[Course of Osteodystrophia fibrosa generalisata in a satin guinea pig]. / Krankheitsverlauf einer Osteodystrophia fibrosa generalisata bei einem Satinmeerschweinchen.

In a 14 months old satin guinea pig Osteodystrophia fibrosa generalisata was diagnosed by clinical and x-ray examination. The guinea pig was treated palliatively with Meloxicam and Natriumrisedronate as well as periodic dental treatment. At the age of 3 years and 10 months the guinea pig died, but necropsy was denied by the owner.

Outbreak of osteodystrophia fibrosa in young goats.

Osteodystrophia fibrosa was diagnosed in young goats which received a dict of 60% wheat straw and 40% barley for 8 months. The ratio of calcium:phosphorus in the diet was 1:1.8. The clinical signs were bilateral and symmetrical enlargement of the face, swelling of the joints, and limb deformities. The laboratory findings showed a low level of serum calcium in all affected goats. Histopathological examination revealed marked fibrous deposition and osteoclasia in bones of the maxilla and mandible.

Osteodystrophia fibrosa in two guinea pigs.

Two adult guinea pigs were examined because they were lethargic and reluctant to walk. Additionally, I guinea pig had otitis media, and the other had dental malocclusion. Both guinea pigs had been fed a commercially available diet of cereals and pellets enriched with vitamin C and formulated for this species. Radiographically, the guinea pigs had coarse trabecular bone patterns, skeletal deformations, pathologic fractures, and polyarthritic degenerative joint disease. A double cortical line was also evident on several long bones, the pelvis, and the vertebrae. A diagnosis of osteopenia was confirmed by use of dual-energy x-ray absorptiometry. Analysis of a food sample fed to 1 guinea pig revealed calcium and phosphorus contents of 0.524 and 0.425%, respectively (Ca:P ratio, 1.23:1). Microscopic examination of bone tissue from both guinea pigs revealed severe fibrous osteodystrophy. Nutritional secondary hyperparathyroidism caused by calcium-phosphorus imbalance was considered to be the underlying cause of osteodystrophia fibrosa in both guinea pigs.

Nutritional secondary hyperparathyroidism in free-living fledgling American crows (Corvus brachyrhynchos brachyrhynchos).

From June 1994 to June 1996, 18 fledgling American crows (Corvus brachyrhynchos brachyrhynchos) from multiple locations on Long Island, New York, were presented with signs of metabolic bone disease characterized by folding fractures of the proximal tibiotarsus. Plasma alkaline phosphatase levels were elevated, and the calcium/phosphorus ratio and 25-hydroxycholecalciferol (25-(OH)D3) levels were decreased. The histopathologic diagnosis was parathyroid hyperplasia and generalized osteodystrophia fibrosa. A diet low in bioavailable calcium and/or vitamin D3 was the probable cause. Also, exposure to xenobiotics could have contributed to the depression of 25-(OH)D3 levels.

Cystic fibrous osteodystrophy of the jaw in two pet kinkajous (Potos flavus).

Two kinkajous (Potos flavus), which were separately owned as pets and fed an inappropriate diet consisting almost exclusively of succulent fruits developed cystic fibrous osteodystrophy of the jaw. In both cases there was a prominent enlargement of the chin and lower jaw, decalcification of facial bones, softening of the gingiva, and severe malocclusion, but no other relevant changes. Clinical, radiographic and histological findings were consistent with cystic fibrous osteodystrophy. The findings suggest that kinkajous with this condition are particularly prone to developing a bulbous enlargement of the chin as the main clinical sign, and that this change is histologically similar to the cystic form of the disease observed in man and monkeys.

Primary hyperparathyroidism with osteodystrophia fibrosa of the facial bones in a pony.

A 17-year-old pony mare was admitted for evaluation of progressive enlargement of the facial bones during the preceding 9 months. Laboratory testing revealed that the pony had hypercalcemia, hypophosphatemia, high urinary fractional excretion of phosphorus, and high serum concentration of intact parathyroid hormone (185.1 pmol/L; reference range, 0.25 to 2.0 pmol/L). On the basis of these findings, a diagnosis of primary hyperparathyroidism was made by ruling out nutritional secondary hyperparathyroidism, chronic renal disease, and pseudohyperparathyroidism resulting from neoplasia. Although primary hyperparathyroidism is best treated by surgical removal of the affected parathyroid gland, the owners declined surgical exploration of the neck in this pony. Because of the poor prognosis, the pony was euthanatized. A functional lesion of the parathyroid tissue was not located on necropsy or histologic examination. Difficulty localizing and grossly identifying parathyroid tissue in horses complicates definitive diagnosis and treatment of primary hyperparathyroidism.

[Skeletal findings in an adult dog recovering from osteodystrophia fibrosa]. / Skelettbefunde bei abgeheilter Osteodystrophia fibrosa eines adulten Hundes.

In a 9-year-old male German Shepherd dog with a body weight of 37 kg which was euthanised because of a spinal meningioma, examination of the carcass revealed severe signs of degradation concerning the whole skeleton which were investigated by radiological, microradiological and pathologic-histological means. The skeletal alterations in form of systemic defects in corticalis and spongiosa in fact correspond to appearance and localisation of bone defects typical of fibrous osteodystrophia, but now are filled by conspicuous cell-poor matured collagenous connective tissue. In this connection it must be emphasised, that there are no osteoclasts detectable in the lacunae of degradation so that the disease process apparently has stopped.

A survey of bone disease in the Alpk/AP rat.

Bone disease in an outbred colony of Alpk/AP rats over a period of more than 20 years is recorded. The incidence of most conditions, including fracture, necrosis, osteomyelitis, osteitis deformans, renal osteitis fibrosa cystica and neoplasia is rare compared with other species and possible reasons for this low incidence are discussed.

A possible case of osteodystrophia fibrosa cystica in a horse.

A case of unilateral front leg lameness with bone changes in the pedal bone suggestive of osteodystrophia fibrosa cystica is reported in an eight year old crossbred gelding. The changes were diagnosed at postmortem examination. The known possible causes are briefly reviewed.

Application of the radiological sciences to advance clinical and fundamental knowledge of the animal kingdom. New Horizons for Radiologists Lecture.

Many radiological techniques are useful in fundamental research. Selected clinical problems in animals as well as certain basic research projects are utilized to emphasize the potential of radiological imaging. The author describes the use of several radiological methods in studies of how birds breathe.

Fibrous osteodystrophy in an opossum.

A free living opossum (Didelphis marsupialis) was found to have severe fibrous osteodystrophy of the maxilla and mandibles. No significant lesions were found in the kidneys, ruling out an etiology of renal secondary hyperparathyroidism. An etiology of primary phperthyroidism or nutritional secondary hyperparathyroidism is suggested.

Fibrous osteodystrophy with facial hyperostosis in a dog with renal cortical hypoplasia.

A five-month-old Great Dane had abnormally small kidneys with narrow cortices and a reduced total number of glomeruli. In the renal cortex, subcapsular nests of primitive structures were associated with radiating streaks of fibrosis and were interpreted to be the result of interference with terminal development. The animal had secondary parathyroid hyperplasia and generalized fibrous osteodystrophy. The most severe skeletal lesions were present in the face and jaws where exuberant proliferation of fibrodystrophic bone had caused boney enlargement with focal hemorrhage and brown node formation.