Diagnóstico y embolización con cianoacrilato de pseudoaneurismas de origen ginecológico / Diagnosis of gynecological pseudoaneurysms and embolization with cyanoacrylate

Los pseudoaneurismas de la arteria uterina son una causa infrecuente, pero muy grave, de hemorragia ginecológica como consecuencia de la manipulación quirúrgica pélvica o de partos instrumentalizados. Las distintas técnicas de imagen tienen vital importancia en el diagnóstico. La arteriografía es la prueba de confirmación y en muchos casos terapéutica. El tratamiento endovascular mediante embolización del pseudoaneurisma se ha consolidado como terapia de elección, lo que evita en muchos casos la histerectomía a mujeres en edad fértil. El objetivo de nuestro trabajo es presentar dos casos de hemorragia ginecológica por pseudoaneurismas, posquirúrgico y posparto, embolizados de manera novedosa con cianoacrilato (AU)

Pseudoaneurysms of the uterine artery are an uncommon cause of severe gynecological bleeding secondary to surgical manipulation of the pelvis or to instrumental delivery. The different imaging techniques are of vital importance in the diagnosis. Angiography is the technique used for confirmation and also for treatment in many cases. Endovascular treatment by embolizing the pseudoaneurysm has become established as the treatment of choice, making it possible to avoid hysterectomy in women of childbearing age. This article presents two cases of gynecological bleeding due to pseudoaneurysms (one secondary to surgery and one secondary to childbirth) that were embolized in a novel way using cyanoacrylate (AU)

Photo-oxidative action in MCF-7 cancer cells induced by hydrophobic cyanines loaded in biodegradable microemulsion-templated nanocapsules.

Searching for photodynamic therapy-effective nanocarriers which enable a photosensitizer to be selectively delivered to tumor cells with enhanced bioavailability and diminished dark cytotoxicity is of current interest. We have employed a polymer-based nanoparticle approach to encapsulate the cyanine-type photosensitizer IR-780 in poly(n-butyl cyanoacrylate) (PBCA) nanocapsules. The latter were fabricated by interfacial polymerization in oil-in-water (o/w) microemulsions formed by dicephalic and gemini saccharide-derived surfactants. Nanocarriers were characterized by SEM, AFM and DLS. The efficiency of PBCA nanocapsules as a potential system of photosensitizer delivery to human breast cancer cells was established by dark and photocytotoxicity as the function of the cellular mitochondria. The photodynamic effect of cyanine IR-780 was determined by investigation of oxidative stress markers. The nanocapsules were the main focus of our studies to examine their cellular uptake and dark and photocytotoxicity as the function of the cellular mitochondria as well as oxidative stress markers (i.e., lipid peroxidation and protein damage) in MCF-7/WT cancer cells. The effects of encapsulated IR-780 were compared with those of native photosensitizer. The penetration of the nanocapsules into cancer cells was visualized by CLSM and their uptake was estimated by FACS analysis. Cyanine IR-780 delivered in PBCA nanocapsules to MCF-7/WT cells retains its sensitivity upon photoirradiation and it is regularly distributed in the cell cytoplasm. The intensity of the photosensitizer-generated oxidative stress depends on IR-780 release from the effective uptake of polymeric nanocapsules and seems to remain dependent upon the surfactant structure in o/w microemulsion-based templates applied to nanocapsule fabrication.

Organic dyes containing furan moiety for high-performance dye-sensitized solar cells.

New metal-free dyes with a furan moiety in the conjugated spacer between the arylamine donor and the 2-cyanoacrylic acid acceptor have been synthesized, and high efficiency dye-sensitized solar cells were fabricated using these molecules as light-harvesting sensitizers.

Monomer conversion and hardness of novel dental cements based on ethyl cyanoacrylate.

OBJECTIVES: The aim of this work was to study the setting of two novel dental cements: (i) a 'hybrid' cement, incorporating an ethyl cyanoacrylate into a glass-ionomer cement (ECGIC) formulation and (ii) an ethyl cyanoacrylate/hydroxyapatite composite cement (ECHC). The mechanical role of the cyanoacrylate and its curing within the cements have been discussed. METHODS: The setting of the cements was characterised using Vickers indentation hardness and near-infrared (near-IR) spectroscopy. RESULTS: The cyanoacrylate component of ECGIC was 100% cured approximately 10min after the initial cement mixing. The ECGIC continued to increase in hardness after the cyanoacrylate component was fully cured. This proved that the fully polymerised network of cyanoacrylate did not prevent the acid-base reactions of the GIC components from continuing. The Vickers hardness number of ECGIC at 18 weeks was approximately 105. The curing of the cyanoacrylate within ECHC was much slower and was still not complete (98%) 18 weeks after the initial cement mixing. The hardness of the ECHC was shown to be correlated with the extent of cyanoacrylate cure. The Vickers hardness number of ECHC at 18 weeks was approximately 21. The primary reasons for the overall lower hardness of ECHC in comparison to ECGIC were the lower powder:liquid ratio and the softer filler type. SIGNIFICANCE: Careful consideration is needed when incorporating cyanoacrylates into dental cements, as speed of cure and hardness are particularly important.

A novel synthesis of (E)-3-methylthio-3-substituted arylamino-2-cyanoacrylates under microwave irradiation.

A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50 degrees C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells.

[Neutrophil and macrophage functional activity during the irradiation of an intestinal anastomosis with a low-intensity laser in the infrared spectral range]. / Funktsional'naia aktivnost' neitrofilov i makrofagov pri obluchenii kishechnogo anastomoza nizkointensivnym lazerom v infrakrasnom diapazone spektra.

The influence of different methods of treatment of intestinal anastomosis in rabbits (group 1: common single-row sutures; group 2: sutures treated with cyanacrylate glue CO-4; group 3: low-intensity laser irradiation through the skin in the infrared spectral range) on the phagocytic and oxidase activity of cells in the peritoneal washings and peripheral blood on days 2, 4 and 7 after the operation was studied. Laser irradiation of the suture was shown to produce a stimulating effect on the macrophagal-phagocytic system of the blood. The oxidase activity of phagocytes in peritoneal washings in the group of animals subjected to laser irradiation was considerably lower than in two other groups. The use of low-intensity laser radiation in the infrared spectral range produced a positive effect of the healing processes in intestinal sutures.