RESUMO
A 67-year-old man presented with headache, middle back pain that radiated to both legs, and paresthesia in the right leg for 1 day. He had eaten raw shrimp 1 week previously. Over the next week after admission, he developed urinary retention and weakness in both legs. The numbness in his right leg expanded to below the umbilicus. Magnetic resonance imaging of the spinal cord showed myelopathy with minimal cord swelling at T9 to the conus medullaris and a hemorrhagic lesion from T10 to T11. A complete blood count on day 28 after the onset of symptoms revealed leukocytosis without eosinophilia and no white blood cells in his cerebrospinal fluid. Results of an immunochromatographic test kit were positive for Angiostrongylus cantonesis but negative for Gnathostoma spinigerum. After a 4-week course of albendazole combined with a tapering dose of dexamethasone, he achieved nearly complete recovery.
Assuntos
Angiostrongylus cantonensis , Helmintíase do Sistema Nervoso Central/diagnóstico , Helmintíase do Sistema Nervoso Central/parasitologia , Infecções por Strongylida/diagnóstico , Infecções por Strongylida/parasitologia , Idoso , Albendazol/uso terapêutico , Animais , Anti-Helmínticos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Helmintíase do Sistema Nervoso Central/tratamento farmacológico , Helmintíase do Sistema Nervoso Central/epidemiologia , Dexametasona/uso terapêutico , Humanos , Masculino , Infecções por Strongylida/tratamento farmacológico , Infecções por Strongylida/epidemiologia , Tailândia/epidemiologiaRESUMO
Toxocarosis is the consequence of human infection by Toxocara spp. larvae and is one of the most common ascarioses, not only in developing countries, but also in the European region, where its prevalence reaches 14%. Due to their particular behavior, children are at higher risk of this parasitic infection, whose clinical features depend on the localization of the Toxocara larvae. Neurotoxocariasis is very uncommon in children and may take different forms depending on the underlying physiopathologic process: immune reaction against the parasite antigens, vasculitis, treatment complications, or, very rarely, brain localization of Toxocara spp. larvae. The association between neurotoxocariasis and the onset of childhood epilepsy has been postulated but is still debated. Moreover, a Toxocara spp. abscess causing epileptic seizures in children has been rarely described, especially in western countries. Hereby we present a 9-year-old patient with a new diagnosis of epilepsy definitely secondary to brain abscess due to the localization of Toxocara canis larvae. Diagnosis was confirmed by neuroimaging and serological test. The successful treatment with albendazole and steroids was documented with a close and long-term clinical and neuroradiological follow-up. Our experience confirms that every case of cryptogenetic epilepsy in children deserves a neuroimaging study and, in case of cystic images, Toxocara serology is mandatory to avoid further unnecessary invasive diagnostic investigations and to set the specific drug therapy.
Assuntos
Antiparasitários/farmacologia , Abscesso Encefálico , Helmintíase do Sistema Nervoso Central , Epilepsia , Esteroides/farmacologia , Toxocara canis/patogenicidade , Toxocaríase , Albendazol/administração & dosagem , Animais , Antiparasitários/administração & dosagem , Abscesso Encefálico/diagnóstico , Abscesso Encefálico/tratamento farmacológico , Abscesso Encefálico/etiologia , Helmintíase do Sistema Nervoso Central/complicações , Helmintíase do Sistema Nervoso Central/diagnóstico , Helmintíase do Sistema Nervoso Central/tratamento farmacológico , Criança , Epilepsia/diagnóstico , Epilepsia/tratamento farmacológico , Epilepsia/etiologia , Humanos , Larva , Esteroides/administração & dosagem , Toxocaríase/complicações , Toxocaríase/diagnóstico , Toxocaríase/tratamento farmacológicoRESUMO
Four free-ranging peregrine falcons (Falco peregrinus) were submitted with a history of unilateral or bilateral blindness and central nervous signs to a veterinary clinic in Germany. There were no indications of trauma or ocular disease. Likewise, other differential diagnoses for CNS signs were ruled out within the diagnostic process. The clinical diagnostic panel in live falcons included general examination, radiography, endoscopy, hematology, ophthalmoscopy and parasitological examination of the feces, blood gas analysis and blood chemistry as well as computed tomography, and magnetic resonance imaging (MRI). A complete pathological and histopathological examination was performed post-mortem. The only common finding in all birds was an infection with the nematode parasite Serratospiculum tendo. The parasite was confirmed morphologically and via PCR. In two falcons intracerebral vermicoses was suspected in MRI and confirmed in subsequent histopathology, but molecular biological identification of the parasite species failed from brain tissue. Until today, S. tendo had been reported to affect the respiratory system, the liver and different parts of the gastrointestinal tract and to cause cachexia, inappetence, regurgitation, dyspnea and general signs of illness such as lethargy, poor plumage, and reduced reproduction. Our findings indicate that aberrant migration should be considered as cause for CNS signs in falcons. As S. tendo might be a possible cause for this, CNS signs might be included in the list of clinical signs of serratospiculiasis in falcons.
Assuntos
Doenças das Aves/diagnóstico , Cegueira/veterinária , Encefalopatias/veterinária , Helmintíase do Sistema Nervoso Central/veterinária , Falconiformes , Infecções por Spirurida/veterinária , Spirurina/isolamento & purificação , Animais , Doenças das Aves/parasitologia , Cegueira/diagnóstico , Cegueira/parasitologia , Encefalopatias/diagnóstico , Encefalopatias/parasitologia , Helmintíase do Sistema Nervoso Central/diagnóstico , Helmintíase do Sistema Nervoso Central/parasitologia , Diagnóstico Diferencial , Feminino , Alemanha , Larva/crescimento & desenvolvimento , Masculino , Infecções por Spirurida/diagnóstico , Infecções por Spirurida/parasitologia , Spirurina/crescimento & desenvolvimentoRESUMO
BACKGROUND: We investigated the proportion of pediatric patients with cerebral paragonimiasis and intracranial hemorrhage who have intracranial pseudoaneurysms. METHODS: Images of 17 pediatric patients with cerebral paragonimiasis that first manifested as secondary intracranial hemorrhage were evaluated. All patients underwent computed tomographic angiography before surgery. A diagnosis of cerebral paragonimiasis was confirmed based on a positive Paragonimus-specific antibody test in serum samples from all 17 patients. Cerebral paragonimiasis in five of the 17 patients was further confirmed by histopathological examination of surgical specimens. RESULTS: Computed tomographic angiographic images for six of the 17 patients (35.3%) showed the presence of intracranial pseudoaneurysms. Follow-up computed tomographic angiographic scans two years later showed that two of the six patients had persistent pseudoaneurysms and underwent aneurysmectomy. The diagnosis of pseudoaneurysm was confirmed by histopathological examination postsurgery. In another two of the six patients, the pseudoaneurysm lesions were absorbed and could no longer be seen on three- to six-month follow-up scans. The final two patients with pseudoaneurysms are still under follow-up. Intracranial pseudoaneurysms with various degrees of surrounding hemorrhage were frequently observed at first manifestation. CONCLUSIONS: The rupture of intracranial pseudoaneurysms is a common characteristic feature of secondary intracranial hemorrhage caused by cerebral paragonimiasis in pediatric patients.
Assuntos
Falso Aneurisma/diagnóstico , Helmintíase do Sistema Nervoso Central/diagnóstico , Hemorragias Intracranianas/diagnóstico , Paragonimíase/diagnóstico , Adolescente , Falso Aneurisma/etiologia , Falso Aneurisma/cirurgia , Helmintíase do Sistema Nervoso Central/sangue , Helmintíase do Sistema Nervoso Central/complicações , Angiografia Cerebral , Criança , Pré-Escolar , Angiografia por Tomografia Computadorizada , Feminino , Seguimentos , Humanos , Hemorragias Intracranianas/etiologia , Masculino , Paragonimíase/sangue , Paragonimíase/complicaçõesRESUMO
Angiostrongylus cantonensis is a tropical lungworm of rats known for central nervous system migration in aberrant primate hosts. Here, we describe A. cantonensis infection in three captive callitrichids from a Texas zoo. The affected animals included a Goeldi's monkey (Callimico goeldii), a cotton-top tamarin (Saguinus oedipus), and a pied tamarin (Saguinus bicolor) that ranged from 8 to 18 years old. Clinical signs included lethargy, ataxia, and seizures. Histologically, these animals had an eosinophilic meningoencephalitis to myelitis and some areas had abundant macrophages and parasite migration tracts. All cases had intralesional metastrongyle parasites, and nematodes were extracted from the formalin-fixed brain specimen in one case. This extracted parasite was identified as Angiostrongylus cantonensis based on morphologic features and diagnosis was confirmed with PCR. These cases represent the first report of this parasite in non-human primates in Texas, highlighting the western spread of A. cantonensis in the continental United States.
Assuntos
Angiostrongylus cantonensis/isolamento & purificação , Callimico , Helmintíase do Sistema Nervoso Central/veterinária , Doenças dos Macacos/diagnóstico , Saguinus , Infecções por Strongylida/veterinária , Animais , Animais de Zoológico , Helmintíase do Sistema Nervoso Central/diagnóstico , Helmintíase do Sistema Nervoso Central/parasitologia , Masculino , Doenças dos Macacos/parasitologia , Infecções por Strongylida/diagnóstico , Infecções por Strongylida/parasitologia , TexasRESUMO
BACKGROUND Spinal sparganosis and racemose (grape-like) neurocysticercosis are rare diseases. Co-infection with spinal sparganosis and racemose neurocysticercosis has never been reported in the English-language literature. CASE REPORT A 41-year-old male presented after having experienced left hip pain with radiation to the leg, progressive weakness and numbness of the left leg, and difficulty urinating for 4 years, all of which was caused by spinal sparganosis. He had also experienced progressive vision and hearing loss on the right side for 3 years, which were caused by racemose neurocysticercosis. Magnetic resonance imaging (MRI) of the lumbosacral spine and the brain revealed intrinsic spinal cord lesion and racemose neurocysticercosis, respectively. Spinal sparganosis was diagnosed by histological examination and an immunochromatographic test. It was treated with a high-dose of praziquantel (75 mg/kg/day) combined with cimetidine; without clinical improvement. Treatment consisted of racemose neurocysticercosis with albendazole for 2 months. A follow-up MRI of the brain revealed a minimal reduction in the amount of racemose neurocysticercosis. Repeat treatment with albendazole was administered. However, further MRI examination of the brain revealed the condition to be unchanged. Vision and hearing loss had also not improved. CONCLUSIONS In this case report, we describe a middle-aged man who presented with spinal cord symptoms (hip pain, progressive weakness and numbness of the leg, and difficulty urinating) and cranial nerve palsies (vision and hearing loss) caused by spinal sparganosis and racemose neurocysticercosis, respectively. Neurological symptoms did not improve with anthelmintic drugs.
Assuntos
Helmintíase do Sistema Nervoso Central/diagnóstico , Neurocisticercose/diagnóstico , Esparganose/diagnóstico , Adulto , Coinfecção/diagnóstico , Humanos , Imageamento por Ressonância Magnética , Masculino , TailândiaRESUMO
Paragonimiasis is a food-borne parasitic disease caused by Paragonimus lung flukes, which are epidemic in Asia. Cerebral paragonimiasis accounts for <1% of symptomatic paragonimiasis but is the most common extrapulmonary infection. Cerebral paragonimiasis often mimics stroke and sometimes causes severe neurological sequelae. A 61-year-old woman was admitted to the hospital for severe headache. A head computed tomography scan revealed intracerebral hemorrhage with subarachnoid hemorrhage. The patient also had lesions in the lungs. She frequently ate Japanese mitten crab. Peripheral blood examination results of increased eosinophilia and immunological testing results confirmed the diagnosis of Paragonimus westermani infection. The patient was successfully treated with praziquantel as the first-line agent. Cerebral paragonimiasis is currently rare in developed countries; however, it is an important disease to consider.
Assuntos
Helmintíase do Sistema Nervoso Central/parasitologia , Hemorragia Cerebral/parasitologia , Países Desenvolvidos , Paragonimíase/parasitologia , Paragonimus westermani/isolamento & purificação , Acidente Vascular Cerebral/parasitologia , Hemorragia Subaracnóidea/parasitologia , Animais , Anti-Helmínticos/uso terapêutico , Helmintíase do Sistema Nervoso Central/diagnóstico , Helmintíase do Sistema Nervoso Central/tratamento farmacológico , Hemorragia Cerebral/diagnóstico , Feminino , Humanos , Japão , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Paragonimíase/diagnóstico , Paragonimíase/tratamento farmacológico , Praziquantel/uso terapêutico , Acidente Vascular Cerebral/diagnóstico , Hemorragia Subaracnóidea/diagnóstico , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Hydatid disease is a parasitic infection whose etiologic agent is Echinococcus granulosus. Human is an accidental intermediate host and the most common site is the liver. The brain involvement is unusual and up to 75% of cases are described in the pediatric population. We present six children with cerebral hydatid disease admitted to the Pediatric Hospital J.P. Garrahan. All had neurological involvement on admission. The images showed single cystic lesion in the brain. They did not present involvement in other organs. Serology was negative in all cases. Medical and surgical treatment in all cases. The clinical outcome was favorable without sequelae in five of them and one had a residual paresis right faciobrachiocrural. This infection should be considered in the differential diagnosis of cystic tumor lesions of the central nervous system.
Assuntos
Encefalopatias/diagnóstico , Helmintíase do Sistema Nervoso Central/diagnóstico , Equinococose/diagnóstico , Encefalopatias/cirurgia , Helmintíase do Sistema Nervoso Central/cirurgia , Criança , Pré-Escolar , Equinococose/cirurgia , Feminino , Humanos , MasculinoRESUMO
Hydatid disease is a parasitic infection whose etiologic agent is Echinococcus granulosus. Human is an accidental intermediate host and the most common site is the liver. The brain involvement is unusual and up to 75% of cases are described in the pediatric population. We present six children with cerebral hydatid disease admitted to the Pediatric Hospital J.P. Garrahan. All had neurological involvement on admission. The images showed single cystic lesion in the brain. They did not present involvement in other organs. Serology was negative in all cases. Medical and surgical treatment in all cases. The clinical outcome was favorable without sequelae in five of them and one had a residual paresis right faciobrachiocrural. This infection should be considered in the differential diagnosis of cystic tumor lesions of the central nervous system.
La hidatidosis es una infección parasitaria causada por Echinococcus granulosus. El ser humano es un hospedero intermediario accidental. La localización más frecuente es la hepática. El compromiso cerebral es inusual, se describe que hasta 75% ocurre en población pediátrica. Se presenta una serie de seis niños con hidatidosis cerebral internados en el Hospital de Pediatría J. P. Garrahan. Todos presentaron compromiso neurológico al ingreso. Las imágenes mostraron lesiones quísticas únicas en el cerebro. No tuvieron compromiso de otros órganos. La serología fue negativa en todos los casos. El tratamiento fue médico-quirúrgico. La evolución clínica fue favorable sin secuelas en cinco de ellos y uno presentó una hemiparesia faciobraquiocrural derecha como secuela. Esta infección debe considerarse entre los diagnósticos diferenciales de lesiones tumorales quísticas del sistema nervioso central.
Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Encefalopatias/diagnóstico , Helmintíase do Sistema Nervoso Central/diagnóstico , Equinococose/diagnóstico , Encefalopatias/cirurgia , Helmintíase do Sistema Nervoso Central/cirurgia , Equinococose/cirurgiaAssuntos
Helmintíase do Sistema Nervoso Central/diagnóstico , Helmintíase do Sistema Nervoso Central/patologia , Esparganose/diagnóstico , Esparganose/patologia , Plerocercoide/isolamento & purificação , Animais , Anti-Helmínticos/administração & dosagem , Povo Asiático , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Helmintíase do Sistema Nervoso Central/diagnóstico por imagem , Helmintíase do Sistema Nervoso Central/terapia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos/métodos , Praziquantel/administração & dosagem , Esparganose/diagnóstico por imagem , Esparganose/terapia , Coluna Vertebral/diagnóstico por imagem , Coluna Vertebral/patologia , Resultado do TratamentoAssuntos
Helmintíase do Sistema Nervoso Central/diagnóstico , Helmintíase do Sistema Nervoso Central/patologia , Esparganose/diagnóstico , Esparganose/patologia , Plerocercoide/isolamento & purificação , Animais , Anti-Helmínticos/administração & dosagem , Povo Asiático , Encéfalo/diagnóstico por imagem , Encéfalo/patologia , Helmintíase do Sistema Nervoso Central/diagnóstico por imagem , Helmintíase do Sistema Nervoso Central/terapia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos/métodos , Praziquantel/administração & dosagem , Esparganose/diagnóstico por imagem , Esparganose/terapia , Coluna Vertebral/diagnóstico por imagem , Coluna Vertebral/patologia , Resultado do TratamentoRESUMO
Filariasis, an endemic zoonosis in the Southeast Asia region, has been reported to affect various organs as well as the central nervous system (CNS). Inflammatory reactions mimicking those from neoplastic lesions clinically and radiologically have been reported in the breast and urinary bladder. To date, a CNS manifestation of filarial infestation has been reported in the form of meningoencephalitis. The authors here present an interesting case of a young man presenting in status epilepticus, which on radiological evaluation appeared to be a glioma. However, postoperative histopathological examination changed the provisional diagnosis to a filarial infection of the CNS mimicking a primary CNS neoplasm.
Assuntos
Neoplasias Encefálicas/diagnóstico , Helmintíase do Sistema Nervoso Central/diagnóstico , Filariose/diagnóstico , Glioma/diagnóstico , Adulto , Diagnóstico Diferencial , Gliose/diagnóstico , Gliose/parasitologia , Humanos , MasculinoRESUMO
We report a case of a hydatid cyst of the eyelid in a 12-year-old boy associated with cerebral involvement. The patient was initially treated by neurosurgeons for brain cysts. The course after an interval of two months was marked by regression of the palpebral cyst on albendazole.
Assuntos
Encefalopatias/diagnóstico , Helmintíase do Sistema Nervoso Central/diagnóstico , Equinococose/diagnóstico , Edema/diagnóstico , Doenças Palpebrais/diagnóstico , Albendazol/uso terapêutico , Encefalopatias/complicações , Encefalopatias/tratamento farmacológico , Encefalopatias/patologia , Helmintíase do Sistema Nervoso Central/complicações , Helmintíase do Sistema Nervoso Central/tratamento farmacológico , Helmintíase do Sistema Nervoso Central/patologia , Criança , Cistos/complicações , Cistos/diagnóstico , Cistos/tratamento farmacológico , Cistos/cirurgia , Equinococose/complicações , Equinococose/tratamento farmacológico , Equinococose/cirurgia , Edema/tratamento farmacológico , Edema/patologia , Edema/cirurgia , Doenças Palpebrais/tratamento farmacológico , Doenças Palpebrais/patologia , Doenças Palpebrais/cirurgia , Humanos , MasculinoRESUMO
While hepatic hydatid cysts are most common in occurrence, intracranial hydatid cyst is less common. Simultaneous presence of both varieties is quite rare and poses a challenge for management in terms of involvement of multidisciplinary team and multiple interventions. An 8-year boy presented with neurological symptoms of a space occupying lesion. There was also hepatomegaly. Radiological investigations revealed giant hydatid cysts involving left cerebral hemisphere and left lobe of liver. Cerebral hydatid cyst was operated first by pediatric neurosurgeons. After 10 days of stabilization period, hepatic lesion was removed by pediatric surgeons. Patient showed uneventful recovery and discharged on oral albendazole for 6 months. There was no recurrence at follow-up.
Assuntos
Helmintíase do Sistema Nervoso Central/diagnóstico , Helmintíase do Sistema Nervoso Central/terapia , Equinococose Hepática/diagnóstico , Equinococose Hepática/terapia , Albendazol/uso terapêutico , Animais , Anti-Helmínticos , Encéfalo/parasitologia , Encéfalo/patologia , Criança , Cistectomia , Equinococose/diagnóstico , Equinococose/terapia , Echinococcus/isolamento & purificação , Humanos , Fígado/parasitologia , Fígado/patologia , Procedimentos Neurocirúrgicos/métodos , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
Alveolar echinococcosis (AE) is a parasitic infestation produced by Echinococcus multilocularis. The parasite is a rare human infestation with a wide geographic distribution. It primarily affects the liver, and may spread hematogenously to produce metastatic foci in the distant organs. AE can metastise to the lungs, brain and bones. Cerebral involvement is rare but may be lethal. Cerebral AE is a rare but life-threatening parasitic disease. Here we report a 52-year-old man with cerebellar involvement of Echinococcus multilocularis.
Assuntos
Encefalopatias/parasitologia , Helmintíase do Sistema Nervoso Central/diagnóstico , Equinococose Hepática/diagnóstico , Equinococose/diagnóstico , Echinococcus multilocularis/fisiologia , Animais , Imagem de Difusão por Ressonância Magnética/métodos , Lobo Frontal/parasitologia , Humanos , Espectroscopia de Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Lobo Temporal/parasitologiaRESUMO
Helminth parasitic infections of the central nervous system (CNS) occur worldwide with high prevalence in tropical and subtropical countries. Clinical evaluation of patients is mandatory, and it is convenient to group the clinical manifestations into syndromes: for example space-occupying lesions, meningitis, and encephalitis. The history should focus on residence or travel to endemic areas, diet, activities, intercurrent medical conditions, and associated clinical clues. Direct parasitological diagnosis can be reached by cerebrospinal fluid and cerebral tissue examination either by microscopy, culture, or immunological techniques. Immunodiagnosis by detection of parasite antibodies or antigens in serum could provide indirect evidence of parasitic infections. In addition, various imaging and radiological techniques e.g., computed tomography (CT) scan and magnetic resonance imaging (MRI) complement the diagnostic work-up of CNS diseases. Finally, the helminthic CNS infections of global impact, such as schistosomiasis, neurotoxocariasis, Strongyloides infection, neurotrichinosis, neurocysticercosis, and echinococcosis will be briefly discussed as regards the principal clinical and diagnostic features.
Assuntos
Helmintíase do Sistema Nervoso Central/diagnóstico , Helmintíase/diagnóstico , Helmintos/classificação , Animais , Helmintíase do Sistema Nervoso Central/epidemiologia , Helmintíase do Sistema Nervoso Central/parasitologia , Saúde Global , Helmintíase/epidemiologia , Helmintíase/parasitologia , Helmintíase/patologia , Helmintos/isolamento & purificação , Humanos , Fatores de RiscoAssuntos
Helmintíase do Sistema Nervoso Central/diagnóstico , Triquinelose/diagnóstico , Adolescente , Albendazol/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Antifúngicos/uso terapêutico , Argentina , Encéfalo/diagnóstico por imagem , Encéfalo/parasitologia , Encéfalo/patologia , Helmintíase do Sistema Nervoso Central/tratamento farmacológico , Feminino , Humanos , Metilprednisolona/uso terapêutico , Radiografia , Triquinelose/tratamento farmacológicoAssuntos
Angiostrongylus , Helmintíase do Sistema Nervoso Central/diagnóstico , Eosinofilia/parasitologia , Meningoencefalite/parasitologia , Infecções por Strongylida/diagnóstico , Idoso , Animais , Eosinofilia/diagnóstico , Humanos , Imageamento por Ressonância Magnética , Masculino , Meningoencefalite/diagnóstico , Tomografia Computadorizada de Emissão de Fóton ÚnicoRESUMO
BACKGROUND: Onchocerciasis has been implicated in the pathogenesis of epilepsy. The debate on a potential causal relationship between Onchocerca volvulus and epilepsy has taken a new direction in the light of the most recent epidemic of nodding syndrome. OBJECTIVE: To document MRI changes in people with different types of epilepsy and investigate whether there is an association with O. volvulus infection. METHODS: In a prospective study in southern Tanzania, an area endemic for O. volvulus with a high prevalence of epilepsy and nodding syndrome, we performed MRI on 32 people with epilepsy, 12 of which suffered from nodding syndrome. Polymerase chain reaction (PCR) of O. volvulus was performed in skin and CSF. RESULTS: The most frequent abnormalities seen on MRI was atrophy (twelve patients (37.5%)) followed by intraparenchymal pathologies such as changes in the hippocampus (nine patients (28.1%)), gliotic lesions (six patients (18.8%)) and subcortical signal abnormalities (three patients (9.4%)). There was an overall trend towards an association of intraparenchymal cerebral pathologies and infection with O. volvulus based on skin PCR (Fisher's Exact Test p=0.067) which was most pronounced in children and adolescents with nodding syndrome compared to those with other types of epilepsy (Fisher's Exact Test, p=0.083). Contrary to skin PCR results, PCR of CSF was negative in all patients. CONCLUSION: The observed trend towards an association of intraparenchymal cerebral pathological results on MRI and a positive skin PCR for O. volvulus despite negative PCR of CSF is intriguing and deserves further attention.