RESUMO
Capillaria hepatica (syn. for Calodium hepaticum) is a zoonotic nematode parasitizing in the livers of rodents as main hosts and in numerous other mammals including humans. It is the causative agent of the rare conditions of hepatic capillariosis and spurious C. hepatica infections in humans. In this review, 163 reported cases of infestations with this parasite (72 reports of hepatic capillariosis, 13 serologically confirmed infestations and 78 observations of spurious infections) are summarized with an overview on the distribution, symptoms, pathology, diagnosis, serology and therapy of this rare human pathogen.
Assuntos
Capillaria/fisiologia , Infecções por Enoplida , Hepatomegalia/parasitologia , Estágios do Ciclo de Vida/fisiologia , Fígado/parasitologia , Doenças dos Roedores , Adulto , África , Animais , Anti-Helmínticos/administração & dosagem , Anti-Helmínticos/uso terapêutico , Anticorpos Anti-Helmínticos/análise , Anticorpos Anti-Helmínticos/imunologia , Biópsia , Capillaria/efeitos dos fármacos , Criança , Pré-Escolar , Reservatórios de Doenças , Infecções por Enoplida/diagnóstico , Infecções por Enoplida/epidemiologia , Infecções por Enoplida/imunologia , Infecções por Enoplida/mortalidade , Infecções por Enoplida/parasitologia , Infecções por Enoplida/patologia , Infecções por Enoplida/fisiopatologia , Infecções por Enoplida/terapia , Ensaio de Imunoadsorção Enzimática , Europa (Continente) , Feminino , Hepatomegalia/imunologia , Hepatomegalia/patologia , Hepatomegalia/fisiopatologia , Humanos , Lactente , Estágios do Ciclo de Vida/efeitos dos fármacos , Fígado/imunologia , Fígado/patologia , Fígado/fisiopatologia , Masculino , América do Norte , Filogeografia , Doenças dos Roedores/diagnóstico , Doenças dos Roedores/epidemiologia , Doenças dos Roedores/imunologia , Doenças dos Roedores/mortalidade , Doenças dos Roedores/parasitologia , Doenças dos Roedores/patologia , Doenças dos Roedores/fisiopatologia , Roedores , América do Sul , Taxa de Sobrevida , Tomografia Computadorizada por Raios XRESUMO
Capillaria philippinensis is an emerging infection in Egypt. Reports in children are scarce. We report here two sisters with C. philippinensis infection, aged 8 and 12 years. Their father was a fisherman and they had a habit of picking small pieces of uncooked fish to eat while their mother prepared their meals. They came from El-Menia governorate, which lies in the northern part of Upper Egypt. Most reported cases from Egypt come from this governorate and nearby areas. Both sisters had persistent profuse watery diarrhea of 12 months' duration. Their weights were below the 5th percentile for age. Both were hypoalbuminemic, but only the younger had pedal edema. Both had hypokalemia and hyponatremia. During the course of their illness they were repeatedly admitted to different hospitals and received intravenous fluids, but the correct diagnosis was not reached. Diagnosis was made by stool examination at our hospital when eggs and larvae were detected in stool samples. Although a diagnosis was promptly made, the older sister who suffered from pneumonia and septic shock unfortunately died a few days after admission. The younger sister was treated successfully with albendazole 200 mg twice daily. Diarrhea abated, pedal edema disappeared, and she started to gain weight.