RESUMO
A newborn infant with subcutaneous fat necrosis after perinatal hypoxia was found to have several abnormalities of plasma lipids. Further studies are needed to determine whether such abnormalities contribute to the pathophysiology of the skin lesions.
Assuntos
Necrose Gordurosa/sangue , Lipídeos/sangue , Asfixia Neonatal/complicações , Necrose Gordurosa/etiologia , Necrose Gordurosa/fisiopatologia , Humanos , Recém-Nascido , Lipoproteínas/sangue , MasculinoRESUMO
Two infants with subcutaneous fat necrosis had hypercalcemia that normalized during glucocorticoid treatment. The combination of hypercalcemia, normal concentration of 25-hydroxyvitamin D, an elevated concentration of 1,25-dihydroxyvitamin D, a suppressed parathyroid hormone level, and low-normal bone turnover indicated abnormal 1,25-dihydroxyvitamin D production with increased intestinal absorption of calcium. Unregulated production of 1,25-dihydroxyvitamin D by the granulomatous cells of fat necrosis may cause hypercalcemia.