RESUMO
PURPOSE: Plasma levels of selected hematopoietic cytokines: interleukin 3 ( IL-3), stem cell factor (SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and macrophage colony-stimulating factor (M-CSF), and the tumor marker carcinoma antigen 15-3 (CA 15-3) in breast cancer (BC) patients were investigated and compared to control groups: benign breast tumor patients and healthy subjects. MATERIAL/METHODS: Cytokine levels were determined by ELISA, CA 15-3 - using the CMIA method. RESULTS: A significant differences in the concentration of cytokines (with the exception of IL-3) and CA15-3 between the groups of BC patients, benign breast tumor patients and the healthy controls have been demonstrated. M-CSF has demonstrated higher or equal to CA 15-3 values of diagnostic sensitivity, specificity and the predictive values of positive and negative test results. The M-CSF area under the ROC curve (AUC) was the largest from all the cytokines tested and marginally lower than the AUC of CA 15-3. CONCLUSION: These findings suggest the usefulness of M-CSF in diagnosing breast cancer, especially when discriminating between cancer and non-carcinoma lesions.
Assuntos
Adenoma/sangue , Biomarcadores Tumorais/sangue , Neoplasias da Mama/sangue , Transformação Celular Neoplásica/metabolismo , Neoplasias/sangue , Adenoma/patologia , Adulto , Idoso , Neoplasias da Mama/patologia , Diagnóstico Diferencial , Feminino , Fibroadenoma/sangue , Fibroadenoma/patologia , Fator Estimulador de Colônias de Granulócitos/sangue , Fator Estimulador de Colônias de Granulócitos e Macrófagos/sangue , Humanos , Interleucina-3/sangue , Fator Estimulador de Colônias de Macrófagos/sangue , Pessoa de Meia-Idade , Mucina-1/sangue , Análise Multivariada , Neoplasias/patologia , Papiloma Intraductal/sangue , Papiloma Intraductal/patologia , Valor Preditivo dos Testes , Curva ROC , Sensibilidade e Especificidade , Fator de Células-Tronco/sangueRESUMO
Despite recent advances in imaging procedures, the correct diagnosis of cystic lesions of the pancreas is lacking in about one third of cases. Cyst fluid analysis can help in the differential diagnosis, particularly in patients with unilocular or paucilocular lesions, thus precluding unjustified resection in patients with benign cystic lesions of the pancreas. Although use of cystic fluid marker analysis is helpful in several situations, it is crucial to carefully evaluate the clinical context with appraisal of patient's demographics, clinical symptoms, and morphologic data. A multidisciplinary approach is advised and should improve the overall diagnostic performance and lead to better management strategies in patients presenting with such tumors of the pancreas.