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2.
Ann Hepatol ; 16(6): 901-908, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29055916

RESUMO

INTRODUCTION AND AIM: Previous studies found famine exposure was associated with a higher risk of metabolic syndrome (MetS). In the study, we investigated the relationship between Chinese famine exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in adult women. MATERIALS AND METHODS: Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014. Women were categorized into the following three groups: control, prenatally exposed, and postnatally exposed. Hepatic steatosis was diagnosed according to the guidelines established for the diagnosis and treatment of NAFLD. RESULTS: The prevalence rates of NAFLD among non-exposed, prenatally, and postnatally exposed women were 17.3, 23.0, and 22.9%, respectively. Pre-exposed and postnatally exposed women had higher risks of NAFLD, exhibiting ORs (95% CI) of 1.33 (1.04-1.70) and 1.26 (1.03-1.55), respectively. Prenatally, but not postnatally, exposed women had significantly higher risks of having abnormal alanine aminotransferase (ALT), with ORs of 1.30 (1.05-1.61). CONCLUSIONS: The results indicate a significant association between famine exposure in early life and the risk of NAFLD in adult women. Prenatally exposed women displayed higher risks of NAFLD and mild, moderate and severe steatosis.


Assuntos
Hepatopatia Gordurosa não Alcoólica/epidemiologia , Efeitos Tardios da Exposição Pré-Natal , Inanição/epidemiologia , Fatores Etários , Alanina Transaminase/sangue , Biomarcadores/sangue , Distribuição de Qui-Quadrado , China/epidemiologia , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , Hepatopatia Gordurosa não Alcoólica/diagnóstico , Razão de Chances , Gravidez , Prevalência , Prognóstico , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Índice de Gravidade de Doença , Fatores Sexuais , Fatores de Tempo
6.
Microbes Infect ; 4(13): 1369-77, 2002 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-12443902

RESUMO

The plant pathogen Phytophthora infestans causes late blight, a devastating disease on potato that led to the Irish potato famine during 1845-1847. The disease is considered a reemerging problem and still causes major epidemics on both potato and tomato crops worldwide. Theories on the origin of the disease based on an examination of the genetic diversity and structure of P. infestans populations and use of historic specimens to understand modern day epidemics are discussed.


Assuntos
Phytophthora/patogenicidade , Doenças das Plantas/história , Solanum tuberosum/microbiologia , Sequência de Bases , DNA Mitocondrial/genética , DNA Ribossômico/genética , Surtos de Doenças/história , História do Século XIX , História do Século XX , Humanos , Irlanda/epidemiologia , México , Dados de Sequência Molecular , Phytophthora/genética , Doenças das Plantas/microbiologia , Análise de Sequência de DNA , Inanição/epidemiologia , Inanição/história
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