Human Elimination of Organochlorine Pesticides: Blood, Urine, and Sweat Study.

Background. Many individuals have been exposed to organochlorinated pesticides (OCPs) through food, water, air, dermal exposure, and/or vertical transmission. Due to enterohepatic reabsorption and affinity to adipose tissue, OCPs are not efficiently eliminated from the human body and may accrue in tissues. Many epidemiological studies demonstrate significant exposure-disease relationships suggesting OCPs can alter metabolic function and potentially lead to illness. There is limited study of interventions to facilitate OCP elimination from the human body. This study explored the efficacy of induced perspiration as a means to eliminate OCPs. Methods. Blood, urine, and sweat (BUS) were collected from 20 individuals. Analysis of 23 OCPs was performed using dual-column gas chromatography with electron-capture detectors. Results. Various OCPs and metabolites, including DDT, DDE, methoxychlor, endrin, and endosulfan sulfate, were excreted into perspiration. Generally, sweat samples showed more frequent OCP detection than serum or urine analysis. Many OCPs were not readily detected in blood testing while still being excreted and identified in sweat. No direct correlation was found among OCP concentrations in the blood, urine, or sweat compartments. Conclusions. Sweat analysis may be useful in detecting some accrued OCPs not found in regular serum testing. Induced perspiration may be a viable clinical tool for eliminating some OCPs.

Tissue distribution and fate of persistent organic pollutants in Indo-Pacific humpback dolphins from the Pearl River Estuary, China.

Eleven persistent organic pollutant (POP) compounds including ∑PCBs, ∑DDTs, ∑HCHs, aldrin, mirex, endrin, ∑CHLs, dieldrin, HCB, heptachlor and pentachlorobenzene were measured in the kidney, liver, muscle, melon and other tissues of Sousa chinensis stranded on the western coast of the Pearl River Estuary in China during 2007-2013. For most parameters of POPs measured, melon tissues contained the highest mean concentrations with the exception of aldrin, which was higher in the kidney and liver tissues. The concentrations of PCBs, DDTs, heptachlor and endrin in the melon tissue exhibited significant correlations with body length, whereas PCBs and heptachlor also displayed significant regression with age. Our studies showed hepatic concentrations of ∑DDTs, ∑HCHs and mirex in S. chinensis were generally higher than those found in cetaceans from other geographic locations. The high levels of POP residues in the testis of one male dolphin suggested an increasing risk of infertility in the species.

Predicting ecotoxicological impacts of environmental contaminants on terrestrial small mammals.

This review examines whether the effects of environmental contaminants on wild small mammals can be predicted from the results of single-species, laboratory toxicity studies. Heavy metals, organochlorines, chlorinated aromatic hydrocarbons, and OP/carbamate pesticides were identified as the groups of xenobiotics for which there are toxicity data for terrestrial small mammals and that, on the basis of persistence, acute toxicity, and bio-accumulation potential, present the greatest hazard to wild mammals. Laboratory-generated toxicity data, which used lethality and reproduction as measurable endpoints, were reviewed and intake and residue LOAELs estimated for representative chemicals (lead, endrin, PCBs) from the heavy metal, organochlorine, and chlorinated aromatic hydrocarbon substance groups; the OPs and carbamates were reviewed as a whole. Intakes and residues of these compounds in wild small mammals were compared with laboratory-defined LOAELs and the likelihood of effects predicted. The accuracy of these predictions was examined and the efficacy of extrapolating toxicity data from laboratory to wild species assessed. Qualitative extrapolation from laboratory to wild species was good for all the chemicals considered, laboratory tests correctly identifying the types of effects chemicals had on a wide range of wild mammals. In contrast, the quantitative extrapolation of dose-response data was either poor or largely unvalidated. This is because interspecies variation in sensitivity to xenobiotics and the effects on toxicity of differences in exposure pattern between laboratory and wild species are largely unquantified. Based upon the limited evidence available, errors in the direct extrapolation of dose-response data from laboratory to field may be as large as three orders of magnitude. Direct extrapolation of residue-response data from laboratory to wild mammals is good both for the effects of heavy metals on specific organs and for residues and acetylcholinesterase inhibition associated with pesticide-induced mortality. The use of organ residues or biomarkers to predict the severity of sublethal effects on reproductive output may be possible, although large residues or biomarker responses are not necessarily indicative of the severity of wider physiological effect. Appropriate residues/biomarkers may differ for various xenobiotics and even between species for the same xenobiotic. Further research is required to identify suitable markers that can be correlated with the occurrence and magnitude of ecologically important effects. Xenobiotics likely to have a direct effect on population dynamics are those that are persistent and adversely affect survival and reproduction. At present, this weak correlation is the only one that can be made between single-species laboratory tests and population effects.(ABSTRACT TRUNCATED AT 400 WORDS)