RESUMO
PURPOSE: In the literature, the propriety of the meta-analytic treatment-effect produced by combining randomized controlled trials (RCT) and non-randomized studies (NRS) is questioned, given the inherent confounding in NRS that may bias the meta-analysis. The current study compared an implicitly principled pooled Bayesian meta-analytic treatment-effect with that of frequentist pooling of RCT and NRS to determine how well each approach handled the NRS bias. MATERIALS & METHODS: Binary outcome Critical-Care meta-analyses, reflecting the importance of such outcomes in Critical-Care practice, combining RCT and NRS were identified electronically. Bayesian pooled treatment-effect and 95% credible-intervals (BCrI), posterior model probabilities indicating model plausibility and Bayes-factors (BF) were estimated using an informative heavy-tailed heterogeneity prior (half-Cauchy). Preference for pooling of RCT and NRS was indicated for Bayes-factors > 3 or < 0.333 for the converse. All pooled frequentist treatment-effects and 95% confidence intervals (FCI) were re-estimated using the popular DerSimonian-Laird (DSL) random effects model. RESULTS: Fifty meta-analyses were identified (2009-2021), reporting pooled estimates in 44; 29 were pharmaceutical-therapeutic and 21 were non-pharmaceutical therapeutic. Re-computed pooled DSL FCI excluded the null (OR or RR = 1) in 86% (43/50). In 18 meta-analyses there was an agreement between FCI and BCrI in excluding the null. In 23 meta-analyses where FCI excluded the null, BCrI embraced the null. BF supported a pooled model in 27 meta-analyses and separate models in 4. The highest density of the posterior model probabilities for 0.333 < Bayes factor < 1 was 0.8. CONCLUSIONS: In the current meta-analytic cohort, an integrated and multifaceted Bayesian approach gave support to including NRS in a pooled-estimate model. Conversely, caution should attend the reporting of naïve frequentist pooled, RCT and NRS, meta-analytic treatment effects.
Assuntos
Teorema de Bayes , Metanálise como Assunto , Ensaios Clínicos Controlados Aleatórios como Assunto , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto/métodos , Ensaios Clínicos Controlados Aleatórios como Assunto/estatística & dados numéricos , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodos , Viés , Modelos EstatísticosRESUMO
La hipertensión arterial es una de las enfermedades crónicas de mayor incidencia a nivel mundial, produce una importante mortalidad y discapacidad. Este trabajo tuvo por objetivo evaluar el efecto del uso de mensajes de texto en dispositivos de telefonía móvil en la adherencia al tratamiento de hipertensión arterial. Se efectuó un estudio de intervención cuasiexperimental, de antes y después, en el cual se entrevistó a pacientes que pertenecían a un programa ambulatorio de enfermedades crónicas. Se formaron 4 grupos, uno de ellos, el grupo control. A los grupos intervenidos se les remitieron mensajes de texto (educativos/motivadores), con diferentes frecuencias de envío, por un período de 2 meses. Al término de la intervención, se pidió llenar el cuestionario Martín-Bayarre-Grau para determinar su adherencia al tratamiento antihipertensivo antes y después de la intervención. Se realizó un análisis bivariado, en el cual se comparó la variable adherencia al tratamiento, antes y después de la intervención, de los cuatro grupos del estudio. Se encontró solo una diferencia significativa en el grupo 3 (p = 0,011), al cual se le enviaron 8 mensajes al mes (2 por semana). También se comparó, después de los 2 meses, a los grupos sometidos a intervención versus el grupo control; se halló una diferencia significativa en el grupo 3 (p = 0,022). La intervención ha demostrado ser útil para mejorar la adherencia en esta población de estudio. Se obtuvo una respuesta positiva en el grupo 3, que recibió 8 mensajes al mes(AU)
Hypertension is one of the chronic diseases with the highest incidence worldwide and a cause of considerable mortality and disability. This paper aims to evaluate the effect of mobile phone text messaging on adherence to hypertension treatment. A quasi-experimental before-after intervention was conducted based on interviews with patients from a chronic disease outpatient program. Four groups were formed, one of which was the control group. The groups intervened were sent encouraging educational text messages at varying frequencies for a period of two months. At the close of the intervention, participants were asked to fill in the Martín Bayarre Grau questionnaire to determine their adherence to antihypertensive treatment before and after the intervention. A bivariate analysis was performed comparing the variable adherence to treatment before and after the intervention in the four study groups. A significant difference was only found in Group 3 (p = 0.011). This group was sent eight messages per month (two messages per week). Additionally, a comparison between the intervention groups and the control group conducted at two months found a significant difference in Group 3 (p = 0.022). The intervention proved was useful to improve adherence in the study population. A positive response was obtained in Group 3, who received eight messages per month(AU)
Assuntos
Humanos , Masculino , Feminino , Fatores de Risco , Telefone Celular , Envio de Mensagens de Texto , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodos , Cooperação e Adesão ao Tratamento/psicologia , Hipertensão/epidemiologiaRESUMO
Introducción: Los síntomas urinarios constituyen el motivo de consulta pediátrica más frecuente en relación con el aparato urinario durante cualquier época del año y a cualquier edad. Los argumentos para el uso o no de la quimioprofilaxis para evitar las recurrencias, son variables. Objetivo: Verificar la efectividad de la quimioprofilaxis para prevenir las recurrencias en la infección del tracto urinario en niños de 1 a 24 meses. Métodos: Se realizó un cuasi-experimento conformado por 58 pacientes que ingresaron en el Hospital Pediátrico de Holguín que cumplieron con los criterios de inclusión. Las variables de estudio fueron: número de recurrencias, momento de aparición durante la observación, presencia de recurrencia, quimioprofilaxis, tipo de quimioprofilaxis, edad, sexo, microorganismo aislado, factor predisponente, clasificación de riesgo. Se trabajó con 95 por ciento de confiabilidad lo que significó que valores de p por debajo de 0,05 fueron considerados como significativos. Se realizó el procesamiento en el programa SPSS versión 22.0. Resultados: De 58 pacientes estudiados solo tuvieron recurrencia 6,9 por ciento; de los que no recibieron quimioprofilaxis ninguno tuvo recurrencia y los que recibieron tratamiento quimioprofiláctico, 4 tuvieron recurrencia, por lo que haber recibido o no quimioprofilaxis no influyó en la aparición de recurrencia y menos después de 18 meses de una primera infección urinaria. Conclusiones: La presencia de recurrencias después de 18 meses de una primera infección urinaria en niños menores de 2 años no es un evento frecuente y parece que la quimioprofilaxis no es efectiva(AU)
Introduction: Urinary symptoms are the most frequent reason for pediatric consultation related to the urinary system during any time of the year and at any age. The arguments for the use or not of chemoprophylaxis to avoid recurrences are variable. Objective: Confirm the effectiveness of chemoprophylaxis to prevent recurrences of urinary tract infections in children aged 1 to 24 months. Methods: A quasi-experiment consisting of 58 patients admitted to the Children's Hospital of Holguín who met the inclusion criteria was conducted. The study variables were: number of recurrences, time of onset during observation, presence of recurrence, chemoprophylaxis, type of chemoprophylaxis, age, sex, isolated microorganism, predisposing factor, risk classification. We worked with 95 percent of reliability which meant that p values below 0.05 were considered significant. Processing was performed in the SPSS version 22.0 program. Results: From the 58 patients studied, only 6.9% had recurrence; of those who did not receive chemoprophylaxis none had recurrence and of those who received chemoprophylactic treatment, 4 had recurrence; so, having received or not chemoprophylaxis did not influence the appearance of recurrence and less after 18 months of a first urinary infection. Conclusions: The presence of recurrences after 18 months of a first urinary tract infection in children under 2 years of age is not a frequent event and it seems that chemoprophylaxis is not effective(AU)
Assuntos
Humanos , Lactente , Recidiva , Sistema Urinário/virologia , Resultado do Tratamento , Quimioprevenção/métodos , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodosRESUMO
Introducción: Los implantes postextractivos acortan el tiempo en lograr la rehabilitación del paciente, resulta esta condicionante un factor esencial para devolver la calidad de vida en corto plazo a un adulto mayor y mejorar rápidamente su función masticatoria. Objetivo: Determinar los valores de estabilidad y la pérdida ósea periimplantaria en implantes postextractivos en pacientes de la tercera edad. Material y Método: Se realizó un estudio cuasi-experimental en 99 pacientes de la tercera edad en la Facultad de Estomatología ¨Raúl González Sánchez¨, 2017-2019. Bajo su consentimiento se colocaron 173 implantes postextractivos. Se determinó tipo de hueso de soporte, estabilidad primaria y secundaria según análisis de frecuencia de resonancia con Osstel Mentor. Se midió el nivel óseo periimplantario y la pérdida ósea hasta 12 meses de colocada la rehabilitación. Resultados: Se posicionaron mayoritariamente implantes en el sitio de implantación incisivo maxilar en 43,3 por ciento de los casos. Los valores promedio de estabilidad primaria y secundaria fueron 48 ISQ y 68 ISQ respectivamente. La pérdida ósea promedio tras un año de rehabilitación fue de 1,04±0,22mm. Conclusiones: Los implantes dentales postextractivos en pacientes de la tercera edad se insertaron preferentemente en el grupo incisivo maxilar y en hueso tipo D2, registraron una estabilidad primaria promedio moderada y una estabilidad secundaria promedio substancial. La pérdida ósea vertical periimplantaria exhibió valores semejantes a los implantes en zonas curadas y dentro del valor estandarizado para pérdida ósea periimplantaria para el primer año tras su colocación(AU)
Introduction: Post-extractive implants shorten the time in achieving the rehabilitation of the patient, being this condition an essential factor to restore the quality of life to elderly patients at short term. Objective: To determine the stability values and peri-implant bone loss in post-extractive implants in elderly patients. Material and Method: A cohort study was carried out in 99 elderly patients at Raúl González Sánchez Dental School of Havana from 2017 to 2019. Under the consent of the patients, 173 post-extractive implants were placed. Bone support type, and primary and secondary stability were determined on the basis of a resonance frequency analysis with Ostell Mentor®. The peri-implant bone level and peri-implant bone loss were measured until 12 months after rehabilitation. Results: Implants were mainly positioned in the maxillary incisive site in 43,3 percent of the cases. The average values of primary and secondary stability were 48 ISQ and 68 ISQ, respectively. The average bone loss after 12 months of rehabilitation was 1,04 ± 0,22 mm. Conclusions: Post-extractive dental implants were inserted preferably in the maxillary incisive site and in D2 bone type, registering moderated average values of primary stability and substantial average values of secondary stability. The peri-implant vertical bone loss exhibited implants with similar values than those in the healed areas and within the standardized value for peri-implant bone loss within the first year after implant placement(AU)
Assuntos
Humanos , Idoso , Idoso de 80 Anos ou mais , Qualidade de Vida , Faculdades de Odontologia , Implantes Dentários , Medicina Bucal , Análise de Frequência de Ressonância , Estudos de Coortes , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodosRESUMO
Abstract Objective: To determine the effect of dental health education for teachers and parents on children aged 7-9 years old. Material and Methods: This was a quasi-experimental study with a nonrandomized control group and a pretest-posttest design. The intervention group comprised 20 teachers and 66 mothers, whereas the control group consisted of 10 teachers and 54 mothers. Data on the knowledge and behavior of teachers and mothers were retrieved by pretest and posttest questionnaires. The 66 children in the intervention group underwent a 16-surface tooth brushing program, whereas the 54 children in the control group were only provided theoretical education by their teachers and mothers. The evaluation was conducted after one month to measure the children's dental plaque index. Results: An increase in teachers' oral health knowledge (16.7%), teachers' oral health behavior (20%), mothers' oral health knowledge (16.7%), and mothers' oral health behavior (20%) was noted; the children's plaque index was decreased (47%). Conclusion: The dental health education of teachers and parents (mothers) supported by the 16-surface teeth brushing program resulted in a significant reduction in the dental plaque index in children aged 7-9 years old.
Assuntos
Humanos , Masculino , Feminino , Escovação Dentária , Conhecimentos, Atitudes e Prática em Saúde , Saúde Bucal/educação , Educação em Saúde Bucal , Indonésia/epidemiologia , Efetividade , Índice de Placa Dentária , Inquéritos e Questionários , Estatísticas não Paramétricas , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodosRESUMO
Objetivos: La psoriasis se asocia a la disfunción endotelial, lo cual provoca un deterioro del funcionamiento vascular. Los inhibidores del TNF-alpha han mostrado la capacidad de mejorar el funcionamiento vascular en la psoriasis. El índice de resistencia de los vasos ungueales (IRVU) evalúa el funcionamiento microvascular en la uña. El objetivo del estudio fue evaluar el efecto de la inhibición del TNF-alpha con adalimumab en el IRVU. Material y métodos: Estudio cuasiexperimental. Quince pacientes con psoriasis moderada-grave recibieron adalimumab 40mg sc según ficha técnica. Se valoró a los participantes al inicio y a las 12, 24 y 52 semanas tras la intervención del estudio. Resultados: En la semana 52 se observó una reducción del IRVU de −0,09±0,02 (p<0,01) y de −11,2±2,41ng/ml (p<0,001) en la E-selectina. Conclusiones: Adalimumab podría producir una reducción progresiva y sostenida de la resistencia de los vasos ungueales y marcadores de disfunción endotelial
Objectives: Psoriasis is associated to endothelial dysfunction, which causes impaired vascular functioning. TNF-alpha blockers have shown the ability to improve vascular functioning in psoriasis. The nailfold vessel resistance index (NVRI) assesses microvascular functioning at nailfold. The objectives of the study is to assess the effect of the TNF-alpha inhibition with adalimumab on NVRI. Material and methods: Quasi-experimental study. Fifteen patients with moderate-severe psoriasis received adalimumab 40mg sc according to label information. Participants were assessed at baseline and at 12, 24 and 52 weeks after study intervention. Results: A reduction of −0.09±0.02 (P<.01) in NVRI and a −11.2±2,41ng/ml (P<.001) in E-selectin was observed at week 52. Conclusions: Adalimumab could produce a progressive and sustained reduction of vessel resistance at nailfold and E-selectin in patients with psoriasis
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Psoríase/fisiopatologia , Endotélio Vascular/fisiopatologia , Adalimumab , Ultrassonografia Doppler/métodos , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodos , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Microvasos/fisiologia , Unhas/irrigação sanguínea , Biomarcadores , Resistência Vascular , Selectina ERESUMO
Objetivo: Evaluar la efectividad de la estrategia educativa dirigida a adultos mayores diabéticos tipo 2 y proveedores de salud. Métodos: Investigación cuasi experimental que evaluó un antes-después con grupo control. El universo de estudio estuvo constituido por adultos mayores diabéticos dispensarizados en los policlínicos Hermanos Cruz (U= 1 369) y Pedro Borrás (U= 1 528), del primero se seleccionó el grupo experimental y en el segundo el grupo control, ambos del municipio y provincia Pinar del Río. Para determinar la muestra se utilizó un Muestreo por Conglomerados Bietápico con probabilidades proporcionales al tamaño de las Unidades de Primera Etapa quedando conformada para ambos grupos por 123 adultos mayores diabéticos tipo 2. Se trabajó con el universo de prestadores del GBT uno (U= 84) del policlínico Hermanos Cruz. La estrategia fue aplicada en el grupo experimental, y evaluada de forma inmediata, a los seis meses y al año. Resultados: Las comparaciones de los grupos en los momentos relacionados con la aplicación de la estrategia estuvieron dentro de lo esperado, generalmente se produjeron cambios significativos en los adultos mayores diabéticos tipo 2 en cuanto a los resultados globales y en cada una de las preguntas examinadas a favor del grupo experimental e igualmente en los proveedores de salud. Conclusiones: La mejoría detectada en los resultados de las variables de respuesta principal y secundarias, en el grupo experimental, dan una medida de la efectividad de la estrategia. Al mismo tiempo su estabilidad a los seis meses y al año considerado como horizonte temporal de evaluación, avalan su sostenibilidad(AU)
Objective: To evaluate the effectiveness of the educational strategy aimed at type 2 diabetic older adults and at health providers. Method: A quasi experimental research study to evaluate the situation before and after the application of this strategy in a control group. The study population consisted of diabetic old patients recruited at Hermanos Cruz (U= 1 369) and Pedro Borrás Astorga (U= 1 528) polyclinics. The experimental group was chosen from the first group and the control group from the second one, both in Pinar del Río municipality in Pinar del Rio province. A two-staged cluster was used with proportional probabilities according to the size of the first stage units and the final sample was 123 type 2 diabetic older adults for both groups. All the basic working team health providers from Hermanos Cruz polyclinics were involved in the study. The strategy was applied in the experimental group and immediately evaluated after six months and after a year. Results: The comparisons of the groups made at the time of the implementation of the strategy were within the expectations; there were significant changes in type 2 diabetics in terms of overall outcomes and each of the analyzed questions, which favored the experimental group along with the health providers. Conclusions: The improvement observed in the results of the answer variables of the experimental group shows the strategy effectiveness. At the same time, the stability of results after six months and a year endorses the strategy sustainability(AU))
Assuntos
Humanos , Masculino , Feminino , Educação de Pacientes como Assunto , Pessoal de Saúde/educação , Diabetes Mellitus Tipo 2 , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodos , CubaRESUMO
Introducción: en el tratamiento de los tumores del sistema nervioso central en niños y adolescentes la irradiación desempeña un papel fundamental en la evolución posterior. Con frecuencia se presentan recurrencias y el tratamiento no ofrece muchas posibilidades de control. En estos pacientes han sido empleados diversos tratamientos: cirugía, poliquimioterapia y reirradiación.Objetivo: presentar los resultados obtenidos en niños y adolescentes reirradiados en el Instituto Nacional de Oncología y Radiobiología, en La Habana.Métodos: se realiza un estudio retrospectivo, no aleatorizado. Doce niños y adolescentes entre 9 y 18 años de edad, con recurrencias de tumores del sistema nervioso central, se irradiaron con acelerador lineal, planificación en 3D, dosis variable entre 36 y 56 Gy.Resultados: en todos los pacientes se obtuvo respuesta, con tasas de supervivencia a 12 y 24 meses de 59,7 y 31,8 por ciento, respectivamente. La mediana del tiempo de supervivencia fue de 13,4, IC 95 por ciento (5,0-21,8) meses. De ellos, se encuentran vivos, 5 pacientes.Conclusión: la reirradiación en las recaídas de estos tumores puede ser una opción a considerar, aun como tratamiento paliativo para prolongar la supervivencia y la mejoría de la calidad de vida(AU)
Assuntos
Humanos , Criança , Adolescente , Neoplasias do Sistema Nervoso Central/complicações , Neoplasias do Sistema Nervoso Central/radioterapia , Reirradiação/métodos , Recidiva Local de Neoplasia/terapia , Estudos Retrospectivos , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodosRESUMO
Objective Our goal was to assess the effects of weight loss on antioxidant enzymes of red blood cells and it’s relation with vitamins A, E and C intake in 30 obese women. Subjects and methods General information, anthropometric measurements, 3-day food recall, and fasting blood samples were collected from 30 obese women at the beginning of the study and after 3 months intervention. Weight loss was set at about 10% of their weight before the intervention. Results Glutathione reductase and catalase activities showed a significant increase (P < 0.01) after weight reduction, but no significant changes were seen in the superoxide dismutase and glutathione peroxidase activities. There was a positive linear correlation between daily vitamin C intake with superoxide dismutase enzyme after intervention (P = 0.004, r = 0.507). There was a negative linear correlation between vitamin E intake and glutathione peroxidase activity before intervention (P = 0.005, r = -0.5). A negative correlation was found between daily vitamin A intake and glutathione reductase enzyme before and after intervention (r = -0.385, r = -0.397, P < 0.05) respectively. No significant correlation was observed between vitamins A, C, E amounts and catalase activity. Conclusions Ten percent weight reduction can have a significant role in increasing antioxidant enzymes activities, especially glutathione reductase, and catalase enzymes in obese women. However, it is important to take into consideration a balanced amount of certain nutrients while administering a diet with limited energy. .
Objetivo Nosso objetivo foi avaliar os efeitos da perda de peso sobre as enzimas antioxidantes de eritrócitos, e a relação destas com a ingestão das vitaminas A, E e C. Sujeitos e métodos Foram coletadas informações gerais e medidas antropométricas, registro alimentar de três dias e amostras de sangue em jejum de 30 mulheres obesas no início do estudo e depois de três meses da intervenção. A perda de peso determinada antes da intervenção foi de 10% do peso. Resultados As atividades da glutationa redutase e da catalase mostraram aumento significativo (P < 0,01) depois da perda de peso, mas não houve mudanças significativas nas atividades da superóxido dismutase e da glutationa peroxidase. Foi observada uma correlação linear positiva entre a ingestão diária de vitamina C e a enzima superóxido dismutase após a intervenção (P = 0,004, r = 0,507). Houve uma correlação linear negativa entre a ingestão de vitamina E e a atividade da glutationa peroxidase antes da intervenção (P = 0,005, r = -0,5). Foi observada uma correlação negativa entre a ingestão diária de vitamina A e a enzima glutationa redutase antes e depois da intervenção (r = -0,385, r = -0,397, P < 0,05), respectivamente. Não foram observadas correlações significativas entre as vitaminas A, C, E e os níveis e a atividade da catalase. Conclusões Uma redução de 10% no peso pode ter um papel significativo no aumento da atividade das enzimas antioxidantes, especialmente na glutationa redutase e catalase em mulheres obesas. Entretanto, é importante levar em consideração uma ingestão equilibrada de certos nutrientes ao se recomendar uma dieta com níveis de energia restritos. .