RESUMO
By midcentury, the U.S.A. will be more ethnically and racially diverse. Skin of colour will soon constitute nearly one-half of the U.S. population, and a full understanding of skin conditions that affect this group is of great importance. Structural and functional differences in the skin, as well as the influence of cultural practices, produce variances in skin disease and presentation based on skin type. In the skin of colour population, dyschromia is a growing concern, and a top chief complaint when patients present to the physician. A thorough understanding of the aetiology and management strategies of facial hyperpigmentation is of importance in caring for those afflicted and also in the development of new therapies.
Assuntos
Dermatoses Faciais/etiologia , Hiperpigmentação/etiologia , Administração Cutânea , Infecções por Alphavirus/complicações , Infecções por Alphavirus/etnologia , Febre de Chikungunya , Dermabrasão/métodos , Fármacos Dermatológicos/uso terapêutico , Combinação de Medicamentos , Dermatoses Faciais/etnologia , Dermatoses Faciais/terapia , Humanos , Hiperpigmentação/etnologia , Hiperpigmentação/terapia , Terapia a Laser/métodos , Líquen Plano/complicações , Líquen Plano/etnologia , Líquen Plano/terapia , Nevo/complicações , Nevo/etnologia , Nevo/terapia , Ocronose/complicações , Ocronose/etnologia , Ocronose/terapia , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/etnologia , Neoplasias Cutâneas/terapiaRESUMO
Authors trace an ochronotic Hungarian family, which moved from Slovakia to Hungary 300 years ago. As the family members lived in a relatively close village community the gene mutation had been survived silently for ages before the clinical symptoms developed. Family tree analysis could detect with the use of allele specific PCR amplification-the p.G161R mutation of the homogentisic acid 1,2-dioxygenase (HGD) gene, which resulted in a specific genotype appearing in the Slovak population. We found a heterozygote member of this family who has children with an alkaptonuria-homozygote and known-heterozygote genotypes so there would be a high risk of alkaptonuria in their offsprings. Therefore genetic counselling is highly recommended to minimize the risk factors.
Assuntos
Homogentisato 1,2-Dioxigenase/genética , Artropatias/genética , Mutação/genética , Ocronose/genética , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , Hungria , Artropatias/etnologia , Masculino , Ocronose/etnologia , Linhagem , Eslováquia/etnologiaAssuntos
Povo Asiático , Fármacos Dermatológicos/efeitos adversos , Hidroquinonas/efeitos adversos , Ocronose/induzido quimicamente , Transtornos da Pigmentação/induzido quimicamente , Administração Cutânea , Feminino , Humanos , Melanose/tratamento farmacológico , Pessoa de Meia-Idade , Ocronose/etnologia , Ocronose/patologia , Transtornos da Pigmentação/etnologia , Transtornos da Pigmentação/patologia , Pele/patologiaRESUMO
Exogenous ochronosis resulting from the topical application of hydroquinone-containing bleaching creams has been reported to occur almost exclusively in black subjects, and only after use of high concentrations of hydroquinone (greater than 3 percent) for many years. A Mexican-American patient is described who experienced exogenous ochronosis after using 2 percent hydroquinone cream for less than six months.
