Clinical Benefit of Preoperative Exercise and Nutritional Therapy for Patients Undergoing Hepato-Pancreato-Biliary Surgeries for Malignancy.

BACKGROUND: The impact of prehabilitation on physical fitness and postoperative course after hepato-pancreato-biliary (HPB) surgeries for malignancy is unknown. The current study aimed to investigate the effect of preoperative exercise and nutritional therapies on nutritional status, physical fitness, and postoperative outcomes of patients undergoing an invasive HPB surgery for malignancy. METHODS: Patients who underwent open abdominal surgeries for HPB malignancies (major hepatectomy, pancreatoduodenectomy, or hepato-pancreatoduodenectomy) between 2016 and 2017 were subjected to prehabilitation. Patients before the introduction of prehabilitation were included as historical control subjects for 1:1 propensity score-matching (no-prehabilitation group). The preoperative nutritional status and postoperative course were compared between the two groups. RESULTS: The prehabilitation group consisted of 76 patients scheduled to undergo HPB surgeries for malignancy. An identical number of patients were selected as the no-prehabilitation group after propensity score-matching. During the waiting period, serum albumin levels were significantly deteriorated in the no-prehabilitation group, whereas this index did not deteriorate or even improved in the prehabilitation group. By performing prehabilitation, a 6-min walk distance and total muscle/fat ratio were significantly increased during the waiting period. Although the overall incidence of postoperative complications did not differ between the two groups, the postoperative hospital stay was shorter in the prehabilitation group than in the no-prehabilitation group (median, 23 vs 30 days; p = 0.045). CONCLUSION: The introduction of prehabilitation prevented nutritional deterioration, improved physical fitness before surgery, and shortened the postoperative hospital stay for the patients undergoing HPB surgeries for malignancy.

Utilidad de las endoprótesis en el manejo de la obstrucción biliar benigna y maligna: resultados en 17 pacientes / Usefulnes of stents in patients with bening and malignant biliary obstruction. Results in 17 patients

Se informan los resultados obtenidos de la colocación de diferentes endoprótesis biliares en 17 pacientes, durante el período de junio de 1991 a junio de 1993. Se utilizaron prótesis plástica de poliuretano en cinco pacientes y en el resto se colocaron prótesis metálicas de diferente tipo, Wallstent en seis Strecker en cinco y Palmaz en uno. La indicación fue por patología maligna en 12 pacientes y en los cinco restantes por obstrucción benigna posquirúrgica (estenosis de derivación biliodigestiva). El resultado y evolución fueron satisfactorios en 13 pacientes (76 por ciento), mientras que en cuatro pacientes se presentaron diferentes complicaciones como obstrucción prematura de la prótesis en tres pacientes, dos de ellos con colangitis asociada y fístula bilioportal en uno y que requirieron procedimientos secundarios para solucionar dichas complicaciones. El uso de endoprótesis metálicas en las vías biliares representa un importante avance el manejo de la obstrucción benigna o maligna, ya que se instalan percutáneamente con mayor facilidad y menor trauma, logrando un mayor diámetro que con las de tipo plástico