RESUMO
To report convergence excess esotropia (CEET) following 0.01% atropine eye drops (Low dose atropine [LDA]). Children who developed CEET that resolved promptly after discontinuation of LDA are described. Three myopes aged 5.3 ± 1.2 years and mean sphere -4.5D were included. All were operated for intermittent exotropia earlier. Mean esotropia was +28.3PD for near and 10.6PD for distance. LDA induced high AC/A ratio and fusion normalized in 3 weeks after discontinuation of LDA. LDA should be used with caution in patients with esophoria or previously operated for intermittent exotropia. Any evidence of the emergence of a CEET should warrant discontinuation of LDA.
Assuntos
Esotropia , Exotropia , Acomodação Ocular , Atropina/efeitos adversos , Criança , Pré-Escolar , Convergência Ocular , Esotropia/induzido quimicamente , Esotropia/diagnóstico , Esotropia/cirurgia , Exotropia/induzido quimicamente , Exotropia/diagnóstico , Exotropia/cirurgia , Humanos , Músculos Oculomotores/cirurgia , Soluções OftálmicasRESUMO
We report a rare case of eye complication following botulinum toxin type A (BTA) injection. A 36-year-old healthy woman received BTA injections on the glabella, forehead, and periocular area to improve her wrinkles. Four days after BTA injection, diplopia and esotropia developed on her right eye.
Assuntos
Toxinas Botulínicas Tipo A/efeitos adversos , Esotropia/induzido quimicamente , Fármacos Neuromusculares/efeitos adversos , Envelhecimento da Pele , Adulto , Toxinas Botulínicas Tipo A/administração & dosagem , Face , Feminino , Humanos , Ritidoplastia/efeitos adversosAssuntos
Doenças dos Nervos Cranianos/tratamento farmacológico , Doenças do Sistema Nervoso Periférico/tratamento farmacológico , Brometo de Piridostigmina/uso terapêutico , Piridoxina/uso terapêutico , Vincristina/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Asparaginase/administração & dosagem , Blefaroptose/induzido quimicamente , Blefaroptose/tratamento farmacológico , Doenças dos Nervos Cranianos/induzido quimicamente , Daunorrubicina/administração & dosagem , Diagnóstico Diferencial , Esotropia/induzido quimicamente , Esotropia/tratamento farmacológico , Feminino , Síndrome de Guillain-Barré/diagnóstico , Humanos , Mesilato de Imatinib/administração & dosagem , Lactente , Doenças do Sistema Nervoso Periférico/induzido quimicamente , Doenças do Sistema Nervoso Periférico/diagnóstico , Leucemia-Linfoma Linfoblástico de Células Precursoras B/complicações , Leucemia-Linfoma Linfoblástico de Células Precursoras B/tratamento farmacológico , Prednisona/administração & dosagem , Quadriplegia/induzido quimicamente , Quadriplegia/tratamento farmacológico , Vincristina/administração & dosagemRESUMO
A 4-year-old boy presented with right esotropia while receiving vincristine and dactinomycin for stage I Wilms' tumour according to the National Wilms Tumour Study-5 protocol. On examination, he had isolated limitation of his right lateral gaze. CT of the brain and cerebrospinal fluid examination were normal. A nerve conduction velocity study which was performed on the peripheral nerves revealed predominant motor polyneuropathy compatible with axonal loss involving the upper limbs. The patient had received a cumulative vincristine dose of 17â mg/m(2) before developing esotropia. Vincristine-induced abducens nerve mononeuropathy and subclinical motor polyneuropathy was suspected. Unilateral esotropia markedly improved after the discontinuation of vincristine and a short course of oral pyridoxine treatment.
Assuntos
Doenças do Nervo Abducente/induzido quimicamente , Antineoplásicos Fitogênicos/efeitos adversos , Esotropia/induzido quimicamente , Polineuropatias/induzido quimicamente , Vincristina/efeitos adversos , Tumor de Wilms/tratamento farmacológico , Antineoplásicos Fitogênicos/uso terapêutico , Pré-Escolar , Humanos , Masculino , Vincristina/uso terapêuticoRESUMO
Eight-year-old girl was admitted to our clinic with the complaint of constant epiphora in the right eye. It was reported that this complaint began after the start of chemotherapy with a diagnosis of Acute Lymphoblastic Leukemia (ALL) about 5 years ago. In addition, eyelid ptosis associated with esotropia also occurred during that period. We found that nasolacrimal duct obstruction did not improve with medical treatment but ptosis and esotropia improved with pyridoxine and pyridostigmine treatment during that period. Examination of the eye on admission revealed nasolacrimal duct obstruction on the right side. Other ocular findings were normal. Nasolacrimal system obstruction, ptosis and esotropia combination has not been reported previously in patients using systemic drugs or receiving chemotherapy due to ALL.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Blefaroptose/induzido quimicamente , Esotropia/induzido quimicamente , Obstrução dos Ductos Lacrimais/induzido quimicamente , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Asparaginase/administração & dosagem , Criança , Daunorrubicina/administração & dosagem , Feminino , Humanos , Metotrexato/administração & dosagem , Ducto Nasolacrimal , Prednisolona/administração & dosagem , Vincristina/administração & dosagemRESUMO
As an infrequent symptom diplopia has been reported with opiate withdrawal, especially heroin, but not dextropropoxyphene. We report incomitant esotropia and diplopia in a case with dextropropoxyphene withdrawal that resolved completely with the resolution of the opiate withdrawal syndrome.
Assuntos
Dextropropoxifeno/efeitos adversos , Diplopia/induzido quimicamente , Esotropia/induzido quimicamente , Entorpecentes/efeitos adversos , Síndrome de Abstinência a Substâncias/etiologia , Adulto , Humanos , MasculinoRESUMO
PURPOSE: To report a case of sixth nerve palsy after intravitreal bevacuzimab injection. METHODS: After intravitreal bevacizumab injection in a 64-year-old man, the patient admitted to our clinic with the complaint of diplopia. A complete ophthalmologic examination was done to clear the symptomatology of patient. RESULTS: Examination of ductions revealed marked limitation of abduction of the right eye and full ductions of the left eye, consistent with right lateral rectus paralysis. CONCLUSIONS: Although intravitreal bevacizumab injections are generally well tolerated, it is possible that some serious systemic adverse events may occur. For this reason, patients must be closely monitored following these injections.
Assuntos
Doenças do Nervo Abducente/induzido quimicamente , Inibidores da Angiogênese/administração & dosagem , Inibidores da Angiogênese/efeitos adversos , Anticorpos Monoclonais/administração & dosagem , Anticorpos Monoclonais/efeitos adversos , Neovascularização de Coroide/diagnóstico , Degeneração Macular/complicações , Doenças do Nervo Abducente/fisiopatologia , Anticorpos Monoclonais Humanizados , Bevacizumab , Neovascularização de Coroide/etiologia , Diabetes Mellitus Tipo 2/complicações , Esotropia/induzido quimicamente , Esotropia/fisiopatologia , Angiofluoresceinografia , Seguimentos , Fundo de Olho , Humanos , Injeções Intraoculares , Masculino , Pessoa de Meia-Idade , Remissão Espontânea , Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores , Corpo VítreoAssuntos
Encéfalo/efeitos dos fármacos , Antagonistas Colinérgicos/efeitos adversos , Esotropia/induzido quimicamente , Músculos Oculomotores/efeitos dos fármacos , Acomodação Ocular/efeitos dos fármacos , Acomodação Ocular/fisiologia , Acetilcolina/metabolismo , Adulto , Amitriptilina/efeitos adversos , Amitriptilina/análogos & derivados , Benzotropina/efeitos adversos , Encéfalo/fisiopatologia , Diplopia/induzido quimicamente , Diplopia/fisiopatologia , Esotropia/fisiopatologia , Exotropia/fisiopatologia , Feminino , Humanos , Hidroxizina/efeitos adversos , Doença Iatrogênica/prevenção & controle , Transtornos do Humor/tratamento farmacológico , Junção Neuromuscular/efeitos dos fármacos , Junção Neuromuscular/fisiopatologia , Músculos Oculomotores/inervação , Músculos Oculomotores/fisiopatologiaAssuntos
Benzotropina/efeitos adversos , Inibidores da Captação de Dopamina/efeitos adversos , Esotropia/induzido quimicamente , Midríase/induzido quimicamente , Adolescente , Esotropia/patologia , Feminino , Humanos , Transtornos Mentais/complicações , Transtornos Mentais/tratamento farmacológico , Midríase/patologia , Pseudo-Hipoaldosteronismo/complicações , Pseudo-Hipoaldosteronismo/tratamento farmacológicoRESUMO
A 5-year-old girl with previously unrecognized hyperopia of approximately +3.00 D developed esotropia while being treated with oxybutynin for enuresis. The esotropia disappeared with cessation of oxybutynin and correction of her hyperopia. When the hyperopic correction was removed, she had a small esophoria. The esotropia was presumably triggered by the anticholinergic effect of oxybutynin, which reduced the ability to accommodate. The increased accommodative effort for vision generated an esotropia as a result of the accommodative convergence/accommodation ratio.
Assuntos
Esotropia/induzido quimicamente , Ácidos Mandélicos/efeitos adversos , Antagonistas Muscarínicos/efeitos adversos , Acomodação Ocular/efeitos dos fármacos , Pré-Escolar , Convergência Ocular/efeitos dos fármacos , Enurese/tratamento farmacológico , Feminino , HumanosAssuntos
Doenças do Nervo Abducente/induzido quimicamente , Inibidores da Angiogênese/efeitos adversos , Anticorpos Monoclonais/efeitos adversos , Esotropia/induzido quimicamente , Degeneração Macular/tratamento farmacológico , Doenças do Nervo Abducente/fisiopatologia , Anticorpos Monoclonais Humanizados , Bevacizumab , Neovascularização de Coroide/tratamento farmacológico , Neovascularização de Coroide/etiologia , Esotropia/fisiopatologia , Humanos , Degeneração Macular/complicações , Masculino , Pessoa de Meia-Idade , Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidoresRESUMO
The authors describe a young female patient with intracranial hypertension associated with ocular manifestations, during treatment with tetracycline. This is a rare adverse effect described in the medication warnings, and in a few reported cases in the scientific literature.
Assuntos
Antibacterianos/efeitos adversos , Esotropia/induzido quimicamente , Hipertensão Intracraniana/induzido quimicamente , Tetraciclina/efeitos adversos , Adulto , Antibacterianos/uso terapêutico , Feminino , Humanos , Otite/tratamento farmacológico , Tetraciclina/uso terapêuticoRESUMO
Os autores relatam o caso de uma paciente jovem, do sexo feminino, que desenvolveu quadro de hipertensão intracraniana benigna com manifestações oculares em concomitância ao uso de tetraciclina para o tratamento de otite. Esta é uma reação adversa rara deste medicamento, descrito em bula e com alguns relatos de caso em literatura internacional.
Assuntos
Adulto , Feminino , Humanos , Antibacterianos/efeitos adversos , Esotropia/induzido quimicamente , Hipertensão Intracraniana/induzido quimicamente , Tetraciclina/efeitos adversos , Antibacterianos/uso terapêutico , Otite/tratamento farmacológico , Tetraciclina/uso terapêuticoAssuntos
Antituberculosos/efeitos adversos , Diplopia/induzido quimicamente , Esotropia/induzido quimicamente , Isoniazida/efeitos adversos , Tuberculose Meníngea/prevenção & controle , Antituberculosos/administração & dosagem , Criança , Diagnóstico Diferencial , Humanos , Isoniazida/administração & dosagem , Masculino , Teste Tuberculínico , Tuberculose Meníngea/diagnósticoRESUMO
BACKGROUND: Esotropia during opiate withdrawal is a new clinical syndrome that has only recently been reported in the literature. METHODS: Clinical case series. RESULTS: Five patients with acute esotropia during opiate withdrawal are presented. In four there was evidence of underlying hyperopia and/or other strabismogenic features. CONCLUSIONS: The precise cause of esotropia with heroin withdrawal is uncertain. Most (and possibly all) of these patients have one or more objective strabismogenic features, and these are probably a large factor in the causation.
Assuntos
Esotropia/induzido quimicamente , Heroína/efeitos adversos , Síndrome de Abstinência a Substâncias , Doença Aguda , Adulto , Suscetibilidade a Doenças , Esotropia/fisiopatologia , Feminino , Humanos , MasculinoRESUMO
QUESTIONS UNDER STUDY: We report on a series of patients with acute strabismus related to heroin and methadone intake or withdrawal, discuss possible mechanisms involved in this clinical picture and make recommendations for work-up and referral. METHODS: Retrospective study. RESULTS: Five patients presented with acute esotropia within days of heroin withdrawal, and two patients developed exotropia related to heroin or methadone intake. Neurological work-up and neuroimaging was non-contributory in all four patients who were examined. CONCLUSION: Acute esotropia with double vision is a disturbing side effect of heroin withdrawal, and, similarly, acute exotropia may be related to heroin intake. In the absence of focal neurological signs, further work-up is not mandatory. Referral to a specialised orthoptic service is beneficial in offering the patient symptomatic treatment and reassurance, thus supporting successful withdrawal therapy.
Assuntos
Esotropia/induzido quimicamente , Heroína/efeitos adversos , Metadona/efeitos adversos , Entorpecentes/efeitos adversos , Síndrome de Abstinência a Substâncias , Adulto , Diplopia/complicações , Esotropia/complicações , Feminino , Humanos , Masculino , Estudos RetrospectivosRESUMO
BACKGROUND: Previous studies have shown an effect of the tranquilizer lorazepam on visual perception. We explored the effects of the drug on binocular vision, visual acuity and accommodation. SUBJECTS AND METHODS: Twenty-four paid healthy volunteers (13 women, 11 men) were recruited from the University of Strasbourg (mean age: 23.6 years, mean weight: 66.8 Kg). They were randomly assigned to one of two parallel groups of 12 subjects each (a placebo group and a lorazepam 0.038 mg/kg group). Visual acuity was measured for each eye separately (Snellen chart and Parinaud scale). Binocular vision was studied using the cover tests, measurement of the fusional amplitudes (with Berens prisms), and the Duane Scale Test (near point rule) measuring convergence and/or accommodation in centimeters or diopters as a function of age. RESULTS: Regarding vision, there was no lorazepam effect, at either 33 cm or 5 m. An esophoria was observed after the intake of lorazepam (0Delta before intake and 2.8Delta after intake, p=0.001). Both fusional convergence and fusional divergence amplitudes decreased by lorazepam, (p=0.008, and p=0.002). Lorazepam also impaired the near point of convergence but did not affect accommodation. CONCLUSION: A single dose of lorazepam induces an esophoric oculomotor imbalance and impaired fusional convergence and divergence amplitudes without impairing visual acuity or accommodation.
Assuntos
Acomodação Ocular/efeitos dos fármacos , Ansiolíticos/farmacologia , Lorazepam/farmacologia , Visão Binocular/efeitos dos fármacos , Acuidade Visual/efeitos dos fármacos , Administração Oral , Adulto , Ansiolíticos/administração & dosagem , Método Duplo-Cego , Esotropia/induzido quimicamente , Feminino , Humanos , Lorazepam/administração & dosagem , Lorazepam/efeitos adversos , Masculino , Estudos ProspectivosRESUMO
PURPOSE: To report the possible effects of heroin withdrawal on binocular vision. METHODS: A case series of patients is presented in whom esotropia developed on cessation of heroin use. RESULTS: In each case the esotropia was concomitant and prismatic correction restored binocular single vision. Intermittent spontaneous control occurred in one patient, the deviation resolved in one and one patient was lost to follow-up. CONCLUSIONS: Heroin withdrawal should be considered as a cause of acute concomitant esotropia. However, an accurate history of other medication is needed to ensure that this is not the cause of decompensation.