1.
Bioorg Med Chem Lett
; 12(11): 1477-80, 2002 Jun 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12031323
RESUMO
SAR studies on the stereoisomers of CP-470,711 suggested that in vivo epimerization was taking place in rats. Further metabolism studies revealed that no epimerization was occurring in dogs, and that no epimerization was expected in humans. A mechanism for the in vivo epimerization is proposed involving an oxidation-reduction pathway of the secondary benzylic alcohol, in contrast to an acid/base-promoted epimerization of the same center during chemical synthesis.