Plastic scintillator-based dosimeters for ultra-high dose rate (UHDR) electron radiotherapy.

This paper reports the development of dosimeters based on plastic scintillating fibers imaged by a charge-coupled device camera, and their performance evaluation through irradiations with the electron Flash research accelerator located at the Centro Pisano Flash Radiotherapy. The dosimeter prototypes were composed of a piece of plastic scintillating fiber optically coupled to a clear optical fiber which transported the scintillation signal to the readout systems (an imaging system and a photodiode). The following properties were tested: linearity, capability to reconstruct the percentage depth dose curve in solid water and to sample in time the single beam pulse. The stem effect contribution was evaluated with three methods, and a proof-of-concept one-dimensional array was developed and tested for online beam profiling. Results show linearity up to 10 Gy per pulse, and good capability to reconstruct both the timing and spatial profiles of the beam, thus suggesting that plastic scintillating fibers may be good candidates for low-energy electron Flash dosimetry.

Possibilities of the use of CeBr3 scintillation detectors for the measurement of the content of radionuclides in samples for environmental monitoring.

The investigation of radioactivity in samples is an application of gamma-ray spectrometry dealing with low and very low level gamma-ray activities of different isotopes. Gamma-ray spectrometry performed in the framework of radiological environmental monitoring may be done after selective sampling processes or after a chemical purification of a sample. Both cases imply that only some specific radionuclides should contribute to the obtained spectrum. Gamma-ray spectrometry performed with medium energy resolution detectors may allow the possible distinction of their photopeaks. Therefore, a cerium bromide (CeBr3) detector can be particularly attractive for routine tasks in radiological environmental monitoring as it has a high efficiency, medium energy resolution and it can work at room temperature. This study describes the conditions under which a CeBr3 detector can serve for some routine analysis in radiological analysis of samples collected in the environment or collected by air-samplers in environmental radiological monitoring programmes.

Quality Assurance for Small-Field VMAT SRS and Conventional-Field IMRT Using the Exradin W1 Scintillator.

BACKGROUND: Plastic scintillator detector (PSD) Exradin W1 has shown promising performance in small field dosimetry due to its water equivalence and small sensitive volume. However, few studies reported its capability in measuring fields of conventional sizes. Therefore, the purpose of this study is to assess the performance of W1 in measuring point dose of both conventional IMRT plans and VMAT SRS plans. METHODS: Forty-seven clinical plans (including 29 IMRT plans and 18 VMAT SRS plans with PTV volume less than 8 cm3) from our hospital were included in this study. W1 and Farmer-Type ionization chamber Exradin A19 were used in measuring IMRT plans, and W1 and microchamber Exradin A16 were used in measuring SRS plans. The agreement between the results of different types of detectors and TPS was evaluated. RESULTS: For IMRT plans, the average differences between measurements and TPS in high-dose regions were 0.27% ± 1.66% and 0.90% ± 1.78% (P = 0.056), and were -0.76% ± 1.47% and 0.37% ± 1.34% in low-dose regions (P = 0.000), for W1 and A19, respectively. For VMAT SRS plans, the average differences between measurements and TPS were -0.19% ± 0.96% and -0.59% ± 1.49% for W1 and A16 with no statistical difference (P = 0.231). CONCLUSION: W1 showed comparable performance with application-dedicated detectors in point dose measurements for both conventional IMRT and VMAT SRS techniques. It is a potential one-stop solution for general radiotherapy platforms that deliver both IMRT and SRS plans.

A layered single-side readout depth of interaction time-of-flight-PET detector.

We are exploring a scintillator-based PET detector with potential of high sensitivity, depth of interaction (DOI) capability, and timing resolution, with single-side readout. Our design combines two previous concepts: (1) multiple scintillator arrays stacked with relative offset, yielding inherent DOI information, but good timing performance has not been demonstrated with conventional light sharing readout. (2) Single crystal array with one-to-one coupling to the photodetector, showing superior timing performance compared to its light sharing counterparts, but lacks DOI. The combination, where the first layer of a staggered design is coupled one-to-one to a photodetector array, may provide both DOI and timing resolution and this concept is here evaluated through light transport simulations. Results show that: (1) unpolished crystal pixels in the staggered configuration yield better performance across all metrics compared to polished pixels, regardless of readout scheme. (2) One-to-one readout of the first layer allows for accurate DOI extraction using a single threshold. The number of multi pixel photon counter (MPPC) pixels with signal amplitudes exceeding the threshold corresponds to the interaction layer. This approach was not possible with conventional light sharing readout. (3) With a threshold of 2 optical photons, the layered approach with one-to-one coupled first layer improves timing close to the MPPC compared to the conventional one-to-one coupling non-DOI detector, due to effectively reduced crystal thickness. Single detector timing resolution values of 91, 127, 151 and 164 ps were observed per layer in the 4-layer design, to be compared to 148 ps for the single array with one-to-one coupling. (4) For the layered design with light sharing readout, timing improves with increased MPPC pixel size due to higher signal per channel. In conclusion, the combination of straightforward DOI determination, good timing performance, and relatively simple design makes the proposed concept promising for DOI-Time-of-Flight PET detectors.

Development of a time-resolved mirrorless scintillation detector.

PURPOSE: We developed a compact and lightweight time-resolved mirrorless scintillation detector (TRMLSD) employing image processing techniques and a convolutional neural network (CNN) for high-resolution two-dimensional (2D) dosimetry. METHODS: The TRMLSD comprises a camera and an inorganic scintillator plate without a mirror. The camera was installed at a certain angle from the horizontal plane to collect scintillation from the scintillator plate. The geometric distortion due to the absence of a mirror and camera lens was corrected using a projective transform. Variations in brightness due to the distance between the image sensor and each point on the scintillator plate and the inhomogeneity of the material constituting the scintillator were corrected using a 20.0 × 20.0 cm2 radiation field. Hot pixels were removed using a frame-based noise-reduction technique. Finally, a CNN-based 2D dose distribution deconvolution model was applied to compensate for the dose error in the penumbra region and a lack of backscatter. The linearity, reproducibility, dose rate dependency, and dose profile were tested for a 6 MV X-ray beam to verify dosimeter characteristics. Gamma analysis was performed for two simple and 10 clinical intensity-modulated radiation therapy (IMRT) plans. RESULTS: The dose linearity with brightness ranging from 0.0 cGy to 200.0 cGy was 0.9998 (R-squared value), and the root-mean-square error value was 1.010. For five consecutive measurements, the reproducibility was within 3% error, and the dose rate dependency was within 1%. The depth dose distribution and lateral dose profile coincided with the ionization chamber data with a 1% mean error. In 2D dosimetry for IMRT plans, the mean gamma passing rates with a 3%/3 mm gamma criterion for the two simple and ten clinical IMRT plans were 96.77% and 95.75%, respectively. CONCLUSION: The verified accuracy and time-resolved characteristics of the dosimeter may be useful for the quality assurance of machines and patient-specific quality assurance for clinical step-and-shoot IMRT plans.

Recovery of inter-detector and inter-crystal scattering in brain PET based on LSO and GAGG crystals.

Gadolinium aluminum gallium garnet (GAGG) is a promising scintillator crystal for positron emission tomography (PET) detectors owing to its advantages of energy resolution, light yield, and absence of intrinsic radiation. However, a large portion of the incident photons undergoes Compton scattering within GAGG crystal because of its low stopping power compared to that of lutetium-based crystals such as Lu2SiO5 (LSO). Inter-detector scattering (IDS) and inter-crystal scattering (ICS) result in loss of sensitivity and image quality of PET, respectively. We performed a Monte Carlo simulation study to evaluate IDS recovery in our currently developing brain-dedicated PET, and extended the idea to ICS recovery. We also compared the impact of the recoveries on LSO- and GAGG-based PET scanners. We measured the sensitivity and spatial resolution of the brain PET, and analyzed the image quality using a lesion phantom, a hot-rod phantom, and a 2D Hoffman phantom with applying IDS or ICS recovery. IDS recovery increased the PET sensitivity and improved the noise level of the reconstructed images. ICS recovery enhanced the spatial resolution and the contrast of the images was improved. As the occurrence rates of IDS and ICS were higher in GAGG than in LSO, the overall impact of IDS or ICS recovery was significant in GAGG. In conclusion, we showed that the proportional method would be suitable for IDS and ICS recoveries of PET, and emphasized the importance of ICS and IDS recoveries for PET using crystals with low stopping power.

Tritium Atom Exchange May Be Responsible for Activity Decrease in Plastic Liquid Scintillation Vials.

Detection and measurement of low-energy beta particles is commonly achieved by liquid scintillation counting, in particular for low-level tritium samples. When samples are contained in plastic scintillation vials for long-term storage, the tritium activity in the vials has been found to decrease faster than expected from its natural radioactive decay. Different explanations for this observation have attributed some of these tritium activity losses to diffusion of the sample, degradation of the LSC cocktail, and the potential long-term changes in quenching effects of the LSC cocktail. An alternative explanation may also be that the tritium organically binds to the carbon chains in the plastic bottle through direct H and H atom exchange. A study was designed and performed to test this latter hypothesis of H and H atom exchange in plastic. Deionized water was introduced in a plastic vial that previously contained tritiated water to assess any increase in tritium activity from the reverse atom exchange between the vial material and the deionized water. A greater loss in activity concentration is observed in plastic vials compared to glass vials as a function of storage time for the tritiated water. Furthermore, the tritium activity concentration in the deionized water increased when storage occurred in plastic vials, an effect that is not observed for storage in glass vials. The study results indicate that hydrogen atom exchange may possibly take place in plastic vials.

Using a small-core graphite calorimeter for dosimetry and scintillator quenching corrections in a therapeutic proton beam.

Organic plastic scintillation detectors (PSDs) are known to produce less light per absorbed dose in highly dense radiations in comparison with e.g. 60Co gamma beams. This so-called ionization density quenching can be experimentally determined by comparison of the scintillator output with the absorbed dose established with a reference detector. The hypothesis of this work was that a newly developed small-core graphite calorimeter (core size: ø5mm × 7mm) can be used as reference for such measurements. The potential benefit of a calorimetric reference would be to have a robust and accurate reference with well-understood dosimetry properties even in high-intensity FLASH beams. As a first step, the hypothesis was tested by comparing previously established quenching parameter estimates for the BCF-60 scintillating material with data obtained with the new instrument at different depths along the central axis of a 170 MeV scanned proton beam. After the calorimetric measurements, scintillator measurements were acquired under equivalent conditions by positioning the PSD in a replica graphite core nominally identical to the core used for calorimetry. To experimentally document details of the irradiations, the spot width was mapped along the central beam axis using a new technique based on a PSD and a time-to-distance conversion procedure. Analysing the proton data in the framework of the Birks model, the graphite calorimeter gave a [Formula: see text] quenching parameter for BCF-60 in agreement with literature values. The consistency between the calorimetric results and the other sources of information supports the validity of the new method, and we therefore aim to apply it for characterization of other detectors in more intense beams where ionometry cannot serve as reference.

A scintillator-based range telescope for particle therapy.

The commissioning and operation of a particle therapy centre requires an extensive set of detectors for measuring various parameters of the treatment beam. Among the key devices are detectors for beam range quality assurance. In this work, a novel range telescope based on a plastic scintillator and read out by a large-scale CMOS sensor is presented. The detector is made of a stack of 49 plastic scintillator sheets with a thickness of 2-3 mm and an active area of 100 × 100 mm2, resulting in a total physical stack thickness of 124.2 mm. This compact design avoids optical artefacts that are common in other scintillation detectors. The range of a proton beam is reconstructed using a novel Bragg curve model that incorporates scintillator quenching effects. Measurements to characterise the performance of the detector were carried out at the Heidelberger Ionenstrahl-Therapiezentrum (HIT, Heidelberg, GER) and the Clatterbridge Cancer Centre (CCC, Bebington, UK). The maximum difference between the measured range and the reference range was found to be 0.41 mm at a proton beam range of 310 mm and was dominated by detector alignment uncertainties. With the new detector prototype, the water-equivalent thickness of PMMA degrader blocks has been reconstructed within ± 0.1 mm. An evaluation of the radiation hardness proves that the range reconstruction algorithm is robust following the deposition of 6,300 Gy peak dose into the detector. Furthermore, small variations in the beam spot size and transverse beam position are shown to have a negligible effect on the range reconstruction accuracy. The potential for range measurements of ion beams is also investigated.

MRI-LINAC beam profile measurements using a plastic scintillation dosimeter.

Plastic scintillation dosimeters (PSDs) possess many desirable qualities for dosimetry with LINACs. These qualities are expected to make PSDs effective for MRI-LINAC dosimetry, however little research has been conducted investigating their dosimetric performance with MRI-LINACs. In this work, an in-house PSD was used to measure 8 beam profiles with an in-line MRI-LINAC, compared with film measurements. One dimensional global gamma indices (γ) and corresponding γ pass rates were calculated to compare PSD and film profiles for the 1%/1 mm, 2%/2 mm and 3%/3 mm criterion. The mean global pass rates were 85.8%, 97.5% and 99.4% for the 1%/1 mm, 2%/2 mm and 3%/3 mm criteria, respectively. The majority of the γ failures occurred in the penumbral regions. Penumbra widths were measured to be slightly narrower with the PSD compared to film, however, the uncertainties in the measured penumbra widths brought the PSD and film penumbra widths into agreement. Differences in dose were calculated between the PSD and film, and remained within 2.2% global agreement for the central regions and 1.5% global agreement for out of field regions. These values for range of agreement were similar to the those reported in the literature for other dosimeters which are trusted for relative MRI-LINAC dosimetry.

Deep learning based methods for gamma ray interaction location estimation in monolithic scintillation crystal detectors.

In this work, we explore deep learning based techniques using the information from mean detector response functions (MDRFs) as a new method to estimate gamma ray interaction location in monolithic scintillation crystal detectors. Compared with searching based methods, deep learning techniques do not require recording all the MDRF information once the prediction networks are trained, which means the memory cost could be significantly reduced. In addition, the event positioning process using deep learning techniques only requires running through the network once, without the need to do searching in the reference dataset. This could greatly speed up the positioning process for each event. We have designed and trained four different neural networks to estimate the gamma ray interaction location given the MDRF data. We have studied network structures consisting only of fully connected (FC) layers, as well as Conv neural networks (CNNs). In addition, we tried to use both regression and classification to generate the final prediction of the gamma ray interaction position. We evaluated the estimation accuracy, testing speed and memory cost (numbers of parameters) of different network architectures, and also compared them with the exhaustive search method. Our results indicate that deep learning based estimation methods with a well designed network structure can achieve a relative positioning error with respect to the ground truth determined by the exhaustive search method of below 1 mm in both x and y directions (depth information is not considered in this work), which would imply a very high performance positioning algorithm for practical monolithic scintillation crystal detectors. The deep learning network also achieves a testing speed that is more than 400 times faster than the exhaustive search method. With proper design of the network structure, the deep learning based positioning methods have the potential to save memory cost by a factor of up to 100.

Technical note: characterization of spectral changes with measurement geometry and magnetic field strength in light guides used for scintillation dosimetry.

The purpose of this work was to characterize the stem-effect signal and the Cerenkov light ratio (CLR) in various light guides as functions of measurement geometry and magnetic field strength. Two PMMA-, two silica-, and one polystyrene-based light guides were considered in this work. Spectra measurements were performed as functions of depth, fiber-beam angle, and magnetic field strength using an optical spectrometer. All measurements were performed using a clinical linear accelerator at a nominal photon beam energy of 6 MV. Depths ranging from 1 cm to 10 cm, fiber-beam angles ranging from 90 degrees to 30 degrees, and magnetic field strengths ranging from 0 T to ± 1.40 T were investigated. The CLR was calculated from each spectrum by taking the ratio of the integral signal between 400 nm and 500 nm to the integral signal between 500 nm and 600 nm. A maximum increase of 80.5% in the stem-effect signal was observed in the magnetic field. Variations in spectral shape and, consequently, the CLR were observed for all of the fibers as functions of magnetic field strength and measurement geometry, particularly for wavelengths less than 400 nm. The plastic fibers exhibited decreases in the CLR as a function of magnetic field strength at all depths investigated, whereas the silica fibers exhibited increases in the CLR with decreasing magnetic field strength. A maximum variation of 11.1% in the CLR was observed for the polystyrene fiber due to the magnetic field. The sensitivity of the CLR to the magnetic field decreased as the fiber-beam angle decreased. The measured spectral response, shape, and CLR were found to be sensitive to the applied magnetic field strength and polarity where the variations in response were unique to each fiber.

Pushing Cherenkov PET with BGO via coincidence time resolution classification and correction.

Bismuth germanate (BGO) shows good properties for positron emission tomography (PET) applications, but was substituted by the development of faster crystals like lutetium oxyorthosilicate (LSO) for time-of-flight PET (TOF-PET). Recent improvements in silicon photomultipliers (SiPMs) and fast readout electronics make it possible to access the Cherenkov photon signal produced upon 511 keV interaction, which makes BGO a cost-effective candidate for TOF-PET. Tails in the time-delay distribution, however, remain a challenge. These are mainly caused by the high statistical fluctuation on the Cherenkov photons detected. To select fast events with a high detected Cherenkov photon number, the signal rise time of the SiPM was used for discrimination. The charge, time delay and signal rise time was measured for two different lengths of BGO crystals coupled to FBK NUV-HD SiPMs and high frequency readout in a coincidence time resolution setup. The recorded events were divided into 5 × 5 categories based on the signal rise time, and time resolutions of 200 ± 3 ps for 2 × 2 × 20 mm3 and 117 ± 3 ps for 2 × 2 × 3 mm3 were measured for the fastest 20% of the events (4% in coincidence). These good timing events can provide additional information for the image reconstruction in order to increase the SNR significantly, without spoiling the detector sensitivity. Putting all photopeak events together and correcting for the time bias introduced by different numbers of Cherenkov photons detected, time resolutions of 259 ± 3 ps for 20 mm long and 151 ± 3 ps for 3 mm long crystals were measured. For a small fraction of events sub-100 ps coincidence time resolution with BGO was reached for a 3 mm short pixel.

End-to-end test to evaluate the comprehensive geometric accuracy of a proton rotating gantry using a cone-shaped scintillator screen detector.

In this study, we aim to evaluate the comprehensive geometric accuracy of proton rotating gantries by performing an end-to-end test using a cone-shaped scintillator screen detector, known as XRV-124. The XRV-124 comprises a cone-shaped sheet-like scintillator and charge-coupled device camera that detects the scintillation light. First, the results of the Winston-Lutz and end-to-end XRV-124 tests performed on a conventional linear accelerator were compared to confirm the reliability of the XRV-124, and the snout position dependency of the geometric accuracy was evaluated for the proton rotating gantry as a pre-verification process. Thereafter, an end-to-end test including computed tomography imaging and irradiation in 30° steps from 0° to 330° for two proton rotating gantries, which have the same specifications, was performed. The results of the pre-verification indicated that sufficient accuracy was obtained for the end-to-end test of the proton rotating gantry. The end-to-end test results showed a peak-to-peak deviation of up to 2 mm for some of the coordinate axes. The two gantries exhibited almost similar results in terms of the absolute quantity; however, a few trends were different. Thus, the beam axis deviations were confirmed to be within the safety margin, as expected in clinical practice. Based on the results of this study, the XRV-124 can be used as a comprehensive end-to-end constancy test tool, as it enables a comparative verification of multiple rotating gantries and geometric accuracy verification of different treatment modalities.

Transversal dose profile reconstruction for clinical proton beams: A detectors inter-comparison.

PURPOSE: The main purpose of this work is the inter-comparison between different devices devoted to the transversal dose profile recostruction for daily QA tests in proton therapy. METHODS: The results obtained with the EBT3 radiochromic films, used as a reference, and other common quality control devices, have been compared with those obtained with a beam profiling system developed at the "Laboratori Nazionali del Sud" of Italian Institute for Nuclear Physics (INFN-LNS, Catania, Italy). It consists of a plastic scintillator screen (thickness 1 mm), mounted perpendicularly to the beam axis and coupled with a highly sensitive CCD detector in a light-tight box. RESULTS AND CONCLUSION: The tests, carried out both at the INFN-LNS and Trento Proton Therapy Center facilities, show, in general, a good agreement between the different detectors. The beam profiling system, in particular, appears to be a promising quality control device for 2-D relative dosimetry, because of its linear response in a dose rate range useful for proton therapy treatments, its high spatial resolution and its short acquisition and processing time.

SciFi detector and associated method for real-time determination of profile and output factor for small fields in stereotactic radiotherapy.

PURPOSE: For determining small-field profile and output factor during stereotactic radiotherapy quality assurance (QA) procedures, we propose a novel system based on the scintillating fiber (SciFi) detector with output image acquisition and processing to allow real-time monitoring of profile and output factor. MATERIALS AND METHODS: The employed detector is a SciFi detector made of tissue-equivalent scintillating plastic fibers arranged in 6-layer fiber ribbons with a fiber pitch of 275 µm in each layer. The scintillating signal at the detector output is acquired by a sCMOS (scientific complementary metal-oxide-semiconductor) camera and represents the projected field profile along the fibers axis. An iterative reconstruction method of the field from its projected profile based on a priori knowledge of some features of the radiation field defined by the stereotactic cones is suggested. The detector with implemented data processing has been tested in clinical conditions, for determining beam profiles and output factors, using cone collimators of different sizes from 4 to 15 mm diameter. The detector under test was placed at 1.4 cm depth and 98.6 cm source to surface distance (SSD) in a water-equivalent phantom and irradiated by a 6 MV photon beam. RESULTS: The reconstructed field profiles obtained from the detector are coherent with data from EBT3 radiochromic films, with differences within ±0.32 mm for both the FWHM and the penumbra region. For real-time determination of the field output factor, the measured data are also in good agreement with data independently determined by the French Institute for Radiological Protection and Nuclear Safety (IRSN) based on radiochromic films and thermoluminescent 1 × 1 mm2 micro-cubes dosimeters (TLD). The differences are within ±1.6% for all the tested cone sizes. CONCLUSIONS: We propose and have tested a SciFi plastic scintillating detector with an optimized signal processing method to characterize small fields defined by cone collimators. It allows the determination of key field parameters such as full width at half maximum (FWHM) and field output factors. The results are consistent with those independently measured using TLD and radiochromic films. As the SciFi detector does not require a correction factor, it is in line with the International Atomic Energy Agency (IAEA) and the American Association of Physicists in Medicine (AAPM) TRS-483 recommendations, and can be suitable for online QA of small radiation fields used in photon beam radiotherapy, and is compatible with MRI-LINAC.

Multi-energy inter-pixel coincidence counters for charge sharing correction and compensation in photon counting detectors.

PURPOSE: Smaller pixel sizes of x-ray photon counting detectors (PCDs) are advantageous for count rate capabilities but disadvantageous for charge sharing. With charge sharing, the energy of an x-ray photon may be split and one photon may produce two or more counts at adjacent pixels, both at lower energies than the incident energy. This "double-counting" increases noise variance and degrades the spectral response. Overall, it has a significantly negative impact on the performance of PCD-based computed tomography (CT). Charge sharing is induced by the detection physics and occurs regardless of count rates; thus, it is impossible to avoid. We propose in this paper a method that has a potential to address both noise and bias added by charge sharing. METHODS: We propose applying a multi-energy inter-pixel coincidence counter (MEICC) technique, which uses energy-dependent coincidence counters, keeps the book of charge sharing events during data acquisition, and provides the exact number of charge sharing occurrences, which can be used to either correct or compensate for them after the acquisition is completed. MEICC does not interfere with the primary counting process; therefore, PCDs with MEICC will remain as fast as those without MEICC. MEICC can be implemented using current electronics technology because its inter-pixel coincidence counters used to handle digital data are rather simple. We evaluated Cramér-Rao lower bound (CRLB) of PCDs with and without MEICC using a Monte Carlo simulation. RESULTS: When the number of energy windows was four or larger and eight neighboring pixels were used, the CRLBs of 225-µm PCD with MEICC normalized by those of the current PCD with the same number of windows were 0.361-0.383 for water density images of two basis functions, which was only 5.7-16.4% worse than those of a PCD without charge sharing (which were at 0.329-0.358). In contrast, the normalized CRLBs of the PCD with one coincidence counter were 0.466-0.499, which were 37.3-45.6% worse than the PCD without charge sharing. The use of eight neighboring pixels provided ~10% better CRLB values than four neighboring pixels for MEICC. With four energy windows, decreasing the number of coincidence counters from 16 to 9 only slightly increased the CRLB from 0.255 to 0.269 (which corresponded to as little as a 5.5% change). The normalized CRLBs of MEICC for K-edge imaging (gold) were 0.295-0.426, while those of the one coincidence counter were 0.926-0.959 and the ideal PCDs were 0.126-0.146. CONCLUSIONS: The proposed MEICC provides spectral information that can be used to address charge sharing problems in PCDs and is expected to satisfy the requirements for clinical x-ray CT. MEICC is very effective, especially for K-edge imaging, which requires accurate spectral information.

Exploring TOF capabilities of PET detector blocks based on large monolithic crystals and analog SiPMs.

Monolithic scintillators are more frequently used in PET instrumentation due to their advantages in terms of accurate position estimation of the impinging gamma rays both planar and depth of interaction, their increased efficiency, and expected timing capabilities. Such timing performance has been studied when those blocks are coupled to digital photosensors showing an excellent timing resolution. In this work we study the timing behaviour of detectors composed by monolithic crystals and analog SiPMs read out by an ASIC. The scintillation light spreads across the crystal towards the photosensors, resulting in a high number of SiPMs and ASIC channels fired. This has been studied in relation with the Coincidence Timing Resolution (CTR). We have used LYSO monolithic blocks with dimensions of 50 × 50 × 15 mm3 coupled to SiPM arrays (8 × 8 elements with 6 × 6 mm2 area) which compose detectors suitable for clinical applications. While a CTR as good as 186 ps FWHM was achieved for a pair of 3 × 3 × 5 mm3 LYSO crystals, when using the monolithic block and the SiPM arrays, a raw CTR over 1 ns was observed. An optimal timestamp assignment was studied as well as compensation methods for the time-skew and time-walk errors. This work describes all steps followed to improve the CTR. Eventually, an average detector time resolution of 497 ps FWHM was measured for the whole thick monolithic block. This improves to 380 ps FWHM for a central volume of interest near the photosensors. The timing dependency with the photon depth of interaction and planar position are also included.

Characterization of novel 3D printed plastic scintillation dosimeters.

We propose a new methodology for the fabrication and evaluation of scintillating detector elements using a consumer grade fusion deposition modeling (FDM) 3D printer. In this study we performed a comprehensive investigation into both the effects of the 3D printing process on the scintillation light output of 3D printed plastic scintillation dosimeters (PSDs) and their associated dosimetric properties. Fabrication properties including print variability, layer thickness, anisotropy and extrusion temperature were assessed for 1 cm3 printed samples. We then examined the stability, dose linearity, dose rate proportionality, energy dependence and reproducibility of the 3D printed PSDs compared to benchmarks set by commercially available products. Experimental results indicate that the shape of the emission spectrum of the 3D printed PSDs do not show significant spectral differences when compared to the emission spectrum of the commercial sample. However, the magnitude of scintillation light output was found to be strongly dependent on the parameters of the fabrication process. Dosimetric testing indicates that the 3D printed PSDs share many desirable properties with current commercially available PSDs such as dose linearity, dose rate independence, energy independence in the MV range, repeatability, and stability. These results demonstrate that not only does 3D printing offer a new avenue for the production and manufacturing of PSDs but also allows for further investigation into the application of 3D printing in dosimetry. Such investigations could include options for 3D printed, patient-specific scintillating dosimeters that may be used as standalone dosimeters or incorporated into existing 3D printed patient devices (e.g. bolus or immobilization) used during the delivery of radiation therapy.