Assuntos
Dermatite Alérgica de Contato , Dermatite Ocupacional , Jardinagem , Testes do Emplastro , Humanos , Dermatite Alérgica de Contato/etiologia , Dermatite Alérgica de Contato/diagnóstico , Dermatite Ocupacional/etiologia , Dermatite Ocupacional/diagnóstico , Masculino , Adulto , Feminino , Asteraceae/efeitos adversos , Pessoa de Meia-IdadeAssuntos
Dermatite Alérgica de Contato , Dermatite Ocupacional , Sesquiterpenos , Tanacetum , Humanos , Sesquiterpenos/efeitos adversos , Dermatite Ocupacional/etiologia , Dermatite Alérgica de Contato/etiologia , Tanacetum/efeitos adversos , Feminino , Lactonas/efeitos adversos , Adulto , Testes do Emplastro , Masculino , Pessoa de Meia-Idade , Asteraceae/efeitos adversosRESUMO
BACKGROUND: Allergic contact dermatitis (ACD) to Compositae is caused by sensitisation to sesquiterpene lactones (SQLs) and subsequent exposure can occur from direct handling or from airborne transmission. Plants from the Compositae family are ubiquitous globally and their plant extracts are also used in various products. OBJECTIVES: Investigation of contact allergy (CA) and allergic contact dermatitis (ACD) to Compositae at a single dermatology centre. METHODS: A retrospective case review was performed on patients undergoing patch testing to Compositae between January 2011 and December 2020 in Melbourne, Australia. RESULTS: Of 3679 patients, 44 (1.2%) patch tested positive to Compositae and 19 (43.2%) reactions were deemed relevant. Thirteen cases (68.4%) were from direct contact with Compositae plants, mostly in gardeners. Six cases (31.6%) were from personal products and all these patients were female. Involvement of the face was significant (p = 0.007). Simultaneous allergic reactions included SQL mix in eight (42.1%), fragrance mix in seven (36.8%), potassium dichromate in three (15.8%) and colophonium in two (10.5%) cases. CONCLUSION: Contact with Compositae from gardening contributed most cases of ACD; however, personal products accounted almost one-third of cases. Treatment options remain limited and avoidance is the most important aspect of management.
Assuntos
Asteraceae , Dermatite Alérgica de Contato , Sesquiterpenos , Alérgenos , Asteraceae/efeitos adversos , Austrália/epidemiologia , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/etiologia , Humanos , Testes do Emplastro/métodos , Plantas , Estudos Retrospectivos , Sesquiterpenos/efeitos adversosAssuntos
Anticorpos Monoclonais Humanizados/uso terapêutico , Asteraceae/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Fármacos Dermatológicos/uso terapêutico , Dermatite Alérgica de Contato/diagnóstico , Dermatite Atópica/tratamento farmacológico , Humanos , Masculino , Pessoa de Meia-Idade , Testes do Emplastro , Adulto JovemRESUMO
BACKGROUND: Fragrances are the most common cause of cosmetic contact allergy. Up-to-date information on contact allergy frequencies and relevance aids primary and secondary preventive measures. OBJECTIVES: To determine the prevalence, associated factors, and concomitant reactions in fragrance allergy among Thais. METHODS: This retrospective study collected data from 2012 to 2019. The patient characteristics of fragrance and nonfragrance allergy groups were compared. Concurrent positive reactions to fragrance allergens (fragrance mix [FM] I, FM II, Myroxylon pereirae resin and hydroxyisohexyl 3-cyclohexene carboxaldehyde) and other baseline-series allergens were analysed. RESULTS: Of 1032 patients, 175 (17.0%) had fragrance allergy, with 57.7% of clinical relevance. FM I showed the highest prevalence (9.4%). The associated factors were being elderly, lesions on the extremities, metal allergy history, and long dermatitis duration. Contact allergies to epoxy resin and Compositae plants were significantly associated with fragrance allergy with an odds ratio of 5.95 (95% confidence interval [CI]: 5.21-6.80) and an odds ratio of 4.42 (95% CI: 1.58-12.36), respectively. No significant associations between colophonium (previously proposed as a fragrance marker) and fragrance allergens were found. CONCLUSIONS: The prevalence of fragrance contact allergy remains high and should be considered in old patients presenting with long-standing eczema on the extremities. Unlike reports from other countries, varied, significant, concomitant reactions were observed.
Assuntos
Alérgenos/efeitos adversos , Cosméticos/efeitos adversos , Dermatite Alérgica de Contato/epidemiologia , Odorantes , Adulto , Fatores Etários , Asteraceae/efeitos adversos , Estudos de Casos e Controles , Dermatite Alérgica de Contato/etiologia , Resinas Epóxi/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes do Emplastro , Prevalência , Estudos Retrospectivos , Tailândia/epidemiologia , Adulto JovemAssuntos
Anti-Inflamatórios/uso terapêutico , Asteraceae/efeitos adversos , Ciclosporina/uso terapêutico , Dermatite Alérgica de Contato/tratamento farmacológico , Fármacos Dermatológicos/uso terapêutico , Imunossupressores/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Dermatite Alérgica de Contato/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
IMPORTANCE: When fragrance- and botanical-related (F/BR) allergy is identified, concomitant reaction (CR) frequencies can help direct avoidance recommendations. OBJECTIVE: This study aimed to determine the CR rates for F/BR allergens. DESIGN: A retrospective cross-sectional analysis of the North American Contact Dermatitis Group data 2007-2016 was conducted. Frequencies of demographics, positive reactions, strength of reactions, trends, and CR rates were calculated. RESULTS: A total of 5504 (22.7%) of 24,246 patients had F/BR allergic reactions. The F/BR-sensitive patients were more likely to be female, older than age 40 years, and White and have face, leg, or anal/genital dermatitis. Top allergens included fragrance mix I (FMI, 10.6%), Myroxylon pereirae (balsam of Peru [BOP], 8%), and fragrance mix II (FMII, 4.9%). There were increasing trends for FMI, FMII, cinnamic aldehyde, and Compositae mix and decreasing trends for BOP and propolis. When patients were positive to any F/BR allergen, they were likely to be positive to FMI, FMII, and BOP. Concomitant reactions were bidirectional between multiple fragrance allergens and propolis, colophony, and Compositae mix. CONCLUSIONS: Concomitant reactions were identified between fragrances, between fragrances and BR allergens, and between BR allergens and fragrances. If CRs of greater than 10% suggest cross-reactivity, then all patients with fragrance sensitivity should avoid BR allergens and vice versa.
Assuntos
Alérgenos/efeitos adversos , Reações Cruzadas , Dermatite Alérgica de Contato/etiologia , Acroleína/efeitos adversos , Acroleína/análogos & derivados , Adolescente , Adulto , Asteraceae/efeitos adversos , Dermatite Alérgica de Contato/terapia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Myroxylon/efeitos adversos , Odorantes , Perfumes/efeitos adversos , Própole/efeitos adversos , Estudos Retrospectivos , Adulto JovemRESUMO
Pyrrolizidine alkaloids (PA) and PA N-oxides (PANO) are secondary plant metabolites exhibiting genotoxic and carcinogenic properties. Apart from the roots and leaves, PA/PANO are particularly present in pollen and nectar. Therefore, the spread of Jacobaea vulgaris in certain regions of northern Germany has an impact on the safety of honey produced in that region. In this study, raw honey samples (n = 437) were collected from usually three individual beehives per site (n = 73) in the district of Ostholstein and analyzed for 25 PA/PANO. The results reveal mean levels of 8.4, 1.5, and 72.6 µg/kg and maximum levels of 111, 59.4, and 3313 µg/kg, depending on the season (summer 2015 and spring/summer 2016, respectively). As far as individual data are concerned, sites near areas with J. vulgaris growth did not necessarily result in high PA/PANO values. Furthermore, intra-site investigations revealed remarkable differences in PA/PANO levels of raw honey collected by different bee colonies at the same site. Consumption of these regionally produced honeys entails an increased exposure to PA/PANO, especially in children and high consumers. Margin of exposure values of <10,000 and an exceedance of the health-based guidance value highlight that regionally produced and marketed honey must be considered with care for a proper risk assessment and risk management.
Assuntos
Asteraceae/metabolismo , Abelhas , Mel/análise , Óxidos/análise , Pólen/metabolismo , Alcaloides de Pirrolizidina/análise , Animais , Asteraceae/efeitos adversos , Qualidade de Produtos para o Consumidor , Alemanha , Pólen/efeitos adversos , Alcaloides de Pirrolizidina/efeitos adversos , Medição de Risco , Estações do Ano , Metabolismo Secundário , Fatores de TempoRESUMO
BACKGROUND: Compositae plant sensitization in children is relatively frequent. From 1995-2006, we found a prevalence of 1.8% sesquiterpene lactone (SL) mix/parthenolide patch test positives among consecutive eczema patients <18 years. OBJECTIVES: To report the results of patch test screening for Compositae sensitization in patients <18 years in the last 13 years. METHODS: Children and adolescents <18 years, diagnosed with Compositae sensitization between 2007 and 2019, were included. RESULTS: Among 388 children tested, 12 (3%) were Compositae-sensitized, and 11 (2.8%) had positive reactions to SL mix. Compositae mix 5% pet. elicited positive reactions in six of seven patients tested, and dandelion extract 2.5% pet. in six of 10 patients tested. The mean age of the five girls and seven boys was 9.4 years and 11.7 years, respectively. Eleven children had a personal and one a family history of atopy, and 11 children had hand eczema. Only two were mono-sensitized to Compositae. CONCLUSIONS: SL mix is a suitable screening agent among children and adolescents in our area, well supplemented with Compositae mix 5% and dandelion extract. The study emphasizes the importance of Compositae screening in children with a personal and/or family history of atopy, hand eczema or widespread airborne dermatitis, summer exacerbation, and plant exposure.
Assuntos
Alérgenos/efeitos adversos , Asteraceae/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Sesquiterpenos/efeitos adversos , Adolescente , Criança , Dinamarca , Feminino , Humanos , Masculino , Extratos Vegetais/efeitos adversos , Sesquiterpenos/administração & dosagemRESUMO
BACKGROUND: Chronic actinic dermatitis (CAD) is a persistent eczematous photodermatitis classically described in older, white men with contact allergy to plants. However, evidence from recent studies suggests that some demographics of CAD patients may be changing. OBJECTIVE: The aims of the study were to determine the frequency of CAD in patients presenting with photosensitive eruptions and to identify the allergens and photoallergens most closely associated with this condition. METHODS: We identified all patients with a diagnosis of CAD from 246 consecutive records of patients undergoing photopatch testing from July 1994 to June 2018 and summarized the demographics and test results in comparison with non-CAD patients. CONCLUSIONS: Nineteen (7.7%) of the 246 patients evaluated had CAD with a male-to-female ratio of 1:1.7 among CAD patients. Compared with non-CAD patients, photocontact allergy and/or contact allergy to sesquiterpene lactone mix and contact allergy to fragrances were significantly more common in CAD. Contact allergy to p-phenylenediamine was also common. The results of this study suggest that CAD presents in a broader demographic range, including both men and women of both light and dark skin types. Phototesting and photopatch testing should be considered when patients present with clinical findings consistent with CAD.
Assuntos
Dermatite Fotoalérgica/epidemiologia , Transtornos de Fotossensibilidade/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Asteraceae/efeitos adversos , Bálsamos/efeitos adversos , Dermatite Fotoalérgica/etiologia , Feminino , Humanos , Cetoprofeno/efeitos adversos , Lactonas/efeitos adversos , Masculino , Pessoa de Meia-Idade , Odorantes , Testes do Emplastro , Fenilenodiaminas/efeitos adversos , Transtornos de Fotossensibilidade/etiologia , Propanóis/efeitos adversos , Sesquiterpenos/efeitos adversos , Distribuição por Sexo , Adulto JovemRESUMO
BACKGROUND: Both florists' chrysanthemums (Chrysanthemum cultivars) and marguerite daisies (Argyranthemum frutescens [L.] Sch.Bip. and its varieties and cultivars) are popular ornamental plants in Denmark. OBJECTIVES: To present results of aimed patch testing with chrysanthemum and marguerite daisy extracts in Danish patients with Compositae sensitization. METHODS: The results of patch testing with chrysanthemum extract 3% petrolatum (pet.) and marguerite daisy extract 3% pet. (and possibly 1% pet.) from 1998 to 2019 were analyzed. RESULTS: Altogether, 111/191 (58%) patients tested positive to chrysanthemum extract and 104/179 (58%) tested positive to marguerite daisy. The majority was recreationally exposed, and most reactions were considered relevant. Feverfew extract 1% pet., Compositae mix 5% or 6% pet., or parthenolide 0.1% pet. may cross-react with chrysanthemum; Compositae mix seems to be best at detecting sensitization to marguerite daisy. CONCLUSIONS: In areas where exposure to chrysanthemum or marguerite daisies is prevalent, it is suggested to include extracts of these plants in the plant series to improve diagnosis of, and advice to, Compositae-allergic patients.
Assuntos
Asteraceae/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Dermatite Ocupacional/etiologia , Exposição Ambiental/efeitos adversos , Flores/efeitos adversos , Adulto , Idoso , Idoso de 80 Anos ou mais , Chrysanthemum/efeitos adversos , Dinamarca/epidemiologia , Dermatite Alérgica de Contato/diagnóstico , Dermatite Alérgica de Contato/epidemiologia , Dermatite Ocupacional/diagnóstico , Dermatite Ocupacional/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes do Emplastro , Extratos Vegetais/efeitos adversosRESUMO
BACKGROUND: Compositae contact sensitization may be difficult to diagnose, because of a lack of reliable screening allergens. OBJECTIVES: To assess the suitability of Compositae mix II 2.5% pet. (CM2.5) as a screening mix in the baseline series combined with sesquiterpene lactone (SL) mix and parthenolide (PTH). METHODS: CM2.5 was added to the baseline series, which included SL mix and PTH 0.1% pet., in January 2015, and PTH was included in TRUE Test Panel 3 in October 2015. All Compositae-sensitive patients diagnosed or tested in the next 4 years were assessed. RESULTS: Altogether, 57 patients (2.7%) presented with Compositae allergy. On primary testing in 53 newly diagnosed patients, SL mix elicited positive reactions most frequently (53% positive), followed by CM2.5 (47% positive), and PTH (45% positive). CM2.5 and PTH pet. elicited a few irritant reactions. Three patients had late reactions. Altogether, 16 patients (28%) were not detected by any of the three screening agents. CONCLUSIONS: SL mix is an indispensable, although insufficient, screening mixture in Denmark. It may be relatively safely supplemented with CM2.5 and PTH in the TRUE Test system for screening, but, when Compositae sensitization is suspected, further extracts should be tested on the basis of the history.
Assuntos
Alérgenos/efeitos adversos , Asteraceae/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Lactonas/efeitos adversos , Extratos Vegetais/efeitos adversos , Sesquiterpenos/efeitos adversos , Adolescente , Adulto , Criança , Pré-Escolar , Dermatite Alérgica de Contato/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes do Emplastro , Adulto JovemRESUMO
BACKGROUND: The Compositae plant family includes many thousands of species, making it one of the most widespread group of plants worldwide. Sensitization to Compositae allergens may occur in private or in occupational settings. OBJECTIVES: To monitor the current spectrum of sensitization to Compositae allergens, especially in cooks and florists. METHODS: We retrospectively analysed patch test results obtained with two Compositae mixes (CMs) (CM I and CM II; switch in October 2011), their individual components, and sesquiterpene lactone (SL) mix in 1492 cooks, 851 florists, and a control group (118 358 other patients) registered in the IVDK, 2007 to 2016. RESULTS: Florists reacted significantly more frequently to CM I and II (CM I, 8.7%; CM II, 10.6%) than did cooks (CM I, 2.1%; CM II, 0.8%) and controls (CM I, 1.3%; CM II, 1.2%). Additional testing with SL mix detected 14.3% more sensitizations than CM I or CM II alone. CONCLUSIONS: Florists are at considerable risk of sensitization to Compositae allergens. Patch testing with both CM and SL mix is recommended.
Assuntos
Asteraceae/efeitos adversos , Dermatite Alérgica de Contato/diagnóstico , Dermatite Ocupacional/diagnóstico , Testes do Emplastro/métodos , Sesquiterpenos/efeitos adversos , Adulto , Alérgenos/efeitos adversos , Dermatite Alérgica de Contato/etiologia , Dermatite Ocupacional/etiologia , Humanos , Extratos Vegetais/efeitos adversos , Estudos RetrospectivosRESUMO
BACKGROUND: Many patients with dermatitis over photo-exposed body areas are positive to many contact allergens and have a pre-existing allergic contact dermatitis. METHODS: This study included patients who presented to a tertiary centre in India with dermatitis on photo-exposed body areas suspected of chronic actinic dermatitis. Their detailed histories were recorded and cutaneous and systemic examinations were performed. Patch testing was done in all the patients and photo-patch testing was carried out in 86 patients. RESULTS: Altogether 101 patients were included (69 males, 32 females). The most common presentation was lichenified hyperpigmented plaques on the photo-exposed sites. Photosensitivity was recorded in 64 (63%) patients and summer exacerbation in 52 (52%). Exposure to the Parthenium hysterophorus weed was recorded in 70 (69%) patients, 27 (26.7%) had a history of hair dye application and 20 (20%) had a history of atopy. Photo-patch test was positive in 11 (12.8%) patients and patch testing was positive in 71 (70%). Parthenium hysterophorus was the most common allergen implicated and was positive in three (4%) photo-patch and 52 (52%) patch tests. Other positive photo-patch test allergens were perfume mix, balsam of Peru, thiuram mix, Compositae mix and promethazine hydrochloride. Other common patch test allergens were parthenolide, colophony, fragrance mix and p-phenylenediamine (PPD) base. CONCLUSION: In the Indian population parthenium and perfume mix are the most common photoallergens in patients with dermatitis over photo-exposed areas, while parthenium, colophony, fragrance mix and PPD are the common positive allergens.
Assuntos
Alérgenos/efeitos adversos , Hiperpigmentação/etiologia , Transtornos de Fotossensibilidade/etiologia , Adulto , Idoso , Asteraceae/efeitos adversos , Bálsamos/efeitos adversos , Feminino , Humanos , Hiperpigmentação/patologia , Índia , Masculino , Pessoa de Meia-Idade , Partenogênese , Testes do Emplastro/métodos , Perfumes/efeitos adversos , Transtornos de Fotossensibilidade/patologia , Extratos Vegetais/efeitos adversos , Luz Solar/efeitos adversos , Centros de Atenção Terciária , Tiram/efeitos adversos , Adulto JovemRESUMO
BACKGROUND: Compositae dermatitis was originally described as airborne contact dermatitis. More recent studies have reported a wider clinical spectrum, but often in polysensitized patients. OBJECTIVE: To evaluate the clinical features of patients sensitized to Compositae only. PATIENTS/METHODS: Consecutive Compositae-sensitive eczema patients, tested between 1990 and 2015, who, at the patch testing session diagnosing their Compositae allergy, were found to be sensitized only to the plant family, were included. RESULTS: Altogether, 529 of 13 139 patients tested (4.0%) were sensitized to Compositae, and 95 (18% of these) were monosensitized. The majority had hand eczema, and 39 (44%) had a vesicular volar pattern. Eighty-one patients were classified into one of three groups of similar size: localized eczema, eczema of exposed skin, and localized eczema turning into widespread eczema. CONCLUSIONS: The prevalence of Compositae sensitization is continuously high in consecutive eczema patients. Sensitization may occur at any age. Clinical features in monosensitized patients vary, but, with continuing exposure, the patients may develop more widespread dermatitis similar to classic Compositae dermatitis. Avoidance may clear the exogenous part, but not endogenous aetiological factors such as vesicular hand eczema or possible photosensitivity. Thorough clinical assessment and patient education are important in reducing the impact of Compositae contact allergy.
Assuntos
Asteraceae/efeitos adversos , Dermatite Alérgica de Contato/epidemiologia , Dermatite Alérgica de Contato/etiologia , Dermatoses da Mão/epidemiologia , Dermatoses da Mão/etiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Dinamarca/epidemiologia , Dermatite Alérgica de Contato/patologia , Dermatite Ocupacional/epidemiologia , Dermatite Ocupacional/etiologia , Eczema/epidemiologia , Eczema/etiologia , Feminino , Jardinagem/estatística & dados numéricos , Dermatoses da Mão/patologia , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Testes do Emplastro , Prevalência , Adulto JovemRESUMO
The objective of this study was to evaluate the effects of the ethanolic crude extracts and fractions of the species Senecio westermanii Dusén on Lactuca sativa L. (lettuce) and Allium cepa L. (onion) seeds. We assessed the germination, growth, root respiration and photosynthesis of the target species in Petri dishes (9.0 cm diameter) containing filter paper n°6. The study was conducted using 50 seeds per plate and held in 4 replicates per concentration of each sample. In the germination there was an inhibitory effect of fractions hexane (FH) and chloroform (FCl) at concentrations of 500 and 1000 µg/mL. There was a reduction in the radicle growth of lettuce by 14 to 24% and a reduction of hypocotilum by 14 to 28%. As for the radicle of the onion was up 74% reduction to the FCl and the coleoptile was 24 and 45% reduction for FH and FCl, respectively. Inhibitory effects in the root respiration of lettuce were detected in all the samples analyzed, with results ranging from 16 to 83%. For the seeds of A. cepa, there was an encouragement for the FCl and ethyl acetate fractions (FAE), with results ranging from 94 to 142% and 76 to 150%, respectively. With regard to the photosynthesis of L. sativa, there was no significant difference between the control, and as for the A. cepa, there was a strain in inhibition concentrations of 250 and 500 µg/mL, which ranged from 27 to 68%. The samples of S. westermanii caused changes in the target species and thus can be used as a natural herbicide.
Assuntos
Sementes/crescimento & desenvolvimento , Extratos Vegetais/efeitos adversos , Lactuca/crescimento & desenvolvimento , Asteraceae/efeitos adversos , Cebolas/crescimento & desenvolvimento , Componentes Aéreos da Planta , Senécio/classificação , Alelopatia/fisiologiaRESUMO
Patients with Compositae sensitization are routinely warned against the ingestion of vegetables, spices, teas and herbal remedies from this family of plants. The evidence for the occurrence of systemic allergic dermatitis caused by sesquiterpene lactone-containing plants is mostly anecdotal and based on statements from patients rather than scientific data. However, a few clinical reports on accidental sensitization and exposure and oral challenge prove the existence of this kind of reaction, most convincingly for strong contact allergens such as costunolide in bay leaves, and less so for weak allergens such as those of lettuce. Other Compositae species suspected of causing systemic reactions are artichoke, mugwort, yarrow, dandelion, feverfew, and elecampane. Some Compositae vegetables and teas, such as lettuce and chamomile tea, may induce systemic reactions through both humoral and cell-mediated mechanisms. It is difficult to disentangle the contribution of these reactions to both local and systemic symptoms of skin and mucous membranes in, for example, lettuce contact allergy. Further studies are needed to assess the prevalence of systemic allergic dermatitis caused by sesquiterpene lactones, and to clarify the pathogenesis for individual haptens.