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1.
Ann Surg ; 267(3): 569-575, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-28067674

RESUMO

OBJECTIVE: The ubiquitous use of polypropylene mesh in hernia surgery has spawned a new clinical syndrome: chronic post-herniorrhaphy neuralgia. A subset of that clinical picture is dysejaculation, sexual pain, and orchialgia. We propose to identify the processes that lead to that pain. SUMMARY OF BACKGROUND DATA: Specimens of vas adherent to polypropylene mesh, explanted in an attempt to control severe, life-changing inguinodynia are extremely difficult to obtain. This scarcity may be due to ingrained attitudes in our society about removal of vas and/or testicles for whatever reason. Attempts at preserving such damaged structures may paradoxically contribute to the chronicity and severity of such pain. METHODS: The medical files of patients who had mesh specimens explanted because of severe chronic post-herniorrhaphy pain were reviewed to identify cases with recorded evidence, at the time of surgery, of involvement of spermatic cord/vas deferens with mesh. These criteria were met in 13 cases and the specimens were analyzed histologically. RESULTS: The vas deferens was resected in 83% (5 of 6) of the patients with a history of sexual pain and/or dysejaculation (vs 14% of those without a history of sexual pain, P = 0.03). Histology demonstrated unequivocal mesh invasion of the spermatic cord, where the initial damage occurred to nerves (autonomic, somatic), then to the smooth muscle of the vas while the lumen remained patent. In 50% (3 of 6), the vas and other cord structures appeared to be completely invaded by the mesh and replaced by scar tissue. CONCLUSIONS: Irreversible damage of the nerves and vas musculature due to mesh migration is one of the mechanisms for sexual pain and dysejaculation. Attempts at all cost to preserve elements of the spermatic cord may not be justified in cases of severe pain, especially sexual pain (and/or dysejaculation) and intraoperative finding of cord involvement by the mesh. Vasectomy with mesh removal may well be indicated and be considered not a radical procedure but a conservative measure given the severity of the pain!


Assuntos
Herniorrafia/efeitos adversos , Disfunções Sexuais Fisiológicas/etiologia , Disfunções Sexuais Fisiológicas/cirurgia , Cordão Espermático/lesões , Telas Cirúrgicas/efeitos adversos , Adulto , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Polipropilenos , Fatores de Tempo
2.
Sci Rep ; 7(1): 15570, 2017 Nov 14.
Artigo em Inglês | MEDLINE | ID: mdl-29138449

RESUMO

Testicular artery torsion (twisting) is one such severe vascular condition that leads spermatic cord injury. In this study, we investigate the recovery response of a torsioned ram testicular artery in an isolated organ-culture flow loop with clinically relevant twisting modes (90°, 180°, 270° and 360° angles). Quantitative optical coherence tomography technique was employed to track changes in the lumen diameter, wall thickness and the three-dimensional shape of the vessel in the physiological pressure range (10-50 mmHg). As a control, pressure-flow characteristics of the untwisted arteries were studied when subjected to augmented blood flow conditions with physiological flow rates up to 36 ml/min. Both twist and C-shaped buckling modes were observed. Acute increase in pressure levels opened the narrowed lumen of the twisted arteries noninvasively at all twist angles (at ∼22 mmHg and ∼35 mmHg for 360°-twisted vessels during static and dynamic flow experiments, respectively). The association between the twist-opening flow rate and the vessel diameter was greatly influenced by the initial twist angle. The biomechanical characteristics of the normal (untwisted) and torsioned testicular arteries supported the utilization of blood flow augmentation as an effective therapeutic approach to modulate the vessel lumen and recover organ reperfusion.


Assuntos
Artérias/fisiopatologia , Torção do Cordão Espermático/fisiopatologia , Cordão Espermático/fisiopatologia , Testículo/fisiopatologia , Animais , Artérias/lesões , Fenômenos Biomecânicos , Hemodinâmica , Humanos , Masculino , Técnicas de Cultura de Órgãos , Fluxo Sanguíneo Regional/fisiologia , Ovinos , Cordão Espermático/irrigação sanguínea , Cordão Espermático/lesões , Testículo/irrigação sanguínea , Doenças Vasculares/sangue , Doenças Vasculares/fisiopatologia
3.
Int Urol Nephrol ; 49(4): 553-561, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28181114

RESUMO

While rare, trauma and injury to the male external genitalia can result in significant consequences regarding function, appearance, psychological effects, and overall quality of life. Due to the relative paucity of literature regarding male external genitalia injuries, few standardized protocols exist. This review aims to outline common clinical causes of male external genitalia injuries by both anatomic location and etiology. Initial stabilization, long-term reconstruction, and coverage options are discussed in detail. Outcomes of complex grafts have favorable success rates of 90-100% in the hands of experienced surgeons. Outcomes of penile, testicular trauma also have favorable outcomes when managed appropriately. Attempts at reconstruction after initial injury stabilization should be undertaken at high-volume centers where a multidisciplinary approach can be employed. This manuscript will be an excellent reference and source that can provide direction for evaluation and management of these complex presentations.


Assuntos
Gangrena de Fournier/terapia , Doenças dos Genitais Masculinos/terapia , Genitália Masculina/lesões , Amputação Traumática/terapia , Queimaduras/terapia , Gangrena de Fournier/complicações , Doenças dos Genitais Masculinos/microbiologia , Humanos , Masculino , Pênis/lesões , Pele/lesões , Transplante de Pele , Cordão Espermático/lesões , Tela Subcutânea/lesões , Retalhos Cirúrgicos , Testículo/lesões , Ferimentos e Lesões/etiologia , Ferimentos e Lesões/terapia
4.
J Orthop Trauma ; 29(6): 290-4, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25470564

RESUMO

OBJECTIVE: Traditional repair of the disrupted pubic symphysis includes application of pointed clamps to the pubic tubercles and/or pubic body for fracture reduction. Recent studies have reported rates of sexual dysfunction of 42%-90% after repair of these injuries. The purpose of this study is to define the anatomy of the spermatic cord relative to the pubic tubercle and other local structures to assess the risk of sustaining an iatrogenic injury during clamp placement. METHODS: Eight intact lower-half fresh male human cadavers were dissected. A window of skin and subcutaneous tissue was excised to expose the low abdominal wall and penile root. Pubic tubercles were identified by palpation and marked. The spermatic cord was identified at the superficial inguinal ring and followed into the scrotum, and any anatomical abnormalities were recorded. The relationship and distance of the spermatic cord to the pubic tubercle, insertion of the inguinal ligament and abdominal wall musculature, and pubic symphysis were recorded. Photographs were taken of the superficial and deep anatomy. RESULTS: Spermatic cords were found to follow a consistent course after exiting the inguinal canal at the lower abdomen: they coursed inferior and medial to a position lateral to the pubic tubercles. In all cases, the spermatic cord lay adjacent, directly lateral to the tubercle with an average separation of 0.8 mm (range, 0-2 mm). The average distances from the lateral aspect of the tubercle and the medial border of the spermatic cord to the pubic symphysis were 26 and 27 mm, respectively. Qualitatively, even with direct visualization, it was not feasible to apply a pointed tenaculum to the pubic tubercles without piercing the spermatic cord, unless one manually retracted the latter. CONCLUSIONS: The spermatic cord is located lateral and immediately adjacent to the pubic tubercle after it exits the inguinal canal and passes into the scrotum. As such, the spermatic cord seems to be at a significant risk of sustaining injury when pointed forceps are placed on the tubercles, as is often recommended during the repair of pubic diastasis.


Assuntos
Fraturas Ósseas/patologia , Fraturas Ósseas/cirurgia , Ossos Pélvicos/anatomia & histologia , Ossos Pélvicos/cirurgia , Cordão Espermático/anatomia & histologia , Cordão Espermático/lesões , Idoso , Idoso de 80 Anos ou mais , Cadáver , Fixação Interna de Fraturas/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Anatômicos
5.
Rev. cuba. med. mil ; 43(4): 481-498, oct.-dic. 2014. Ilus
Artigo em Espanhol | LILACS, CUMED | ID: lil-735366

RESUMO

Entre los tumores paratesticulares, los del cordón espermático y las túnicas escrotales son los más frecuentes y en su mayoría benignos. En este trabajo se realizó la actualización del tema; se hizo énfasis en aspectos del diagnóstico y tratamiento. Se efectuó una búsqueda bibliográfica en libros de consulta, así como en las bases de datos de Hinari, PubMed/MEDLINE, LILACS y en el motor de búsquedas de Google, entre el 2009 y el 2013. Se utilizaron los términos del MeSH, en idiomas español e inglés: tumores paratesticulares, tumores intraescrotales, tumores del cordón espermático y tumores de las túnicas escrotales. Clínicamente, es básico realizar el diagnóstico diferencial con la hernia inguinal y con el hidrocele. El ultrasonido es el estudio de imagen de elección para su valoración inicial, aunque por su inespecificidad se recurre a la tomografía axial computarizada y a la resonancia magnética nuclear, para obtener más detalles. Para establecer el diagnóstico de certeza, se recomienda la biopsia por congelación transoperatoria, vía inguinotomía. La citología aspirativa con aguja fina, es una opción confiable para clasificarlos si existe sospecha preoperatoria de benignidad, es posible la tumorectomía en los benignos y se evita la orquiectomía radical con ligadura alta del cordón espermático, indicada para los malignos. Una vez confirmado el diagnóstico histológico y el estadio, el manejo debe ser onco-urológico para decidir la conveniencia de tratamientos adyuvantes. Los tumores malignos recurren con mucha frecuencia y a veces tardíamente, lo que obliga al seguimiento estricto y prolongado de estos pacientes.


Among the paratesticular tumors, the spermatic cord and the scrotal tunica tumors are the most frequent and benign. This paper updated this topic, making emphasis in diagnosis and treatment issues. A literature search was made in books and in Hinari, PubMed/MEDLINE, LILACS databases and in Goggle in the period of 2009 through 2013. The MeSH terms in English and Spanish were used: paratesticular tumors, intrascrotal tumors, spermatic cord tumors and scrotal tunica tumors. From the clinical viewpoint, it is fundamental to make the differential diagnosis with the inguinal hernia and hydrocele. The US testing is the imaging study of choice for initial assessment, although its lack of specificity makes specialists to resort to computer axial tomography and nuclear magnetic resonance to have more details of the case. For the purpose of reaching a precise diagnosis, the transoperative freezing biopsy through inguinotomy was recommended. The fine needle aspiration cytology is a reliable option to classify them if the case is suspected of benignancy preoperatively. It is possible to perform tumorectomy in the benign tumors, thus avoiding radical orchiectomy with upper ligature of the spermatic cord, which is the indicated approach to the malignant ones. Once the histological diagnosis and the staging are confirmed, the management should be oncological and urological in order to decide whether the adjuvant treatments are convenient or not. The malignant tumors recurred very frequently and sometimes in later phases, so these patients must be strictly followed-up for a long time.


Assuntos
Humanos , Escroto/lesões , Cordão Espermático/lesões , Diagnóstico por Imagem , Literatura de Revisão como Assunto , Biópsia por Agulha Fina/métodos , Doenças dos Genitais Masculinos
6.
Rev. cuba. med. mil ; 43(4)oct.-dic. 2014.
Artigo em Espanhol | CUMED | ID: cum-67092

RESUMO

Entre los tumores paratesticulares, los del cordón espermático y las túnicas escrotales son los más frecuentes y en su mayoría benignos. En este trabajo se realizó la actualización del tema; se hizo énfasis en aspectos del diagnóstico y tratamiento. Se efectuó una búsqueda bibliográfica en libros de consulta, así como en las bases de datos de Hinari, PubMed/MEDLINE, LILACS y en el motor de búsquedas de Google, entre el 2009 y el 2013. Se utilizaron los términos del MeSH, en idiomas español e inglés: tumores paratesticulares, tumores intraescrotales, tumores del cordón espermático y tumores de las túnicas escrotales. Clínicamente, es básico realizar el diagnóstico diferencial con la hernia inguinal y con el hidrocele. El ultrasonido es el estudio de imagen de elección para su valoración inicial, aunque por su inespecificidad se recurre a la tomografía axial computarizada y a la resonancia magnética nuclear, para obtener más detalles. Para establecer el diagnóstico de certeza, se recomienda la biopsia por congelación transoperatoria, vía inguinotomía. La citología aspirativa con aguja fina, es una opción confiable para clasificarlos si existe sospecha preoperatoria de benignidad, es posible la tumorectomía en los benignos y se evita la orquiectomía radical con ligadura alta del cordón espermático, indicada para los malignos. Una vez confirmado el diagnóstico histológico y el estadio, el manejo debe ser onco-urológico para decidir la conveniencia de tratamientos adyuvantes. Los tumores malignos recurren con mucha frecuencia y a veces tardíamente, lo que obliga al seguimiento estricto y prolongado de estos pacientes(AU)


Among the paratesticular tumors, the spermatic cord and the scrotal tunica tumors are the most frequent and benign. This paper updated this topic, making emphasis in diagnosis and treatment issues. A literature search was made in books and in Hinari, PubMed/MEDLINE, LILACS databases and in Goggle in the period of 2009 through 2013. The MeSH terms in English and Spanish were used: paratesticular tumors, intrascrotal tumors, spermatic cord tumors and scrotal tunica tumors. From the clinical viewpoint, it is fundamental to make the differential diagnosis with the inguinal hernia and hydrocele. The US testing is the imaging study of choice for initial assessment, although its lack of specificity makes specialists to resort to computer axial tomography and nuclear magnetic resonance to have more details of the case. For the purpose of reaching a precise diagnosis, the transoperative freezing biopsy through inguinotomy was recommended. The fine needle aspiration cytology is a reliable option to classify them if the case is suspected of benignancy preoperatively. It is possible to perform tumorectomy in the benign tumors, thus avoiding radical orchiectomy with upper ligature of the spermatic cord, which is the indicated approach to the malignant ones. Once the histological diagnosis and the staging are confirmed, the management should be oncological and urological in order to decide whether the adjuvant treatments are convenient or not. The malignant tumors recurred very frequently and sometimes in later phases, so these patients must be strictly followed-up for a long time(AU)


Assuntos
Humanos , Cordão Espermático/lesões , Doenças dos Genitais Masculinos/diagnóstico , Escroto/lesões , Literatura de Revisão como Assunto , Diagnóstico por Imagem , Biópsia por Agulha Fina/métodos
7.
Acta Cir Bras ; 29(8): 499-507, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-25140591

RESUMO

PURPOSE: To determine whether tension in the spermatic cord of rats causes lesions in the testis, epididymis or vas deferens. METHODS: Forty Wistar rats were randomly allocated into four groups. A traction force of 1.6 Newton (N) in group I and 1 N in group II was applied to the right spermatic cord. Group III was the sham, and group IV served as the control. RESULTS: Testicular lesions occurred on the right side in 66.7% of the rats and on the left side in 46.1% of the rats. The testes showed a decreased number of Sertoli cells, necrosis and a decreased number of germ cells in the seminiferous tubules. Anatomopathological changes in the vas deferens were not identified. There was no decrease in the thickness of the muscle wall of the vas deferens. In the right epididymis, 71.8% of the animals showed a reduction and 5% showed an absence of intraluminal sperm. In the left epididymis, 37.5% of the rats showed a reduction. The volume and the final testicular weight of the right side in group IV was different from those in the other groups. CONCLUSIONS: Anatomopathological lesions were found in the testis and epididymis.


Assuntos
Cordão Espermático/patologia , Tração/efeitos adversos , Animais , Epididimo/lesões , Epididimo/patologia , Masculino , Modelos Animais , Necrose/etiologia , Tamanho do Órgão , Ratos Wistar , Túbulos Seminíferos/patologia , Cordão Espermático/lesões , Testículo/lesões , Testículo/patologia , Ducto Deferente/patologia
8.
Acta cir. bras ; 29(8): 499-507, 08/2014. tab, graf
Artigo em Inglês | LILACS | ID: lil-719185

RESUMO

PURPOSE: To determine whether tension in the spermatic cord of rats causes lesions in the testis, epididymis or vas deferens. METHODS: Forty Wistar rats were randomly allocated into four groups. A traction force of 1.6 Newton (N) in group I and 1 N in group II was applied to the right spermatic cord. Group III was the sham, and group IV served as the control. RESULTS: Testicular lesions occurred on the right side in 66.7% of the rats and on the left side in 46.1% of the rats. The testes showed a decreased number of Sertoli cells, necrosis and a decreased number of germ cells in the seminiferous tubules. Anatomopathological changes in the vas deferens were not identified. There was no decrease in the thickness of the muscle wall of the vas deferens. In the right epididymis, 71.8% of the animals showed a reduction and 5% showed an absence of intraluminal sperm. In the left epididymis, 37.5% of the rats showed a reduction. The volume and the final testicular weight of the right side in group IV was different from those in the other groups. CONCLUSIONS: Anatomopathological lesions were found in the testis and epididymis. .


Assuntos
Animais , Masculino , Cordão Espermático/patologia , Tração/efeitos adversos , Epididimo/lesões , Epididimo/patologia , Modelos Animais , Necrose/etiologia , Tamanho do Órgão , Ratos Wistar , Túbulos Seminíferos/patologia , Cordão Espermático/lesões , Testículo/lesões , Testículo/patologia , Ducto Deferente/patologia
9.
Am J Surg ; 204(4): 503-9, 2012 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-22578405

RESUMO

BACKGROUND: The treatment of inguinal hernia has changed considerably over the past 15 years. We reviewed the preclinical and clinical literature to find out the effect of inguinal hernia surgery on male fertility because it has been suggested that hernia surgery may impair testicular function and male fertility. DATA SOURCES: A search on Embase, MEDLINE, and the Cochrane Library was performed to find related articles. CONCLUSIONS: Animal models show substantial effects of hernia repair on the structures in the spermatic cord, which is more pronounced in mesh repairs. Although the number of studies and the included numbers of patients were limited, clinical studies indicate that these potential adverse effects do not seem to have a clinical impact on male fertility in humans with inguinal hernias. Future clinical studies, preferably with bilateral patients, are necessary to investigate the clinical relevance of the effects of inguinal hernia and hernia surgery on male fertility.


Assuntos
Hérnia Inguinal/cirurgia , Herniorrafia/efeitos adversos , Infertilidade Masculina/etiologia , Infertilidade Masculina/fisiopatologia , Telas Cirúrgicas , Animais , Hérnia Inguinal/complicações , Hérnia Inguinal/fisiopatologia , Herniorrafia/métodos , Humanos , Incidência , Infertilidade Masculina/patologia , Isquemia/etiologia , Masculino , Modelos Animais , Orquite/etiologia , Dor/etiologia , Cordão Espermático/irrigação sanguínea , Cordão Espermático/lesões , Cordão Espermático/fisiopatologia , Testículo/irrigação sanguínea , Testículo/lesões , Testículo/fisiopatologia , Ducto Deferente/lesões , Ducto Deferente/fisiopatologia
10.
J Orthop Trauma ; 26(5): 263-8, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22337488

RESUMO

OBJECTIVES: To determine what anatomic structures are at risk after the application of a subcutaneous anterior pelvic internal fixator (APIF), from an incision over the anterior iliac crest to an incision centered over the pubic symphysis (Pfannenstiel). METHODS: A laboratory investigation was performed using 5 fresh, frozen, nonpreserved cadaveric specimens (3 male specimens, 2 female specimens). Dissections were carried out to identify the relationships and proximity between the fixator screw constructs and various anatomic structures, including the (1) lateral femoral cutaneous nerve (LFCN), (2) ilioinguinal nerve (IIN), (3) iliohypogastric nerve (IHN), (4) femoral nerve, (5) femoral artery, (6) femoral vein, (7) genitofemoral nerve; and (8) spermatic cord or round ligament. The mean and range of distance from each of these structures to the implant were measured with calipers. RESULTS: Despite variations in pelvic anatomy and width of pelvic brims, precontoured fixators (3.5 locking reconstruction plates) did not violate any pelvic neurovascular structures using this recommended application of an APIF. The spermatic cord was easily avoided as they were directly visualized using our application technique (mean, 0.4 cm, range, 0-2 cm). Abdominal musculature protected the IHN and IIN for most of their course, with the precontoured plates remaining inferior to their course and resting superficial to their branches (IHN mean, 1.5 cm, range, 1.2-1.8 cm and IIN mean, 2.1 cm, range, 0.9-4 cm). The LFCN traveled safely posterior to the inguinal ligament, thus being bridged by the internal spanning fixation without visualized disruption, impingement, or violation (mean, 1.5 cm, range, 0.6-4 cm). Finally, the femoral nerve, artery, and vein collectively demonstrated safe distance from the risk of compression (mean, 2.2 cm, range, 0.8-3.7 cm). CONCLUSIONS: The anatomic structures hypothesized to be potentially endangered because of the lack of direct visualization during APIF placement, include the LFCN, IIN, IHN, femoral nerve, femoral artery, and femoral vein. Based upon our anatomic study, APIF, which may be used for treatment augmentation of anterior pelvic ring disruptions, does not place these structures at significant risk. In addition, the reproductive structures (round ligament and spermatic cord) are in direct visualization and can easily be avoided during implant placement.


Assuntos
Fraturas Ósseas/etiologia , Fraturas Ósseas/patologia , Fixadores Internos/efeitos adversos , Ossos Pélvicos/lesões , Ossos Pélvicos/cirurgia , Traumatismos dos Nervos Periféricos/etiologia , Cordão Espermático/lesões , Cadáver , Feminino , Humanos , Masculino , Modelos Anatômicos , Órgãos em Risco , Traumatismos dos Nervos Periféricos/prevenção & controle , Medição de Risco
11.
Surg Endosc ; 25(1): 146-52, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20532568

RESUMO

BACKGROUND: Mesh implantation is regarded as the standard treatment of inguinal hernias. Obstructive azoospermia induced by mesh implantation is a rare but serious complication. Whether different operative techniques or mesh materials used have an effect on the integrity of the testicle and spermatic cord remains unclear. MATERIALS: In 12 minipigs a bilateral inguinal hernia repair, either open or laparoscopic, was performed using a standard small-pore polypropylene (PP) or large-pore polyvinyliden fluoride (PVDF) mesh. Next to measurement of the testicular size, thermography of the groin and testicle as a parameter for perfusion was performed preoperatively and at a follow-up at 6 months. Obstructions of the vas deferens were estimated radiographically. Testicular function (Johnson score) and mesh integration (granuloma size, apoptotic cells) were analyzed histologically. RESULTS: Mean testicular size did not change significantly in follow-up compared to preoperative values. Technique and mesh material used failed to have a significant influence. Thermography of the groin following the Lichtenstein technique had significantly higher values at follow-up regardless of the mesh used. This could not been shown for laparoscopic treatment. Thermographic measurements at the testicle showed a significantly increased temperature in all groups compared to preoperative measurements. Only the Lichtenstein PP group showed significantly decreased values in testicular function. Quantity and quality of obstructions seen at vasography were most detectable in the Lichtenstein PP group. There was significantly decreased granuloma formation following PVDF mesh implantation compared to the PP mesh group regardless of the technique used. CONCLUSIONS: Both the technique and the mesh material have an impact on integrity of spermatic cord and testicular function. According to the results of this study, the laparoscopic TAPP procedure using a large-pore PVDF mesh has the least effect compared to preoperative values.


Assuntos
Hérnia Inguinal/cirurgia , Complicações Intraoperatórias/etiologia , Implantação de Prótese/efeitos adversos , Cordão Espermático/lesões , Telas Cirúrgicas/efeitos adversos , Testículo/fisiopatologia , Animais , Azoospermia/etiologia , Azoospermia/prevenção & controle , Desenho de Equipamento , Reação a Corpo Estranho/etiologia , Masculino , Polipropilenos , Polivinil , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Implantação de Prótese/métodos , Radiografia , Sus scrofa , Suínos , Termografia , Ducto Deferente/diagnóstico por imagem
13.
Fertil Steril ; 93(6): 1907-10, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-19249033

RESUMO

OBJECTIVE: To assess the improvement of seminal characteristics and pregnancy rates after microsurgical varicocelectomy in men with subclinical varicocele. DESIGN: Retrospective study. SETTING: University infertility clinic. PATIENT(S): One hundred forty-three patients with a subclinical left-sided varicocele. INTERVENTION(S): Patients who agreed to microsurgical varicocelectomy (n = 25, surgery group), medical treatment with L-carnitine (n = 93 drug group), and those who did not agree to any treatment (n = 25, observation group) were enrolled. MAIN OUTCOME MEASURE(S): Semen characteristics were reevaluated twice 6 months after treatment. The natural pregnancy rates were estimated by telephone interview between 1 and 2 years after treatment. RESULT(S): In the surgery group, sperm counts improved significantly after microsurgical varicocelectomy. In the drug group, however, sperm parameters did not significantly improve after treatment. Natural pregnancy rates were 60.0% in the surgery group, 34.5% in the drug group, and 18.7% in the observation group. The natural pregnancy rate of the surgery group was higher than the other groups, and there were statistically significant differences among the three groups. CONCLUSION(S): Surgical treatment is the best option for management of subclinical varicocele.


Assuntos
Procedimentos Cirúrgicos Urogenitais/reabilitação , Varicocele/reabilitação , Varicocele/cirurgia , Adulto , Carnitina/uso terapêutico , Feminino , Seguimentos , Humanos , Masculino , Microcirurgia/efeitos adversos , Microcirurgia/métodos , Microcirurgia/reabilitação , Tamanho do Órgão , Complicações Pós-Operatórias/epidemiologia , Gravidez , Taxa de Gravidez , Estudos Retrospectivos , Análise do Sêmen , Cordão Espermático/lesões , Testículo/patologia , Procedimentos Cirúrgicos Urogenitais/efeitos adversos , Procedimentos Cirúrgicos Urogenitais/métodos , Varicocele/tratamento farmacológico , Varicocele/patologia
14.
J Pediatr Surg ; 44(11): 2163-7, 2009 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-19944227

RESUMO

PURPOSE: This study was performed to investigate whether compression/stretching of the spermatic cord or blunt dissection influences testicular development and fertility. In addition, the authors evaluated whether the extents of testicular damage differ between these 2 surgical manipulations. METHODS: Forty-four prepubertal male Sprague-Dawley (SD) rats (Harlan Sprague-Dawley Inc, Indianapolis, Ind) were divided into 3 groups: (1) the control group (CG) animals underwent a sham operation in the right groin, (2) the experimental group 1 (EG1) underwent compression/stretching of the right spermatic cord, and (3) the experimental group 2 (EG2) underwent dissection around the right spermatic cord structures. Testicular volumes, weights, mean seminiferous tubular diameters (MSTDs), mean testicular biopsy scores, and numbers of offspring and of pregnant females were evaluated. RESULTS: Right (operative) and left (nonoperative) testicular volumes were smaller in the EG2 group than in the CG or EG1 groups. Left MSTDs in the EG1 and EG2 groups increased more than in the CG group. Numbers of Sertoli cells in left testes differed in the 3 groups, in the order EG1 < CG < EG2. Mean testicular biopsy scores, offspring numbers, and pregnant female numbers were no different in the 3 groups. CONCLUSIONS: Both surgical manipulations influenced testicular growth, but they did not compromise spermatogenesis or fertility in SD rats.


Assuntos
Fertilidade/fisiologia , Cordão Espermático/fisiologia , Estresse Mecânico , Testículo/crescimento & desenvolvimento , Animais , Dissecação/efeitos adversos , Dissecação/métodos , Feminino , Lateralidade Funcional , Humanos , Masculino , Modelos Animais , Tamanho do Órgão , Paridade/fisiologia , Gravidez , Ratos , Ratos Sprague-Dawley , Células de Sertoli/citologia , Cordão Espermático/lesões , Cordão Espermático/cirurgia , Espermatogênese/fisiologia , Testículo/citologia , Ferimentos não Penetrantes/etiologia
15.
J Pediatr Surg ; 43(9): 1705-10, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18779011

RESUMO

BACKGROUND/PURPOSE: Operations for the treatment of inguinal diseases are the most frequent in childhood. Bleeding owing to trauma to the spermatic vessels is frequent and can cause testicular atrophy. The goal of this work was to determine the effects of the trauma to the spermatic vessels in the prepubertal and postpubertal histopathologic alterations in an experimental model in Wistar rats. METHODS: Eighty albino Wistar rats were divided in 4 groups for the histopathologic analysis. In group A, they were submitted to digital compression of the spermatic vessels for 45 seconds; in group B, the spermatic vessels were clamped with hemostats for 5 seconds; in group C, the spermatic vessels were cauterized for 2 seconds. Group D was the control group, in which the animals were submitted to inguinotomy solely. RESULTS: The prepubertal histopathologic alterations were significantly decreased in group A for testicular weight (0.97 +/- 0.10); in group B, for testicular weight (0.81 +/- 0.24), testicular volume (0.522 +/- 0.192), and mean testicular biopsy score (7.2 +/- 2.7); and in group C, for the 5 parameters studied, testicular weight (0.69 +/- 0.28), testicular weight per 100 g of body weight (0.498 +/- 0.188), testicular volume (0.765 +/- 0.308), mean seminiferous tubular diameter (236.6 +/- 62.5), and mean testicular biopsy score (6.9 +/- 3.1). The postpubertal histopathologic alterations were not significant for any of the 5 parameters studied, in the 3 groups. CONCLUSIONS: The prepubertal histopathologic alterations were more intense in the group submitted to cauterization of the spermatic vessels, intermediate in the group submitted to clamping of the spermatic vessels with hemostats, and less severe in the rats submitted to digital compression of the spermatic vessels. The postpubertal histopathologic alterations demonstrated the capability of the young testicle to recuperate from a vascular trauma.


Assuntos
Canal Inguinal/cirurgia , Cordão Espermático/lesões , Testículo/patologia , Fatores Etários , Animais , Masculino , Ratos , Ratos Wistar
16.
Chirurg ; 79(9): 854-8, 2008 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-18542894

RESUMO

BACKGROUND: In the examinations of the appraisal commission of Northern Rhine the third most frequent urologic errors are ascertained after surgical procedures. In order to prevent them, it is adequate to evaluate their causes. MATERIAL AND METHODS: Urologic claims were examined that came before the appraisal commission for treatment errors of the Northern Rhine Physicians' Authority between 1975 and 2005. The results of the first 23 years were compared with those of the last 7 years. The judgment criteria were professional standards and required care. RESULTS: Ninety-five treatment errors were registered in 1975-2005. From 1975 to 1998 there were 60 such errors (2.6 per year) and from 1999 to 2005 there were 35 (5.0 per year). These errors concerned diagnosis in 14.7% of cases (mainly testicular torsion), indication in 7.5%, and explanations of the surgery in 2.1%. About half the cases (46.3%) applied to surgical technique, especially for injuries to the spermatic cord, urinary bladder, ureter, or urethra. In nearly one third of cases (29.4%), errors were found in postoperative care, concerning especially lesions of the spermatic cord and ureter. CONCLUSIONS: There is considerable risk of misjudging or even causing urologic disorders in abdominal and vascular surgery. This applies most strongly to diagnosis, above all for testicular torsion. Hernia surgery and colon resection are the treatments leading to the highest number of injuries to testicular vessels, ureter, bladder, and/or urethra. Such occurrences cannot be tolerated if they can be avoided or, if unavoidable, not recognized promptly and adequately managed.


Assuntos
Erros Médicos , Cordão Espermático/lesões , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Ureter/lesões , Uretra/lesões , Bexiga Urinária/lesões , Urologia , Adolescente , Adulto , Alemanha , Humanos , Masculino , Erros Médicos/estatística & dados numéricos , Torção do Cordão Espermático/diagnóstico , Doenças Urológicas/etiologia
17.
Urology ; 70(3): 590.e15-6, 2007 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-17905126

RESUMO

A 62-year-old man with Gerstmann-Straüssler-Scheinker syndrome, an inherited prion disease, presented after having manually externalized both his testes, including self-castration of his left testis. The left testis was avulsed, along with 12 in. of spermatic cord. Given the patient's hospice status and the wishes of his family, the patient was not taken to the operating room for an inguinal exploration. This represents an unusual case of genital self-mutilation.


Assuntos
Doença de Gerstmann-Straussler-Scheinker/psicologia , Lacerações/etiologia , Automutilação/etiologia , Testículo/lesões , Cateterismo , Terapia Combinada , Desbridamento , Técnicas Hemostáticas , Cuidados Paliativos na Terminalidade da Vida , Humanos , Lacerações/cirurgia , Lacerações/terapia , Masculino , Pessoa de Meia-Idade , Escroto/lesões , Escroto/cirurgia , Automutilação/cirurgia , Automutilação/terapia , Cordão Espermático/lesões , Técnicas de Sutura , Testículo/cirurgia
18.
Actas urol. esp ; 31(8): 911-914, sept. 2007. ilus
Artigo em Es | IBECS | ID: ibc-056342

RESUMO

En los sarcomas paratesticulares, salvo en el rabdomiosarcoma, el único tratamiento factible y resolutivo es el quirúrgico radical. La vía obligatoria e ideal será la inguinotomía, con exéresis del cordón funicular y teste adyacente. Exige controles periódicos a largo plazo, dada las recidivas que pueden ocurrir incluso mucho tiempo después del diagnóstico. Ante una eventual recidiva la cirugía volverá a ser el único arma a nuestro alcance para el control de este tipo tumoral. Presentamos 2 casos de leiomiosarcoma paratesticular, un tumor de escasa frecuencia


Radical surgery is the only feasible and successful treatment for paratesticular sarcomas, with the exception of rabdomyosarcoma. The inguinal approach is the ideal and obligatory one, including excision of the spermatic cord and adjacent testicle. Long-term periodic follow-up visits are mandatory because relapses may ocurre even long time after diagnosis: In the case of relapse, surgery is again the only tool we have to control this type of tumor. We present two cases of paratesticular leiomyosarcoma, a tumor un common


Assuntos
Masculino , Pessoa de Meia-Idade , Humanos , Leiomiossarcoma/complicações , Leiomiossarcoma/diagnóstico , Cordão Espermático/lesões , Cordão Espermático/patologia , Cordão Espermático/cirurgia , Rabdomiossarcoma/complicações , Biomarcadores , Biomarcadores/análise , Orquiectomia/métodos , Leiomiossarcoma/epidemiologia , Leiomiossarcoma/cirurgia , Leiomiossarcoma , Escroto/cirurgia , Escroto
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