Beyond Mendelism and Biometry.

Historiographical analyses of the development of genetics in the first decade of the 20th century have been to a great extent framed in the context of the Mendelian-Biometrician controversy. Much has been discussed on the nature, origin, development, and legacy of the controversy. However, such a framework is becoming less useful and fruitful. This paper challenges the traditional historiography framed by the Mendelian-Biometrician distinction. It argues that the Mendelian-Biometrician distinction fails to reflect the theoretical and methodological diversity in the controversy. It also argues that the Mendelian-Biometrician distinction is not helpful to make a full understanding of the development of genetics in the first decade of the twentieth century.

Galton, reversion and the quincunx: The rise of statistical explanation.

Over the last six decades there has been a consistent trend in the philosophy literature to emphasize the role of causes in scientific explanation. The emphasis on causes even pervades discussions of non-causal explanations. For example, the concern of a recent paper by Marc Lange (2013b) is whether purported cases of statistical explanation are "really statistical" or really causal. Likewise, Michael Strevens (2011) argues that the main task of statistical idealizations is to distinguish between the causal factors that make a difference to the phenomenon to be explained and those that do not. But, the philosophy literature poorly reflects the history of the development of statistical explanation in the sciences. Francis Galton's (19th century) explanation for the laws of heredity is our case. Galton's statistical explanation was both innovative for his time and influential to our contemporary sciences. The key points to understanding Galton's statistical explanation for reversion is that it is autonomous from the real-world biological properties that make up an instance of reversion while still being approximately true of many real-world biological phenomena. Ours is an expanded discussion of ideas originated in Hacking (1990) and Sober (1980). We will articulate these features and compare our account with that of Lange and Strevens.

François Pourfour du Petit (1664-1741): pioneer in ocular biometry.

PURPOSE: To outline the important contributions of the French physician Petit to the development of ocular biometry. CONTENT: After a brief review of Petit's life and his studies in neurology, anatomy, and cataract surgery, the methodology and results of his work in measuring many of the biometric parameters of the human eye are discussed. Among other techniques, he made use of frozen sections of eyes to explore their dimensions and employed an immersion technique to avoid the effect of corneal refraction on the appearance of the iris. His pioneering biometric results have been largely confirmed by modern studies. Those on the changes in the crystalline lens with age are particularly striking and suggest that these ocular aging effects have changed little over the last 300 years. Although largely forgotten today, his biometric work exercised a considerable influence on his more immediate successors, including Porterfield and Thomas Young. SUMMARY: François Pourfour du Petit deserves to be remembered as an important contributor to our understanding of the structure and dimensions of the human eye.

Statistical Reasoning and Methods in Epidemiology to Promote Individualized Health: In Celebration of the 100th Anniversary of the Johns Hopkins Bloomberg School of Public Health.

Epidemiology is concerned with determining the distribution and causes of disease. Throughout its history, epidemiology has drawn upon statistical ideas and methods to achieve its aims. Because of the exponential growth in our capacity to measure and analyze data on the underlying processes that define each person's state of health, there is an emerging opportunity for population-based epidemiologic studies to influence health decisions made by individuals in ways that take into account the individuals' characteristics, circumstances, and preferences. We refer to this endeavor as "individualized health." The present article comprises 2 sections. In the first, we describe how graphical, longitudinal, and hierarchical models can inform the project of individualized health. We propose a simple graphical model for informing individual health decisions using population-based data. In the second, we review selected topics in causal inference that we believe to be particularly useful for individualized health. Epidemiology and biostatistics were 2 of the 4 founding departments in the world's first graduate school of public health at Johns Hopkins University, the centennial of which we honor. This survey of a small part of the literature is intended to demonstrate that the 2 fields remain just as inextricably linked today as they were 100 years ago.

More than a Mentor: Leonard Darwin's Contribution to the Assimilation of Mendelism into Eugenics and Darwinism.

This article discusses the contribution to evolutionary theory of Leonard Darwin (1850-1943), the eighth child of Charles Darwin. By analysing the correspondence Leonard Darwin maintained with Ronald Aylmer Fisher in conjunction with an assessment of his books and other written works between the 1910s and 1930s, this article argues for a more prominent role played by him than the previously recognised in the literature as an informal mentor of Fisher. The paper discusses Leonard's efforts to amalgamate Mendelism with both Eugenics and Darwinism in order for the first to base their policies on new scientific developments and to help the second in finding a target for natural selection. Without a formal qualification in biological sciences and as such mistrusted by some "formal" scientists, Leonard Darwin engaged with key themes of Darwinism such as mimicry, the role of mutations on speciation and the process of genetic variability, arriving at important conclusions concerning the usefulness of Mendelian genetics for his father's theory.

The role of empirical Bayes methodology as a leading principle in modern medical statistics.

This paper reviews and discusses the role of Empirical Bayes methodology in medical statistics in the last 50 years. It gives some background on the origin of the empirical Bayes approach and its link with the famous Stein estimator. The paper describes the application in four important areas in medical statistics: disease mapping, health care monitoring, meta-analysis, and multiple testing. It ends with a warning that the application of the outcome of an empirical Bayes analysis to the individual "subjects" is a delicate matter that should be handled with prudence and care.

The curious case of blending inheritance.

For more than a century, geneticists have consistently identified the origins of their science with Gregor Mendel's experiments on peas. Mendelism, they have said, demonstrated at long last that biological inheritance was not, as had so often been supposed, "blending," but particulate. Many historians of biology continue to interpret the conflict of biometricians and Mendelians at the start of the twentieth century in these terms, identifying biometry with the (incorrect) blending mechanism. But this view of blending is history as war by other means. While Francis Galton's contrast between blended and alternate inheritance had become familiar by 1905, he and his interpreters understood the two forms as differing outcomes of breeding, not as rival theories. Only a few biologists in this period went beyond blending as a description of results of breeding to a blending mechanism, and these were not biometricians. Recognizing this, we can see also that statistical methods and models were central to evolutionary genetics right from the start. The evolutionary synthesis, while reshaping their role, did not create it.

Fisher in Adelaide.

R. A. Fisher spent much of his final 3 years of life in Adelaide. It was a congenial place to live and work, and he was much in demand as a speaker, in Australia and overseas. It was, however, a difficult time for him because of the sustained criticism of fiducial inference from the early 1950s onwards. The article discusses some of Fisher's work on inference from an Adelaide perspective. It also considers some of the successes arising from this time, in the statistics of field experimentation and in evolutionary genetics. A few personal recollections of Fisher as houseguest are provided. This article is the text of a article presented on August 31, 2012 at the 26th International Biometric Conference, Kobe, Japan.

Sir Ronald A. Fisher and the International Biometric Society.

The year 2012 marks the 50th anniversary of the death of Sir Ronald A. Fisher, one of the two Fathers of Statistics and a Founder of the International Biometric Society (the "Society"). To celebrate the extraordinary genius of Fisher and the far-sighted vision of Fisher and Chester Bliss in organizing and promoting the formation of the Society, this article looks at the origins and growth of the Society, some of the key players and events, and especially the roles played by Fisher himself as the First President. A fresh look at Fisher, the man rather than the scientific genius is also presented.

R.A. Fisher's gene-centred view of evolution and the Fundamental Theorem of Natural Selection.

The background to R.A. Fisher's enunciation of his Fundamental Theorem of Natural Selection in 1930 is traced and the Theorem in its original form explained. It can now be seen as the centrepiece of Fisher's introduction of the gene-centred approach to evolutionary biology. Although this paper is a sequel to Edwards (1994) it is not a review of the recent literature on the Theorem, to which, however, reference is made at the end.

O Gabinete Biometrico da Escola de Educacao Fisica do Exercito: medir e classificar para produzir corpos ideais, 1930-1940* / The Biometric Cabinet of the Escola de Educacao Fisica do Exercito: measuring and classifying to produce ideal bodies, 1930-1940

Analisa práticas biométricas e biotipológicas do Gabinete Biométrico da Escola de Educação Física do Exército, Rio de Janeiro, presentes na Revista de Educação Física do Exército nas décadas de 1930 e 1940. Era preciso classificar, controlar periodicamente os resultados dos exercícios e medir aspectos morfológicos dos corpos. As classificações eram feitas segundo modelos estrangeiros, e buscava-se classificar tipo, qualidades e defeitos. A análise das práticas do Gabinete demonstra que biometria e biotipologia foram mobilizadas complementarmente pela educação física, objetivando a normatização dos corpos.

This paper analyzes biometrical and biotypological practices of the Biometric Cabinet of the Escola de Educação Física do Exército (Physical Education School of the Army) in Rio de Janeiro in the 1930s and 1940s, published in Revista de Educação Física do Exército. It was necessary to classify, monitor the results of the exercises periodically and measure morphological aspects of the bodies. The classifications were made in accordance with foreign parameters and an attempt was made to classify by type, quality and defects. The analysis of the practices of the Cabinet shows that biometrics and biotypology were complementary aspects of physical education, aiming at the standardization of bodies.

Presidential Address: XXVI International Biometric Conference, Kobe, Japan, August 2012 education in developing countries--the role of IBS.

Here we discuss the building of statistical knowledge, mainly in developing countries. We highlight some words from Past IBS Presidents and IBS actions that show the role of IBS in education with an emphasis on developing countries. Some examples show that international exchanges are a well-known way of improving the quality of teaching, learning and research and stress the point that individual initiatives are very important (and fruitful) for education, but we should encourage some more general actions.

Internal social processes of discipline formation: the case of kinanthropometry.

In 1972, the term 'kinanthropometry', derived from the Greek words 'kinein' (to move), 'anthropos' (human) and 'metrein' (to measure), was launched in the international, Francophone journal Kinanthropologie by the Canadian William Ross and the Belgians, Marcel Hebbelinck, Bart Van Gheluwe and Marie-Louise Lemmens. The authors defined this neologism as 'the scientific discipline for the study of the size, shape, proportion, scope and composition of the human being and its gross motor functions'. Presenting a theoretical framework for the analysis of the internal social processes of discipline formation - derived from the social history-of-science tradition - this article critically examines whether kinanthropometry was indeed promoted and developed by its community members as a scientific discipline. Therefore, the focus will be on its conceptualisation and positioning within the field of kinanthropology/kinesiology and on its development by a scholarly association, i.e. the International Working Group on Kinanthropometry (IWGK). The strong emphasis of the kinanthropometry community on the standardisation of measurement techniques and its practical and professional application hampered its disciplinary development. Findings of this study could serve as a basis for future 'fundamental' investigations addressing questions of disciplinary development within the field(s) of physical education, kinesiology and sport science(s).

Miquel Crusafont, George Simpson y la internacionalización de los estudios de paleontología evolutiva en España / One foot in heaven and the other in science. The productive interactions of Miquel Crusafont (1910-1983)

El paleontólogo catalán Miquel Crusafont Pairó (1910-1983) fue un destacado especialista en los mamíferos fósiles del Terciario de la Península Ibérica. Además, fue el introductor de nuevos enfoques en torno a la biología evolutiva en España. A pesar de las numerosas dificultades que había para investigar en evolución en la España franquista, Crusafont logró alcanzar una posición notable en la comunidad internacional de paleontólogos. Aparte de ser un científico competente, se vio favorecido por la amistad del paleontólogo estadounidense George Gaylord Simpson (1902-1984), uno de los impulsores de la síntesis evolucionista. Este artículo se ocupa de la relación entre ambos científicos y enfatiza el papel fundamental que Simpson representó en la internacionalización del trabajo de Crusafont (AU)

Catalan palaeontologist Miquel Crusafont Pairó (1910-1983) was a leading specialist on fossil mammals of the Iberian Tertiary. He also introduced new quantitative approaches to biological evolution into Spain. Despite many difficulties in carrying out research on evolution in Franco's Spain, Crusafont achieved an outstanding position in the international community of palaeontologists. Besides being a competent scientist, he benefitted from the friendship of American palaeontologist George Gaylord Simpson (1902-1984), a major proponent of the evolutionary synthesis. This paper explores the relationship between both scientists and stresses the crucial role that Simpson played in the internationalization of Crusafont's work (AU)