RESUMO
A follow-up study is reported of 18 children 4 y after treatment for the Trichuris dysentery syndrome (TDS) and matched control children. The TDS children were initially severely stunted and had extremely low developmental levels. They showed catch-up in height of 1.9 z-scores even though they remained in very poor environments. Their intelligence quotients, school achievement and cognitive function remained significantly lower than those of the controls. Controlling for their earlier developmental levels, the TDS children showed a small improvement in mental development relative to the controls (Au)
Assuntos
Criança , Pré-Escolar , Feminino , Humanos , Masculino , Disenteria/tratamento farmacológico , Disenteria/fisiopatologia , Disenteria/parasitologia , Crescimento , Tricuríase/fisiopatologia , Antinematódeos/uso terapêutico , Cognição , Seguimentos , Mebendazol/uso terapêuticoRESUMO
A follow-up study is reported of 18 children 4 y after treatment for the Trichuris dysentery syndrome (TDS) and matched control children. The TDS children were initially severely stunted and had extremely low developmental levels. They showed catch-up in height of 1.9 z-scores even though they remained in very poor environments. Their intelligence quotients, school achievement and cognitive function remained significantly lower than those of the controls. Controlling for their earlier developmental levels, the TDS children showed a small improvement in mental development relative to the controls.
Assuntos
Disenteria/fisiopatologia , Crescimento , Tricuríase/fisiopatologia , Antinematódeos/uso terapêutico , Criança , Pré-Escolar , Cognição , Disenteria/tratamento farmacológico , Disenteria/parasitologia , Feminino , Seguimentos , Humanos , Masculino , Mebendazol/uso terapêuticoRESUMO
Este trabalho realiza uma revisäo sobre os principais enteropatógenos bacterianos, enfocando principalmente aspectos de sistemática, fatores de virulência e algumas características fisiológicas
Assuntos
Humanos , Aeromonas/patogenicidade , Bacillus cereus/patogenicidade , Clostridium/patogenicidade , Diarreia/fisiopatologia , Disenteria/fisiopatologia , Enterocolite/fisiopatologia , Escherichia coli/patogenicidade , Gastroenterite/fisiopatologia , Salmonella/patogenicidade , Shigella/patogenicidade , Vibrio cholerae/patogenicidade , Vibrio parahaemolyticus/patogenicidade , Virulência , Yersinia/patogenicidadeRESUMO
Shigella sp and Escherichia coli (EIEC) are casual agents of bacillary dysentery, mainly in developing countries. Shigella and EIEC share biochemical, antigenic and genetic properties and probably they have the same mechanism of pathogenicity. Both species harbor a 120-140 megadalton plasmid, which is associated to the virulence and whose expression is regulated by chromosomal genes. Shigella sp and EIEC invade colonic epithelium and present virulence auxiliary factors, such as mucinases, superoxide dismutase and aerobactine production. On the other hand, cytotoxin production contributes to the illness' severity. The first step in invasion of the colonic mucosa is epithelium adherence, followed by endocytosis, lysis of the phagocytic vacuole, intracellular multiplication, intra-intercellular spread and killing of the host cell. Identification of these invasive organisms is carried out with the Sereny test, chicken embryo lethality and invasion to culture cells assays, DNA probe hibridization, polimerase chain reaction, ELISA, Congo red binding, and biochemical and serological tests.
Assuntos
Disenteria Bacilar/fisiopatologia , Disenteria/fisiopatologia , Infecções por Escherichia coli/fisiopatologia , Escherichia coli/patogenicidade , Shigella/patogenicidade , Animais , Aderência Bacteriana/genética , Cápsulas Bacterianas/fisiologia , Proteínas de Bactérias/fisiologia , Toxinas Bacterianas/efeitos adversos , Embrião de Galinha , Cromossomos Bacterianos/genética , Disenteria/diagnóstico , Disenteria/microbiologia , Disenteria Bacilar/diagnóstico , Escherichia coli/genética , Genes Bacterianos , Humanos , Mucosa Intestinal/microbiologia , Plasmídeos/genética , Shigella/genética , Virulência/genéticaRESUMO
The Trichuris Dysentery Syndrome (Ramsey, 1962) is an insidious, chronic condition which has clinical features similar to Crohn's ileocolitis and ulcerative colitis, diseases similarly associated with growth retardation. The attained heights and weights of 19 children at the time of diagnosis of intens, -2.4 Standard Deviation (Z) scores from the Tanner-Whitehouse median with weight, adjusted for height-age, -1.3 Z. We present data on the growth velocities of 11 of the children in the half-year following worm expulsion by mebendazole. These children returned to their home environments without food supplementation or close follow-up, but showed an average height velocity of +5.5 Z and weight velocity (for height-age) of +2.4 Z. Of 8 children with unequivocal height spurts only 3 had any weight spurt. We suggest that the pattern of catch-up growth points to the existence of some specific link between allergy or inflammation in the lower intestinal tract and suppression of linear growth, rather than to stunting due to general deprivation and undernutrition.
Assuntos
Estatura , Peso Corporal , Disenteria/fisiopatologia , Tricuríase/fisiopatologia , Animais , Criança , Pré-Escolar , Doença Crônica , Disenteria/tratamento farmacológico , Disenteria/parasitologia , Feminino , Humanos , Masculino , Mebendazol/uso terapêutico , Tricuríase/tratamento farmacológico , Tricuríase/parasitologiaRESUMO
The Trichuris Dysentery Syndrome (Ramsey, 1962) is an insidious, chronic condition which has clinical features similar to Chron's ileocolitis and ulcerative colitis, disease similarly associated with growth retardation. The attained heights and weights of 19 children at the time of diagnosis of intense, symptomatic Trichuris (whipworm) infection showed and average height of -2,4 Standard Deviation (Z) scores from the Tanner-Whitehouse median with weight, adjusted for height-age, -1.3 Z. We present data on the growth velocities of 11 of the children, in the half-year following worm explusion by mebendazole. These children returned to their home environment without food supplementation or close follow-up, but showed and average height velocity of + 5.5 Z and weight velocity (for height-age) of + 2.4 Z. Of 8 children with unequivocal height spurts only 3 had any weight spurt. We suggest that the pattern of catch-up growth points to the existence of some specific link between allergy or inflamation in the lower intestinal tract and suppression of linear growth, rather than to stunting due to general deprivation and undernutrition. (AU)
Assuntos
Humanos , Pré-Escolar , Criança , 21003 , Masculino , Feminino , Estatura , Peso Corporal , Disenteria/fisiopatologia , Tricuríase/fisiopatologia , Doença Crônica , Disenteria/tratamento farmacológico , Disenteria/parasitologia , Mebendazol/uso terapêutico , Tricuríase/tratamento farmacológico , Tricuríase/parasitologiaRESUMO
DISENTERIA-Compreende-se por disenteria um quadro mórbido cujo sintoma predominante é a diarréia misturada com sangue e muco.Há três variedades distintas:1., a disenteria provocada por Protozoários;2., a disenteria bacilar, e3., a disenteria provocada por Helmintos....