The flavonoids luteolin and quercetagetin inhibit lipoteichoic acid actions on H9c2 cardiomyocytes.

Dental focal infections are infections in the mouth that cause subsequent infection and symptoms in other parts of the body. Dental conditions such as periodontitis have been associated with coronary heart disease. In this study, we investigated the effect of flavonoids on activation of mitogen-activated protein kinase (MAPK) family members, protein kinase B (AKT), and IL-1 beta expression by rat heart embryonic (H9c2) cells upon stimulation with LTA. Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression. Our findings indicate that flavonoids interfere with LTA signal transduction.

[Level of lysozyme in saliva of patients suffering from dental infection and treated with herbal drugs]. / Ocena stezenia lizozymu w slinie w przebiegu terapii zapalen zebopochodnych lekiem naturalnym.

The aim of this study was to examine the level of lysozyme in saliva of the 17 patients with dental infections treated with herbal drug applied locally. Mixed, unstimulated saliva samples were taken tree times; group 1--before treatment, group 2--3-4 days and group 3--14 days after the treatment had been started. The data were compared with 30 healthy controls. The level of lysozyme was measured according to ELISA method. The statistical analysis (t-Student test) showed differences between examined groups and the control with no significance. Statistically significant differences were between men and women, depending on age. The results suggested that the stimulation of immunological system can be observed in course of the treatment with herbal drug.