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Dermatol Online J ; 12(6): 1, 2006 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-17083881

RESUMO

Cutaneous warts are caused by human papillomavirus (HPV). Prevalence studies of the types of HPV present in cutaneous warts have been carried out more frequently in immunosuppressed patients. The present study was designed to study the association of high-risk HPV in cutaneous warts of immunocompetent patients. A total of 45 cases of cutaneous warts from various sites in immunocompetent subjects were analyzed for HPV. Samples included both archival material i.e., paraffin embedded and fresh tissue. Highly sensitive and comprehensive polymerase chain reaction (PCR) methodology for detection of HPV of high oncogenic potential, HPV 16/18, was employed. Human papillomavirus 16 was detected in 3 (6.6%) patients. None of the lesions demonstrated HPV 18. None of the cutaneous warts demonstrated histopathological features associated with dysplasia or neoplasia. The identification of HPV 16 in cutaneous warts, which are benign proliferations of the skin, further expands the spectrum of HPV-linked lesions. It remains of critical interest to determine whether these types are specifically associated with the development of malignant lesions analogous to those seen in anogenital cancer.


Assuntos
Dermatoses Faciais/virologia , Dermatoses do Pé/virologia , Dermatoses da Mão/virologia , Papillomavirus Humano 16/isolamento & purificação , Papillomavirus Humano 18/isolamento & purificação , Infecções por Papillomavirus/virologia , Reação em Cadeia da Polimerase , Dermatoses do Couro Cabeludo/virologia , Verrugas/virologia , Parede Abdominal/virologia , Adolescente , Adulto , Idoso , Braço/virologia , Sondas de DNA de HPV , DNA Viral/análise , Dermatoses Faciais/epidemiologia , Feminino , Dermatoses do Pé/epidemiologia , Dermatoses da Mão/epidemiologia , Papillomavirus Humano 16/genética , Papillomavirus Humano 16/patogenicidade , Papillomavirus Humano 18/genética , Papillomavirus Humano 18/patogenicidade , Humanos , Imunocompetência , Índia/epidemiologia , Masculino , Pessoa de Meia-Idade , Infecções por Papillomavirus/epidemiologia , Dermatoses do Couro Cabeludo/epidemiologia , Parede Torácica/virologia , Verrugas/epidemiologia
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