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1.
J Nippon Med Sch ; 91(2): 249-251, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38777786

RESUMO

Stridor is caused by oscillation of the narrowed upper airway. The most common cause of neonatal stridor is laryngomalacia, followed by vocal fold abduction dysfunction. Herein, we present two neonatal cases of idiopathic dysfunction of vocal fold abduction. A neonate was admitted to the neonatal intensive care unit (NICU) on day 4 of life for inspiratory stridor, intermittent subcostal retraction, and cyanosis. A second neonate was admitted to the NICU on day 7 of life for inspiratory stridor and cyanosis when crying. Neither patient had dysmorphic features or unusual cardiac ultrasonography findings. The diagnosis was confirmed by laryngo-bronchoscopy. Conservative treatment with biphasic positive airway pressure was effective in both cases and symptoms resolved within a few months. Resolution of vocal fold abduction dysfunction was confirmed by repeat endoscopy. Clinical manifestations of vocal fold abduction dysfunction vary widely. Although most cases resolve spontaneously, prolonged tube feeding, or even tracheostomy, is needed in some severe cases. Diagnosis of vocal fold abduction dysfunction requires a laryngo-bronchoscopy study; thus, there may be a large number of undiagnosed patients. Vocal fold abduction dysfunction should be considered in the differential diagnosis for neonatal inspiratory stridor.


Assuntos
Sons Respiratórios , Disfunção da Prega Vocal , Humanos , Recém-Nascido , Sons Respiratórios/etiologia , Disfunção da Prega Vocal/etiologia , Disfunção da Prega Vocal/diagnóstico , Disfunção da Prega Vocal/fisiopatologia , Disfunção da Prega Vocal/terapia , Masculino , Prega Vocal/fisiopatologia , Prega Vocal/diagnóstico por imagem , Laringoscopia , Feminino , Broncoscopia , Resultado do Tratamento , Diagnóstico Diferencial , Tratamento Conservador
2.
Surgery ; 175(4): 1040-1048, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38135552

RESUMO

BACKGROUND: It is unknown whether intraoperative nerve monitoring is associated with reduced vocal cord dysfunction after parathyroidectomy. We aimed to investigate intraoperative nerve monitoring use among Collaborative Endocrine Surgery Quality Improvement Program surgeons and factors associated with vocal cord dysfunction after parathyroidectomy. METHODS: Patients who underwent parathyroidectomy included in the Collaborative Endocrine Surgery Quality Improvement Program (2014-2022) were identified. The annual percent change in parathyroidectomies performed with intraoperative nerve monitoring was calculated using joinpoint regression. Multivariable logistic regression was used to compare outcomes between patients undergoing parathyroidectomy with/without intraoperative nerve monitoring. To compare surgeon-specific trends, Collaborative Endocrine Surgery Quality Improvement Program thyroidectomy and parathyroidectomy datasets (2014-2021) were combined. Parathyroidectomies performed by surgeons who used intraoperative nerve monitoring consistently in thyroidectomy were identified. Factors associated with intraoperative nerve monitoring were examined using multivariable logistic regression. RESULTS: A total of 9,813 patients underwent parathyroidectomy. Intraoperative nerve monitoring was used in 49% of cases (n = 4,818). There was an increase in parathyroidectomies with intraoperative nerve monitoring from 2014 to 2018 (annual percent change 22.2, P = .01), followed by a plateau (2018-2022 annual percent change -0.66, P = .85). Few patients (0.44%, n = 43) developed vocal cord dysfunction. Vocal cord dysfunction was not associated with intraoperative nerve monitoring (adjusted odds ratio 0.92, P = .75). Whereas 41% (n = 56/138) of surgeons used intraoperative nerve monitoring routinely in parathyroidectomy, 65% (n = 90/138) used it routinely in thyroidectomy. Among surgeons who used intraoperative nerve monitoring routinely in thyroidectomy, only 57% used it routinely in parathyroidectomy; factors associated with intraoperative nerve monitoring during parathyroidectomy included reoperation (adjusted odds ratio 2.51, P < .01), secondary/tertiary hyperparathyroidism (adjusted odds ratio 1.42, P = .02), multiglandular disease (adjusted odds ratio 1.76, P < .001), and non-localized disease (adjusted odds ratio 1.65, P < .001). CONCLUSION: Endocrine surgeons use intraoperative nerve monitoring selectively. Surgeons who routinely use intraoperative nerve monitoring during thyroidectomy are more likely to use it during parathyroidectomy. Future studies should determine who may benefit most from intraoperative nerve monitoring in parathyroidectomy.


Assuntos
Cirurgiões , Disfunção da Prega Vocal , Humanos , Tireoidectomia/efeitos adversos , Paratireoidectomia/efeitos adversos , Disfunção da Prega Vocal/etiologia
3.
Respirology ; 28(7): 615-626, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37221142

RESUMO

Vocal cord dysfunction/inducible laryngeal obstruction (VCD/ILO), is a common condition characterized by breathlessness associated with inappropriate laryngeal narrowing. Important questions remain unresolved, and to improve collaboration and harmonization in the field, we convened an international Roundtable conference on VCD/ILO in Melbourne, Australia. The aims were to delineate a consistent approach to VCD/ILO diagnosis, appraise disease pathogenesis, outline current management and model(s) of care and identify key research questions. This report summarizes discussions, frames key questions and details recommendations. Participants discussed clinical, research and conceptual advances in the context of recent evidence. The condition presents in a heterogenous manner, and diagnosis is often delayed. Definitive diagnosis of VCD/ILO conventionally utilizes laryngoscopy demonstrating inspiratory vocal fold narrowing >50%. Computed tomography of the larynx is a new technology with potential for swift diagnosis that requires validation in clinical pathways. Disease pathogenesis and multimorbidity interactions are complex reflecting a multi-factorial, complex condition, with no single overarching disease mechanism. Currently there is no evidence-based standard of care since randomized trials for treatment are non-existent. Recent multidisciplinary models of care need to be clearly articulated and prospectively investigated. Patient impact and healthcare utilization can be formidable but have largely escaped inquiry and patient perspectives have not been explored. Roundtable participants expressed optimism as collective understanding of this complex condition evolves. The Melbourne VCD/ILO Roundtable 2022 identified clear priorities and future directions for this impactful condition.


Assuntos
Obstrução das Vias Respiratórias , Doenças da Laringe , Disfunção da Prega Vocal , Humanos , Disfunção da Prega Vocal/diagnóstico , Disfunção da Prega Vocal/etiologia , Doenças da Laringe/diagnóstico , Doenças da Laringe/complicações , Doenças da Laringe/terapia , Obstrução das Vias Respiratórias/etiologia , Prega Vocal/diagnóstico por imagem , Prega Vocal/patologia , Laringoscopia/efeitos adversos , Laringoscopia/métodos , Diagnóstico Diferencial
4.
Respir Care ; 68(4): 520-523, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36810361

RESUMO

BACKGROUND: Vocal cord dysfunction is an upper-airway disorder characterized by exaggerated and transient glottic constriction causing respiratory and laryngeal symptoms. Common presentation is with inspiratory stridor often in the context of emotional stress and anxiety. Other symptoms include wheezing (which may be on inspiration), frequent cough, choking sensation, or throat and chest tightness. This is seen commonly in teenagers, particularly in adolescent females. The COVID-19 pandemic has been a trigger for anxiety and stress with an increase in psychosomatic illness. Our objective was to find out if the incidence of vocal cord dysfunction increased during COVID-19 pandemic. METHODS: We performed a retrospective chart review of all the subjects with a new diagnosis of vocal cord dysfunction who were seen at the out-patient pulmonary practice at our children's hospital between January 2019-December 2020. RESULTS: The incidence of vocal cord dysfunction in 2019 was found to be 5.2%, (41/786 subjects seen) compared to 10.3% (47/457 subjects seen) in 2020, which is a nearly 100% increase in incidence (P < .001). CONCLUSIONS: It is important to recognize that vocal cord dysfunction has increased during the COVID-19 pandemic. In particular, physicians treating pediatric patients, as well as respiratory therapists, should be aware of this diagnosis. It is imperative to avoid unnecessary intubations and treatments with bronchodilators and corticosteroids as opposed to behavioral and speech training to learn effective voluntary control over the muscles of inspiration and the vocal cords.


Assuntos
COVID-19 , Disfunção da Prega Vocal , Feminino , Adolescente , Humanos , Criança , Estudos Retrospectivos , Pandemias , COVID-19/epidemiologia , COVID-19/complicações , Disfunção da Prega Vocal/epidemiologia , Disfunção da Prega Vocal/etiologia , Disfunção da Prega Vocal/diagnóstico , Prega Vocal , Sons Respiratórios/etiologia
6.
Laryngoscope ; 132(3): 701-705, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-34378798

RESUMO

OBJECTIVES/HYPOTHESIS: Infants who undergo congenital heart surgery are at risk of developing vocal fold motion impairment (VFMI) and swallowing difficulties. This study aims to describe the dysphagia in this population and explore the associations between surgical complexity and vocal fold mobility with dysphagia and airway protection. STUDY DESIGN: Retrospective chart review. METHODS: This is a retrospective chart review of infants (age <12 months) who underwent congenital heart surgery between 7/2008 and 1/2018 and received a subsequent videofluoroscopic swallow study (VFSS). Demographic information, Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery (STAT) category of each surgery, vocal fold mobility status, and VFSS findings were collected and analyzed. RESULTS: Three hundred and seventy-four patients were included in the study. Fifty-four percent of patients were male, 24% were premature, and the average age at the time of VFSS was 59 days. Sixty percent of patients had oral dysphagia and 64% of patients had pharyngeal dysphagia. Fifty-one percent of patients had laryngeal penetration and 45% had tracheal aspiration. Seventy-three percent of these aspirations were silent. There was no association between surgical complexity, as defined by the STAT category, and dysphagia or airway protection findings. Patients with VFMI after surgery were more likely to have silent aspiration (odds ratio = 1.94, P < .01), even when adjusting for other risk factors. CONCLUSION: Infants who undergo congenital heart surgery are at high risk for VFMI and aspiration across all five STAT categories. This study demonstrates the high prevalence of silent aspiration in this population and the need for thorough postoperative swallow evaluation. LEVEL OF EVIDENCE: 4 Laryngoscope, 132:701-705, 2022.


Assuntos
Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Transtornos de Deglutição/etiologia , Cardiopatias Congênitas/cirurgia , Disfunção da Prega Vocal/etiologia , Procedimentos Cirúrgicos Cardíacos/métodos , Transtornos de Deglutição/diagnóstico por imagem , Feminino , Fluoroscopia , Humanos , Lactente , Recém-Nascido , Masculino , Estudos Retrospectivos , Disfunção da Prega Vocal/fisiopatologia , Prega Vocal/fisiopatologia
7.
J Asthma ; 59(6): 1157-1161, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-33781154

RESUMO

INTRODUCTION: Vocal cord dysfunction (VCD) often coexists with asthma and exacerbates respiratory symptoms. A noninvasive method could be considered beneficial for the detection and follow-up of VCD complicated by asthma. Here, we report a case of VCD complicated by asthma, highlighting the effectiveness of colored three-dimensional (3-D) imaging of respiratory impedance using a broadband frequency forced oscillation technique (MostGraph). CASE STUDY: A 74-year-old woman with difficult-to-treat asthma, in whom mepolizumab treatment was ineffective, was referred to our hospital. Stridulous sounds were loudest over the anterior neck. Pulmonary function tests' results were normal; however, a flattening of the inspiratory flow-volume curve was detected. RESULTS: Remarkably, prominent spikes were observed in the inspiratory phase in the colored 3-D imaging of respiratory resistance, which was superimposed on increased respiratory resistance in the expiratory phase. Flexible laryngoscopy revealed the adduction of vocal cords on inspiration. The patient was diagnosed with asthma complicated by VCD. After successful treatment of VCD by speech therapy, inspiratory spikes of respiratory resistance disappeared, and normal vocal cord movement was observed on laryngoscopy. CONCLUSION: The present case report indicates the effectiveness of forced oscillometry in evaluating dynamic changes in respiratory resistance for detecting and monitoring VCD complicated by asthma.


Assuntos
Asma , Disfunção da Prega Vocal , Idoso , Asma/complicações , Asma/diagnóstico por imagem , Diagnóstico Diferencial , Feminino , Humanos , Imageamento Tridimensional , Laringoscopia , Disfunção da Prega Vocal/diagnóstico por imagem , Disfunção da Prega Vocal/etiologia , Prega Vocal/diagnóstico por imagem
8.
Am Fam Physician ; 104(5): 471-475, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34783512

RESUMO

Vocal cord dysfunction (i.e., vocal cords closing when they should be opening, particularly during inspiration) should be suspected in patients presenting with inspiratory stridor or wheezing; sudden, severe dyspnea (without hypoxia, tachypnea, or increased work of breathing); throat or chest tightness; and anxiety, particularly in females. Common triggers include exercise, asthma, gastroesophageal reflux disease, postnasal drip, upper or lower respiratory tract infection, and irritants. Nasolaryngoscopy and pulmonary function testing, with provocative exercise and methacholine, can help diagnose vocal cord dysfunction and are helpful to evaluate for other etiologies. Conditions that can trigger vocal cord dysfunction should be optimally treated, particularly asthma, gastroesophageal reflux disease, and postnasal drip, while avoiding potential irritants. Therapeutic breathing maneuvers and vocal cord relaxation techniques are first-line therapy for dyspnea that occurs with vocal cord dysfunction. A subset of vocal cord dysfunction leads to dysphonia, as opposed to dyspnea, secondary to abnormal laryngeal muscle spasms (vocal cord closure is less severe). OnabotulinumtoxinA injections may be helpful for spasmodic dysphonia and for treating dyspnea in certain cases, although evidence is limited.


Assuntos
Laringoscopia/métodos , Disfunção da Prega Vocal , Manuseio das Vias Aéreas/métodos , Humanos , Testes de Função Respiratória , Terapia Respiratória/métodos , Fonoterapia/métodos , Disfunção da Prega Vocal/diagnóstico , Disfunção da Prega Vocal/etiologia , Disfunção da Prega Vocal/fisiopatologia , Disfunção da Prega Vocal/terapia , Prega Vocal/diagnóstico por imagem
10.
Chest ; 159(3): e163-e166, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33678286

RESUMO

CASE PRESENTATION: A 50-year-old woman was initially seen in 2016 for sleep disorders consultation, referred by Neurology because of progressive cerebellar ataxia syndrome with possible autonomic involvement and sleep-disordered breathing described as having stridorous sounds during her sleep. She had initially presented to Neurology because of issues with balance, and she had frequent falls at home. In 2016, her speech was clear, and she was able to ambulate steadily with a cane. She underwent a diagnostic polysomnogram that did not demonstrate clinically significant sleep apnea. However, the study demonstrated rapid eye movement (REM) sleep without atonia in 62% of REM epochs (normal, up to 27%) and a soft inspiratory stridor during non-REM and REM sleep. The patient was lost to follow-up until she presented to us for reevaluation 3 years later. In the interim, she had been diagnosed with multiple system atrophy-cerebellar type (MSA-C) at another health-care institution.


Assuntos
Ataxia Cerebelar , Atrofia de Múltiplos Sistemas , Cuidados Paliativos/métodos , Sons Respiratórios , Síndromes da Apneia do Sono , Disfunção da Prega Vocal , Doenças do Sistema Nervoso Autônomo/diagnóstico , Doenças do Sistema Nervoso Autônomo/etiologia , Doenças do Sistema Nervoso Autônomo/fisiopatologia , Ataxia Cerebelar/etiologia , Ataxia Cerebelar/fisiopatologia , Deambulação com Auxílio , Progressão da Doença , Evolução Fatal , Feminino , Humanos , Pessoa de Meia-Idade , Atrofia de Múltiplos Sistemas/diagnóstico , Atrofia de Múltiplos Sistemas/fisiopatologia , Polissonografia/métodos , Respiração com Pressão Positiva/métodos , Equilíbrio Postural , Prognóstico , Sons Respiratórios/diagnóstico , Sons Respiratórios/etiologia , Sons Respiratórios/fisiopatologia , Síndromes da Apneia do Sono/diagnóstico , Síndromes da Apneia do Sono/etiologia , Síndromes da Apneia do Sono/terapia , Disfunção da Prega Vocal/etiologia , Disfunção da Prega Vocal/fisiopatologia
11.
Epileptic Disord ; 23(1): 173-179, 2021 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-33720021

RESUMO

We report two cases highlighting the diversity of vagal nerve stimulation (VNS)-related effects on voice and breathing in patients with refractory epilepsy. The patients had both implantation and stimulation-related side effects, which lasted for several months, impacting on their quality of life. The adverse effects appear to be due to recurrent laryngeal nerve paralysis-related vocal cord hypofunction and stimulation-related vocal fold spasms, however, their inter-relationship is complex. In one of the patients, we were able to utilize the novel programming capabilities of the VNS device to reduce the laryngeal side effects without compromising therapeutic efficacy. [Published with video sequences].


Assuntos
Epilepsia Resistente a Medicamentos/terapia , Transtornos Respiratórios/etiologia , Estimulação do Nervo Vago/efeitos adversos , Disfunção da Prega Vocal/etiologia , Voz , Adulto , Dispneia/etiologia , Humanos , Masculino , Pessoa de Meia-Idade
12.
Arerugi ; 70(1): 33-38, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-33597344

RESUMO

Although an important cause of vocal cord dysfunction (VCD) is psychogenic reaction, VCD may be associated with severe asthma and must be distinguished from the disease. A 30-years-old woman was admitted to our hospital with dyspnea despite treatment for asthma. Inspiratory stridor and expiratory wheezes were noted, and neck and chest computed tomography showed normal airways and lungs. Fractional exhaled nitric oxide levels were also normal. Pulmonary function test with a flow-volume loop curve showed normal expiratory loop with flattening of the inspiratory loop after methacholine inhalation. During the attack, bronchoscopy revealed the vocal cord closing with stridor during the inspiratory phase. Therefore, the patient was diagnosed with VCD. The dyspnea improved with respiratory rehabilitation and pursed-lip breathing. VCD should be considered in the differential diagnosis of intractable severe asthma. In this case, bronchoscopy and bronchial inhalation challenge with methacholine helped in the diagnosis.


Assuntos
Asma , Disfunção da Prega Vocal , Adulto , Asma/diagnóstico , Testes de Provocação Brônquica , Broncoscopia , Diagnóstico Diferencial , Feminino , Humanos , Disfunção da Prega Vocal/diagnóstico , Disfunção da Prega Vocal/etiologia , Prega Vocal
13.
J Am Coll Surg ; 232(5): 690-698, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33556502

RESUMO

BACKGROUND: A recurrent tracheo-esophageal fistula can complicate esophageal atresia and tracheo-esophageal fistula (TEF) repair in children. Therapeutic approaches and the rate of recurrence vary widely. Most reports are limited by small cohorts and short-term follow-up, and rates of re-recurrence are substantial, making it difficult to select the treatment of choice. We aimed to review our experience with the treatment of recurrent TEF using posterior tracheopexy, focusing on operative risks and long-term outcomes. STUDY DESIGN: We conducted a retrospective review of patients with esophageal atresia TEF with recurrent TEF treated at 2 institutions from 2011 to 2020. We approach recurrent TEFs surgically. Once the TEF is divided and repaired, the membranous trachea is sutured to the anterior longitudinal ligament of the spine (posterior tracheopexy) and the esophagus is rotated into the right chest (rotational esophagoplasty), separating the suture lines widely. To detect re-recurrence, patients undergo endoscopic surveillance during follow-up. RESULTS: Sixty-two patients with a recurrent TEF were surgically treated (posterior tracheopexy/rotational esophagoplasty) at a median age of 14 months. All had significant respiratory symptoms. On referral, 24 had earlier failed endoscopic and/or surgical attempts at repair. Twenty-nine required a concomitant esophageal anastomotic stricturoplasty or stricture resection. Postoperative morbidity included 3 esophageal leaks, and 1 transient vocal cord dysfunction. We have identified no recurrences, with a median follow-up of 2.5 years, and all symptoms have resolved. CONCLUSIONS: The surgical treatment of recurrent TEFs that incorporates a posterior tracheopexy and rotational esophagoplasty is highly effective for preventing re-recurrence with low perioperative morbidity.


Assuntos
Fístula Anastomótica/epidemiologia , Atresia Esofágica/cirurgia , Prevenção Secundária/métodos , Toracotomia/métodos , Fístula Traqueoesofágica/cirurgia , Disfunção da Prega Vocal/epidemiologia , Anastomose Cirúrgica/efeitos adversos , Fístula Anastomótica/diagnóstico , Fístula Anastomótica/etiologia , Criança , Pré-Escolar , Atresia Esofágica/diagnóstico , Esofagoscopia , Esôfago/diagnóstico por imagem , Esôfago/cirurgia , Feminino , Seguimentos , Humanos , Lactente , Laringoscopia , Masculino , Recidiva , Estudos Retrospectivos , Técnicas de Sutura/efeitos adversos , Toracotomia/efeitos adversos , Traqueia/diagnóstico por imagem , Traqueia/cirurgia , Fístula Traqueoesofágica/diagnóstico , Resultado do Tratamento , Disfunção da Prega Vocal/etiologia
14.
Sci Rep ; 11(1): 653, 2021 01 12.
Artigo em Inglês | MEDLINE | ID: mdl-33436789

RESUMO

Patients with end-stage renal disease (ESRD) may demonstrate secondary hyperparathyroidism (SHPT), characterized by parathyroid hormone oversecretion in response to electrolyte imbalance (e.g., hypocalcemia and hyperphosphatemia). Moreover, this electrolyte imbalance may affect vocal cord muscle contraction and lead to voice change. Here, we explored the effects of SHPT on the voices of patients with ESRD. We used data of 147,026 patients with ESRD from the registry for catastrophic illness patients, a sub-database of Taiwan National Health Insurance Research Database. We divided these patients into 2 groups based on whether they had hyperparathyroidism (HPT) and compared vocal dysfunction (VD) incidence among them. We also prospectively included 60 ESRD patients with SHPT; 45 of them underwent parathyroidectomy. Preoperatively and postoperatively, voice analysis was used to investigate changes in vocal parameters. In the real-world database analysis, the presence of HPT significantly increased VD incidence in patients with ESRD (p = 0.003): Cox regression analysis results indicated that patients with ESRD had an approximately 1.6-fold increased VD risk (p = 0.003). In the clinical analysis, the "jitter" and "shimmer" factors improved significantly after operation, whereas the aerodynamic factors remained unchanged. In conclusion, SHPT was an independent risk factor for VD in patients with ESRD, mainly affecting their acoustic factors.


Assuntos
Hiperparatireoidismo Secundário/fisiopatologia , Falência Renal Crônica/complicações , Paratireoidectomia/métodos , Qualidade de Vida , Disfunção da Prega Vocal/prevenção & controle , Idoso , Feminino , Humanos , Incidência , Masculino , Estudos Prospectivos , Fatores de Risco , Taiwan/epidemiologia , Disfunção da Prega Vocal/epidemiologia , Disfunção da Prega Vocal/etiologia
15.
J Voice ; 35(1): 40-51, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31416749

RESUMO

PURPOSE: The primary purpose of the current study was to determine the usefulness of Buteyko breathing technique (BBT) in reducing dyspnea in patients with one form of Paradoxical Vocal Fold Motion (PVFM), exertion-induced PVFM (EI-PVFM), concomitant with hyperventilation. The secondary purpose was to determine whether BBT had an effect on physiological markers of hyperventilation, as speculated by BBT theory: respiratory tidal minute volume (RTMV), end-tidal carbon dioxide (ETCO2), and resting heart rate (HR). METHODS: Using a within-subjects, repeated measures group design, 12 participants with EI-PVFM and hyperventilation underwent 12 weeks of BBT, following an initial no-treatment control condition. Outcome measures of PVFM-dyspnea frequency and severity-and of hyperventilation-HR, RTMV, and ETCO2-were acquired pre- and post-treatment. RESULTS: Results showed post-treatment decreases in dyspnea severity, HR, and RTMV, as well as increases in ETCO2. Decreases in dyspnea and RTMV measures remained after correction for alpha inflation. CONCLUSIONS: Findings suggest BBT may be useful for some individuals with EI-PVFM and hyperventilation. The high prevalence of hyperventilation in EI-PVFM found in the current study warrants further investigation.


Assuntos
Esforço Físico , Disfunção da Prega Vocal , Dispneia/diagnóstico , Dispneia/etiologia , Humanos , Volume de Ventilação Pulmonar , Disfunção da Prega Vocal/diagnóstico , Disfunção da Prega Vocal/etiologia , Disfunção da Prega Vocal/terapia , Prega Vocal
16.
J Voice ; 35(2): 323.e9-323.e15, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31537408

RESUMO

OBJECTIVES: Paradoxical vocal fold motion disorder (PVFMD), or induced laryngeal obstruction (ILO), is a clinical phenomenon characterized by inappropriate adduction of the true vocal folds during inspiration. The resultant episodes of acute respiratory distress marked by exercise-induced cough, inspiratory stridor, throat tightness, and shortness of breath are often misattributed to asthma despite normal pulmonary function testing results. Although the pathogenesis of the disease remains unclear, the etiology is likely multifactorial with an inflammatory, neurological, and psychiatric basis. Our trigger reduction approach, consisting of a plant-based, Mediterranean-style diet to treat laryngopharyngeal reflux and sinus toilet, aims to dampen the peripheral neuronal hyperexcitability of the laryngopharyngeal tissues that is hypothesized to contribute to this disorder. The primary objective of the present study was to assess for therapeutic efficacy by analyzing pre- and post-treatment subjective scores using four validated indices: Voice Handicap Index (VHI), Reflux Symptom Index (RSI), Dyspnea Index (DI), and Cough Severity Index (CSI). METHODS: A retrospective chart review of all patients age ≤18 years seen by the senior author between 2012 and 2018 who reported laryngeal spasm (J35.5) as a presenting complaint with no underlying organic diagnosis that otherwise explained the symptom identified the study cohort. Patients were excluded if another cause of their laryngeal spasm was identified or their medical records were incomplete. RESULTS: Of 80 patients, 24 met the criteria. The most frequent presenting symptom was exercise-induced dyspnea (79%). Of the four measured indices, only a change in DI (P = 0.024) met statistical significance. Of 24 patients, 18 (75%) demonstrated a reduction in DI following our treatment protocol. Using reduction in DI as a continuous variable to assess response, the patient cohort experienced a 4.62 (95% confidence interval [CI]: 0.65-8.6) mean point reduction. Using the eight-point reduction (improvement) in DI as an accepted clinical response to treatment, 8 of 24 patients (33%) experienced a clinically relevant response. Changes in CSI (P = 0.059), RSI (P = 0.27), and VHI (P = 0.25) did not meet statistical significance. Of 24 patients, 8 (33%), 11 (46%), and 7 (29%) demonstrated a reduction in CSI, RSI, and VHI following our trigger reduction protocol, respectively. The patient cohort experienced a mean point reduction of 1.8 (95% CI: -0.1 to 3.7), 1.3 (95% CI: -1.1 to 3.7), and 1.3 (95% CI: -1.0 to 3.6) in CSI, RSI, and VHI, respectively. CONCLUSIONS: Paradoxical vocal fold motion disorder is a multifactorial disease that poses diagnostic and therapeutic challenges. Early diagnosis and treatment are critical to ensure patient safety, satisfaction, and reduction in health care costs, as mistreatment with asthma pharmacotherapy, intubation, or tracheostomy may exacerbate their dyspnea and lead to preventable hospitalizations. Our results demonstrate that a trigger reduction approach consisting of a plant-based, Mediterranean-style diet and sinus toilet alone may not achieve a clinically meaningful response in the majority of patients. However, given their favorable safety profile, our therapeutic regimen, along with respiratory retraining therapy, may provide symptom relief for selected patients who would otherwise continue to suffer.


Assuntos
Doenças da Laringe , Refluxo Laringofaríngeo , Disfunção da Prega Vocal , Adolescente , Criança , Humanos , Doenças da Laringe/diagnóstico , Doenças da Laringe/terapia , Laringoscopia , Estudos Retrospectivos , Disfunção da Prega Vocal/diagnóstico , Disfunção da Prega Vocal/etiologia , Disfunção da Prega Vocal/terapia , Prega Vocal
17.
Laryngoscope ; 131(7): 1639-1646, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-33274767

RESUMO

OBJECTIVES/HYPOTHESES: The primary objective of this study was to determine whether the diagnosis and treatment of pediatric Paradoxical Vocal Fold Motion Disorder (PVFMD) leads to decreased asthma medication use. Our secondary objective was to determine dyspnea outcomes following diagnosis and treatment for PVFMD. STUDY DESIGN: Prospective observational study. METHODS: Patients with newly diagnosed PVFMD between the ages of 11 and 17 were recruited at a single pediatric institution. A medication questionnaire and Dyspnea Index (DI) were completed at the initial visit, at the first return visit, and at greater than 6 months post-diagnosis and therapy. Laryngeal Control Therapy (LCT) consisted of teaching breathing techniques and identifying emotional, physical, and environmental contributing factors and strategies to reduce them. RESULTS: Twenty-six patients were recruited to the study. There were 19/26 (73%) patients diagnosed with asthma prior to a diagnosis of PVFMD, and 26/26 (100%) patients were using an inhaler prior to the enrollment visit. Twenty-two (85%) patients completed follow-up questionnaires. Five patients participated in no therapy, seven patients in partial therapy, and 14 patients in full therapy. Significant reduction in asthma medication use was seen in the full therapy group (P < .05) and in those with exercise as their only trigger (P < .05). Furthermore, symptoms as scored by the DI decreased overall from 25.5 to 18.8 (P < .001). CONCLUSIONS: Diagnosis and treatment of pediatric PVFMD leads to a decline in asthma medication use in those patients who participate in at least two LCT sessions and in those with exercise-induced PVFMD. LCT for pediatric PVFMD leads to a significant decrease in symptoms as measured by the DI. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:1639-1646, 2021.


Assuntos
Antiasmáticos/uso terapêutico , Asma/diagnóstico , Exercícios Respiratórios , Dispneia/diagnóstico , Disfunção da Prega Vocal/terapia , Adolescente , Asma/complicações , Asma/terapia , Criança , Dispneia/etiologia , Dispneia/terapia , Feminino , Seguimentos , Humanos , Laringoscopia , Masculino , Estudos Prospectivos , Índice de Gravidade de Doença , Inquéritos e Questionários/estatística & dados numéricos , Resultado do Tratamento , Disfunção da Prega Vocal/diagnóstico , Disfunção da Prega Vocal/etiologia
19.
Rev. logop. foniatr. audiol. (Ed. impr.) ; 40(2): 48-54, abr.-jun. 2020. tab
Artigo em Espanhol | IBECS | ID: ibc-193697

RESUMO

INTRODUCCIÓN: Los cantantes son uno de los grupos de profesionales de la voz con mayor prevalencia de patología vocal y están expuestos a muchos factores de riesgo. Esto se acrecienta en el caso de los cantantes de coros amateurs que no suelen recibir nociones de técnica vocal. MÉTODO: Se estudiaron las características vocales y los factores de riesgo de 39 cantantes de coros amateur mediante el índice de incapacidad vocal abreviado (VHI-10), el índice de incapacidad vocal para el canto (S-VHI), laringoestroboscopia y análisis vocal. RESULTADOS: Los cantantes que no habían recibido clases de técnica vocal obtuvieron puntuaciones más altas tanto en el VHI-10 (10.5; p=.001) como en el S-VHI (55.9; p=.010) frente a los que sí (4 en el VHI-10 y 31.4 en el S-VHI). Respecto al sexo, encontramos que las mujeres alcanzan puntuaciones más altas (51.6) que los hombres (35) en el S-VHI (p=.019). En la muestra encontramos 9 sujetos (23.1%) con signos de fatiga vocal y 6 (15.4%) con reflujo. En el análisis acústico la frecuencia es más alta en la voz cantada (278.1HZ) que en la hablada (168.4Hz), los armónicos también son mayores en voz cantada (28dB) que en voz hablada (22dB), los valores de jitter son más altos en la voz hablada (0.24) que en la cantada (0.14) y los del shimmer también son más altos en la voz hablada (1.71) que en la cantada (1.23). CONCLUSIONES: La falta de nociones de técnica vocal en cantantes de coros amateur condiciona una mayor puntuación en los test VHI-10 y S-VHI, así como alteraciones en la laringe


INTRODUCTION: Singers are one of the groups of voice professionals with a higher incidence of vocal disorders which expose them to many risk factors. These risks are even higher in singers in amateur choirs, who usually lack vocal technique. METHOD: Vocal traits and risk factors of 39 amateur choir singers were studied using the VHI-10, the S-VHI, laryngeal examination and acoustic analysis. RESULTS: The singers who had not received lessons in vocal technique obtained higher marks in VHI-10 (10.5; P=.001) as well as in S-VHI (55.9; P=.010) compared to those who had (4 in VHI-10 and 31.4 in S-VHI). As regards sex, we find that women achieve higher marks (51.6) than men (35) in the S-VHI (P=.019). In the sample we find 9 subjects (23.1%) with evidence of vocal fatigue and 6 (15.4%) with reflux. In the acoustic analysis we observe that the frequency is higher in the singing voice (278.1HZ) than in the speaking voice (168.4Hz), the harmonics are also higher in the singing voice (28dB) than in the speaking voice (22dB), the jitter values are higher in the speaking voice (.24) than in the singing voice (.14), and shimmer values are also higher in the speaking voice (1.71) than in the singing voice (1.23). CONCLUSION: The lack of vocal technique in amateur choir singers determines a higher mark in the VHI-10 and S-VHI tests together with alterations to the larynx


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Disfunção da Prega Vocal/diagnóstico , Disfunção da Prega Vocal/etiologia , Distúrbios da Voz/etiologia , Distúrbios da Voz/diagnóstico , Canto/fisiologia , Inquéritos e Questionários , Fatores de Risco
20.
Respir Med ; 168: 105990, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32364960

RESUMO

BACKGROUND AND AIM: Vocal Cord Dysfunction (VCD) and chronic cough (CC) are challenging conditions which lead to significant quality of life impairment. The underlying mechanisms are poorly understood, but laryngeal dysfunction may be common to both conditions. The aim of this study was to determine the characteristics of cough in VCD and whether patients with cough have coexisting VCD. METHOD: Participants included 51 patients with VCD and a comparison group of 39 patients with chronic cough that was refractory to medical treatment. Participants underwent a comprehensive assessment including questionnaires, laryngoscopy, cough frequency monitoring and voice testing. RESULTS: Patients with VCD had significant cough morbidity with an increased cough frequency of 17.3 coughs/hour and reduced cough quality of life with mean Leicester Cough Questionnaire Score of 12.8. Breathing pattern abnormalities were also common in VCD and there was a strong correlation between the number of breathing pattern abnormalities and cough frequency (r = -0.827, p = 0.002). Cough measures were not significantly different between patients with VCD and those with CC. Moderate-severe PVFM was present in 69% of patients with CC. Abnormal vocal fold closure during phonation was also present in patients with chronic cough and was similar between the VCD (n = 40, 78.4%) and cough (n = 25, 64.1%) groups, p = 0.240. CONCLUSION: Cough is an important symptom in VCD. Patients presenting with chronic cough may have underlying VCD as a cause of their cough. Since cough and VCD symptoms co-occur clinicians need to consider cough when are treating VCD and VCD when treating chronic cough.


Assuntos
Tosse/diagnóstico , Doenças da Laringe/complicações , Disfunção da Prega Vocal/diagnóstico , Adulto , Idoso , Doença Crônica , Tosse/etiologia , Feminino , Humanos , Laringoscopia , Masculino , Pessoa de Meia-Idade , Morbidade , Fonação , Respiração , Transtornos Respiratórios/complicações , Transtornos Respiratórios/fisiopatologia , Inquéritos e Questionários , Disfunção da Prega Vocal/etiologia , Prega Vocal/fisiopatologia
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