Assuntos
Interferons/história , Interferons/imunologia , Interferência Viral/imunologia , Animais , Embrião de Galinha , Membrana Corioalantoide/imunologia , Membrana Corioalantoide/metabolismo , Membrana Corioalantoide/virologia , História do Século XX , Temperatura Alta , Vírus da Influenza A/imunologia , Interferons/metabolismoAssuntos
Interferons/história , Interferons/imunologia , Interferência Viral/imunologia , Animais , Embrião de Galinha , Membrana Corioalantoide/imunologia , Membrana Corioalantoide/metabolismo , Membrana Corioalantoide/virologia , História do Século XX , Temperatura Alta , Vírus da Influenza A/imunologia , Interferons/metabolismo , Vírus da Doença de Newcastle/imunologia , Estabilidade Proteica , Vírus Sendai/imunologia , Vacínia/imunologiaRESUMO
In 1957, the discovery of interferon was reported by Isaacs and Lindenmann in the prestigious journal Proceedings of the Royal Society (1957) [1,2]. This discovery was definitely one of the scientific landmarks in cell biology of the past century. It was the result of an initially unplanned and amazingly creative collaboration with Alick Isaacs that lasted from July 1956 to June 1957 at Mill Hill in London. Jean Lindenmann died in Zürich on January 15, 2015, at the age of 90, after having survived Alick Isaacs (1921-1967) for almost five decades.
Assuntos
Interferons/história , Croácia , Morte , História do Século XX , História do Século XXI , Humanos , SuíçaAssuntos
Interferons , Vírus , França , História do Século XX , História do Século XXI , Interferons/história , Estados UnidosRESUMO
A brief discussion is devoted to the 55-year long history of interferons and the contribution of domestic researchers to the study of this problem.
Assuntos
Interferons , História do Século XX , História do Século XXI , Humanos , Interferons/genética , Interferons/história , Interferons/metabolismoAssuntos
Fibroblastos/metabolismo , Interferons/isolamento & purificação , Animais , Clonagem Molecular , Eletroforese , História do Século XX , Humanos , Interferons/história , Interferons/imunologia , Células L , Camundongos , Infecções por Vírus de RNA/imunologia , Proteínas Recombinantes , RhinovirusRESUMO
Molecular biological peculiarities of interferon system function in PV-infected persons have been found. It is evident that the interferon production, anti-inflammatory cytokines and their receptors and also defensines play an important role in the mechanism of virus interaction with sensitive cells of macroorganism with development of pathological process. The new conception of expediency for the use of interferons and their inducers as the polyfunctional regulators with a broad spectrum of activity for the treatment of PV-infected patients was suggested. Patents for the method of treatment of PV-infected patients were obtained. New inducers of interferon as well as recombinant IFN-alpha-2b was developed. Our results were introduced in the medical practice.
Assuntos
Antivirais , Interferons , Infecções por Papillomavirus , Academias e Institutos/história , Animais , Antivirais/história , Antivirais/farmacologia , Antivirais/uso terapêutico , História do Século XX , História do Século XXI , Humanos , Interferons/biossíntese , Interferons/história , Interferons/uso terapêutico , Microbiologia/história , Infecções por Papillomavirus/tratamento farmacológico , Infecções por Papillomavirus/imunologia , Infecções por Papillomavirus/metabolismo , Ucrânia , Virologia/históriaRESUMO
The collaboration between Alick Isaacs and myself started in the summer of 1956. Our initial project was to show, by electron microscopy, that interference between inactivated influenza virus and live virus involved the transfer of material from the interfering virus to the host cell. This approach failed for technical reasons. However, in the course of this work it appeared that more interfering activity remained in the system than we were entitled to expect. One possible explanation was that a substance, not identical with the initial interfering virus, was being generated. Subsequent experiments, aimed at checking this hypothesis, led to the description of interferon.
