RESUMO
Seizures are the most common neurological emergency in the neonatal period and in contrast to those in infancy and childhood, are often provoked seizures with an acute cause and may be electrographic-only. Hence, neonatal seizures may not fit easily into classification schemes for seizures and epilepsies primarily developed for older children and adults. A Neonatal Seizures Task Force was established by the International League Against Epilepsy (ILAE) to develop a modification of the 2017 ILAE Classification of Seizures and Epilepsies, relevant to neonates. The neonatal classification framework emphasizes the role of electroencephalography (EEG) in the diagnosis of seizures in the neonate and includes a classification of seizure types relevant to this age group. The seizure type is determined by the predominant clinical feature. Many neonatal seizures are electrographic-only with no evident clinical features; therefore, these are included in the proposed classification. Clinical events without an EEG correlate are not included. Because seizures in the neonatal period have been shown to have a focal onset, a division into focal and generalized is unnecessary. Seizures can have a motor (automatisms, clonic, epileptic spasms, myoclonic, tonic), non-motor (autonomic, behavior arrest), or sequential presentation. The classification allows the user to choose the level of detail when classifying seizures in this age group.
Assuntos
Epilepsia Neonatal Benigna/classificação , Epilepsia/classificação , Convulsões/classificação , Comitês Consultivos , Diagnóstico Diferencial , Eletroencefalografia , Epilepsia/diagnóstico , Epilepsia Neonatal Benigna/diagnóstico , Humanos , Recém-Nascido , Convulsões/diagnósticoAssuntos
Epilepsia Neonatal Benigna/classificação , Epilepsia Neonatal Benigna/genética , Fatores Etários , Idade de Início , Epilepsia Neonatal Benigna/diagnóstico , Variação Genética/genética , Genótipo , Humanos , Lactente , Recém-Nascido , Canal de Potássio KCNQ1/genética , Canal de Potássio KCNQ3/genética , Canal de Sódio Disparado por Voltagem NAV1.2 , Proteínas do Tecido Nervoso/genética , Canais de Sódio/genética , Terminologia como AssuntoRESUMO
Continuous synchronized video-EEG-polygraphic recordings allow us to better define the electroclinical patterns of epileptic events and to study the semiological features of neonatal seizures. Recently, complex behaviours and motor automatisms in newborns have been reported as being epileptic in nature. However, the debate on physiopathology (cortical or brainstem release phenomena) is ongoing. We present the synchronized video-EEG documentation of epileptic complex motor behaviours in a newborn male. Our case contributes to the discussion regarding the semiological classification of the neonatal seizures.[Published with video sequences].
Assuntos
Automatismo/diagnóstico , Epilepsia Motora Parcial/diagnóstico , Convulsões/diagnóstico , Automatismo/classificação , Eletroencefalografia/estatística & dados numéricos , Epilepsia Neonatal Benigna/classificação , Epilepsia Neonatal Benigna/diagnóstico , Epilepsia Motora Parcial/classificação , Seguimentos , Humanos , Recém-Nascido , Masculino , Monitorização Fisiológica/estatística & dados numéricos , Atividade Motora/fisiologia , Convulsões/classificação , Síndrome , Terminologia como Assunto , Gravação de VideoteipeAssuntos
Epilepsia Neonatal Benigna/classificação , Convulsões/classificação , Adolescente , Fatores Etários , Doenças do Sistema Nervoso Autônomo/classificação , Doenças do Sistema Nervoso Autônomo/fisiopatologia , Criança , Pré-Escolar , Consenso , Eletroencefalografia , Epilepsia Neonatal Benigna/fisiopatologia , Humanos , Convulsões/fisiopatologia , SíndromeRESUMO
Benign familial neonatal convulsions (BFNC) are characterized by unprovoked seizures during the first weeks of life with spontaneous remission after a few months. Mutations have been identified in the voltage-gated potassium ion channels KCNQ2 and KCNQ3. The authors performed a mutation analysis of KCNQ2 and KCNQ3 in six patients of whom four had no family history of neonatal seizures. The authors identified three KCNQ2 mutations in four patients that all arose de novo.
