Analysis of local, regional, and distant recurrence of disease in mucoepidermoid tumors of larynx: A systematic review.

The aim of this systematic review is to analyze epidemiology, clinical presentation, histopathological features, treatment and oncological outcomes in laryngeal mucoepidermoid cancer (MEC) in order to improve the knowledge on the management of such a rare malignant neoplasm. Specifically, authors highlight patients' and tumors' features about local, regional, and distant recurrence of disease. PRISMA 2020 guidelines were applied in this systematic literature review. A computerized search was performed using the Embase/Pubmed, Scopus, and Cochrane databases, for articles published from 1971 to December 2023. A descriptive and univariate analysis including selected papers with low or intermediate risk of bias was performed. Twenty-seven papers (11 case series and 16 case reports) were included in this review. Fifty-six patients were included in the analyses, with a mean age of 56.7 years; 84% of them were males. Most patients (86%) underwent a primary surgical approach. Clinical stage was reported as follows: early stage (26 patients) and locally advance and advanced stage (19 patients). Overall survival (OS) and disease-free survival (DFS) at 2 years was 80% and 78%, respectively. The mean time to local recurrence was 18.7 months (range 8-36 months). The survival after recurrence is about 85% and 70% at 5 years, respectively. The mean time of lymph node recurrence was 14.7 months (range 7-19 months). Finally, the mean time of distant recurrence was 15 months (range 7-36 months) with a poor prognosis: all patients died due to the disease in a range of 0-7 months after metastasis evidence. Laryngeal MEC is a rare neoplasm of minor salivary glands in the larynx. No guidelines or indications about the management of this neoplasm are reported in the literature. The lower incidence of regional recurrence of the disease and the better OS and DFS underline how the prognosis of MEC is more favorable respect to other malignant histotypes.

Salivary gland-type cancers: cross-organ demographics of a rare cancer.

BACKGROUND: Salivary gland-type cancers (SGTCs) are histologically heterogeneous and can affect organs other than the salivary glands. Some tumors outside the salivary glands are diagnosed on their unique histological characteristics. Comprehensive cross-organ studies on SGTCs are limited. METHODS: We retrospectively analyzed the data of patients with salivary duct carcinoma (SDC), adenoid cystic carcinoma (AdCC), mucoepidermoid carcinoma (MEC), epithelial-myoepithelial carcinoma (EMC), acinic cell carcinoma (AcCC), and polymorphous adenocarcinoma (PAC) who visited our institution between 2009 and 2019. The primary tumor sites were classified into four categories; major salivary glands, head/neck (H/N) excluding (exc) major salivary glands (MSG) regions, broncho-pulmonary regions, and "others". H/N exc MSG was further divided into three subcategories, nasal/paranasal sinus, oral and pharynx/larynx. RESULTS: We identified 173 patients with SGTCs, with SDC, AdCC, MEC, EMC, AcCC, and PAC accounting for 20%, 42%, 27%, 3%, 8%, and 1% of the cases, respectively. The most frequent primary site was the major salivary glands (64%), followed by H/N exc MSG regions (27%), broncho-pulmonary regions, and "others", thus non-salivary gland origins accounted for 9% of all cases. Patients with SDC, MEC, AcCC, or SGTC of the major salivary glands and broncho-pulmonary regions were more frequently treated by surgery. The overall survival time of the patients with MEC was significantly better than that of patients with SDC or EMC. CONCLUSIONS: This cross-organ study highlights the clinical significance of SGTCs, underscoring the need for developing novel therapies for this rare disease entity.

Retrospective study of 149 cases of salivary gland carcinoma in a Spanish hospital population

BACKGROUND: The clinical and histological characteristics of salivary gland tumors vary widely, complicating their diagnosis and management, and major differences have been recorded in the distribution of histopathological diagnoses among different countries. MATERIAL AND METHODS: This retrospective study reviewed the demographic (age, sex) and clinicopathological (pathology diagnosis and localization) characteristics of cases diagnosed with primary SGC between June 1992 and May 2014 in the Pathology Department of the 12 de Octubre Hospital of Madrid. Diagnoses were recorded according to the 2005 WHO classification. RESULTS: The study included 149 SCG patients, aged between 11 and 94 yrs., with mean age at onset of 55.56 yrs and peak incidence in the eighth decade of life. The male: female ratio was 1.01. The parotid gland was the most frequently involved (75.2%). The most frequent carcinoma was mucoepidermoid carcinoma (24.2%), followed by acinic cell carcinoma (15.4%). CONCLUSIONS: The demographic and histopathological characteristics of patients with salivary gland carcinomas in Spain, reported here for the first time, are broadly similar to those found in other countries

Minor intraoral salivary gland tumors: a clinical-pathological study / Neoplasias intraorais de glândula salivar menor: estudo clínico-patológico

ABSTRACT Objective To evaluate the clinical-pathological profile of patients with minor salivary gland neoplasms. Methods A retrospective study of specific cases diagnosed as benign and malignant tumors of the minor salivary glands was performed. The data were collected from medical records of patients seen at a hospital over a period of 15 years. The sample was made up of 37 cases. For the pathological study, slides containing 5μm thick sections stained with hematoxylin and eosin were used. The data were tabulated using descriptive statistics. Results Malignant neoplasms represented 70.3% of cases. The mucoepidermoid carcinoma was the most common neoplasm (45.9%), followed by pleomorphic adenoma (24.4%). Most patients were female (70.3%), aged between 71 and 80 years. The palate (67.6%) and the retromolar region (10.8%) were the most affected sites. Conclusion Mucoepidermoid carcinoma was the most common tumor in minor salivary glands. These tumors are more common in females aged over 40 years. The palate was the most common affected site.

RESUMO Objetivo Avaliar o perfil clínico-patológico de pacientes com neoplasias de glândula salivar menor. Métodos Foi realizado um estudo retrospectivo de casos específicos diagnosticados como neoplasias benignas ou malignas de glândula salivar menor. Os dados foram coletados dos prontuários dos pacientes atendidos em um hospital no período de 15 anos. A amostra final foi de 37 casos. Para o estudo histopatológico, foram usadas lâminas contendo secções com 5μm de espessura, coradas pela técnica de hematoxilina e eosina. Os dados foram tabulados de forma descritiva. Resultados As neoplasias malignas representaram 70,3% dos casos. O tipo histológico mais prevalente foi o carcinoma mucoepidermoide (45,9%), seguido do adenoma pleomórfico (24,4%). A maioria dos pacientes era do sexo feminino (70,3%), com idade entre 71 e 80 anos. O palato (67,6%) e a região retromolar (10,8%) foram os sítios mais acometidos. Conclusão O carcinoma mucoepidermoide foi o tumor mais comum das glândulas salivares menores. Estes tumores foram mais comuns em mulheres com mais de 40 anos. O palato foi o sítio mais acometido.

Mucoepidermoid carcinoma of the salivary glands: a retrospective study of 51 cases and review of the literature / Carcinoma mucoepidermoide de glándulas salivales. estudio retrospectivo de 51 casos y revisión de la literatura

The aim of this study is to present the casuistic of mucoepidermoid carcinoma of salivary glands in patients diagnosed at “Dr. Eduardo Cáceres Graziani” National Institute for Neoplastic Diseases, Lima, Perú. From January 2002 to December 2012, 51 cases were diagnosed as mucoepidermoid carcinoma. The number of female patients was higher, with 28 cases (54.9%), and regarding age distribution, 33.3% of the patients were under 30 years old. Pain was one of the main symptoms, and 74.5% of the mucoepidermoid carcinomas were located in the parotid gland. It is concluded that epidemiology regarding age and gender of the 51 cases analyzed was in the same range as other studies, and that most cases were located in major salivary glands, in agreement with reports on other populations. Other characte ristics showed a homogeneous distribution.

El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el Instituto Nacional de Enfermedades Neoplásicas “Dr. Eduardo Cáceres Graziani” Lima, Perú, desde el 2002 hasta el 2012. Realizamos un estudio retrospectivo en el cual fueron incluidos sujetos con diagnóstico primario de carcinoma mucoepidermoide en glándulas salivales. Entre enero de 2002 y diciembre de 2012, se registraron 51 casos. El número de pacientes de sexo femenino fue mayor, con 28 casos (54,9%) y con respecto a la distribución por edades, el 33,3% de los pacientes eran menores de 30 años de edad. El dolor fue uno de los síntomas principales. El 74,5% de los carcinomas mucoepidermoides se localizaron en la glándula parótida. De los hallazgos obtenidos se concluye principalmente que en lo que respecta a la distribución epidemiológica de edad y género de los 51 casos analizados estas variaron en el mismo rango de otros estudios. También se distingue que el mayor número de casos estuvieron localizados en glándulas salivales mayores, dato en concordancia con otras poblaciones reporta das. Las demás características presentaron una distribución homogénea.

Lesiones intraorales de glándulas salivales menores / Intraoral lesions of minor salivary glands: analysis of 59 patients

Background: Most salivary gland lesions are benign. Tumors are uncommon. Pleomorphic adenoma and cystic adenoid carcinoma are the most common benign and malignant lesions. Aim: To assess the incidence management and evolution of intraoral lesions among patients consulting in a head and neck surgical service. Material and Methods: Retrospective review of medical records of patients consulting for intraoral lesions of minor salivary glands between 1975 and 2009 in a head and neck surgical service. Results: Thirty five females and 24 males are reported. Forty eight (81 percent) had benign lesions. Of these, 35 (73 percent). were non neoplastic lesions. Eleven patients had malignant lesions. Of these, four (36 percent) had a mucoepidermoid carcinoma, two (18 percent) had an adenoid-cystic carcinoma, two (18 percent) had an acinous cell carcinoma and one patient each had an undifferentiated carcinoma, an adenocarcinoma and an epidermoid carcinoma. Conclusions: In this series of patients, benign lesions predominated. Benign lesions were excised and the management of malignant lesions depended on the type of tumor.

Introducción: Las lesiones de glándulas salivales menores son en su mayoría benignas. Los tumores son infrecuentes y conforman un grupo heterogéneo, siendo el adenoma pleomorfo la neoplasia benigna más frecuente y el carcinoma adenoideo-quístico el tumor maligno más encontrado. Objetivos: El propósito de este estudio es evaluar la incidencia, manejo y evolución de las lesiones intraorales de glándulas salivales menores en el Servicio de Cirugía de Cabeza y Cuello del Hospital Barros Luco-Trudeau. Material y Método: Se presenta estudio retrospectivo de 59 casos tratados entre 1975 y 2009 en dicho hospital. Resultados: Encontramos 35 mujeres y 24 hombres. En 48 pacientes (81,3 por ciento) se encontró lesiones benignas, de las cuales 35 (73 por ciento) correspondieron a lesiones no neoplásicas y 13 (27 por ciento) a neoplasias. Las neoplasias malignas fueron 11 (18,6 por ciento del total), 4 (36,3 por ciento) con Ca mucoepidermoide, 2 (18 por ciento) con Ca adenoideo-quístico, 2 (18 por ciento) con Ca de células acinosas, 1 (9 por ciento) con Ca indiferenciado, 1 (9 por ciento) con adenocarcinoma y 1 (9 por ciento) con Ca epidermoide. Conclusiones: Las lesiones de glándulas salivales menores en nuestro hospital se caracterizan por ser predominantemente benignas. Se encontró similar frecuencia de tumores benignos y malignos. Predominó el adenoma pleomorfo entre los primeros y el carcinoma mucoepidermoide entre los segundos. Los tumores benignos, luego de su extirpación, se manejaron con cierre del lecho tumoral mediante rotación de colgajos locales de mucosa oral para cobertura y, en algunos casos, cierre por segunda intención. La evolución fue en general excelente. En el caso de los tumores malignos, el manejo dependió de Ia histología.

Tumors of the salivary gland in Mexicans. A retrospective study of 360 cases

Objective: To establish distribution frequency and demographic characteristics of salivary gland tumours (SGT)in order to identify possible risk profiles. Design of study: The present report constitutes an eight year retrospective study (January 2000-August 2007). The archives of the Clinical and Experimental Pathology Laboratory (Graduate and Research Division, Dental School, National Autonomous University of Mexico) as well as archives of the Surgical Pathology Service (General Hospital, Mexico City) were subject to revision in order to select all cases where SGT tumour diagnoses were emitted. Age and gender of patients as well as SGT topography were obtained from medical records. Selected cases were classified according to location of the lesion, histological lineage and biological behaviour. Results: 360 cases of SGT were included, 227 (67%) cases were benign tumours, while 83 cases (23%) were malignant tumours. SGT were most frequent in women with ages ranging from their 3rd to 5th decades of life.275 tumours were located in major salivary glands, 78.9% of them were identified in the parotid gland. The most frequent location of tumours arising from minor salivary glands (33 cases, 38%) was found in the palatine glands. Tumours of epithelial lineage were the predominant histological type. The most frequent benign tumours were pleomorphic adenomas (86.1%) and papillary cyst adenoma lymphomatosum (7.3%). The most frequent malignant tumours were adenoid cystic carcinomas (25%) and mucoepidermoid carcinomas (23.6%) (AU)

Neoplasias de glándulas salivales menores: estudio de 10 años / Minor salivary gland tumours: a 10-year study

Las neoplasias de las glándulas salivales representan aproximadamente un 2-6,5 % de todos los tumores de la cabeza y cuello. El objetivo de este trabajo es identificar la frecuencia de neoplasias de glándulas salivales menores en pacientes de Medicina Oral de la Universidad Federal de Paraná atendidos de 1997 a 2007. Se realizó un estudio retrospectivo mediante el análisis de 1.923 laudos histopatológicos, y se halló 14 casos de neoplasias de glándulas salivales. Las lesiones encontradas fueron 7 tumores benignos y 7 malignos. Las alteraciones, en su mayoría, se encontraban en la mucosa palatina (71,5 %). En cuanto al tipo histológico, el 50 % se caracterizó como adenoma pleomorfo; el 28,6 %, como carcinoma mucoepidermoide; el 14,3 %, como carcinoma adenoide quístico, y el 7,1 %, como adenocarcinoma polimorfo. Estos resultados permiten concluir que las neoplasias de glándulas salivales tienen una baja incidencia en la población y que el adenomapleomorfo es el tipo de neoplasia más común, seguido del carcinoma mucoepidermoide (AU)

Salivary gland tumours represent between 2 % and 6.5 %, approximately, of all head and neck tumours. The aim of this paper was to identify the frequency of minor salivary gland tumours among patients in the Oral Medicine Clinic of the Federal University of Paraná during the period from 1997 to 2007. A retrospective study was conducted on 1,923 histopathological analyses of oral lesions. Fourteen cases of salivary gland tumours were found, of which 7 were benign and 7 malignant. The lesions were localized mainly in the palate (71.5 %). By histological type, 50 %of the lesions were characterized as pleomorphic adenoma, 28.6 % mucoepidermoid carcinoma, 14.3 % cystic adenoid carcinoma and 7.1 % as polymorphous adenocarcinoma. These findings suggest that salivary gland tumours have a low incidence in the population and that the pleomorphic adenoma is the most common type of tumour, followed by mucoepidermoid carcinoma (AU)

Tumores de la conjuntiva / Conjuctival tumors

Los tumores de la conjuntiva son unos de los más frecuentes del ojo y anejos. Abarcan un amplio espectro desde lesiones benignas como el papiloma a otras malignas que pueden poner en peligro la función visual y la vida del paciente, como el carcinoma epidermoide y el melanoma. Pueden surgir de cualquiera de las células que componen la conjuntiva aunque los más frecuentes son los de origen epitelial y melanocítico. El diagnóstico precoz es fundamental para prevenir la extensión ocular y sistémica y para preservar la función visual. En este artículo se revisan las características clínicas de los tumores conjuntivales más frecuentes y se discute su tratamiento

Conjunctival tumors are one of the most frequent of the eye and adnexa. They comprise a large variety of conditions, from benign lesions such as nevus or papiloma, to malignant lesions such as epidermoid carcinoma or melanoma which may threaten visual function and the life of the patient. They can arise from any cellular component, but the most frequent are of epithelial and melanocytic origin. Early diagnosis is essential for preventing ocular and systemic spread and to preserve visual function. In this paper we review the clinical characteristics of the most frequent conjunctival tumors, and we discuss tumor management (Arch Soc Esp Oftalmol 2009; 84: 7-22)

Intraoral mucoepidermoid carcinoma of salivary glands: lack of association among clinicopathological features and immunoexpression of c-erbB-2 in 29 cases

The association among clinicopathological features and c-erbB-2 oncoprotein expression was evaluated in twenty-nine cases of intra-oral mucoepidermoid carcinoma (MEC). MEC was prevalent in the female gender (79.3 percent), tumors were more frequent in ages between 21 and 40 years (48.3 percent), and the palate was the most commonly affected site (72.4 percent). Microscopically, 27 cases (93.1 percent) were classified as low grade of malignancy. The c-erbB-2 expression was considered positive in 9 (31 percent) cases and no significant association (p>0.05) was found among protein expression and gender nor between patient age and site or histological grade of the lesion. c-erbB-2 expression in MEC may reflect intrisinc biologic properties of salivary gland neoplasms and may be linked to histogenesis and cellular differentiaton.

Fueron evaluados 29 casos de carcinoma mucoepidermoide intraoral en sus aspectos clínico-patológicos, además de la expresión de la oncoproteina c-erbB-2. El carcinoma mucoepidermoide fue predominante en las mujeres (79,3 por ciento), siendo más frecuente en individuos entre 21 y 40 años de edad (48,3 por ciento). El paladar fue el sitio más comunmente afectado (72,4 por ciento). Microscópicamente, 27 casos (93,1 por ciento) fueron clasificados como de baja malignidad. La expresión del c-erbB-2 se consideró positiva en 9 (31 por ciento) casos y no fue observada ninguna asociación significativa (p>0,05) entre la expresión de la proteína y género, ni entre la edad de los pacientes y el sitio o el grado histológico de la lesión. La expresión de la c-erbB-2 en el carcinoma mucoepidermoide puede mostrar las propiedades biológicas intrísecas de las neoplasias de las glándulas salivales.

Tumores de las glándulas parótidas en Las Tunas: 2004 - 2006 / Parotid glands tumors in Las Tunas: 2004 - 2006

El cáncer es la segunda causa de muerte y la primera razón de años de vida potencialmente perdidos en Cuba. Los tumores malignos de glándulas salivales representan el 5 6 por ciento del cáncer de cabeza y cuello, una localización oncológica con incidencia creciente; mientras que entre el 65 y el 80 por ciento de los tumores de las glándulas salivales afectan a la parótida. Se realizó una investigación observacional descriptiva transversal en pacientes con tumores de parótida que asistieron a la consulta de Patología de Cabeza y Cuello del Hospital Dr. Ernesto Guevara de Las Tunas, durante el periodo de enero de 2004 a enero de 2006, para determinar el comportamiento de un conjunto de variables demográficas, tales como la edad, el sexo, los tipos predominantes de tumores benignos y malignos, entre otros. Los tumores benignos fueron más frecuentes en las mujeres; en los hombres las neoplasias se diagnosticaron a edades más avanzadas. El adenoma pleomorfo, entre las neoplasias benignas, y el carcinoma mucoepidermoide, entre las malignas, fueron las variedades histológicas con mayor incidencia en la muestra estudiada, con 70por ciento y 44,8 por ciento, respectivamente (AU)

Cancer is the second cause of death and the first reason of years of life potentially lost in Cuba. Malignant tumors of the salivary glands represent a 5 - 6 per cent of head and neck cancer, an oncological site with an increasing incidence, while between 65 per cent and 80per cent of the tumors of the salivary glands affect the parotid. An observational descriptive transversal investigation was carried out in patients with parotid tumors who attended the Office of Head and Neck Pathology of Dr. Ernesto Guevara Hospital, in Las Tunas, in the period from January 2004 to January 2006, to determine the behaviour of a set of demographic variables such as age, sex, the predominant types of benign and malignant tumors, among others. The benign tumors were most frequent in women, while in men neoplasias were diagnosed at advanced years. The pleomorphic adenoma among benign neoplasias and the mucoepidermoid carcinoma among the malignant neoplasias were the histological varieties with greater incidence in the sample studied, with 70 per cent and 44,8 per cent, respectively(AU)

Tumor mucoepidermoide de glándula salival menor / Mucoepidermoid tumor of salivary minor gland

Las glándulas salivares menores se presentan en mayor proporción en el paladar. Es allí donde los tumores benignos o malignos de las mismas aparecen con mayor frecuencia. El carcinoma mucoepidermoide (CM) es el segundo en frecuencia, tras el cilindroma, que puede aparecer en este tipo de glándulas. Su diagnóstico precoz y tratamiento quirúrgico se hacen necesarios dada su tendencia a la invasión tisular local o la formación de metástasis a distancia (AU)