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1.
Retina ; 43(1): 152-157, 2023 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-32134801

RESUMO

PURPOSE: To describe a minimally invasive technique for the repair of large traumatic cyclodialysis clefts using intrascleral sewing machine suture and overhand friction knot techniques in pars plana vitrectomy. METHODS: This prospective, noncomparative, interventional case series included seven eyes of seven patients with a large traumatic cyclodialysis cleft. The sewing machine technique was modified by an intrascleral approach. The procedure was transconjunctival or subconjunctival performed without scleral flaps/grooves. An overhand friction knot was used to lead the cutting ends of the suture buried in the scleral tunnel. RESULTS: The closure of the cyclodialysis cleft was achieved in seven eyes. The mean follow-up duration was 49.1 ± 15.6 weeks (range, 30-70 weeks). The intraocular pressure increased from 7.3 ± 2.1 mm Hg (range, 5-11 mmHg) preoperatively to 13.6 ± 2.4 mm Hg (range, 10-17 mmHg) postoperatively ( P < 0.01). The best-corrected visual acuity improved from a mean of 2.76 ± 2.77 logarithm of the minimum angle of resolution preoperatively to 0.63 ± 0.82 logarithm of the minimum angle of resolution at the final follow-up ( P < 0.01). CONCLUSION: In conclusion, the present technique is safe and effective in the treatment of large traumatic cyclodialysis clefts with minimal surgical trauma and a decreased surgical duration.


Assuntos
Fendas de Ciclodiálise , Traumatismos Oculares , Humanos , Vitrectomia , Fendas de Ciclodiálise/cirurgia , Estudos Prospectivos , Corpo Ciliar/cirurgia , Corpo Ciliar/lesões , Traumatismos Oculares/cirurgia , Pressão Intraocular , Estudos Retrospectivos
2.
Eur J Ophthalmol ; 32(6): 3712-3719, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-35229674

RESUMO

BACKGROUND: Cyclodialysis cleft is an uncommon finding due to blunt ocular trauma. A larger and more chronic cyclodialysis requires surgical repair. The aim of this study was to introduce a minimally invasive suturing technique for the lens-sparing repair of traumatic cyclodialysis cleft and evaluate outcomes. METHODS: This study was a retrospective case series. The medical and surgical records of five patients with traumatic cyclodialysis cleft who underwent this surgery were reviewed. The surgeon (Y.S.) dissected a fornix-based conjunctival flap and created a 90° circumferential and limbal-based scleral flap. Several small incisions parallel to the limbus were made within the scleral bed 1.5 and 3 mm posterior to the limbus. After suprachoroidal fluid drainage, tiny bumps in the ciliary body were exposed from the incisions and sewn directly onto the scleral bed with 10-0 nylon sutures. RESULTS: The mean age of the patients was 37.8 ± 1.3 years. The mean duration from injury to surgery was 14.8 ± 16.7 months. Mean best-corrected visual acuity (BCVA) was 0.56 ± 0.70 and intraocular pressure (IOP) was 5.2 ± 1.9 mmHg. In all patients, IOP normalized and BCVA then returned to baseline following this procedure. Mean postoperative BCVA was 1.17 ± 0.86 and IOP was 17.8 ± 1.3 mmHg. Mean IOP and BCVA recovery times were 82.0 ± 139.6 and 294.3 ± 284.3 days, respectively. CONCLUSIONS: Partial ciliary body direct suturing under the scleral flap is a less invasive surgical option without lensectomy and considered safe and effective as a primary surgical repair for traumatic cyclodialysis cleft.


Assuntos
Fendas de Ciclodiálise , Traumatismos Oculares , Ferimentos não Penetrantes , Adulto , Corpo Ciliar/lesões , Corpo Ciliar/cirurgia , Traumatismos Oculares/cirurgia , Humanos , Pressão Intraocular , Nylons , Estudos Retrospectivos , Suturas , Resultado do Tratamento , Ferimentos não Penetrantes/cirurgia
3.
J Craniofac Surg ; 33(4): e355-e358, 2022 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-35225590

RESUMO

PURPOSE: To evaluate the ciliary body mechanical load during low speed impact using finite element method to explain the mechanism of the cause of angle recession and cyclodialysis cleft. METHODS: Optical coherence tomography images were obtained to assess the patient's ciliary body angle recession. A finite element eye model was established based on Virginia Tech eye model with the consideration of dynamic impact of a projectile striking an eye. The mechanical properties of the ocular tissues were obtained from literatures. The stress and strain were evaluated. RESULTS: The stress distribution of the eye was calculated. The stress concentration at zonules was observed after 0.75 ms of the impact. The maximum stress at the cornea reached 3.8 MPa. The maximum stress at ciliary body was 57 KPa, which has high probability to cause ciliary body injury. The maximum stress at zonules was 0.98 MPa. The lateral expansion also reduces the forces transmitted along the sclera to the rear part of the eye. CONCLUSIONS: The eye under frontal impact will result in lateral expansion, which increase the stretch force of the lens, zonules and ciliary body. This mechanism can be seen as the protection for retina. The boundary of ciliary body is the most vulnerable position, where angle recession and cyclodialyses cleft will occur before retina damage occurrence. TRANSLATIONAL RELEVANCE: The finite element model explains the blunt low speed impact induced ciliary body related injuries, which enables us to assess the ocular injury for low energy impact and better diagnosis and treatment in clinics.


Assuntos
Corpo Ciliar , Traumatismos Oculares , Corpo Ciliar/diagnóstico por imagem , Corpo Ciliar/lesões , Simulação por Computador , Traumatismos Oculares/diagnóstico por imagem , Traumatismos Oculares/etiologia , Análise de Elementos Finitos , Humanos , Esclera
4.
Retina ; 41(6): 1174-1181, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-33079790

RESUMO

PURPOSE: Comparing the anatomical and functional outcomes of vitrectomy, silicone oil endotamponade without cyclopexy (VEWOC) and with cyclopexy (VEWC) in patients with traumatic cyclodialysis clefts and severe ocular comorbidities. METHODS: A total of 55 patients (55 eyes) with traumatic cyclodialysis clefts were divided into VEWOC and VEWC groups according to the surgery undergone. Besides the cyclodialysis clefts, all study eyes had one or more additional conditions caused by severe ocular trauma: cataract, lens dislocation, vitreous hemorrhage, retinal detachment, choroidal detachment, maculopathy, suprachoroidal hemorrhage, subretinal hemorrhage, or proliferative vitreoretinopathy. The minimum postoperative follow-up period for all patients was six months. The main measures of outcome were rate of successful anatomical repair, intraocular pressure, and best-corrected visual acuity. RESULTS: Both the VEWOC group (33 eyes) and the VEWC group (22 eyes) showed significant improvement in postoperative best-corrected visual acuity and intraocular pressure at the final follow-up. The groups had no significant differences in terms of anatomical success rates (VEWOC 29/33 vs. VEWC 20/22, P = 1.000), final best-corrected visual acuity (VEWOC 1.60 ± 0.76 [median Snellen acuity: counting fingers, range: light perception to 20/20] vs. VEWC 1.46 ± 0.66 [median Snellen acuity: 20/800, range: light perception to 20/32], P = 0.485), and final intraocular pressure (VEWOC 13.40 [8.20-17.80] vs. VEWC 11.40 [6.65-14.00] mmHg, P = 0.311). However, the intraocular pressure on postoperative Day 1 was significantly different between the groups (VEWOC 10.40 [6.40-14.60] vs. VEWC 6.40 [4.70-7.98] mmHg, P = 0.002). CONCLUSION: This study showed that both surgical approaches were equally effective in treating cyclodialysis clefts secondary to severe ocular trauma. Therefore, it may be unnecessary to perform cyclopexy in addition to the vitrectomy procedure in such cases.


Assuntos
Corpo Ciliar/cirurgia , Fendas de Ciclodiálise/cirurgia , Tamponamento Interno/métodos , Traumatismos Oculares/complicações , Óleos de Silicone/farmacologia , Acuidade Visual , Vitrectomia/métodos , Adulto , Idoso , Corpo Ciliar/diagnóstico por imagem , Corpo Ciliar/lesões , Fendas de Ciclodiálise/diagnóstico , Fendas de Ciclodiálise/etiologia , Traumatismos Oculares/diagnóstico , Traumatismos Oculares/cirurgia , Feminino , Seguimentos , Gonioscopia , Humanos , Pressão Intraocular/fisiologia , Masculino , Microscopia Acústica , Pessoa de Meia-Idade , Estudos Retrospectivos , Índices de Gravidade do Trauma , Adulto Jovem
5.
BMC Ophthalmol ; 20(1): 117, 2020 Mar 23.
Artigo em Inglês | MEDLINE | ID: mdl-32293350

RESUMO

BACKGROUND: A cyclodialysis cleft often leads to direct communication between the anterior chamber and the suprachoroidal space. It is a rare condition that is encountered with blunt trauma, and less commonly, after surgery. Hypotony is the major sequelae that may lead to hypotonous maculopathy, optic disc edema, corneal folds, and astigmatism. These may cumulatively lead to visual loss. We describe how endoscopy in a cyclodialysis repair allowed us to accurately locate the cleft and guided its appropriate management avoiding unnecessary cryopexy. CASE PRESENTATION: A 41-year-old male experienced a traumatic cyclodialysis cleft, which resulted in persistent hypotony. Pars plana vitrectomy was performed to treat vitreous hemorrhage. Scleral indentation was attempted to visualize the cyclodialysis cleft. However, the depression distorted the visualization. Intraocular endoscopy was therefore used to evaluate the cleft. Guided by this assessment, only intraocular gas tamponade was used to reposition the ciliary body. The patient's intraocular pressure was restored to 13 mmHg 3 days after the operation, and OCT confirmed cleft closure 1 month after the operation. CONCLUSION: Endoscopy-assisted repair of cyclodialysis is an approach that enhances visualization and can guard against common causes of persistent cleft and hypotony, as well as reveal the causes of recurrent failure. Hence, it can eliminate unnecessary cryopexy that might worsen the hypotonous state. In our case, intraocular endoscopy was effective for the evaluation of a cyclodialysis cleft and the subsequent selection of an appropriate management technique, gas tamponade, that was more conservative than other approaches initially considered.


Assuntos
Corpo Ciliar/lesões , Fendas de Ciclodiálise/diagnóstico , Endoscopia , Traumatismos Oculares/complicações , Hipotensão Ocular/diagnóstico , Ferimentos não Penetrantes/complicações , Adulto , Doenças da Túnica Conjuntiva/diagnóstico , Doenças da Túnica Conjuntiva/etiologia , Doenças da Túnica Conjuntiva/cirurgia , Fendas de Ciclodiálise/etiologia , Fendas de Ciclodiálise/cirurgia , Hemorragia Ocular/diagnóstico , Hemorragia Ocular/etiologia , Hemorragia Ocular/cirurgia , Traumatismos Oculares/diagnóstico , Glucocorticoides/uso terapêutico , Humanos , Hifema/diagnóstico , Hifema/etiologia , Hifema/cirurgia , Pressão Intraocular , Subluxação do Cristalino/diagnóstico , Subluxação do Cristalino/etiologia , Subluxação do Cristalino/cirurgia , Cristalino/cirurgia , Masculino , Hipotensão Ocular/tratamento farmacológico , Hipotensão Ocular/etiologia , Tonometria Ocular , Transtornos da Visão/diagnóstico , Transtornos da Visão/etiologia , Acuidade Visual/fisiologia , Vitrectomia , Ferimentos não Penetrantes/diagnóstico
6.
J Glaucoma ; 29(1): 67-70, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31460884

RESUMO

During blunt ocular trauma, the anteroposterior compressive forces confronted lead to consequent equatorial expansion of the globe. This may result in ciliary body trauma, typically manifesting as angle recession or cyclodialysis. The authors hypothesize that a likely asymmetric contraction between the longitudinal and circular ciliary fibers, and an intrinsic weak "oblique buffer zone" creates a plane of separation between the 2, resulting in angle recession. When stronger forces are met with, the equatorial expansion of the sclera may outperform the ability of the ciliary body to follow it, and the taut longitudinal ciliary fibers may subsequently disinsert from the scleral spur causing cyclodialysis. In addition to this, the routinely thought dismembering aqueous jets directed toward the angle may also accentuate ciliary body trauma. Therefore, the vivid distractive external forces along with the complex ciliary muscle anatomy and differential functionality may play a crucial role in causation of post-traumatic angle recession and cyclodialysis.


Assuntos
Segmento Anterior do Olho/patologia , Corpo Ciliar/lesões , Fendas de Ciclodiálise/etiologia , Traumatismos Oculares/complicações , Ferimentos não Penetrantes/complicações , Feminino , Humanos , Pressão Intraocular/fisiologia , Masculino
7.
Exp Eye Res ; 190: 107858, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31669044

RESUMO

In order to study the pathophysiological alterations of the ciliary body (CB) during persistent hypotony, it is necessary to develop an animal model without CB injury. In this study, we successfully established a modified model of persistent hypotony without CB injury in New Zealand rabbits. A 23-gauge pars plana vitrectomy (PPV) was performed and a trocar-formed fistula was allowed to remain in situ, to produce a continuous outflow of intraocular fluid. Both eyes underwent PPV with normal intraocular pressure (IOP); eyes with no surgical intervention were used as controls. The IOP was monitored and used to evaluate the reliability of the model. Secondary changes of hypotony were evaluated by slit-lamp biomicroscopy and B scans while morphological changes of the CB were observed by haematoxylin and eosin staining. The mean IOP in the hypotony groups were consistently lower than 6 mmHg. Furthermore, there were no significant differences in IOP between the PPV control group and normal eyes. Collectively, our data indicate that this model successfully simulates the secondary changes of hypotony, including a reduction in corneal size, corneal oedema, anterior chamber inflammation, morphological alterations of the CB, cataract, retinal detachment, and choroidal detachment. The morphological structure of the CB tissue changed dramatically after persistent hypotony, indicating that normal IOP may be required in order to maintain normal function in the CB. This model of persistent hypotony potentially represents a valuable tool for future studies aiming to investigate the pathophysiological mechanisms underlying CB dysfunction and other secondary changes that occur during hypotony.


Assuntos
Corpo Ciliar/lesões , Modelos Animais de Doenças , Pressão Intraocular/fisiologia , Hipotensão Ocular/etiologia , Animais , Catarata/diagnóstico , Catarata/etiologia , Doenças da Coroide/diagnóstico , Doenças da Coroide/etiologia , Corpo Ciliar/diagnóstico por imagem , Corpo Ciliar/fisiopatologia , Córnea/anormalidades , Edema da Córnea/diagnóstico , Edema da Córnea/etiologia , Traumatismos Oculares/fisiopatologia , Hipotensão Ocular/fisiopatologia , Coelhos , Descolamento Retiniano/diagnóstico , Descolamento Retiniano/etiologia , Microscopia com Lâmpada de Fenda , Tonometria Ocular , Ultrassonografia , Uveíte Anterior/diagnóstico , Uveíte Anterior/etiologia , Vitrectomia
9.
Indian J Ophthalmol ; 67(10): 1748-1750, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31546552

RESUMO

A 17-years-old boy presented with cataract, 360° choroidal effusion and disc oedema secondary to chronic hypotony. Gonioscopy and AS-OCT revealed 2 clock hours of cyclodialysis in the superonasal quadrant. The case was successively managed with phacoemulsification with foldable IOL in the bag and Cionni's ring sutured in the superonasal quadrant. Post surgery, the BCVA improved from counting finger 1 meter to 20/40. IOP returned to normal and there was resolution of choroidal effusion and fundus signs. The case highlights the use of Cionni's ring in management of small cyclodialysis cleft by providing internal compression.


Assuntos
Corpo Ciliar/lesões , Fendas de Ciclodiálise/cirurgia , Traumatismos Oculares/complicações , Implante de Lente Intraocular , Facoemulsificação/métodos , Ferimentos não Penetrantes/complicações , Adolescente , Corpo Ciliar/diagnóstico por imagem , Corpo Ciliar/cirurgia , Fendas de Ciclodiálise/diagnóstico , Fendas de Ciclodiálise/etiologia , Traumatismos Oculares/diagnóstico , Humanos , Masculino , Desenho de Prótese , Tomografia de Coerência Óptica/métodos , Ferimentos não Penetrantes/diagnóstico
10.
J Fr Ophtalmol ; 42(8): 852-863, 2019 Oct.
Artigo em Francês | MEDLINE | ID: mdl-31202775

RESUMO

INTRODUCTION: Cyclodialysis is a rare condition that is difficult to manage. We present the case of a woman with a cyclodialysis complicated by chronic hypotony requiring two surgeries to achieve reattachment of the ciliary body. We also report the results of a review of the literature regarding the treatment of this condition. DESCRIPTION: This is a 46-year-old woman with history of trauma to the right eye. Examination revealed an intra-ocular pressure (IOP) of 7mmHg, a shallow anterior chamber and signs of chronic hypotony on fundus examination (vascular tortuosity, hypotony maculopathy) due to an extensive 360° cyclodialysis, confirmed by ultrasound biomicroscopy. Transcleral cryotherapy as a first-line approach did not achieve reattachment of the ciliary body. Secondary pars plana vitrectomy with gas tamponade (C2F6) reattached the ciliary body and restored the intraocular pressure (12mmHg) and normal fundus appearance. The patient recovered corrected visual acuity of 20/20. DISCUSSION: To our knowledge, there is no standardized management for cyclodialysis. The study of the literature available on the Medline database showed that direct cyclopexy remains the most common treatment, followed by vitrectomy with internal tamponade. Neither the extent nor the duration of the cyclodialysis can predict the visual recovery, which can be major even after weeks of hypotony. CONCLUSION: The management of cyclodialysis is not well-defined; it remains a true therapeutic challenge.


Assuntos
Fendas de Ciclodiálise/terapia , Corpo Ciliar/lesões , Corpo Ciliar/patologia , Terapia Combinada , Crioterapia/métodos , Fendas de Ciclodiálise/diagnóstico , Fendas de Ciclodiálise/etiologia , Traumatismos Oculares/complicações , Traumatismos Oculares/terapia , Feminino , Humanos , Pessoa de Meia-Idade , Hipotensão Ocular/diagnóstico , Hipotensão Ocular/etiologia , Hipotensão Ocular/terapia , Padrões de Prática Médica/estatística & dados numéricos , Padrões de Prática Médica/tendências , Tonometria Ocular , Vitrectomia/métodos
13.
J Cataract Refract Surg ; 45(1): 3-7, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30391153

RESUMO

We describe a modified sewing machine technique that is ab interno and minimally invasive. The single-suture, single-knot endocyclopexy (internal suture fixation) is performed to correct cyclodialysis. This inside-out technique is an alternative to existing standard cleft repair procedures, such as external direct/indirect cyclopexy and endocyclotamponade (internal mechanical tamponade using extraneous agents). Results in 1 case indicate that the modified technique can be used as a primary procedure and in eyes in which previous cyclopexy failed.


Assuntos
Traumatismos por Explosões/cirurgia , Corpo Ciliar/lesões , Traumatismos Oculares/cirurgia , Iris/lesões , Técnicas de Sutura , Traumatismos por Explosões/etiologia , Traumatismos por Explosões/fisiopatologia , Catarata/etiologia , Extração de Catarata , Criança , Corpo Ciliar/cirurgia , Tamponamento Interno , Gonioscopia , Humanos , Pressão Intraocular/fisiologia , Iris/cirurgia , Implante de Lente Intraocular , Masculino , Microscopia Acústica , Procedimentos Cirúrgicos Minimamente Invasivos , Hipotensão Ocular/etiologia , Polipropilenos , Suturas , Acuidade Visual/fisiologia
14.
Eur J Ophthalmol ; 29(5): NP9-NP13, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30270659

RESUMO

PURPOSE: To report a case that presented with post blunt trauma cataract, zonular dialysis, cyclodialysis and iridodialysis and its successful single-sitting management. METHODS: After lens aspiration, a capsular tension ring and multipiece intraocular lens were placed in the bag to support the zonules, a single eyelet Cionni ring was fixed in the sulcus to provide endocyclotamponade, and iridodialysis repair was done using the 'stroke and dock technique'. RESULT: Successful centration of the intraocular lens, closure of the cleft and apposition of the iris root to its base were achieved at the end of the surgery. CONCLUSION: A single-sitting surgery correcting all the three dialysis can curtail the burden of repeated surgeries and their complications, providing early visual recovery and cost-effectivity.


Assuntos
Traumatismos por Explosões/cirurgia , Corpo Ciliar/lesões , Traumatismos Oculares/cirurgia , Iris/lesões , Cristalino/lesões , Implantação de Prótese , Ferimentos não Penetrantes/cirurgia , Traumatismos por Explosões/etiologia , Catarata/etiologia , Criança , Traumatismos Oculares/etiologia , Humanos , Iris/cirurgia , Implante de Lente Intraocular , Lentes Intraoculares , Ligamentos/lesões , Masculino , Microscopia Acústica , Facoemulsificação , Próteses e Implantes , Ferimentos não Penetrantes/etiologia
15.
Middle East Afr J Ophthalmol ; 26(4): 240-242, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-32153337

RESUMO

We report the trans-operative approach and short-term outcome of a patient who suffered a traumatic avulsion of the cilioretinal artery branch during the surgical management of a cilioretinal arterial branch occlusion (CRABO) with intraocular embolectomy. A patient with acute CRABO underwent a pars plana vitrectomy with in situ embolectomy. The blocked artery was incised using 25 gauge vertical scissors, and embolus manipulation was done using microsurgical forceps. During embolus extraction, the occluded cilioretinal artery and its branch were inadvertently avulsed and torn with subsequent intense bleeding. Laser and endodiathermy were used for acute hemostasis. The maneuvers created an unintended retinochoroidal anastomosis. Visual field improvement was noted 3 months after the surgery. In the event of a complicated surgical embolectomy with the avulsion of the artery, the formation of a retinochoroidal anastomosis and reperfusion of the occluded may occur along with the improvement of visual fields in some cases.


Assuntos
Corpo Ciliar/lesões , Embolectomia/efeitos adversos , Oclusão da Artéria Retiniana/etiologia , Artéria Retiniana/lesões , Idoso , Humanos , Masculino
16.
BMC Ophthalmol ; 18(Suppl 1): 219, 2018 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-30255821

RESUMO

BACKGROUND: This case highlights the important sequelae that can occur following the inadvertent implantation of a single-piece intraocular lens into the ciliary sulcus during cataract surgery; secondary pigment dispersion glaucoma, recurrent anterior uveitis and macular oedema. CASE PRESENTATION: A 67-year-old lady underwent routine left cataract surgery in a separate unit but subsequently attended our eye casualty with recurrent hypertensive anterior uveitis. She was found to have secondary pigment dispersion glaucoma as the intraocular lens had been inadvertently placed into the ciliary sulcus. She underwent a trabeculectomy to control the intraocular pressure and initially settled well but 12 months later developed persistent anterior segment inflammation and macular oedema. She subsequently had the intraocular lens removed and the macular oedema was treated successfully with intravitreal Bevacizumab. CONCLUSIONS: We provide a summary of the evidence and a discussion over the management options available in managing such a difficult case.


Assuntos
Corpo Ciliar/lesões , Síndrome de Exfoliação/etiologia , Traumatismos Oculares/etiologia , Glaucoma de Ângulo Aberto/etiologia , Implante de Lente Intraocular/efeitos adversos , Edema Macular/etiologia , Uveíte Anterior/etiologia , Idoso , Inibidores da Angiogênese/uso terapêutico , Bevacizumab/uso terapêutico , Remoção de Dispositivo , Síndrome de Exfoliação/diagnóstico , Síndrome de Exfoliação/cirurgia , Feminino , Glaucoma de Ângulo Aberto/diagnóstico , Glaucoma de Ângulo Aberto/cirurgia , Humanos , Pressão Intraocular/fisiologia , Lentes Intraoculares , Edema Macular/diagnóstico , Edema Macular/tratamento farmacológico , Facoemulsificação , Recidiva , Tomografia de Coerência Óptica , Trabeculectomia , Uveíte Anterior/diagnóstico , Uveíte Anterior/cirurgia
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