Assuntos
Hormônios Esteroides Gonadais/uso terapêutico , Gonadotropinas Hipofisárias/uso terapêutico , Terapia de Reposição Hormonal/história , Aborto Habitual/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Amenorreia/tratamento farmacológico , Sinergismo Farmacológico , Quimioterapia Combinada , Feminino , Hormônios Esteroides Gonadais/administração & dosagem , Gonadotropinas Hipofisárias/administração & dosagem , História do Século XX , Humanos , Pessoa de Meia-Idade , Gravidez , Testes de Gravidez , Gravidez em Diabéticas/tratamento farmacológico , Extratos de Tecidos/administração & dosagem , Extratos de Tecidos/uso terapêutico , Hemorragia Uterina/tratamento farmacológicoRESUMO
With the purpose of investigating if placental prolactin production had an influence on maternal prolactin serum concentrations, this hormone was quantitated in serum of a women with partial Sheehan syndrome (deficient gonadotrophin and prolactin production). Her pregnancy was induced by pituitary gonadotrophins and the deficient prolactin pituitary reserve was shown by means of pituitary stimulation test with metoclopramide of pituitary stimulation test with metoclopramide and TRH. Quantitative analysis of prolactin was made by RIA utilizing the double antibody method. Serum prolactin concentrations remained persistently low during pregnancy with a minimal increase (1 - 16 ng/ml) at the end of pregnancy when comparing with concentrations observed in normal pregnant women (20 +/- 10 ng/ml at the beginning of pregnancy, and 250 +/- 150 ng/ml mean +/- 3 SD at the end). Prolactin concentration in the umbilical cord was found to be within normal values (252 ng/ml). Results obtained showed that fetal and placental prolactin does not pass on to the mother and confirm the idea that maternal serum prolactin during pregnancy is exclusively of a maternal pituitary origin.