitos dos fármacos , Eritrócitos/imunologia , Reações Falso-Positivas , Hemólise/imunologia , História do Século XX , História do Século XXI , Humanos , beta-Lactamas/efeitos adversosRESUMO
This review updates new findings in drug-induced immune- hemolytic anemia (DIIHA) since the 2007 review in Immunohematology by these authors. Twelve additional drugs have been added to the three tables listing drugs associated with drug-dependent antibodies, drugs associated with drug-independent antibodies, and drugs associated with nonimmunologic protein adsorption. Other updated findings include (1) piperacillin is currently the most commonly encountered cause of DIIHA, (2) new data on blood group specificity of drug-dependent antibodies, (3) drug-dependent antibodies detected in healthy donors, (4) DIIHA associated with transplantation, and(5) DIIHA associated with chemotherapeutic drugs.
Assuntos
Anemia Hemolítica Autoimune/imunologia , Complexo Antígeno-Anticorpo/sangue , Autoanticorpos/sangue , Adsorção , Anemia Hemolítica Autoimune/induzido quimicamente , Anemia Hemolítica Autoimune/diagnóstico , Anemia Hemolítica Autoimune/história , Antibacterianos/efeitos adversos , Proteínas Sanguíneas/química , Proteínas Sanguíneas/imunologia , Células Cultivadas , Teste de Coombs , Eritrócitos/efeitos dos fármacos , Eritrócitos/imunologia , Hemólise/imunologia , História do Século XXI , Humanos , Imunossupressores/efeitos adversos , Transplante de Órgãos , Piperacilina/efeitos adversosRESUMO
Drug-induced immune hemolytic anemia (DIIHA) is a rare condition that occurs primarily as a result of drug-induced antibodies, either drug-dependent or drug-independent. Drug- dependent antibodies can be detected by testing drug-treated red blood cells (RBCs) or untreated RBCs in the presence of a solution of drug. Drug-independent antibodies react with untreated RBCs (no drug added) and cannot be distinguished from warm autoantibodies. Many changes have occurred during the last 30 years, such as which drugs most commonly cause DIIHA, the optimal testing methods for identifying them, and the theories behind the mechanisms by which they react. This article reviews the major changes in DIIHA since the early 1980s involving the immune complex mechanism, cephalosporins, nonimmunologic protein adsorption, and penicillins. Because serologic results associated with DIIHA can mimic those expected with autoimmune hemolytic anemia or hemolytic transfusion reactions, DIIHA may go undetected in some cases.
Assuntos
Anemia Hemolítica Autoimune/imunologia , Complexo Antígeno-Anticorpo/sangue , Autoanticorpos/sangue , Anemia Hemolítica Autoimune/induzido quimicamente , Anemia Hemolítica Autoimune/diagnóstico , Anemia Hemolítica Autoimune/história , Antibacterianos/efeitos adversos , Proteínas Sanguíneas/química , Proteínas Sanguíneas/imunologia , Células Cultivadas , Cefalosporinas/efeitos adversos , Teste de Coombs , Eritrócitos/efeitos dos fármacos , Eritrócitos/imunologia , Hemólise/imunologia , História do Século XX , História do Século XXI , Humanos , Penicilinas/efeitos adversos , Ligação ProteicaAssuntos
Anemia Hemolítica Autoimune/história , Hormônio Adrenocorticotrópico/história , Hormônio Adrenocorticotrópico/uso terapêutico , Anemia Hemolítica Autoimune/imunologia , Anemia Hemolítica Autoimune/terapia , Especificidade de Anticorpos , Anti-Hipertensivos/efeitos adversos , Anti-Hipertensivos/história , Autoanticorpos/imunologia , Transfusão de Sangue/história , Colite Ulcerativa/complicações , Colite Ulcerativa/história , Cortisona/história , Cortisona/uso terapêutico , Eritrócitos/imunologia , Heparina/história , Heparina/uso terapêutico , História do Século XX , Humanos , Imunossupressores/história , Imunossupressores/uso terapêutico , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/história , Transtornos Linfoproliferativos/complicações , Transtornos Linfoproliferativos/história , Metildopa/efeitos adversos , Metildopa/história , EsplenectomiaAssuntos
Anemia Hemolítica Autoimune/história , Anemia Hemolítica Autoimune/classificação , Anemia Hemolítica Autoimune/diagnóstico , Autoanticorpos/classificação , Eritrócitos/imunologia , Eritrócitos/patologia , História do Século XV , História do Século XVI , História do Século XVII , História do Século XVIII , História do Século XIX , História do Século XX , HumanosRESUMO
After 1940, the number of splenectomies performed in the United States and elsewhere increased rapidly. Splenectomy for Banti's disease and malaria decreased gradually into disrepute. Removal of the spleen for idiopathic thrombocytopenic purpura, congenital spherocytic anemia and acquired hemolytic anemia became accepted practice. However, debate still continues regarding the proper indications for splenectomy in Gaucher's disease, Felty's syndrome and leukemia.