Examining the cost-effectiveness of baseline left ventricular function assessment among breast cancer patients undergoing anthracycline-based therapy.

BACKGROUND: There is a lack of consensus to guide which breast cancer patients require left ventricular function assessment (LVEF) prior to anthracycline therapy; the cost-effectiveness of screening this patient population has not been previously evaluated. METHODS: We performed a retrospective analysis of the Yale Nuclear Cardiology Database, including 702 patients with baseline equilibrium radionuclide angiography (ERNA) scan prior to anthracycline and/or trastuzumab therapy. We sought to examine associations between abnormal baseline LVEF and potential cardiac risk factors. Additionally, we designed a Markov model to determine the incremental cost-effectiveness ratio (ICER) of ERNA screening for women aged 55 with stage I-III breast cancer from a payer perspective over a lifetime horizon. RESULTS: An abnormal LVEF was observed in 2% (n = 14) of patients. There were no significant associations on multivariate analysis performed on self-reported risk factors. Our analysis showed LVEF screening is cost-effective with ICER of $45,473 per QALY gained. For a willingness-to-pay threshold of $100,000/ QALY, LVEF screening had an 81.9% probability of being cost-effective. Under the same threshold, screening was cost-effective for non-anthracycline cardiotoxicity risk of RR ≤ 0.58, as compared to anthracycline regimens. CONCLUSIONS: Age, preexisting cardiac risk factors and coronary artery disease did not predict a baseline abnormal LVEF. While the prevalence of an abnormal baseline LVEF is low in patients with breast cancer, our results suggest that cardiac screening prior to anthracycline is cost-effective.

First annual Mario S. Verani, MD, Memorial lecture: clinical value of myocardial perfusion imaging in coronary artery disease.

I am honored to give this lecture in memory of Dr Mario S. Verani, a friend and a respected colleague in the field of nuclear cardiology. Dr Verani made many immense contributions to the field of nuclear cardiology during his lifetime. He was a pioneer in the field of pharmacologic stress imaging and played a leading role in validating the utility of intravenous adenosine infusion for stress imaging in detecting significant coronary stenoses and assessing prognosis. He and his colleagues at Baylor reported that pharmacologic stress imaging could separate high- and low-risk patient subsets after acute myocardial infarction, particularly among patients who underwent thrombolytic therapy. He informed us that certain drugs that patients took could influence perfusion defect severity. This work led to a clinical study showing that ischemic defect size could be substantially reduced with medical therapy in patients who had recently had an acute infarction. An outcome of this observation was the launching of the INSPIRE (adenosINe technetium-99m Sestamibi single-photon emission computed tomography Post-InfaRction Evaluation) trial in which postinfarction patients are randomized to medical therapy or revascularization. Dr Verani was an able debater when assigned the position for advocating for stress radionuclide perfusion imaging against stress echocardiography. He engaged in these debates with substantial knowledge but always with a touch of humor. Dr Verani's courage was an inspiration to all of us during his illness. His legacy as a pioneer will endure as the field of nuclear cardiology continues to mature and expand.

Clinical and economic impact of multiple gated acquisition scan monitoring during anthracycline therapy.

The clinical and economic impacts of monitoring cardiac function in patients given doxorubicin have yet to be determined, especially in relation to patient age, cumulative doxorubicin dose, and the relative efficacies of doxorubicin-based vs alternative regimens. We developed a decision analysis model that includes these factors to estimate the incremental survival benefit and cost-effectiveness of using multiple gated acquisition scans to measure left-ventricular ejection fraction before and during doxorubicin chemotherapy. Probability distributions for the incidences of abnormal left-ventricular ejection fraction findings and congestive heart failure were derived from a retrospective review of 227 consecutive cases at The University of Michigan Medical Center and published findings. Multiple gated acquisition-scan monitoring minimally improved the probability of 5-year survival (<1.5% in the base--case scenario). For patients who received up to 350 mg m(-2) of doxorubicin, multiple gated acquisition-scan screening had an incremental cost of $425 402 per life saved for patients between the ages of 15--39. This incremental cost markedly decreased to $138 191, for patients between the ages of 40--59, and to $86 829 for patients older than 60 years. The small gain in 5-year survival probability secondary to multiple gated acquisition scan monitoring doubled for all age groups when the average cumulative dose for doxorubicin reached 500 mg m(-2). Variations in the cure rate differences between the doxorubicin and alternative regimens had insignificant effects on the improvement in 5-year survival rates from multiple gated acquisition-scan screening. The use of multiple gated acquisition scans for pretreatment screening appears to be more cost-effective for patients who are 40 years or older, when cumulative doxorubicin dose is 350 mg m(-2) or less.

Role of nuclear cardiology in the evaluation of acute coronary syndromes.

Over the last 20 years, nuclear cardiology has become a mainstay in the evaluation of ischemic heart disease. In the setting of acute coronary syndromes (myocardial infarction or unstable angina), myocardial perfusion imaging has emerged as an important tool in assessing the functional significance of angiographic coronary stenoses, evaluating the efficacy of therapeutic interventions, and risk-stratifying patients in the postinfarction period. Recent literature has demonstrated the diagnostic and prognostic value, as well as the cost-effectiveness, of perfusion imaging in acute chest pain syndromes and the diagnostic superiority of perfusion imaging compared with two-dimensional echocardiography. Acute perfusion imaging is now being included in the algorithm for the triage and management of acute chest pain syndromes. Emergency physicians are increasingly using nuclear cardiac imaging modalities for aid in the evaluation of patients who present with chest pain of uncertain origin.

Prior restraint: a Bayesian perspective on the optimization of technology utilization for diagnosis of coronary artery disease.

In conclusion, at least 1/3 of patients with suspected coronary artery disease are inappropriately referred for scintigraphic diagnostic testing from a Bayesian such as those described in this report, may be a powerful mechanism for encouraging more appropriate technology utilization while simultaneously controlling costs, and are thereby deserving of a formal prospective demonstration trial. However, since only half the patients currently being tested are referred for diagnostic purposes, analogous strategies must be developed with respect to prognostic and therapeutic evaluation.