RESUMO
RESUMEN La larva migrans visceral es una enfermedad que se produce al ingerir huevos infectantes de nematodos parásitos de gatos y perros (Toxocaracanis y Toxocaracati); los cuales eclosionan en el intestino del hombre y las larvas se distribuyen en todo el organismo, principalmente hígado, pulmón, corazón y cerebro. Las larvas en su migración dejan trazos de hemorragias, necrosis y células inflamatorias; algunas son destruidas por la respuesta inmune del huésped y otras forman granulomas eosinofílicos. Los síntomas dependen del tejido u órgano afectado, de la intensidad de la infección y del grado de la respuesta inmunológica inducida. Se presenta un caso del sexo masculino de 72 años que ingresa en el Servicio de Medicina del Hospital Militar Docente Dr. Mario Muñoz Monroy, de Matanzas, por cuadro de fiebre, diarreas, tos seca, astenia, anorexia y pérdida de peso al que se le diagnosticó larva migrans visceral. Por lo atípico de la edad del paciente y la complejidad del diagnóstico decidimos presentar este caso (AU).
ABSTRACT Visceral larva migrans is a disease produced after the ingestion of infectant eggs of cat´s and dog´s nematode parasites (Toxocara canis and Toxocara cati). These parasites harch in the men´s intestines and the larvas are distributed around the organism, mainly in the following organs: liver, lungs, hearth and brain. In their migration, the larvas leave traces of hemorrhage, necrosis and inflammatory cells; several of them are destroyed by the host´s immune answer and others form eosinophilic granulomas. The symptoms depend on the affected tissue or organ, on the infection intensity and on the level of induced immunologic answer. The case of a male patient, aged 72 years-old is presented. He entered the Medicine Service of the Teaching Military Hospital Dr. Mario Muñoz Monroy, of Matanzas with fever, diarrhea, dry cought, asthenia, anorexia and weight loss.Visceral larva migrans was diagnosed. The presentation of the case was decided because of the atypical patient´s age and the complexity of the diagnosis (AU).
Assuntos
Humanos , Masculino , Idoso , Doenças Parasitárias/prevenção & controle , Toxocara , Larva Migrans Visceral/complicações , Larva Migrans Visceral/diagnóstico , Larva Migrans Visceral/etiologia , Larva Migrans Visceral/tratamento farmacológico , Larva Migrans Visceral/diagnóstico por imagem , Toxocara canis , Parasitologia/métodos , Controle de Doenças Transmissíveis , Fatores de Risco , Técnicas de Laboratório Clínico , Testes Diagnósticos de Rotina , América Latina/epidemiologiaRESUMO
RESUMEN La larva migrans visceral es una enfermedad que se produce al ingerir huevos infectantes de nematodos parásitos de gatos y perros (Toxocaracanis y Toxocaracati); los cuales eclosionan en el intestino del hombre y las larvas se distribuyen en todo el organismo, principalmente hígado, pulmón, corazón y cerebro. Las larvas en su migración dejan trazos de hemorragias, necrosis y células inflamatorias; algunas son destruidas por la respuesta inmune del huésped y otras forman granulomas eosinofílicos. Los síntomas dependen del tejido u órgano afectado, de la intensidad de la infección y del grado de la respuesta inmunológica inducida. Se presenta un caso del sexo masculino de 72 años que ingresa en el Servicio de Medicina del Hospital Militar Docente Dr. Mario Muñoz Monroy, de Matanzas, por cuadro de fiebre, diarreas, tos seca, astenia, anorexia y pérdida de peso al que se le diagnosticó larva migrans visceral. Por lo atípico de la edad del paciente y la complejidad del diagnóstico decidimos presentar este caso (AU).
ABSTRACT Visceral larva migrans is a disease produced after the ingestion of infectant eggs of cat´s and dog´s nematode parasites (Toxocara canis and Toxocara cati). These parasites harch in the men´s intestines and the larvas are distributed around the organism, mainly in the following organs: liver, lungs, hearth and brain. In their migration, the larvas leave traces of hemorrhage, necrosis and inflammatory cells; several of them are destroyed by the host´s immune answer and others form eosinophilic granulomas. The symptoms depend on the affected tissue or organ, on the infection intensity and on the level of induced immunologic answer. The case of a male patient, aged 72 years-old is presented. He entered the Medicine Service of the Teaching Military Hospital Dr. Mario Muñoz Monroy, of Matanzas with fever, diarrhea, dry cought, asthenia, anorexia and weight loss.Visceral larva migrans was diagnosed. The presentation of the case was decided because of the atypical patient´s age and the complexity of the diagnosis (AU).
Assuntos
Humanos , Masculino , Idoso , Doenças Parasitárias/prevenção & controle , Toxocara , Larva Migrans Visceral/complicações , Larva Migrans Visceral/diagnóstico , Larva Migrans Visceral/etiologia , Larva Migrans Visceral/tratamento farmacológico , Larva Migrans Visceral/diagnóstico por imagem , Toxocara canis , Parasitologia/métodos , Controle de Doenças Transmissíveis , Fatores de Risco , Técnicas de Laboratório Clínico , Testes Diagnósticos de Rotina , América Latina/epidemiologiaRESUMO
The home surroundings (109 places) of 120 children with diagnosed toxocarosis were examined to assess if the presence of Toxocara spp. eggs in the soil corresponds with the occurrence of clinical cases. 31 places (28.4%) were found to be contaminated. The highest level of soil contamination was revealed in rural and suburban regions (15.6% and 11.9%, respectively), while in urban areas it was 0.9%. These results confirmed that soil contamination might be recognized as a very important factor in the epidemiology of human toxocarosis.
Assuntos
Exposição Ambiental/análise , Monitoramento Ambiental , Larva Migrans Visceral/etiologia , Solo/parasitologia , Toxocara canis/isolamento & purificação , Toxocaríase/epidemiologia , Animais , Gatos/parasitologia , Criança , Cães/parasitologia , Monitoramento Epidemiológico , Humanos , Contagem de Ovos de Parasitas , Polônia/epidemiologia , Prevalência , Logradouros Públicos , Fatores de RiscoRESUMO
Larva migrans visceral é uma infecção universal que ocorre mais frequentemente em crianças menores de 10 anos de idade, caracterizada por febre, hepatomegalia, doença pulmonar e eosinofilia. O agente é o ascaris intestinal de cães e gatos. O benefício das drogas anti-helmínticas não está definido. O tratamento com tiabendazol, albendazol ou mebendazol está indicado nas complicações da doença. A transmissão da infecção pode ser prevenida estimulando as crianças a lavarem suas mãos após brincarem em áreas onde há cães
Assuntos
Humanos , Pré-Escolar , Toxocaríase/fisiopatologia , Larva Migrans Visceral/diagnóstico , Larva Migrans Visceral/etiologia , Larva Migrans Visceral/prevenção & controle , Larva Migrans Visceral/tratamento farmacológico , Ácidos Heterocíclicos , Anti-Helmínticos/uso terapêutico , Compostos Heterocíclicos/uso terapêutico , Pneumopatias ParasitáriasRESUMO
The association between hepatic abscesses and schistosomiasis mansoni was confirmed by clinical and experimental studies. Other parasites may cause systemic immunologic changes and local structural alterations in the affected organs that can facilitate the seeding of these areas by bacteria. Tropical pyomyositis, pyogenic liver and renal abscesses are frequent diseases in tropical areas. The visceral larva migrans syndrome is caused by the presence, in the human body, of larvae of worms that have other animals as their definitive host, most commonly being caused by Toxocara canis. The larvae migrate to various body organs leading to many inflammatory reactions in the form of granuloma and tissue necrosis. In this review we discuss the possible host-parasite-bacteria interactions that would favour the formation of abscesses in the organs involved by the larva of T. canis and present preliminary results of a clinical and experimental study undertaken during the last four years to define the role of this parasite in the pathogenesis of the abscesses.
Assuntos
Abscesso/etiologia , Nefropatias/etiologia , Larva Migrans Visceral/complicações , Abscesso Hepático/etiologia , Doenças Musculares/etiologia , Toxocara canis , Abscesso/diagnóstico , Abscesso/epidemiologia , Abscesso/parasitologia , Abscesso/terapia , Animais , Interações Hospedeiro-Parasita , Humanos , Nefropatias/diagnóstico , Nefropatias/epidemiologia , Nefropatias/parasitologia , Nefropatias/terapia , Larva Migrans/parasitologia , Larva Migrans Visceral/diagnóstico , Larva Migrans Visceral/epidemiologia , Larva Migrans Visceral/etiologia , Larva Migrans Visceral/terapia , Abscesso Hepático/diagnóstico , Abscesso Hepático/epidemiologia , Abscesso Hepático/parasitologia , Abscesso Hepático/terapia , Doenças Musculares/diagnóstico , Doenças Musculares/epidemiologia , Doenças Musculares/parasitologia , Doenças Musculares/terapia , PrognósticoRESUMO
A 24-year -old woman 2-3 months after a normal parturation presented geophagy. Due to hypermenorrhea she consulted a gynecologist and in a hemogram a 57 percent (6, 893 x mm3) hypereosinophilia was detected. A chest TAC showed bilateral pulmonary nodules. The following tests resulted positive: ELISA IgG for toxocariasis 1: 1000, isohemagglutinins anti A 1:2048 and anti B 1:512. The patient was treated with albendazole and prednisone during 10 days. One month after treatment eosinophilia decreased to 2.590 x mm3 and ELISA IgG for toxocariasis descended to 1:128. Different aspect of human toxocariasis are commented. When hypereosinophia is observed in adult patients, toxocariasis must be checked
Assuntos
Humanos , Feminino , Adulto , Granuloma/etiologia , Larva Migrans Visceral/complicações , Síndrome Hipereosinofílica/etiologia , Albendazol/uso terapêutico , Ensaio de Imunoadsorção Enzimática , Larva Migrans Visceral/diagnóstico , Larva Migrans Visceral/tratamento farmacológico , Larva Migrans Visceral/etiologia , Prednisona/uso terapêutico , Toxocara canis/isolamento & purificação , Toxocara canis/patogenicidade , Toxocaríase/etiologiaRESUMO
The syndrome of Visceral Larva Migrans is a zoonotic disease due to the migration in human of nematodes larval, specially ascarid. Since the larvae fail to complete their migrating cycle in humans, the diagnosis of Toxocariasis infection remains only serologic. We have been able to demonstrate by the technique of agar diffusion and the Western-blotting method that the etiology due to Toxocara canis was twice as much frequent as the one due to Toxocara cati in the syndrome of Visceral and Ocular Larva Migrans. The use of numerous antigens from adult nematodes, mainly Ascaris suum, has shown, than in France, in the syndrome of VLM at least 12% of the cases were certainly due to other nematodes. Nippostrongylus brasiliensis (or another similar nematode) of the rat might be responsible. The existence of numerous clinical and biological cases found negative in serology, allow us to suggest that some other larval nematodes, may be from wild animals, might play an etiological role.
Assuntos
Larva Migrans Visceral/etiologia , Zoonoses , Animais , Ascaris/fisiologia , Humanos , Síndrome , Toxocara/fisiologiaRESUMO
La toxocariasis humana es una enfermedad producida por la infestación de huésped por larvas de Toxocara canis. Las formas clínicas son variadas y dependen del órgano afectado. Se han descrito la forma de larva migrans visceral, toxocariasis ocular, toxocariasis oculta y una forma asintomática. El diagnóstico se basa en las pruebas serológicas, siendo el Elisa la más confiable. El tratamiento es controversial y se indica dependiendo de la severidad del cuadro ya que no existe una droga totalmente efectiva. El objetivo es presentar la evolución de un caso clínico de larva migrans visceral durante un año quien mantiene eosinofilia persistente con exacerbaciones clínicas a pesar del tratamiento con albendazol, probablemente causadas por reinfección ya que se mantiene en el mismo medio ambiente. Se enfatizan las medidas de prevención para evitar la infección y reinfección
Assuntos
Pré-Escolar , Humanos , Masculino , Albendazol/uso terapêutico , Larva Migrans Visceral/etiologia , Toxocaríase/epidemiologia , Toxocaríase/diagnóstico , Toxocaríase/terapiaRESUMO
El presente trabajo tiene como propósito presentar 3 casos clínicos pediátricos, diagnosticados de toxocariasis, vistos en Lima-Perú, entre los años 1987 y 1989. Los tres pacientes son menores de 5 años de edad, con antecedentes de comer tierra, que presentaron leucocitosis leve o severa con hipereosinofilia (1500 eosinofilos por mm3). el primer paciente tuvo además hipergammaglobulinemia y gran compromiso del estado general, requiriendo el uso de tiabendazol. El segundo paciente presentó dolor abdominal crónico y la biopsia hepática reveló granulomas con abundantes eosinófilos. el tercer paciente tuvo dolor articular crónico de rodilla derecha con sinovitis en los dedos de la manos y pies. Los tres pacientes tuvieron títulos en sangre para toxocariasis en la prueba de ELISA a 1/4096, (CDC de Atlanta). Se trata del primer reporte clínico de larva migrans visceral en el Perú.
Assuntos
Humanos , Criança , Larva Migrans Visceral/diagnóstico , Larva Migrans Visceral/etiologia , Larva Migrans Visceral/epidemiologia , Toxocara/efeitos dos fármacos , Toxocara/parasitologia , Toxocara/patogenicidade , Eosinofilia/diagnósticoRESUMO
Up to present time the data concerning toxocariasis++ have been presented. Toxocariasis++ is difficult for diagnosis because of lack of specificity and multiorgan changes due to the invasion by Toxocara canis or cati. We pay attention the problem distribution of this parasitosis in Poland and world is still actual especially among children. We have presented epidemiological data and means diagnosis of this diseases and the treatment patients and prophylaxis has been stressed.
Assuntos
Doenças do Gato/parasitologia , Doenças do Cão/parasitologia , Larva Migrans Visceral/etiologia , Toxocaríase/veterinária , Adulto , Animais , Antinematódeos/uso terapêutico , Doenças do Gato/transmissão , Gatos , Criança , Doenças do Cão/transmissão , Cães , Humanos , Larva Migrans Visceral/diagnóstico , Larva Migrans Visceral/tratamento farmacológico , Toxocaríase/parasitologia , Toxocaríase/transmissãoAssuntos
Microbiologia de Alimentos , Larva Migrans Visceral/etiologia , Carne , Adulto , Animais , Galinhas , Contaminação de Alimentos , Humanos , MasculinoRESUMO
After the suggestion was made that the "Palm Island mystery disease" might have been an epidemic of visceral larva migrans that was caused by the flying fox parasite, Toxocara pteropodis, work was undertaken to elucidate this nematode's life-cycle and pathogenicity. Studies of infections in various laboratory animals have shown unexpectedly variable susceptibility patterns, with mice harbouring most larvae for the longest time period. However, in all susceptible animals (which include mice, guinea-pigs and suckling rats), the larvae demonstrated marked hepatotropism. Experimental infections in monkeys demonstrated that primates are susceptible to this infection, but large doses of 20,000 infective eggs produced blood eosinophilia and focal granulomatous hepatitis without clinical disease or biochemical abnormalities in the blood. It is concluded that humans are susceptible to larval infections with this nematode, but that clinical manifestations would be unlikely to develop.
Assuntos
Ascaríase/parasitologia , Surtos de Doenças/etiologia , Larva Migrans Visceral/etiologia , Toxocaríase/parasitologia , Animais , Austrália , Galinhas , Patos , Raposas/parasitologia , Hepatite Animal/etiologia , Humanos , Larva Migrans Visceral/parasitologia , Macaca fascicularis , Camundongos , Gambás , Coelhos , Ratos , Suínos , Toxocara/patogenicidade , Toxocaríase/complicaçõesRESUMO
The AA describe a case of Larva Migrans Visceral syndrome in a two year-old boy in systemic form with negative outcome. The autoptic examination showed a "granulomatous hepatitis with marked component of eosinophil cells'. The presence of "eosinophil granuloma' in liver has led to the diagnosis of Visceral Larva Migrans Syndrome; other possible causes of Ipereosinophilous Syndrome have been excluded on the basis of anamnestic, clinic and laboratory data. The discovery in the medical history of frequent contacts with a dog which was affected by a serious toxocara canis infections, has led to the diagnosis of Larva Migrans Syndrome from Toxocara canis.
Assuntos
Larva Migrans Visceral/etiologia , Pré-Escolar , Diagnóstico Diferencial , Humanos , Larva Migrans Visceral/diagnóstico , Masculino , Síndrome de Reye/diagnósticoAssuntos
Larva Migrans Visceral/epidemiologia , Adolescente , Adulto , Fatores Etários , Idoso , Criança , Pré-Escolar , Feminino , França , Humanos , Imunoeletroforese , Lactente , Recém-Nascido , Larva Migrans Visceral/diagnóstico , Larva Migrans Visceral/etiologia , Masculino , Pessoa de Meia-Idade , Plantas Comestíveis , Fatores Sexuais , SíndromeRESUMO
In two cases of ectopic localization of Angiostrongylus costaricensis adult worms and eggs were seen in the liver, causing a granulomatous inflammatory reaction with dense eosinophilic infiltration and necrosis. In the first case, although antibodies for A. costaricensis had been demonstrated, a clinical diagnosis of visceral larva migrans was recorded; however, further examination of a liver biopsy revealed eggs of A. costaricensis. In the second case, severity of the intestinal pathology masked the presence of lesions and an adult A. costaricensis that were discovered in a retrospective study of the liver 13 years later. A close similarity between the visceral larva migrans syndrome and ectopic localization (liver) of A. costaricensis is established.