Assuntos
Transplante de Medula Óssea/história , Leucemia Experimental/história , Animais , Transplante de Medula Óssea/efeitos adversos , Terapia Combinada , Doença Enxerto-Hospedeiro/história , Doença Enxerto-Hospedeiro/prevenção & controle , Efeito Enxerto vs Leucemia , História do Século XX , Leucemia Experimental/radioterapia , Leucemia Experimental/terapia , CamundongosAssuntos
Transplante de Medula Óssea/história , Leucemia Experimental/história , Animais , Terapia Combinada/história , Relação Dose-Resposta à Radiação , Efeito Enxerto vs Leucemia , História do Século XX , Leucemia Experimental/radioterapia , Leucemia Experimental/terapia , Camundongos , Camundongos Endogâmicos , Células-Tronco Neoplásicas/efeitos da radiação , Quimera por Radiação , Tolerância a Radiação , Irradiação Corporal Total/históriaRESUMO
Work done in the late 1950s and in the 1960s revealed the role of the thymus in virus-induced leukemia in mice. Thymectomizing mice at birth to test whether the virus first multiplied in thymus tissue and then spread elsewhere ultimately led to the conclusion that the thymus was essential to the normal development of the immune system. Subsequent testing to try to understand how the thymus contributes to the pool of immunocompetent lymphocytes opened a new chapter in immunology and required a reappraisal of many immunological phenomena and an understanding of the molecular interactions that take place during cell-to-cell interactions.
Assuntos
Alergia e Imunologia/história , Imunocompetência , Animais , Animais Recém-Nascidos , Austrália , Linfócitos B/imunologia , História do Século XX , Leucemia Experimental/história , Leucemia Experimental/imunologia , Camundongos , Linfócitos T/imunologia , Timectomia , Timo/imunologia , Timo/transplanteRESUMO
Publication in this journal of the abstracts of the Nineteenth Symposium of the International Association for Comparative Research on Leukemia and Related Diseases in Mannheim/Heidelberg led editor and publisher to suggest an article introducing comparative research in leukemia and related diseases. Our survey briefly summarizes the history of this symposium, as it evolved from a meeting on animal leukemia virus into one dealing with viral and genetic aspects of human and animal leukemia and related diseases. The scientific evolution of the Abelson murine leukemia virus with its abl oncogene in the 1970s to what currently appears as the most reliable marker for human chronic myeloid leukemia is merely one example.
Assuntos
Leucemia Experimental , Leucemia , Animais , História do Século XX , Humanos , Leucemia/etiologia , Leucemia/genética , Leucemia/história , Leucemia Experimental/etiologia , Leucemia Experimental/genética , Leucemia Experimental/história , CamundongosRESUMO
The thymus has been an enigmatic organ for centuries. Its true function was revealed only in 1961 when it was shown to be responsible for the proper development of the immune system. This finding has revolutionized the science of immunology and has led to a better understanding of the mechanisms involved in resistance to infections and of the pathogenesis of autoimmune and immunodeficiency diseases.
