Assuntos
Falso Aneurisma/imunologia , Aneurisma Cardíaco/imunologia , Doença Relacionada a Imunoglobulina G4/imunologia , Imunoglobulina G/análise , Insuficiência da Valva Mitral/imunologia , Miocárdio/imunologia , Plasmócitos/imunologia , Falso Aneurisma/diagnóstico por imagem , Falso Aneurisma/patologia , Falso Aneurisma/cirurgia , Biomarcadores/análise , Feminino , Fibrose , Glucocorticoides/uso terapêutico , Aneurisma Cardíaco/diagnóstico por imagem , Aneurisma Cardíaco/patologia , Aneurisma Cardíaco/cirurgia , Implante de Prótese de Valva Cardíaca , Humanos , Doença Relacionada a Imunoglobulina G4/complicações , Doença Relacionada a Imunoglobulina G4/diagnóstico , Doença Relacionada a Imunoglobulina G4/tratamento farmacológico , Anuloplastia da Valva Mitral , Insuficiência da Valva Mitral/diagnóstico por imagem , Insuficiência da Valva Mitral/patologia , Insuficiência da Valva Mitral/cirurgia , Miocárdio/patologia , Resultado do Tratamento , Adulto JovemAssuntos
Arterite/diagnóstico por imagem , Arterite/imunologia , Aneurisma Cardíaco/diagnóstico por imagem , Aneurisma Cardíaco/imunologia , Doença Relacionada a Imunoglobulina G4/diagnóstico por imagem , Doença Relacionada a Imunoglobulina G4/imunologia , Imunoglobulina G/imunologia , Esteroides/efeitos adversos , Esteroides/uso terapêutico , Aortite , Aneurisma Cardíaco/complicações , Humanos , Imunoglobulina G/sangue , Doença Relacionada a Imunoglobulina G4/complicações , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/diagnóstico por imagem , Imagem de Perfusão do Miocárdio , Revascularização Miocárdica , Tomografia Computadorizada por Raios X/métodosRESUMO
BACKGROUND: Systemic thromboembolism is a serious, major complication in patients with an atrial septal aneurysm (ASA). Paroxysmal atrial fibrillation (AF) is more common in patients with ASA than in the normal population. Neutrophil/lymphocyte ratio (NLR) has been associated with postoperative AF development in patients who have undergone cardiac surgery. This study investigated NLR in a group of ASA patients compared with a control group of healthy volunteers. PATIENTS AND METHODS: The study group consisted of 40 patients with ASA; the control group consisted of 30 age-, sex-, and body mass index-matched healthy volunteers. All patients and control subjects underwent echocardiographic examination. No patient had a recent history of an acute infection or an inflammatory disease. Baseline NLR was measured by dividing neutrophil count by lymphocyte count. RESULTS: No statistically significant difference was found between the two groups in terms of basic characteristics. Mean NLR was significantly higher among persons with ASA compared with controls (3.4 ± 1.5 vs 1.6 ± 0.97, P < 0.001). CONCLUSION: Our results suggest that a higher NLR, an emerging marker of inflammation, has a positive correlation with ASA. The measurement of NLR may be used to indicate an increased risk of arrhythmia, such as AF, in ASA patients.
Assuntos
Septo Interatrial , Aneurisma Cardíaco/sangue , Linfócitos , Neutrófilos , Adulto , Idoso , Septo Interatrial/diagnóstico por imagem , Estudos de Casos e Controles , Ecocardiografia Doppler em Cores , Eletrocardiografia , Feminino , Aneurisma Cardíaco/diagnóstico por imagem , Aneurisma Cardíaco/imunologia , Humanos , Contagem de Linfócitos , Linfócitos/imunologia , Masculino , Pessoa de Meia-Idade , Neutrófilos/imunologia , Valor Preditivo dos TestesRESUMO
Aortic regurgitation (AR) and first-degree atrioventricular heart block (FDAVB) are encountered in ankylosing spondylitis (AS). This rheumatological disease also presents in 90% of the cases an immunogenetic marker that is Human Leucocyte Antigen-B27 (HLA-B27). In this report we describe a case of a patient presenting with AR, FDAVB, aneurysm and thinning of the ascending aortic wall, aneurysm of the sinuses of Valsalva and inferior myocardial infarction-like electrocardiographic pattern with unknown cardiac AS and absence of other AS-related systemic manifestations.
Assuntos
Insuficiência da Valva Aórtica/imunologia , Antígeno HLA-B27/imunologia , Aneurisma Cardíaco/imunologia , Bloqueio Cardíaco/imunologia , Infarto Miocárdico de Parede Inferior/imunologia , Espondilite Anquilosante/imunologia , Insuficiência da Valva Aórtica/diagnóstico , Insuficiência da Valva Aórtica/genética , Insuficiência da Valva Aórtica/fisiopatologia , Angiografia Coronária , Ecocardiografia Transesofagiana , Eletrocardiografia , Aneurisma Cardíaco/diagnóstico , Aneurisma Cardíaco/genética , Aneurisma Cardíaco/fisiopatologia , Bloqueio Cardíaco/diagnóstico , Bloqueio Cardíaco/genética , Bloqueio Cardíaco/fisiopatologia , Humanos , Infarto Miocárdico de Parede Inferior/diagnóstico , Infarto Miocárdico de Parede Inferior/genética , Infarto Miocárdico de Parede Inferior/fisiopatologia , Masculino , Pessoa de Meia-Idade , Espondilite Anquilosante/diagnóstico , Espondilite Anquilosante/genética , Espondilite Anquilosante/fisiopatologiaAssuntos
Falso Aneurisma/imunologia , Anticorpos Anticardiolipina/imunologia , Aneurisma Cardíaco/imunologia , Ventrículos do Coração , Falso Aneurisma/diagnóstico , Falso Aneurisma/cirurgia , Biomarcadores/sangue , Diagnóstico Diferencial , Ecocardiografia , Feminino , Aneurisma Cardíaco/diagnóstico , Aneurisma Cardíaco/cirurgia , Humanos , Pessoa de Meia-Idade , Valva MitralRESUMO
OBJECTIVE: Multiple humoral and cellular abnormalities in Kawasaki disease (KD) have already been described. In this study an analysis of immunological findings in a cohort of 34 Italian children affected with KD is reported, and the potential clinical significance of such alterations in predicting the development of coronary aneurysm and the prognosis of the disease is evaluated. METHODS: Levels of circulating immune complexes (CIC), antinuclear antibodies (ANA), anticardiolipin (aCL), antineutrophil cytoplasmic antibodies (ANCA), and anti-endothelial cells (AECA) and the T cell profile were determined in both the acute and the convalescent phases, and were compared to febrile, sex- and age-matched children. RESULTS: CIC were present in 66% of the patients, 18 of whom were in the acute phase and 13 in the convalescent phase. In the control group CIC were detected in 47% of the children. ANA were negative in both the KD and in the febrile group. ANCA were present in 8%, AECA in 26%, and aCL in 30% of KD patients (IgG aCL antibodies were found in 14 patients, IgM aCL in, 1 and 1 had both). Among the controls, aCL antibodies were found in 5 patients (22%); in particular 1 (4.4%) had IgG and 4 (17.4%) had IgM aCL. An altered T cell profile, with an inverted CD4/CD8 ratio, was found in all KD children. All of the immune alterations showed a lower incidence in the convalescent than in the acute phase. No significant relationship between any of these immune findings and cardiac involvement or any other clinical manifestations was found. CONCLUSION: Our data confirms the previously reported immunological anomalies in KD both in the acute and the convalescent phases, with a decreased incidence of such alterations in the convalescent phase. No prognostic significance for the occurrence of aneurysm could be demonstrated.