Assuntos
Depressores do Apetite , Modelos Animais de Doenças , Hipertensão Pulmonar/induzido quimicamente , Oxazóis , Equilíbrio Ácido-Base , Aminas , Animais , Temperatura Corporal , Peso Corporal , Cães/efeitos dos fármacos , Ventrículos do Coração/efeitos dos fármacos , Placebos , Resistência Vascular , Equilíbrio HidroeletrolíticoRESUMO
Three techniques for using the dog as an assay organism for Clostridium perfringens enterotoxin are described. These are believed to be more convenient than ligated ileal-loop procedures.
Assuntos
Clostridium perfringens/patogenicidade , Cães/efeitos dos fármacos , Enterotoxinas/toxicidade , Administração Oral , Animais , Cápsulas , Corantes , Preparações de Ação Retardada , Diarreia/induzido quimicamente , Modelos Animais de Doenças , Enterotoxinas/administração & dosagem , Fatores de TempoRESUMO
Triamcinolone acetonide was administered in excessive dosage to dogs to study the renal mechanism responsible for polyuria which is a clinically undesirable side effect of long term glucocorticoid therapy.Polyuria occurred coincident with a significant increase in urinary solute output. Although continuous administration of triamcinolone acetonide at 0.1 or 0.2 mg/lb/day caused a small but significant increase in creatinine output, the primary mechanism for the polyuria was increased solute excretion. Associated with the polyuria was pronounced hyperphagia and polydipsia. The cause of the hyperphagia was not established. The increase in electrolyte excretion caused by this synthetic steroid was probably compensated for by the hyperphagia. Because all the dogs showed muscle weakness and loss of body condition, it is likely that alteration in protein and amino acid metabolism was responsible for the hyperphagia.
