RESUMO
Experience in treatment of 91 patients with peritonitis on various genesis using antiseptic Dekasan are presented. A marked clinical efficacy compared with that of other antiseptics in the complex treatment of peritonitis was noted.
Assuntos
Anti-Infecciosos Locais/uso terapêutico , Compostos de Decametônio/uso terapêutico , Drenagem/métodos , Peritonite/tratamento farmacológico , Peritonite/cirurgia , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Anti-Infecciosos Locais/administração & dosagem , Anti-Infecciosos Locais/efeitos adversos , Terapia Combinada , Compostos de Decametônio/administração & dosagem , Compostos de Decametônio/efeitos adversos , Quimioterapia Combinada , Humanos , Peritonite/etiologia , Resultado do TratamentoAssuntos
Compostos de Decametônio/história , Fármacos Neuromusculares Despolarizantes/história , Succinilcolina/história , Bradicardia/induzido quimicamente , Queimaduras/fisiopatologia , Queimaduras/terapia , Criança , Compostos de Decametônio/efeitos adversos , Relação Dose-Resposta a Droga , Eletromiografia , Parada Cardíaca/induzido quimicamente , História do Século XX , Humanos , Dor Musculoesquelética/induzido quimicamente , Miastenia Gravis/complicações , Fármacos Neuromusculares Despolarizantes/efeitos adversos , Potássio/sangue , Succinilcolina/efeitos adversosRESUMO
Experience in local application of antiseptic Dekasan in the complex treatment of abdominal infections of various origins are presented. The clinical and economic efficacy of the drug application is notice.
Assuntos
Abdome/cirurgia , Anti-Infecciosos Locais/uso terapêutico , Peritonite/cirurgia , Abdome/microbiologia , Anti-Infecciosos Locais/administração & dosagem , Anti-Infecciosos Locais/efeitos adversos , Compostos de Decametônio/administração & dosagem , Compostos de Decametônio/efeitos adversos , Compostos de Decametônio/uso terapêutico , Drenagem , Humanos , Peritonite/tratamento farmacológico , Peritonite/microbiologia , Infecção da Ferida Cirúrgica/prevenção & controle , Resultado do TratamentoRESUMO
Intradermal testing and RIA testing for specific IgE antibodies to neuromuscular blocking drugs (NMBDs) were performed in patients referred to an Anaesthetic Allergy Clinic. Six patients were initially investigated four to 29 years after clinical anaphylaxis during anaesthesia and two of these patients and sixteen others were investigated by intradermal testing on two occasions at least four years apart. Seven patients had RIA tests for NMBD-specific IgE antibodies on two occasions at the time of skin testing. In all but two patients the evidence for drug-specific antibodies persisted 4-29 years after the reactions. In one patient all tests became negative and in another the skin test became negative but the positive RIA persisted. Evidence of antibodies to NMBDs persisted in 21 of 22 patients who had had anaphylactic reactions to these drugs during anaesthesia. In the absence of evidence of allergy diminishing with time in the majority of patients it would seem wise to avoid drugs responsible for reactions for the rest of the patient's life.
Assuntos
Hipersensibilidade a Drogas/diagnóstico , Bloqueadores Neuromusculares/efeitos adversos , Alcurônio/efeitos adversos , Alcurônio/análise , Anafilaxia/diagnóstico , Anafilaxia/metabolismo , Anticorpos/análise , Compostos de Decametônio/efeitos adversos , Compostos de Decametônio/análise , Hipersensibilidade a Drogas/metabolismo , Trietiodeto de Galamina/efeitos adversos , Trietiodeto de Galamina/análise , Humanos , Imunoglobulina E/análise , Bloqueadores Neuromusculares/análise , Radioimunoensaio , Testes Cutâneos , Succinilcolina/efeitos adversos , Succinilcolina/análise , Fatores de Tempo , Tubocurarina/efeitos adversos , Tubocurarina/análiseRESUMO
The effects of decamethonium and succinylcholine on hypotonic haemolysis of erythrocytes were studied. These drugs at concentrations of 5 X 10(-8) M to 10(-4) M caused a dose-dependent inhibition of haemolysis of erythrocytes in 0.45% NaCl but lysis occurred when the drug concentrations were increased to 10(-3) M. These results indicate that decamethonium and succinylcholine may have a membrane stabilization-lysis effect on erythrocytes.
Assuntos
Compostos de Decametônio/farmacologia , Membrana Eritrocítica/efeitos dos fármacos , Succinilcolina/farmacologia , Compostos de Decametônio/efeitos adversos , Hemólise/efeitos dos fármacos , Humanos , Técnicas In Vitro , Succinilcolina/efeitos adversosRESUMO
The cholinomimetic compounds carbachol, decamethonium, neostigmine, succinylcholine, trimethylphenylammonium, and others were tested for their interference with normal chick development. All these compounds led to abnormalities of the cervical vertebrae; at higher dosage interference with normal morphogenesis involved the whole vertebral column. Hypoplasia of the leg muscles occurred with lower incidence. Responses, tested with carbachol, rose from 24 to 72 and 96 h, then declined to 120 h of incubation. Two of the cholinometic compounds used in combined treatment produced a high degree of synergism. Gallamine, benzoquinomium, butyrylcholine, and bethanechol had protective effects. Acetylcholine, at high dosage, caused defects different from the above. It is suggested that the cholinomimetic teratogens interfere with normal development by displacing acetylcholine from its receptors or by forming complexes with it.
Assuntos
Embrião de Galinha/efeitos dos fármacos , Parassimpatomiméticos/efeitos adversos , Teratogênicos/efeitos adversos , Acetilcolina/efeitos adversos , Animais , Carbacol/efeitos adversos , Colina/efeitos adversos , Colina/análogos & derivados , Inibidores da Colinesterase , Compostos de Decametônio/efeitos adversos , Sinergismo Farmacológico , Trietiodeto de Galamina/efeitos adversos , Sistema Musculoesquelético/embriologia , Neostigmina/efeitos adversos , Nicotina/efeitos adversos , Fisostigmina/efeitos adversos , Brometo de Piridostigmina/efeitos adversos , Compostos de Amônio Quaternário/efeitos adversos , Succinilcolina/efeitos adversosRESUMO
Decamethonium and succinylcholine were used to study the effects of depolarizing muscle relaxants on serum potassium in 60 patinets, free of neuromuscular disease, during major orthopedic surgery. Significant increases in serum K+ were found after administration of decamethonium or succinylcholine in the usual clinical doses. The abnormal elevations of serum K+ found in patients with burns, massive trauma, or muscle denervation are thus accentuations of the process that occurs in normal man following use of these depolarizing drugs. The administration of any depolarizing agent to these abnormal patient groups would, therefore, appear contraindicated.