RESUMO
In recent years, naturally biodegradable polyhydroxyalkanoate (PHA) monopolymers have become focus of public attentions due to their good biocompatibility. However, due to its poor mechanical properties, high production costs, and limited functionality, its applications in materials, energy, and biomedical applications are greatly limited. In recent years, researchers have found that PHA copolymers have better thermal properties, mechanical processability, and physicochemical properties relative to their homopolymers. This review summarizes the synthesis of PHA copolymers by the latest biosynthetic and chemical modification methods. The modified PHA copolymer could greatly reduce the production cost with elevated mechanical or physicochemical properties, which can further meet the practical needs of various fields. This review further summarizes the broad applications of modified PHA copolymers in biomedical applications, which might shred lights on their commercial applications.
Assuntos
Materiais Biomédicos e Odontológicos/química , Poli-Hidroxialcanoatos/biossíntese , Poli-Hidroxialcanoatos/química , Animais , Bactérias/metabolismo , Materiais Biocompatíveis/química , Materiais Biocompatíveis/uso terapêutico , Plásticos Biodegradáveis/química , Biodegradação Ambiental , Materiais Biomédicos e Odontológicos/economia , Materiais Biomédicos e Odontológicos/uso terapêutico , Portadores de Fármacos , Humanos , Poli-Hidroxialcanoatos/economia , Poli-Hidroxialcanoatos/uso terapêutico , Polímeros/química , Engenharia TecidualRESUMO
Evidence-based management of medical disposable materials pays attention to collect evidence comprehensively and systematically, accumulate and create evidence through its own work and also evaluate evidence strictly. This can be used as a function to guide out job. Medical disposable materials evidence system contains product register qualification, product quality certification, supplier's behavior, internal and external communication evidence. Managers can find different ways in creating and using evidence referring to specific inside and outside condition. Evidence-based management can help accelerating the development of management of medical disposable materials from traditional experience pattern to a systematic and scientific pattern. It also has the very important meaning to improve medical quality, control the unreasonable growth of medical expense and make purchase and supply chain be more efficient.