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1.
J Hazard Mater ; 477: 135422, 2024 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-39106727

RESUMO

Environmental pollutant is considered to be one of the important factors affecting adolescent growth. However, the effects of volatile organic compounds (VOCs) exposure on adolescent growth have not been assessed. Data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018 was used to examine the associations between VOCs exposure and adolescent growth indicators through three statistical models. The mediating effect of bone mineral density (BMD) on these associations was examined. The potential pathways and key targets were identified by the network pharmacology analysis methods. This study included 746 adolescents. Three statistical methods consistently showed a negative correlation between VOCs exposure and adolescent growth indicators. Furthermore, BMD mediated the relationship between VOCs exposure and adolescent growth indicators, with mediated proportion ranging from 4.3 % to 53.4 %. Network pharmacology analysis found a significant enrichment in IL-17 signaling pathway. Moreover, the adverse effects of VOCs exposure on adolescent growth were observed to significantly attenuate in adolescents with high serum vitamin D levels. Our results suggested that VOCs exposure was an adverse factor affecting adolescent growth, with BMD playing a significant regulatory role, and IL-17 signaling pathway was the underlying mechanism. Vitamin D supplementation may be a viable strategy to prevent VOCs exposure from affecting adolescent growth.


Assuntos
Densidade Óssea , Compostos Orgânicos Voláteis , Compostos Orgânicos Voláteis/toxicidade , Adolescente , Humanos , Feminino , Masculino , Densidade Óssea/efeitos dos fármacos , Exposição Ambiental , Vitamina D/sangue , Inquéritos Nutricionais , Interleucina-17 , Desenvolvimento do Adolescente/efeitos dos fármacos , Poluentes Atmosféricos/toxicidade
2.
Proc Natl Acad Sci U S A ; 121(33): e2314074121, 2024 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-39121162

RESUMO

Adolescent development of human brain structural and functional networks is increasingly recognized as fundamental to emergence of typical and atypical adult cognitive and emotional proodal magnetic resonance imaging (MRI) data collected from N [Formula: see text] 300 healthy adolescents (51%; female; 14 to 26 y) each scanned repeatedly in an accelerated longitudinal design, to provide an analyzable dataset of 469 structural scans and 448 functional MRI scans. We estimated the morphometric similarity between each possible pair of 358 cortical areas on a feature vector comprising six macro- and microstructural MRI metrics, resulting in a morphometric similarity network (MSN) for each scan. Over the course of adolescence, we found that morphometric similarity increased in paralimbic cortical areas, e.g., insula and cingulate cortex, but generally decreased in neocortical areas, and these results were replicated in an independent developmental MRI cohort (N [Formula: see text] 304). Increasing hubness of paralimbic nodes in MSNs was associated with increased strength of coupling between their morphometric similarity and functional connectivity. Decreasing hubness of neocortical nodes in MSNs was associated with reduced strength of structure-function coupling and increasingly diverse functional connections in the corresponding fMRI networks. Neocortical areas became more structurally differentiated and more functionally integrative in a metabolically expensive process linked to cortical thinning and myelination, whereas paralimbic areas specialized for affective and interoceptive functions became less differentiated, as hypothetically predicted by a developmental transition from periallocortical to proisocortical organization of the cortex. Cytoarchitectonically distinct zones of the human cortex undergo distinct neurodevelopmental programs during typical adolescence.


Assuntos
Imageamento por Ressonância Magnética , Neocórtex , Humanos , Adolescente , Feminino , Masculino , Neocórtex/diagnóstico por imagem , Neocórtex/crescimento & desenvolvimento , Neocórtex/fisiologia , Adulto , Adulto Jovem , Mapeamento Encefálico/métodos , Desenvolvimento do Adolescente/fisiologia , Rede Nervosa/fisiologia , Rede Nervosa/diagnóstico por imagem , Rede Nervosa/crescimento & desenvolvimento , Encéfalo/diagnóstico por imagem , Encéfalo/crescimento & desenvolvimento , Encéfalo/fisiologia
3.
Wiad Lek ; 77(6): 1237-1242, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39106386

RESUMO

OBJECTIVE: Aim: To investigate the influence of judo club activities on the physical development indicators of 16-17-year-old young males. PATIENTS AND METHODS: Materials and Methods: The research, conducted in 2022-2024, involved 54 young males aged 16-17, who were divided into experimental (EG) and control (CG) groups of 27 each. The physical development was assessed by body weight, hand dynamometry, lung capacity, heart rate, and blood pressure indicators. Cooper, Rufier, Stange, Genchi, vital, strength, body weight, Robinson, and maximum oxygen consumption indices were calculated. RESULTS: Results: The positive influence of judo club activities on the physical development of 16-17-year-old young males was revealed: all studied indicators significantly improved in the EG young males during the experiment. Judo training sessions had the most effective impact on the indicators characterizing the development of the muscular system and the level of strength qualities. At the end of the experiment, young males of the EG showed significantly better physical development than the CG representatives in terms of strength index (by 6.33 %), static endurance of stronger (by 2.07 s) and weaker (2.03 s) hands. According to the indicators characterizing the state of cardiovascular and respiratory systems, the indicators of young males of both groups were significantly the same. CONCLUSION: Conclusions: It has been established that judo club activities, which were conducted taking into account the age characteristics of 16-17-year-old young males, create the most favorable conditions for the harmonious physical development of boys, promoting their health and preparing them for future educational and professional activities.


Assuntos
Artes Marciais , Humanos , Masculino , Adolescente , Artes Marciais/fisiologia , Força Muscular/fisiologia , Frequência Cardíaca/fisiologia , Peso Corporal , Desenvolvimento do Adolescente/fisiologia , Consumo de Oxigênio/fisiologia
4.
Wiad Lek ; 77(6): 1205-1210, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39106381

RESUMO

OBJECTIVE: Aim: To substantiate the methodology for assessing the biological age of adolescent high schoolers (boys and girls). PATIENTS AND METHODS: Materials and Methods: Boys aged 14-15 (n = 102) and girls aged 12-13 (n = 101) were studied. The choice of these age groups is explained by the presence of the most significant individual differences in morphological and functional characteristics in these adolescents. Methods: anthropometry, somatometry, somatoscopy, tonometry, spirometry, dynamometry, Stange's test, Rufier and Robinson indices. The interaction of the results of different methods of assessing biological age was conducted on one sex-age sample using factor analysis (principal components method). RESULTS: Results: It has been established that the biological age of adolescents can be reliably determined using a set of three components: an assessment of the level of physical development, the index of heterochronicity, and the degree of manifestation of secondary sexual characteristics (for boys with a probability of 90.2 %, for girls - 92.1 %). The percentage ratio of these components has sexual peculiarities. Methodologies for assessing biological age for scientific purposes and rapid assessment for use in the practice of physical education and sports have been proposed. The indicators of rapid assessment are body length and the degree of hair development in the axilla. The reliability of the rapid assessment is 81.4 % for boys and 83.2 % for girls. CONCLUSION: Conclusions: Developing adequate physical activities for adolescents of different biological ages will help improve the physical health of the younger generation.


Assuntos
Antropometria , Humanos , Adolescente , Masculino , Feminino , Antropometria/métodos , Criança , Desenvolvimento do Adolescente
5.
BMC Psychol ; 12(1): 372, 2024 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-38951933

RESUMO

Effective approaches to addressing mental health challenges faced by adolescents require a deep understanding of the factors contributing to optimal development, well-being, and prosperity. From the perspective of Positive Youth Development (PYD), this study proposes to examine the relationship between the 5Cs of PYD (Competence, Confidence, Connection, Character, and Caring) and symptoms of depression, anxiety, stress, and emotional distress among Chilean adolescents. A quantitative, cross-sectional, non-experimental study was conducted with 425 adolescents (ages 12 to 19, M = 14.95, SD = 1.81) from three Chilean cities: Arica (23%), Alto Hospicio (32%), and Iquique (46%). Data analysis included the use of confirmatory factor analysis (CFA) and structural equation modeling (SEM). The results indicate that two of the 5Cs, Confidence and Connection, have a significant negative direct effect on the four evaluated criterion indicators. These findings contribute to the literature on positive youth development in Latin America and underscore the importance of fostering confidence and connection in interventions aimed at promoting the mental health of adolescents in Chile and in similar contexts.


Assuntos
Ansiedade , Depressão , Angústia Psicológica , Estresse Psicológico , Humanos , Adolescente , Chile , Feminino , Masculino , Ansiedade/psicologia , Ansiedade/epidemiologia , Depressão/psicologia , Depressão/epidemiologia , Estudos Transversais , Estresse Psicológico/psicologia , Criança , Adulto Jovem , Desenvolvimento do Adolescente
6.
J Res Adolesc ; 34(2): 513-516, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38973284

RESUMO

The field of developmental science explores the rich interplay between individuals and their contexts, which dynamically shift across time and place. In Asia, context-specific research and practice are essential for promoting culturally relevant program and policy approaches to improving adolescent well-being. This involves critically examining how localized social structures and power dynamics shape individual experiences and outcomes. The landscape for Asian adolescents today differs significantly from that of previous generations due to rapid changes in these structures, and societal transformation has created the opportunity for traditional and modern values to coexist. This commentary draws across articles from this special issue to describe the dynamics of adolescent-context relations across diverse Asian contexts using developmental science methods. This includes interrogating risk factors, opportunities, and trajectories for adolescents growing up in non-Western settings while also questioning the application of Western, adult-centric discourses on adolescent well-being globally.


Assuntos
Desenvolvimento do Adolescente , Humanos , Adolescente , Ásia , Feminino , Colonialismo
7.
Curr Opin Psychol ; 58: 101847, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-39084055

RESUMO

A popular topic in developmental science is self-regulation, an aspect of functioning viewed as contributing to optimal development. Of particular theoretical importance is top-down (frontal cortically based) self-regulation (TDSR). This article briefly reviews recent research on TDSR's relation to four areas of development: maladjustment, social competence, prosocial development, and academic development. Recent studies on the topic often involve sophisticated methods and designs; moreover, several relevant meta-analyses have been published in the recent past. In general, a higher level of TDSR has been associated with better adjustment, social competence, prosociality, and success in the school setting. Limitations in the research and extant meta-analyses are briefly noted.


Assuntos
Desenvolvimento do Adolescente , Desenvolvimento Infantil , Autocontrole , Habilidades Sociais , Humanos , Criança , Adolescente , Comportamento Social
8.
Dev Psychol ; 60(8): 1384-1400, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38976429

RESUMO

Both parasympathetic nervous system regulation and receipt of social support from close relationships contribute to prosocial development, although few studies have examined their combined influences in adolescence and particularly within racially and ethnically minoritized populations. In this longitudinal study of 229 U.S. Mexican-origin adolescents (48% female-identifying), youths reported on receipt of social support from family and friends from 10 to 16 years, had their baseline respiratory sinus arrhythmia (RSA) measured at 17 years, reported their prosocial behavior and completed the Mind in the Eyes test to assess cognitive empathy at 17 and 19 years, and reported their prosocial civic behavior (i.e., community activity) at 19 years. Family social support predicted prosocial behavior at 17 years, and friend social support predicted prosocial civic behavior at 19 years. Compared to youths with lower or higher baseline RSA, youths with moderate RSA reported more prosocial civic behavior, had greater cognitive empathy, and tended to report more general prosocial behavior at 19 years. The quadratic association between baseline RSA and cognitive empathy was stronger for youths with greater family social support. These findings are the first to extend the evidence that moderate baseline parasympathetic nervous system activity supports prosocial development into late adolescence and with the U.S. Mexican-origin community, and these findings address calls for more integrative biopsychosocial studies of prosociality. (PsycInfo Database Record (c) 2024 APA, all rights reserved).


Assuntos
Empatia , Família , Amigos , Americanos Mexicanos , Sistema Nervoso Parassimpático , Arritmia Sinusal Respiratória , Comportamento Social , Apoio Social , Humanos , Adolescente , Feminino , Masculino , Sistema Nervoso Parassimpático/fisiologia , Estudos Longitudinais , Empatia/fisiologia , Arritmia Sinusal Respiratória/fisiologia , Adulto Jovem , Criança , Estados Unidos , Comportamento do Adolescente/fisiologia , Comportamento do Adolescente/etnologia , Desenvolvimento do Adolescente/fisiologia
9.
Clin Psychol Rev ; 112: 102465, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-39002184

RESUMO

Adolescence is a time when important decisions about the future are made and vulnerability to mental health problems increases. We reviewed longitudinal studies examining the reciprocal pathways between future-related thinking (hopelessness, hope, optimism/positive future expectations) and adolescent depression and anxiety symptoms. Evidence from 22 studies (N = 10,682) found that negative future-related thinking predicted subsequent depression (r = 0.27, p < .001), an effect still significant after controlling for baseline depression (r = 0.23, p < .001). Higher hopelessness (r = 0.34, p < .001), lower hope (r = 0.16, p < .001), and reduced optimism/positive future expectations (r = 0.18, p < .001) were associated with subsequently increased depressive symptoms. Negative future-related thinking also predicted later increased anxiety symptoms (r = 0.15, p = .021). Concerning the reciprocal pathway, depressive symptoms were associated with later negative future-related thinking (r = 0.32, p < .001), which remained after baseline levels of future-related thinking were controlled (r = 0.07, p = .02). There were insufficient studies to infer reciprocal links between anxiety and future-related thinking. Our analyses provided evidence of a reciprocal developmental relationship between depressive symptoms and future-related thinking, implying a negative cycle. Identifying precursors of this cycle could provide the basis for depression prevention in adolescents and promote better decision-making about the future.


Assuntos
Ansiedade , Depressão , Pensamento , Humanos , Adolescente , Depressão/psicologia , Ansiedade/psicologia , Pensamento/fisiologia , Estudos Longitudinais , Desenvolvimento do Adolescente/fisiologia
10.
J Sch Health ; 94(9): 848-857, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38967535

RESUMO

BACKGROUND: Youth violence, victimization, and bullying are pervasive in schools across the United States and are detrimental for learning and healthy development. K-12 school safety is an increasingly urgent issue to research and understand from multiple perspectives. Physical and psychological safety in school is linked to better student and school outcomes and is fundamental to fostering well-being and prosocial behavior. METHODS: Despite research demonstrating positive outcomes associated with school safety, there is no comprehensive conceptual model in the literature that considers precursors, strategies, mechanisms, and outcomes of school safety together. The current paper presents an equity-centered comprehensive model of school safety, which is intended as a holistic representation of the multiple factors and pathways that contribute to school safety and positive youth development. RESULTS: This model can guide research and practice through an equity-centered and comprehensive approach. This model can enable practitioners, researchers, and policymakers to make informed decisions and reach consensus regarding planning and decisions related to reducing violence and establishing supportive school environments. CONCLUSION: Our model suggests that a comprehensive approach can ensure the safety and well-being of students and staff. By thinking ecologically, schools, communities, and stakeholders can ensure that all aspects of the school context are included in school safety.


Assuntos
Bullying , Segurança , Instituições Acadêmicas , Violência , Humanos , Adolescente , Bullying/prevenção & controle , Bullying/psicologia , Estados Unidos , Violência/prevenção & controle , Criança , Estudantes/psicologia , Vítimas de Crime/psicologia , Desenvolvimento do Adolescente
11.
J Adolesc Health ; 75(3): 461-470, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39001748

RESUMO

PURPOSE: Research has documented that adolescent sleep is impacted by various stressors, including interpersonal experiences and structural disadvantage. This study extends existing knowledge by empirically examining interconnected individual experiences of structural inequity and assessing its association with subjective and objective sleep outcomes. METHODS: We utilized data from the Adolescent Brain and Cognitive Development Study to identify seven conceptual domains of structural inequity: perceived discrimination, low school inclusivity, neighborhood safety, unmet medical needs, legal problems, material hardship, and housing insecurity. We operationalized experiences of structural inequity as latent classes, a cumulative exposure, and each domain separately. Sleep disturbances were measured using the Sleep Disturbance Scale, and sleep duration was assessed using Fitbits. Mixed effects linear regression estimated the association between our measures of structural inequity, longitudinal sleep disturbances, and cross-sectional sleep duration. RESULTS: Latent class analysis revealed common exposure profiles (low risk, interpersonal, and systemic) of experiences of structural inequity across our sample. In longitudinal models, structural inequity was associated with higher Sleep Disturbance Scale scores, whether measured as latent classes, a cumulative exposure, or individual domains. Individuals with interpersonal exposures, those with at least one exposure, and those with legal problems, material hardship, and housing insecurity had lower mean sleep duration. DISCUSSION: Results are consistent with literature that frames structural inequity as a lifelong determinant of sleep disturbance and duration. Adolescence represents a crucial time for interventions aimed at improving sleep and redressing inequities throughout the life course; our work can inform the development of policies and interventions toward this end.


Assuntos
Transtornos do Sono-Vigília , Humanos , Adolescente , Masculino , Feminino , Estudos Transversais , Sono/fisiologia , Estudos Longitudinais , Fatores Socioeconômicos , Desenvolvimento do Adolescente/fisiologia , Características de Residência
12.
Neurosci Biobehav Rev ; 164: 105820, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39032845

RESUMO

Waves of research and public discourse have characterized adolescence as periods of developmental risk and opportunity. Underlying this discussion is the recognition that adolescence is a period of major biological and social transition when experience may have an outsized effect on development. This article updates and expands upon prior work suggesting that adolescence may be a sensitive period for sociocultural processing specifically. By integrating evidence from developmental psychology and neuroscience, we identify how trajectories of social and neurobiological development may relate to adolescents' ability to adapt to and learn from their social environments. However, we also highlight gaps in the literature, including challenges in attributing developmental change to adolescent experiences. We discuss the importance of better understanding variability in biology (e.g., pubertal development) and cultural environments, as well as distinguishing between sensitive periods and periods of heightened sensitivity. Finally, we look toward future directions and translational implications of this research.


Assuntos
Desenvolvimento do Adolescente , Humanos , Adolescente , Desenvolvimento do Adolescente/fisiologia , Encéfalo/fisiologia , Meio Social , Comportamento Social
13.
Hum Brain Mapp ; 45(11): e26754, 2024 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-39046031

RESUMO

Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, the existing findings lack consistency or are restricted to a particular brain region, a specific brain feature, or a relatively narrow age range. Here, we investigated associations between brain asymmetry and age as well as sex in one of the largest pediatric samples to date (n = 4265), aged 1-18 years, scanned at 69 sites participating in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our study revealed that significant brain asymmetries already exist in childhood, but their magnitude and direction depend on the brain region examined and the morphometric measurement used (cortical volume or thickness, regional surface area, or subcortical volume). With respect to effects of age, some asymmetries became weaker over time while others became stronger; sometimes they even reversed direction. With respect to sex differences, the total number of regions exhibiting significant asymmetries was larger in females than in males, while the total number of measurements indicating significant asymmetries was larger in males (as we obtained more than one measurement per cortical region). The magnitude of the significant asymmetries was also greater in males. However, effect sizes for both age effects and sex differences were small. Taken together, these findings suggest that cerebral asymmetries are an inherent organizational pattern of the brain that manifests early in life. Overall, brain asymmetry appears to be relatively stable throughout childhood and adolescence, with some differential effects in males and females.


Assuntos
Encéfalo , Imageamento por Ressonância Magnética , Caracteres Sexuais , Humanos , Adolescente , Masculino , Criança , Feminino , Pré-Escolar , Lactente , Encéfalo/diagnóstico por imagem , Encéfalo/crescimento & desenvolvimento , Encéfalo/anatomia & histologia , Fatores Etários , Desenvolvimento Infantil/fisiologia , Lateralidade Funcional/fisiologia , Desenvolvimento do Adolescente/fisiologia
14.
Hum Brain Mapp ; 45(11): e26766, 2024 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-39046072

RESUMO

Mood variability, the day-to-day fluctuation in mood, differs between individuals and develops during adolescence. Because adolescents show higher mood variability and average mood than children and adults, puberty might be a potential biological mechanism underlying this increase. The goal of this preregistered developmental study was to examine the neural and hormonal underpinnings of adolescent-specific within-person changes in mood variability, with a specific focus on testosterone, cortisol, pubertal status, and resting-state functional brain connectivity. Data from two longitudinal cohorts were used: the L-CID twin study (aged 7-13, N at the first timepoint = 258) and the accelerated Leiden Self-Concept study (SC; aged 11-21, N at the first timepoint = 138). In both studies resting-state functional magnetic resonance imaging (rs-fMRI) data was collected, as well as daily mood. Additionally, in the SC study self-reported puberty testosterone and cortisol were collected. Random intercept cross-lagged panel models (RI-CLPM) were used to study the within-person relations between these biological measures and mood variability and average mood. Mood variability and average mood peaked in adolescence and testosterone levels and self-reported puberty also showed an increase. Connectivity between prefrontal cortex (dlPFC and vmPFC) and subcortical regions (caudate, amygdala) decreased across development. Moreover, higher testosterone predicted average negative mood at the next time point, but not vice versa. Further, stronger vmPFC-amygdala functional connectivity predicted decreases in mood variability. Here, we show that brain connectivity during development is an important within-person biological mechanism of the development of mood in adolescents. PRACTITIONER POINTS: Mood variability peaks in adolescence. Within-person changes in testosterone predict within-person changes in mood. Within-person changes in vmPFC-amygdala connectivity predict within-person changes in mood variability.


Assuntos
Afeto , Hidrocortisona , Imageamento por Ressonância Magnética , Puberdade , Testosterona , Humanos , Adolescente , Criança , Masculino , Testosterona/sangue , Afeto/fisiologia , Feminino , Hidrocortisona/sangue , Hidrocortisona/metabolismo , Estudos Longitudinais , Puberdade/fisiologia , Adulto Jovem , Encéfalo/diagnóstico por imagem , Encéfalo/crescimento & desenvolvimento , Encéfalo/fisiologia , Adulto , Conectoma , Córtex Pré-Frontal/diagnóstico por imagem , Córtex Pré-Frontal/fisiologia , Córtex Pré-Frontal/crescimento & desenvolvimento , Tonsila do Cerebelo/diagnóstico por imagem , Tonsila do Cerebelo/fisiologia , Tonsila do Cerebelo/crescimento & desenvolvimento , Desenvolvimento do Adolescente/fisiologia
15.
Pediatr Clin North Am ; 71(4): 707-727, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-39003012

RESUMO

In the adolescent mental health crisis, negative narrative communication has unitended consequences. Supportive communication involves reframing communications to find a new narrative that does not evoke biases. This narrative must emphasize agency and highlight the strengths, potential, and common experiences of young people. It is clear that supporting positive development and well-being is an "us" endeavor. There is a place in this communication strategy for pediatric professionals to address young people, caregivers, other health care professionals, and the community. The science of framing helps us shape a more supportive and productive discourse.


Assuntos
Saúde Mental , Humanos , Adolescente , Transtornos Mentais/psicologia , Transtornos Mentais/terapia , Comunicação , Desenvolvimento do Adolescente , Saúde do Adolescente , Defesa do Paciente
16.
Pediatr Transplant ; 28(5): e14812, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38895788

RESUMO

BACKGROUND: As pediatric transplant patients reach adolescence, care teams must prepare them for an eventual transition to adult-oriented care. Care teams must provide patients with the necessary knowledge and skills to manage their medical needs independently, but the level of learning required to successfully self-manage a transplant is substantial. Furthermore, adolescence is also a dynamic developmental period that includes significant cognitive development and changes in social motivations. METHODS: Within this report, we offer insights into some of the key developmental mechanisms of adolescence that may influence their learning in a medical context. We also review key concepts that should be included in patient education across a range of domains. Finally, we consider how patients with comorbid developmental disorders may require tailored education. RESULTS: Key domains for education include (1) personal health history, (2) medication knowledge/adherence, (3) navigation of the healthcare system, and (4) communication with others about their health. Teams should intentionally track patient progress in their education, although few formalized tools are currently available to support tracking. Accommodations to learning for patients with developmental needs include varied instructional modalities (e.g., verbal, written, and modeling), opportunities to practice skills in a controlled manner, and establishment of family/community support that can persist into adulthood. CONCLUSIONS: Education of transplant patients is a critical but long-term process that supports the successful transition to adulthood. Care teams should develop intentional plans to transfer knowledge and build skills across adolescence, while remaining open to adaptive approaches to support the learning of all patients.


Assuntos
Educação de Pacientes como Assunto , Transplantados , Humanos , Adolescente , Transplantados/psicologia , Transição para Assistência do Adulto , Transplante de Órgãos , Conhecimentos, Atitudes e Prática em Saúde , Desenvolvimento do Adolescente
17.
Cereb Cortex ; 34(6)2024 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-38880786

RESUMO

Neuroimaging is a popular method to map brain structural and functional patterns to complex human traits. Recently published observations cast doubt upon these prospects, particularly for prediction of cognitive traits from structural and resting state functional magnetic resonance imaging (MRI). We leverage baseline data from thousands of children in the Adolescent Brain Cognitive DevelopmentSM Study to inform the replication sample size required with univariate and multivariate methods across different imaging modalities to detect reproducible brain-behavior associations. We demonstrate that by applying multivariate methods to high-dimensional brain imaging data, we can capture lower dimensional patterns of structural and functional brain architecture that correlate robustly with cognitive phenotypes and are reproducible with only 41 individuals in the replication sample for working memory-related functional MRI, and ~ 100 subjects for structural and resting state MRI. Even with 100 random re-samplings of 100 subjects in discovery, prediction can be adequately powered with 66 subjects in replication for multivariate prediction of cognition with working memory task functional MRI. These results point to an important role for neuroimaging in translational neurodevelopmental research and showcase how findings in large samples can inform reproducible brain-behavior associations in small sample sizes that are at the heart of many research programs and grants.


Assuntos
Encéfalo , Cognição , Imageamento por Ressonância Magnética , Neuroimagem , Humanos , Adolescente , Imageamento por Ressonância Magnética/métodos , Encéfalo/crescimento & desenvolvimento , Encéfalo/diagnóstico por imagem , Encéfalo/fisiologia , Masculino , Feminino , Cognição/fisiologia , Neuroimagem/métodos , Memória de Curto Prazo/fisiologia , Criança , Desenvolvimento do Adolescente/fisiologia , Mapeamento Encefálico/métodos
18.
Dev Cogn Neurosci ; 67: 101403, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38852381

RESUMO

Our society faces a great diversity of opportunities for youth. The 10-year Growing Up Together in Society (GUTS) program has the long-term goal to understand which combination of measures best predict societal trajectories, such as school success, mental health, well-being, and developing a sense of belonging in society. Our leading hypothesis is that self-regulation is key to how adolescents successfully navigate the demands of contemporary society. We aim to test these questions using socio-economic, questionnaire (including experience sampling methods), behavioral, brain (fMRI, sMRI, EEG), hormonal, and genetic measures in four large cohorts including adolescents and young adults. Two cohorts are designed as test and replication cohorts to test the developmental trajectory of self-regulation, including adolescents of different socioeconomic status thereby bridging individual, family, and societal perspectives. The third cohort consists of an entire social network to examine how neural and self-regulatory development influences and is influenced by whom adolescents and young adults choose to interact with. The fourth cohort includes youth with early signs of antisocial and delinquent behavior to understand patterns of societal development in individuals at the extreme ends of self-regulation and societal participation, and examines pathways into and out of delinquency. We will complement the newly collected cohorts with data from existing large-scale population-based and case-control cohorts. The study is embedded in a transdisciplinary approach that engages stakeholders throughout the design stage, with a strong focus on citizen science and youth participation in study design, data collection, and interpretation of results, to ensure optimal translation to youth in society.


Assuntos
Autocontrole , Humanos , Adolescente , Adulto Jovem , Masculino , Feminino , Encéfalo/crescimento & desenvolvimento , Estudos de Coortes , Adulto , Desenvolvimento do Adolescente/fisiologia
19.
Dev Psychobiol ; 66(6): e22515, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38923470

RESUMO

Theories of adolescent development suggest that elevated neural sensitivity to social evaluation confers tradeoffs for adolescents' wellbeing, promoting adaptation to changing social contexts but increasing risk for emotional distress and depression. This study investigated whether the association between neural processing of peer feedback and depressive symptoms depends on teacher-reported executive function (EF) ability in adolescent girls. Girls showed activation to negative and positive peer feedback in regions implicated in social-emotional processing that interacted with EF to predict depressive symptoms. Specifically, activation predicted more depression in youth with poorer EF but less depression in youth with better EF, suggesting that the impact of increased social sensitivity may depend on youths' ability to regulate this sensitivity in adaptive ways.


Assuntos
Depressão , Função Executiva , Grupo Associado , Humanos , Feminino , Função Executiva/fisiologia , Adolescente , Depressão/fisiopatologia , Retroalimentação Psicológica/fisiologia , Criança , Desenvolvimento do Adolescente/fisiologia , Percepção Social
20.
Soc Cogn Affect Neurosci ; 19(1)2024 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-38902015

RESUMO

Both self-concept, the evaluation of who you are, and the physical body undergo changes throughout adolescence. These two processes might affect the development of body image, a complex construct that comprises one's thoughts, feelings, and perception of one's body. This study aims to better understand the development of body image in relation to self-concept development and its neural correlates. Adolescents (aged 11-24) from the longitudinal Leiden Self-Concept study were followed for three consecutive years (NT1 = 160, NT2 = 151, and NT3 = 144). Their body image was measured using a figure rating scale and body dissatisfaction questionnaire. Body estimation was calculated based on figure ratings relative to their actual body mass index (BMI). Additionally, participants evaluated their physical appearance traits in an functional magnetic resonance imaging (fMRI) task. Results revealed that body estimation and body dissatisfaction increased with age. Heightened inferior parietal lobe (IPL) activation during physical self-evaluation was associated with lower body estimation, meaning that the neural network involved in thinking about one's physical traits is more active for individuals who perceive themselves as larger than they are. IPL activity showed continued development during adolescence, suggesting an interaction between neural development and body perception. These findings highlight the complex interplay between affective, perceptual, and biological factors in shaping body image.


Assuntos
Imagem Corporal , Imageamento por Ressonância Magnética , Autoimagem , Humanos , Adolescente , Imagem Corporal/psicologia , Feminino , Masculino , Imageamento por Ressonância Magnética/métodos , Criança , Adulto Jovem , Estudos Longitudinais , Encéfalo/fisiologia , Encéfalo/diagnóstico por imagem , Encéfalo/crescimento & desenvolvimento , Mapeamento Encefálico/métodos , Índice de Massa Corporal , Inquéritos e Questionários , Desenvolvimento do Adolescente/fisiologia
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