RESUMO
AIM: Extranodal natural killer cell/T-cell lymphoma of nasal-type (NKTCL) is an aggressive human lymphoma, but its predicted biomarkers after chemotherapy are less known. The aim of this study is to find some potential predicted biomarkers in cerebrospinal fluid (CSF) of NKTCL patients with ethmoidal sinus metastasis (NESM). MATERIALS AND METHODS: The CSF samples were obtained from NKTCL patients with NESM before and after chemotherapy from Cancer Center of West China Hospital. Comparative proteomic profiling using label-free method was performed to characterize the fold change of proteins in NESM patients. KEY FINDING: In this study, 102 proteins with <1% false discovery rate in CSF of NKTCL with NESM patients were quantified. Furthermore, significantly reduced IGFBP2, SERP1NC1, AMBP and GPX3, as well as dramatically increased CPE levels were observed in the CSF of NKTCL patients after cytarabine chemotherapy. SIGNIFICANCE: IGFBP2, SERP1NC1, AMBP, GPX3 and CPE together or alone have a potential to be predicted indicators of NKTCL with NESM in response to chemotherapy.
Assuntos
Biomarcadores Tumorais/líquido cefalorraquidiano , Líquido Cefalorraquidiano/metabolismo , Seio Etmoidal/patologia , Linfoma Extranodal de Células T-NK/líquido cefalorraquidiano , Neoplasias Nasais/líquido cefalorraquidiano , Proteômica/métodos , Adulto , Antineoplásicos/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , China , Citarabina/uso terapêutico , Feminino , Perfilação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Humanos , Linfoma Extranodal de Células T-NK/patologia , Masculino , Espectrometria de Massas , Pessoa de Meia-Idade , Metástase Neoplásica , Neoplasias Nasais/patologia , Prognóstico , Espectrometria de Massas em TandemAssuntos
Tronco Encefálico/patologia , Linfoma Extranodal de Células T-NK/patologia , Neoplasias Nasais/patologia , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Asparaginase/administração & dosagem , Tronco Encefálico/virologia , Líquido Cefalorraquidiano/citologia , Líquido Cefalorraquidiano/virologia , Cisplatino/administração & dosagem , DNA Viral/líquido cefalorraquidiano , DNA Viral/isolamento & purificação , Desoxicitidina/administração & dosagem , Desoxicitidina/análogos & derivados , Dexametasona/administração & dosagem , Etoposídeo/administração & dosagem , Herpesvirus Humano 4/isolamento & purificação , Humanos , Ifosfamida/administração & dosagem , Linfoma Extranodal de Células T-NK/líquido cefalorraquidiano , Linfoma Extranodal de Células T-NK/virologia , Masculino , Metotrexato/administração & dosagem , Células-Tronco Neoplásicas/patologia , Células-Tronco Neoplásicas/virologia , Oftalmoplegia/etiologia , Doenças do Nervo Trigêmeo/etiologia , Carga Viral , GencitabinaAssuntos
Linfoma Extranodal de Células T-NK/patologia , Pia-Máter/patologia , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Asparaginase/administração & dosagem , Carboplatina/administração & dosagem , Líquido Cefalorraquidiano/citologia , Dexametasona/administração & dosagem , Etoposídeo/administração & dosagem , Feminino , Cefaleia/etiologia , Humanos , Ifosfamida/administração & dosagem , Vértebras Lombares , Linfoma Extranodal de Células T-NK/líquido cefalorraquidiano , Linfoma Extranodal de Células T-NK/complicações , Linfoma Extranodal de Células T-NK/diagnóstico , Linfoma Extranodal de Células T-NK/tratamento farmacológico , Imageamento por Ressonância Magnética , Metotrexato/administração & dosagem , Invasividade Neoplásica , Polirradiculopatia/etiologiaRESUMO
BACKGROUND: Lymphomas that infiltrate the nervous system in children correspond to those of precursor B cells, such as lymphoblastic and Burkitt's lymphoma. In adults, infiltration occurs in mature B-cell lymphomas, such as mantle cell lymphoma, and, rarely, in Hodgkin's lymphoma or peripheral NK/T-cell lymphomas. CASE: We report the case of a 48-year-old man, who two years before death was diagnosed with extranodal nasal NK/T-cell lymphoma nasal in the left nostril. He received radiotherapy and a year later presented tumor activity. He also presented infiltration to the bone marrow and underwent chemotherapy. Afterward, he presented paresthesia and paresis of the lower extremities, difficulty walking, loss of sphincter control, and seizures. Infiltration to the central nervous system was revealed by computed axial tomography, and cytologic study of cerebrospinal fluid revealed malignant lymphoid cells; he then received intrathecal chemotherapy. He died 3 months later. CONCLUSION: In Mexico, extranodal nasal NK/T-cell lymphoma occurs frequently. It is highly destructive and tightly related with the Epstein-Barr virus. Infiltration to the central nervous system is rare, and the neoplastic cells can be confused with other tumors, such as metastatic carcinomas.
