Assuntos
Carcinoma/genética , Cromossomos Humanos Par 9/genética , Variação Genética/genética , Ceratoacantoma/genética , Proteínas Serina-Treonina Quinases/genética , Receptores de Fatores de Crescimento Transformadores beta/genética , Dermatopatias/genética , Carcinoma/etnologia , Estudos de Casos e Controles , Mutação em Linhagem Germinativa/genética , Humanos , Ceratoacantoma/etnologia , Receptores Patched , Polimorfismo de Nucleotídeo Único/genética , Receptor do Fator de Crescimento Transformador beta Tipo I , Receptores de Superfície Celular/genética , Escócia , Dermatopatias/etnologiaRESUMO
BACKGROUND: This is the first incidence report of keratoacanthoma (KA) in a Japanese ethnic population. METHODS: The study was designed as a 5-year prospective incidence study using an island-wide survey of Japanese residents in Kauai, Hawaii, during the years 1983 through 1987. RESULTS: Eleven Japanese residents of Kauai, three men and eight women, had KA. The crude incidence is 22.1 per 100,000 Japanese Kauaiian population. Two thirds of the lesions were on the extremities. No recurrence was noted, but a nonmelanoma skin cancer developed in some patients. CONCLUSIONS: The incidence of KA in a Japanese ethnic population is not low. Ultraviolet light exposure must, in part, contribute to the development of KA. This is supported by fact that the incidence of KA in Japanese residents in Kauai is much higher than in Japan and that most of the KAS appear on exposed skin.
Assuntos
Ceratoacantoma/etnologia , Idoso , Idoso de 80 Anos ou mais , Feminino , Havaí/epidemiologia , Humanos , Incidência , Japão/etnologia , Ceratoacantoma/epidemiologia , Masculino , Pessoa de Meia-Idade , Estudos ProspectivosRESUMO
BACKGROUND: Non-melanoma skin cancer is the most common malignancy in the white population of the United States with an estimated 700,000 new cases each year. Regrettably, data on minority racial groups are either scarce or lacking entirely. METHODS: This study was designed as a 5-year prospective incidence study of non-melanoma skin cancer and keratoacanthoma by using an island-wide survey of Kauai's Filipino residents and covers the years of 1983 to 1987. RESULTS: Seven basal cell carcinoma (incidence: 12.3/100,000), one squamous cell carcinoma (incidence: 1.8/100,000) and four keratoacanthoma (incidence: 7/100,000) patients are reported. CONCLUSIONS: To the best of our knowledge, this is the first population-based incidence report on non-melanoma skin cancer and keratoacanthoma in this population.
Assuntos
Doença de Bowen/etnologia , Doença de Bowen/epidemiologia , Carcinoma Basocelular/etnologia , Carcinoma Basocelular/epidemiologia , Carcinoma de Células Escamosas/etnologia , Carcinoma de Células Escamosas/epidemiologia , Ceratoacantoma/etnologia , Ceratoacantoma/epidemiologia , Neoplasias Cutâneas/etnologia , Neoplasias Cutâneas/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Doença de Bowen/patologia , Carcinoma Basocelular/patologia , Carcinoma de Células Escamosas/patologia , Feminino , Havaí , Humanos , Incidência , Ceratoacantoma/patologia , Masculino , Pessoa de Meia-Idade , Filipinas/etnologia , Estudos Prospectivos , Neoplasias Cutâneas/patologiaRESUMO
Standard microlymphocytic cytotoxic test was used in 43 cases of solitary keratoacanthoma. Increased incidence of HLA-B16 and HLA-B18 antigens was established. Presence of HLA-A2 was shown to adversely influence the course of the disease.