RESUMO
For a long time, corynebacteria were considered simple cutaneous contaminants with little potential pathogenicity. Corynebacterium striatum is a known saprophytic cutaneous bacterium; however, in the last decade, this organism has been increasingly recognized as a pathogen. It has been mostly implicated in respiratory tract and blood infections. To our knowledge, we report the first case of meningitis due to C. striatum. Treatment with intravenous vancomycin resulted in therapeutic success. We also thoroughly review all previously reported cases of C. striatum infection. Identification of Corynebacterium species can be difficult because of rapid taxonomic changes, and susceptibility testing for these microorganisms is not yet standardized. However, because of their growing clinical importance, data on these bacteria are accumulating.
Assuntos
Infecções por Corynebacterium , Corynebacterium/isolamento & purificação , Meningites Bacterianas , Adulto , Corynebacterium/efeitos dos fármacos , Infecções por Corynebacterium/líquido cefalorraquidiano , Infecções por Corynebacterium/tratamento farmacológico , Infecções por Corynebacterium/microbiologia , Infecções por Corynebacterium/fisiopatologia , Humanos , Injeções Intravenosas , Masculino , Meningites Bacterianas/líquido cefalorraquidiano , Meningites Bacterianas/tratamento farmacológico , Meningites Bacterianas/microbiologia , Meningites Bacterianas/fisiopatologia , Testes de Sensibilidade Microbiana , Vancomicina/uso terapêuticoRESUMO
We report the case of a neonate who developed ventriculitis following insertion of a ventriculoperitoneal shunt. Corynebacterium xerosis was isolated from CSF and from the tip of the catheter after it was removed. The isolate was resistant to multiple antibiotics, but the infant responded to treatment with vancomycin.
Assuntos
Infecções por Corynebacterium/líquido cefalorraquidiano , Derivação Ventriculoperitoneal/efeitos adversos , Ciprofloxacina/uso terapêutico , Infecções por Corynebacterium/tratamento farmacológico , Infecções por Corynebacterium/microbiologia , Resistência Microbiana a Medicamentos , Contaminação de Equipamentos , Humanos , Recém-Nascido , Masculino , Especificidade da Espécie , Vancomicina/uso terapêuticoRESUMO
A 4-week-old female was hospitalized because of vomiting, irritability, and nuchal rigidity. A spinal fluid culture yielded Corynebacterium aquaticum. The diagnosis of C. aquaticum meningitis in this infant was supported by the following cerebrospinal fluid findings: Gram stain, elevated protein, hypoglycorrhachia, positive C-reactive protein, and polymorphonuclear leukocytosis. Antigen studies for common bacterial causes of meningitis were negative. C. aquaticum is a rare cause of human disease and may be initially confused with Listeria monocytogenes, which is a more common gram-positive, motile rod associated with meningitis in infants.
