U-Shaped Relationship of Rare Earth Element Lanthanum and Oral Cancer Risk: A Propensity Score-Based Study in the Southeast of China.

As an important rare earth element (REE) extensively applied to industry, agriculture, and medicine, lanthanum (La) has attracted a host of health concerns. This study aimed to explore the relationship between La exposure and the risk of developing oral cancer through a case-control study with a large sample size. Serum La levels of 430 oral cancer patients and 1,118 healthy controls were detected by inductively coupled plasma mass spectrometry (ICP-MS). The association of La level with the risk of oral cancer was assessed in two ways: (1) as a continuous scale based on restricted cubic splines (RCS); (2) as a priori defined centile categories using multivariate logistic regression model, based on propensity score matching (PSM) and inverse probability of treatment weighting (IPTW). The RCS revealed a non-linear U-shaped relationship between serum La and oral cancer risk. Serum La deficiency or excess was associated with an increased risk of oral cancer. When the La level was analyzed as a categorical variable, a similar U-shaped association was observed. Of note, compared to those with La concentrations of 0.243-0.341 µg/L (reference quantiles, 41st-60th), the risk was increased in those with the lower or higher quantiles (0.132-0.242 µg/L vs. 0.243-0.341 µg/L: OR = 1.80, 95%CI: 1.07-3.02; 0.342-0.497 µg/L vs. 0.243-0.341 µg/L: OR = 2.30, 95%CI: 1.38-3.84). The results were generally consistent with the PSM and IPTW analyses. This preliminary study provides strong evidence that there was a U-shaped relationship between serum La levels and oral cancer risk. Much additional work is warranted to confirm our findings.

Lanthanum and Gadolinium availability in aquatic mediums: New insights to ecotoxicology and environmental studies.

Studies dealing with Rare Earth Elements (REE) ecotoxicological behavior are scattered and with potential conflicting results. Climate change impacts on aquatic biota and is known to modify contaminants toxicokinetic. Nevertheless, the current knowledge on the potential interactions between climate change and REE is virtually non-existent. Therefore, we focus our research on La and Gd as representatives of Light and Heavy REE that also are of great environmental concern. Experiments on different mediums (fresh-, brackish- and seawater) were designed to run at present-day and near-future conditions (T°=+4 °C, pH=△-0.4). Sampling was taken at different time scales from minutes to hours for one day. The main challenge was to evaluate the availability of La and Gd under environmental conditions closely related to climate changes scenarios. Furthermore, this study will contribute to the baseline knowledge by which future research towards understanding REE patterns and toxicity will build upon. Lanthanum and Gd behave differently with salinity. Temperature also affects the availability of dissolved La in freshwater. On the other hand, pH reduction causes the decrease of Gd in freshwater. In this medium, concentrations reduce sharply, presumably due to sorption processes or precipitates. In the brackish water experiment only the dissolved La levels in the Warming (T°=+4 °C) and Warming & Acidification (T°=+4 °C, pH=△0.4) diminished significantly through time. Dissolved La and Gd levels in seawater were relatively constant with time. The speciation of both elements is also of great relevance for ecotoxicological experiments. The trivalent free ions (La3+ and Gd3+) were the most common species in the trials. However, as ionic strength increases, the availability of other complexes rose, which should be subject of great attention for upcoming ecotoxicological studies.

The combined effects of macrophytes (Vallisneria denseserrulata) and a lanthanum-modified bentonite on water quality of shallow eutrophic lakes: A mesocosm study.

Establishment of submerged macrophyte beds and application of chemical phosphorus inactivation are common lake restoration methods for reducing internal phosphorus loading. The two methods operate via different mechanisms and may potentially supplement each other, especially when internal phosphorous loading is continuously high. However, their combined effects have so far not been elucidated. Here, we investigated the combined impact of the submerged macrophyte Vallisneria denseserrulata and a lanthanum-modified bentonite (Phoslock®) on water quality in a 12-week mesocosm experiment. The combined treatment led to stronger improvement of water quality and a more pronounced reduction of porewater soluble reactive phosphorus than each of the two measures. In the combined treatment, total porewater soluble reactive phosphorus in the top 10 cm sediment layers decreased by 78% compared with the control group without Phoslock® and submerged macrophytes. Besides, in the upper 0-1 cm sediment layer, mobile phosphorus was transformed into recalcitrant forms (e.g. the proportion of HCl-P increased to 64%), while in the deeper layers, (hydr)oxides-bound phosphorus species increased 17-28%. Phoslock®, however, reduced the clonal growth of V. denseserrulata by 35% of biomass (dry weight) and 27% of plant density. Our study indicated that Phoslock® and submerged macrophytes may complement each other in the early stage of lake restoration following external nutrient loading reduction in eutrophic lakes, potentially accelerating the restoration process, especially in those lakes where the internal phosphorus loading is high.

Arbuscular mycorrhizal fungi alter microbiome structure of rhizosphere soil to enhance maize tolerance to La.

Rhizosphere microbes are essential partners for plant stress tolerance. Recent studies indicate that arbuscular mycorrhizal fungi (AMF) can facilitate the revegetation of soils contaminated by heavy metals though interacting with rhizosphere microbiome. However, it is unclear how AMF affect rhizosphere microbiome to improve the growth of plant under rare earth elements (REEs) stress. AMF (Claroideoglomus etunicatum) was inoculated to maize grown in soils spiked with Lanthanum (0 mg kg-1, La0; 10 mg kg-1, La10; 100 mg kg-1, La100; 500 mg kg-1, La500). Plant biomass, nutrient uptake, REE uptake and rhizosphere bacterial and fungal community were evaluated. The results indicated that La100 and La500 decreased significantly root colonization rates and nutrition uptake (K, P, Ca and Mg content). La500 decreased significantly α-diversity indexes of bacterial and fungal community. AMF enhanced significantly the shoot and root fresh and dry weight of maize in all La treatments (except for the root fresh and dry weight of La0 and La10 treatment). For La100 and La500 treatments, AMF increased significantly nutrition uptake (K, P, Ca and Mg content) in shoot of maize by 27.40-441.77%. For La500 treatment, AMF decreased significantly shoot La concentration by 51.53% in maize, but increased significantly root La concentration by 30.45%. In addition, AMF decreased bacterial and fungal Shannon index in La0 treatment, but increased bacterial Shannon index in La500 treatment. Both AMF and La500 affected significantly the bacterial and fungal community composition, and AMF led to more influence than La. AMF promoted the enrichment of bacteria, including Planomicrobium, Lysobacter, Saccharothrix, Agrococcus, Microbacterium, Streptomyces, Penicillium and other unclassified genus, and fungi (Penicillium) in La500, which showed the function for promoting plant growth and tolerance of heavy metal. The study revealed that AMF can regulate the rhizosphere bacterial and fungal composition and foster certain beneficial microbes to enhance the tolerance of maize under La stress. Phytoremediation assisted by AMF is an attractive approach to ameliorate REEs-contaminated soils.

Deposition patterns of iatrogenic lanthanum and gadolinium in the human body depend on delivered chemical binding forms.

BACKGROUND: Recently, gadolinium from linear GBCAs has been reported to deposit in various regions of the body. Besides gadolinium, other lanthanides are used in medical care. In the current study, we investigated deposition of lanthanum in two patients who received lanthanum carbonate as a phosphate binder due to chronic kidney injury and compared it to additionally found Gd deposition. METHODS: Tissue specimens of two patients with long-term application of lanthanum carbonate as well as possible GBCA application were investigated. Spatial distribution of gadolinium and lanthanum was determined by quantitative laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) imaging of tissue sections. The deposition of gadolinium and lanthanum in different organs was compared, and the ratio of Gd concentration to La concentration (Gd-to-La-ratio) was investigated on an individual pixel base within the images. RESULTS: Deposition of Gd and La was found in all investigated tissues of both patients. Gd and La exhibited high spatial correlation for all samples, with the main deposition being located in the middle coat (tunica media) of blood vessels. The Gd-to-La-ratio was similar in the tissues investigated (between 8 ±â€¯4 (mean ±â€¯standard deviation) and 10 ±â€¯2), except for the thyroid vasculature and surrounding tissue (90 ±â€¯17) as well as the cerebellum (270 ±â€¯18). Here, the ratio was significantly increased towards higher Gd concentration. CONCLUSION: The results of this study demonstrate long-term deposition of La and comparable localization of additionally found Gd in various tissues of the body. La deposition was relatively low, considering the total administered amount of lanthanum carbonate of up to 11.5 kg, indicating a low absorption and/or high excretion of lanthanum. However, the total amount of deposited La is significant and raises questions about possible adverse side effects. The ratio-approach allows for the usage of the additionally generated Gd data, without detailed knowledge about possible GBCA applications. The significantly decreased Gd-to-La-ratio in the brain might be explained by the lanthanum being released and taken up as free La3+ ion in the stomach that impedes a crossing of the blood-brain-barrier while the intravenously injected GBCAs might dechelate first when they have already crossed the blood-brain-barrier.

Rare earth elements in umbilical cord and risk for orofacial clefts.

Questions remain about the effects of rare earth elements (REEs) on reproductive health, and no study has explored in utero exposure to REEs and risk of orofacial clefts (OFCs). We recruited subjects from a case-control study conducted in Shanxi Province, China. Concentrations of fifteen REEs were quantified in umbilical cord samples by means of Inductively Coupled Plasma Mass Spectrometry measurements. We employed logistic regression and weighted quantile sum (WQS) regression models to estimate the association between REEs exposures and OFCs. Of 226 subjects included in our study, 34 were cleft lip only, 44 were cleft lip with cleft palate and 6 were cleft palate only. In the logistic regression model, concentrations above the median of all subjects were associated with an increased OFCs risk of 2.35-fold (95% CI: 1.22, 4.53) for Lanthanum and 2.12-fold for Neodymium (95% CI: 1.10, 4.10) adjusting for maternal age, BMI, gestational weeks, sex of infants and passive smoking. In WQS model, a quartile increase in the index resulting in an increase of 3.10 (95% CI: 1.38, 6.96) in the odds of OFC. Lanthanum and Neodymium were suggested to be important factors. The results were largely consistent for OFC subtypes. In conclusion, in utero exposure to mixtures of REEs increased the risk of OFCs. Lanthanum and Neodymium were likely to be important factors in the development of OFCs.

La, Ce and Nd in the soil-plant system in a vegetation experiment with barley (Hordeum vulgare L.).

Rare earth elements (REEs) have received enormous attention in recent years. However, there are many gaps in the understanding of their behavior in the soil-plant system. The aim of this study is to investigate the behavior of three most common REEs (La, Ce, Nd) in the soil-plant system directly on soil samples using barley (Hordeum vulgare L.) in a vegetation experiment. We attribute the absence of significant changes in plant biomass and photosynthetic pigment content to the reduced availability of REEs in soil samples. The concentration of water-soluble forms of La, Ce and Nd didn't exceed 1 mg/kg, while the concentration of exchangeable forms varied and decreased in a row La > Ce > Nd. The transfer factor (TF) from soil to above-ground biomass was low for all three elements (<1). The stem-to-leaf TF increased with the increase in REEs concentration in soil. The concentration in plant material increased in the row Ce < Nd < La. REEs concentrations in barley leaves didn't exceed 1-3% of the corresponding element concentration in soil samples. REEs concentration in plant tissues is in close direct correlation with the REEs total concentration in soil, water-soluble and exchange forms. REEs concentration in barley leaves is 3-4 times higher than in the stems and for the group with extraneous concentration of 200 mg/kg for La, Ce and Nd was 6.20 ± 1.48, 2.10 ± 0.51, 6.90 ± 3.00 mg/kg, respectively. We show that there were no major changes in barley plants, but further study is needed of the relationship between the absorption of lanthanides by plants and the content of various forms of lanthanides in the soil.

Recovery of Lanthanum(III) and Nickel(II) Ions from Acidic Solutions by the Highly Effective Ion Exchanger.

The recovery of La(III) and Ni(II) ions by a macroporous cation exchanger in sodium form (Lewatit Monoplus SP112) has been studied in batch experiments under varying HNO3 concentrations (0.2-2.0 mol/dm3), La(III) and Ni(II) concentrations (25-200 mg/dm3), phase contact time (1-360 min), temperature (293-333 K), and resin mass (0.1-0.5 g). The experimental data revealed that the sorption process was dependent on all parameters used. The maximum sorption capacities were found at CHNO3 = 0.2 mol/dm3, m = 0.1 g, and T = 333 K. The kinetic data indicate that the sorption followed the pseudo-second order and film diffusion models. The sorption equilibrium time was reached at approximately 30 and 60 min for La(III) and Ni(II) ions, respectively. The equilibrium isotherm data were best fitted with the Langmuir model. The maximum monolayer capacities of Lewatit Monoplus SP112 were equal to 95.34 and 60.81 mg/g for La(III) and Ni(II) ions, respectively. The thermodynamic parameters showed that the sorption process was endothermic and spontaneous. Moreover, dynamic experiments were performed using the columns set. The resin regeneration was made using HCl and HNO3 solutions, and the desorption results exhibited effective regeneration. The ATR/FT-IR and XPS spectroscopy results indicated that the La(III) and Ni(II) ions were coordinated with the sulfonate groups.

Effects of the dialysate calcium concentrations and mineral bone disease treatments on mortality in The French Renal Epidemiology and Information Network (REIN) registry.

BACKGROUND: In patients on hemodialysis (HD), the various chemical elements in the dialysate may influence survival rates. In particular, calcium modifies mineral and bone metabolism and the vascular calcification rate. We studied the influence of the dialysate calcium concentration and the treatments prescribed for mineral bone disease (MBD) on survival. METHODS: All patients in REIN having initiated HD from 2010 to 2013 were classified according to their exposure to the different dialysate calcium concentrations in their dialysis unit. Data on the individual patients' treatments for MBD were extracted from the French national health database. Cox proportional hazard models were used to estimate mortality hazard ratios (HR) associated with time-dependent exposure to dialysate calcium concentrations and MBD therapies, adjusted for comorbidities, laboratory and technical data. RESULTS: Dialysate calcium concentration of 1.5 mmol/L was used by 81% of the dialysis centers in 2010 and in 83% in 2014. Most centers were using several formulas in up to 78% for 3 formulas in 2010 to 86% in 2014. In full adjusted Cox survival analyses, the percentage of calcium >1.5 mmol/L and <1.5 mmol/l by center and the number of formula used per center were not associated with survival. Depending on the daily dose used, the MBD therapies were associated with survival improvement for calcium, native vitamin D, active vitamin D, sevelamer, lanthanum and cinacalcet in the second and third tertiles of dose. CONCLUSION: No influence of the dialysate calcium concentration was evidenced on survival whereas all MBD therapies were associated with a survival improvement depending on the daily dose used.

Effective extraction and recovery of rare earth elements (REEs) in contaminated soils using a reusable biosurfactant.

Tea saponin (TS), a plant derived biosurfactant, was used to investigate on its effectiveness on the extraction of three typically selected rare earth elements (REEs, light lanthanum (La), medium arrowhead (Dy) and heavy erbium (Er)) from contaminated soils, in the presence of important toxic heavy metals (lead (Pb) and cadmium (Cd)). A complete procedure, involving the extraction of REEs in soils, the recovery of REEs and TS in the extraction leachates and the reuse of the recovered TS, was established. Experimental results showed that the optimal extraction parameters were consumption of 1.2 g/g (TS/soil), pH of 5 and the extraction time of 24 h. The recovery efficiencies of La, Dy, Er, Cd and Pb achieved 96.9%, 88%, 84.3%, 88% and 91.1% using 0.3 g/g (Ca(OH)2/soil). The overall extraction efficiencies of La, Dy, Er, Cd and Pb were 53.9%, 73.2%, 71.7%, 95.9% and 38.8% by three times using the recovered TS solution. The extractable fractions of La, Dy, Er, Cd and Pb in soil were found to be highest in their acid soluble and reducible forms. Mechanisms studies indicated the increased binding strength (IR) and the decreased mobility (MF) of REEs and metals after the flushing with TS. Carboxyl groups in TS were attributed to the formation of complexation and agglomeration between TS and studied REEs and other metals, confirmed by the analysis of both the X-ray photoelectron spectroscopy (XPS) and the dynamic light scattering (DLS). This study established an environmentally-friendly contaminated soil remediation and the recovery of valuable REEs by the combination use of TS and calcium hydroxide.

Investigating coherent normalization and dosimetry for the 241Am-La K XRF system.

OBJECTIVES: Lanthanum (La) retention in bone has been shown to occur in individuals who are orally administered lanthanum carbonate (LaC), a drug to treat hyperphosphatemia. The breakdown of LaC in the gastrointestinal tract into La3+ and carbonate ions results in residual quantities of La being deposited in bone. We previously reported on a non-invasive x-ray fluorescence (XRF) system that was developed to quantify bone La concentrations and applied it to a series of excised cadaver tibiae. However, given interpatient variability in bone shape and size, differential signal attenuation that occurs in bone and tissue, patient movement and overlying tissue thickness at the measurement site, quantifying bone La concentrations during in vivo measurements in live subjects needs to be investigated further along with the radiation dose associated with the measurement. APPROACH: Coherent normalization was investigated as a function of overlying tissue thickness, source-subject distance and bone radius through Monte Carlo simulation and experimental work. This was accomplished by observing the ratio of the net La K x-ray peak area to the coherently scattered peak area at 59.5 keV. In addition, the dose delivered during a 2000 s measurement was determined using radiochromic film. MAIN RESULTS: The coherent normalization of the La x-ray signal was shown to be independent of overlying tissue thickness, source-subject movement and bone radius, which indicates that this normalization procedure can correct for these factors. The equivalent skin dose and effective dose were 18.0 mSv and 3.2 µSv, respectively for a five-year-old. SIGNIFICANCE: While coherent normalization for the bone lead (Pb) and bone gadolinium (Gd) systems has been shown to be successful, we also report that this normalization procedure can correct for these interpatient variabilities in the in vivo 241Am-La K XRF system.

Effects of exogenous lanthanum(III) exposure on the positive interaction between mutually beneficial populations.

Rare earth elements (REEs) are widely used in various fields, and their accumulation has been reported to pose environmental risks. Most studies confirmed the damage of excessive REE exposure to individual plants; however, little attention has been given to their effects on plant populations. A positive interaction indicates a mutually beneficial relationship between two populations, which is beneficial to the survival and growth of the populations. However, it remains unknown whether exogenous REEs affect the positive interactions between populations. This study investigated the effects of exogenous lanthanum(III) [La(III)] exposure on the positive interaction between soybean (Glycine max L.) and wheat (Triticum aestivum L.) populations by their modules. At normal nutrient level (½-strength Hoagland), the inhibition of excessive La(III) on population modules decreased with increasing population density. Decreases of 39.26 to 1.05% for soybean and 41.45 to 2.41% for wheat indicated the inhibition of La(III) on the positive interaction of both populations weakened with increasing population density. At low nutrient level (»-strength Hoagland), the inhibition of excessive La(III) on population modules increased with increasing population density. Decreases of 5.82-57.14% for soybean and 4.22-59.04% for wheat indicated the inhibition of La(III) on the positive interaction of both population was strengthened with increasing population density. In summary, the inhibitory effects of exogenous La(III) exposure on the positive interaction between populations vary with both nutrient level and population density. This is a new factor that needs to be considered when evaluating the safety risks of REEs in the environment.

Investigative Analysis of Lanthanum Oxide Nanoparticles on Elements in Bone of Wistar Rats After 30 Days of Repeated Oral Administration.

Accumulation of lanthanum oxide nanoparticles (La2O3NPs) in the femur bone of rats after 30 days of oral administration was explored. Also, the influence of La2O3NPs on macro and trace elements in the rats' femur bone was assessed. Inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical spectrometry (ICP OES) were used for total element determination in the bone after decomposition while laser ablation-ICP-MS (LA-ICP-MS) was used to investigate element distribution (bio-imaging) in the bone. Some differences in element concentrations in the bone between the rats treated with La2O3NPs at 1.0 mg kg-1 (T1), 10.0 mg kg-1 (T2), and 100 mg kg-1 (T3) body weight (bw) and the control rats (CTR) were observed. More differences were observed in the bone of rat treated with 10.0 mg kg-1 La2O3NPs bw. However, the highest change observed was for Mg, which concentration ranged from 5230 ± 12 µg kg-1 for the CTR group to 4130 ± 138 µg kg-1 for the T3 group. Minor changes were observed for Ba, Ca, Cr, Cu, Fe, Mg, Na, Pb, Sr, and Zn between CTR and animals treated with La2O3NPs at the different levels of concentration. It was possible to observe from LA-ICP-MS analysis that La2O3NPs were accumulated only on the surface of the bone, not deeper than about 5 µm. LA-ICP-MS allowed also to investigate the distribution of La and the other elements in a cross section of the femur bone head, where higher amounts of the elements are present at the external part of the bone. Therefore, it was demonstrated that La2O3NPs are incorporated on the surface of the bone and it has a small influence on some of the other elements evaluated.

Distribution of lanthanum carbonate in the gastric mucosa confirmed by electron microscopy with a magnified endoscopy: a case report and literature review.

We describe the case of a 70-year-old man with diabetic nephropathy undergoing hemodialysis. Four years following hemodialysis, he started taking lanthanum carbonate 1500 mg/day and lansoprazole 30 mg/day. Nine years following hemodialysis, he underwent screening esophagogastroduodenoscopy, which demonstrated the presence of the whitish cobblestone-like mucosa in the gastric corpus and multiple reddish depressed lesions with annular whitish mucosa in the antrum. With magnified narrow-band imaging endoscopy, a yellowish-white substance was observed in the villous structure, and subepithelial vessels were observed on the yellowish-white substance. Biopsies were taken from the whitish cobblestone-like mucosa of the upper corpus, a reddish depressed part of the antrum. Histologically, aggregates of cells containing amphophilic fine granular material were found in the mucosal interstitium. These cells stained positive for CD68 and were identified as histiocytes. Since he had been taking lanthanum carbonate for 5 years, we considered the possibility of histiocyte-mediated phagocytosis of lanthanum. Digital mapping via scanning electron microscopy with energy-dispersive X-ray spectrometry showed the presence of lanthanum and phosphorus in the interstitium and cytoplasm of histiocytes. The white, rough mucosa in the gastric body appeared 6 months following the commencement of lanthanum administration and still exists 3 years and 5 months after discontinuation of lanthanum.

Robotic Dispersal Technique for 35 GBq of 140La in an L-polygon Pattern.

In 2018, Defence Research and Development Canada, in partnership with Natural Resources Canada, led a field trial of survey and mapping of a large dispersion of radioactivity using Unmanned Aerial Vehicles (UAVs). The intent was to disperse La material in a 3,200 m L-polygon with an approximate activity level of 10 MBq m and to measure the radioactive material using sensors carried by UAVs. Due to the potential radiological hazard to personnel, the activity was approved only if Unmanned Ground Vehicles (UGVs) were able to completely handle and disperse the material remotely. One UGV was equipped with a traditional agricultural sprayer to disperse the material, and one UGV was equipped with a force feedback manipulator arm. Due to the freezing temperatures during dispersal, the 35 GBq of La was dispersed non-uniformly as one sprayer boom failed to perform as tested. However, rough analysis of the electronic dosimetry on the UGV concluded that 99% of the material was dispersed on the ground. The dosimeter placed closest to the robot manipulator arm, used for dispersal of material, indicated a contact dose of 33.5 mSv. The electronic dosimeter placed where the driver would have sat on the sprayer vehicle if it were not unmanned indicated a dose of 22.3 mSv. Thus, the use of UGVs for material dispersion substantially reduced the external exposure to personnel. The use of UGVs eliminated the potential of internal exposure as well. The Radiation Safety Officer received the highest dose at approximately 3 µSv, with the majority of the exposure coming from the handling of the Type A container.

[Determination of samarium oxide and lanthanum oxide in the air of workplace by inductively coupled plasmamass spectrometry].

Objective: To establish a method for the determination ofsamarium oxide and lanthanum oxide by inductively coupled plasmamass spectrometryin the air of workplace. Methods: Samarium, lanthanum and their compounds in the air of workplace were collected through microporous filter. The samples were digested by nitricacid and perhydrol (V/V=4∶1) and detected by inductively coupled plasmamass spectrometry. Results: The linear range ofsamarium oxide and lanthanum oxide was 0-50.00 µg/L, Sm(2)O(3): y=0.0119x, r=0.9999; La(2)O(3): y=0.0617x, r=0.9998. The detection limits were less than 0.1 µg/L, and the minimum detection concentration were less than 1.52×10(-5) mg/m(3). The sampling efficiency were 100%, the recovery rates were 95.70%-102.01%, and the precision were 0.78%-1.58%. Conclusion: The indicators established in this study are conformed with the requirements of Chinese Occupational Standars of GBZ/T 210.4-2008, "The Guidelines for the Development of Occupational Hygiene StandarsMehods Part 4: Determination of Chemical Substances in the Air of Workplace".

Ex vivo quantification of lanthanum and gadolinium in post-mortem human tibiae with estimated barium and iodine concentrations using K x-ray fluorescence.

OBJECTIVES: Lanthanum (La) and gadolinium (Gd) are known to deposit in bone of exposed populations, namely those who are orally administered lanthanum carbonate (LaC, La2(CO3)3) or are injected with Gd-based contrast agents, respectively. In this work, bone La and Gd concentrations from the environment and diet were measured using x-ray fluorescence in ten post-mortem human tibiae. As a secondary objective, bone barium (Ba) and iodine concentrations were estimated. APPROACH: Two calibration lines were produced for La and Gd and the minimum detection limits (MDLs) of the system were determined using a 180° irradiation-detection geometry. MAIN RESULTS: The MDLs of the system were 0.4 µg La g-1 bone mineral and 0.5 µg Gd g-1 bone mineral. The mean concentrations were -0.02 ± 0.1 µg La g-1 bone mineral and 0.1 ± 0.2 µg Gd g-1 bone mineral in tibiae. The average Ba and iodine concentrations estimated from the experimental La calibration line and Monte-Carlo derived sensitivity factors were determined to be 3.4 ± 0.8 µg Ba g-1 bone mineral and -0.5 ± 0.3 µg iodine g-1 bone mineral. Since it was discovered that four donors previously received an iodine-based contrast agent, the mean concentrations in these donors was 27.8 ± 28.4 µg iodine g-1 bone mineral. SIGNIFICANCE: The XRF system has determined baseline concentrations of these four heavy metals in trace quantities from natural exposure pathways (with the exception of iodine in four donors). This indicates that the system can measure low levels in ex vivo tibiae samples and can potentially be further developed for in vivo studies involving live subjects who are directly exposed to these metals.

Simultaneous adsorption of lanthanum and yttrium from aqueous solution by durian rind biosorbent.

This paper presents the adsorption capacity of a biosorbent derived from the inner part of durian (Durio zibethinus) rinds, which are a low-cost and abundant agro-waste material. The durian rind sorbent has been successfully utilized to remove lanthanum (La) and yttrium (Y) ions from their binary aqueous solution. The effects of several adsorption parameters including contact time, pH, concentrations of La and Y, and temperature on the removal of La and Y ions were investigated. The adsorption isotherm and kinetics of the metal ions were also evaluated in detail. Both La and Y ions were efficiently adsorbed by the biosorbent with optimum adsorption capacity as high as 71 mg La and 35 mg Y per gram biosorbent, respectively. The simultaneous adsorption of La and Y ions follows Langmuir isotherm model, due to the favorable chelation and strong chemical interactions between the functional groups on the surface of the biosorbent and the metal ions. The addition of oxygen content after adsorption offers an interpretation that the rare-earth metal ions are chelated and incorporated most probably in the form of metal oxides. With such high adsorption capacity of La and Y ions, the durian rind sorbent could potentially be used to treat contaminated wastewater containing La and Y metal ions, as well as for separating and extracting rare-earth metal ions from crude minerals.

[Deposits of lanthanum in the gastric mucosa of a patient with chronic kidney disease]. / Depósito de lantano en la mucosa gástrica de paciente con enfermedad renal crónica.

Lanthanum carbonate is a non-calcium phosphorus chelator used in the treatment of hyperphosphatemia associated with chronic renal disease. Deposits of lanthanum in the gastrointestinal wall have been recently described but its clinical significance is uncertain. We present a case of a 62-year-old male with chronic renal disease treated with lanthanum carbonate for 3 years, with deposits in his gastric mucosa, found on biopsy for dyspepsia. The deposits were acellular and of irregular shape, surrounded by macrophages and foreign body giant cells. The presence of lanthanum in the deposits was confirmed by X-ray spectroscopy. Diagnosis is reached with knowledge of its microscopic appearance and a thorough clinical history.

Investigation of rare earth elements in urine and drinking water of children in mining area.

To compare the contents of rare earth elements in urine and drinking water of children in the mining and control areas and evaluate the health risk of children in the mining area.Urine and drinking water of 128 children in the mining area and 125 children in the control area were collected from June to July 2015. The contents of rare earth elements were determined using inductively coupled plasma mass spectrometry.The detection rates of rare earth elements, including yttrium (Y), lanthanum (La), cerium (Ce), praseodymium (Pr), neodymium (Nd), and samarium (Sm), in the urine of children in the exposed group were all 100%, except for samarium (98%); the rates in the control group were 85.7%, 100%, 100%, 98%, 98%, and 59.2%, respectively, and the remaining elements were not detectable. The concentrations of Y, La, Ce, Pr, Nd, and Sm in the urine of children in the exposed group were significantly higher than that in the control group (P < .01). In addition, the composition ratio of lanthanum was higher than that in the control group. The detection rates of lanthanum and Ce in the drinking water of children in the exposed group were 1.44% and 0.72%, respectively. The others were not detectable; the rates in the control group were all 0%.The pollution caused by the presence of Y, La, Ce, Pr, Nd, and Sm in the mining area might affect the health of children in the area, but drinking water might not be the cause.