Penfigoide bolhoso em cão / Bullous pemphigoid in a dog

Background: In dogs, bullous pemphigoid (BP) is a subepithelial autoimmune disease, a rare dermatopathy in the clinicalroutine. BP is characterized by formation of vesicles and subepidermal blisters that result from dissolution of the dermalepithelial junction. Clinical signs of BP usually include severe dermatological alterations with a variable prognosis. Theaim of this work is to report a case of BP in a dog to contribute information for diagnosis, and to present clinical andpathological aspects that emerge during development of BP.Case: An adult male mongrel dog exhibited hyperemic, exudative, crusty lesions on the lip commissure and periocularareas. Results from laboratory tests were normal. Results from parasitological and mycological tests on skin scrapingswere negative. Imprint cytology of the crusts revealed presence of gram-positive cocci bacteria. In the histopathologicalanalysis of punch biopsy material, the epidermis was detached from the dermis, leading to formation of vesicles. Therewere inflammatory infiltrates containing neutrophils, eosinophils, and high amounts of fibrin, and areas of multifocalorthokeratotic hyperkeratosis. Multifocal infiltrates containing lymphocytes, histiocytes, and plasma cells were observedon the superficial portions of the dermis, which indicated a diagnosis of BP. After the definitive clinical diagnosis, theanimal was treated with enrofloxacin (Baytril Flavour®; 5 mg/kg once a day for 10 days), and prednisolone (Prediderm®;2 mg/kg once a day until further instructions). On the follow-up visit, 15 days later, the clinical picture had improved, andthe lesions had decreased. Continuity of the treatment was prescribed, along with a gradual decrease in the corticoid dose.The dose of prednisolone was initially reduced to 1 mg/kg once a day, and later to 0.5 mg/kg until improvement of theclinical status of the patient. Remission of the lesions was observed 13 weeks later...(AU)

Penfigoide bolhoso em cão / Bullous pemphigoid in a dog

Background: In dogs, bullous pemphigoid (BP) is a subepithelial autoimmune disease, a rare dermatopathy in the clinicalroutine. BP is characterized by formation of vesicles and subepidermal blisters that result from dissolution of the dermalepithelial junction. Clinical signs of BP usually include severe dermatological alterations with a variable prognosis. Theaim of this work is to report a case of BP in a dog to contribute information for diagnosis, and to present clinical andpathological aspects that emerge during development of BP.Case: An adult male mongrel dog exhibited hyperemic, exudative, crusty lesions on the lip commissure and periocularareas. Results from laboratory tests were normal. Results from parasitological and mycological tests on skin scrapingswere negative. Imprint cytology of the crusts revealed presence of gram-positive cocci bacteria. In the histopathologicalanalysis of punch biopsy material, the epidermis was detached from the dermis, leading to formation of vesicles. Therewere inflammatory infiltrates containing neutrophils, eosinophils, and high amounts of fibrin, and areas of multifocalorthokeratotic hyperkeratosis. Multifocal infiltrates containing lymphocytes, histiocytes, and plasma cells were observedon the superficial portions of the dermis, which indicated a diagnosis of BP. After the definitive clinical diagnosis, theanimal was treated with enrofloxacin (Baytril Flavour®; 5 mg/kg once a day for 10 days), and prednisolone (Prediderm®;2 mg/kg once a day until further instructions). On the follow-up visit, 15 days later, the clinical picture had improved, andthe lesions had decreased. Continuity of the treatment was prescribed, along with a gradual decrease in the corticoid dose.The dose of prednisolone was initially reduced to 1 mg/kg once a day, and later to 0.5 mg/kg until improvement of theclinical status of the patient. Remission of the lesions was observed 13 weeks later...

Estomatite vesico-bolhosa possivelmente causada por penfigóidemucomembranoso em um cão: relato de caso

O penfigóide mucomembranoso (PMM) é uma doença rara que acomete mucosa e junção mucocutânea, levando a vesículas, erosões e úceras em cavidade oral, perioral, plano nasal, olhos, conduto auditivo, anus e genitália. O objetivo deste trabalho é relatar o caso de cão, fêmea, 8 anos, ovariohisterectomizada, com histórico de úlceras e erosões em mucosa jugal, palatina, anal e vulvo-vaginal, disfagia, halitose e sialorréia mucopurulenta. O exame histopatológico revelou presença de fenda subepidermal extensacontendo discreta quantidade de restos celulares ou sangue. Pelos sinais clínicos e a análise histopatológica,suspeita se que a estomatite vesico-bolhosa era devido ao PMM. O controle parcial da doença foi obtido com uso de ciclosporina diário com corticosteroide intermitente. (AU)

Estomatite vesico-bolhosa possivelmente causada por penfigóidemucomembranoso em um cão: relato de caso

O penfigóide mucomembranoso (PMM) é uma doença rara que acomete mucosa e junção mucocutânea, levando a vesículas, erosões e úceras em cavidade oral, perioral, plano nasal, olhos, conduto auditivo, anus e genitália. O objetivo deste trabalho é relatar o caso de cão, fêmea, 8 anos, ovariohisterectomizada, com histórico de úlceras e erosões em mucosa jugal, palatina, anal e vulvo-vaginal, disfagia, halitose e sialorréia mucopurulenta. O exame histopatológico revelou presença de fenda subepidermal extensacontendo discreta quantidade de restos celulares ou sangue. Pelos sinais clínicos e a análise histopatológica,suspeita se que a estomatite vesico-bolhosa era devido ao PMM. O controle parcial da doença foi obtido com uso de ciclosporina diário com corticosteroide intermitente.

Manifestações clínicas graves de pênfigo eritematoso em cão / Severe clinical manifestations pemphigus erythematosus in dog

Descreve-se o diagnóstico e a terapia instituída em um caso de pênfigo eritematoso com grave manifestaçãoclínica, em uma cadela da raça Border Collie. Os sinais clínicos incluíam dermatite eritematosa e ulcerativa nas junções mucocutâneas, além de eritema e erosões extensas nas regiões de axilas, abdômen ventral, pavilhão auricular e regiões interdigitais. No plano nasal e focinho verificou-se ulceração e despigmentação. O exame histopatológico da biópsia cutânea revelou presença de dermatite pustularcom acantólise, associada à dermatite da interface não supurativa e lesões degenerativas indicativas de agressão à membrana basal, compatível com pênfigo eritematoso. O tratamento com altas doses de prednisona associado com azatioprina e enrofloxacina promoveu remissão dos sinais clínicos. Conclui-se que o pênfigo eritematoso pode cursar com manifestações mucocutâneas graves e que a associação de dois imunossupressores pode ser efetiva no tratamento de pênfigo eritematoso grave. (AU)

In this work, we described the diagnosis and therapy adopted in a case of pemphigus erythematosus with a severe clinical presentation in a Border Colie bitch. Clinical signs included ulcerative and erythematous dermatitis in the mucocutaneous junctions, in addition to hyperemia and extensive erosions inthe axillary regions, ventral abdomen, auricle and interdigital regions. Ulceration and depigmentationon the nasal planum and nose pad were observed. The histopathological examination of skin biopsy showedthe presence of pustular acantholytic dermatitis associated to the dermatitis of the non-suppurative interface and degenerative lesions indicative of aggression to the basal membrane and consistent with pemphigus erythematosus. The long term treatment with high dosages of prednisone associated with azathioprine and enrofloxacin resulted in remission of clinical signs. It is possible to conclude that pemphigus erythematosus can attend with severe mucocutaneous manifestations and that the association of two immunosuppresors can be effective in the treatment of severe pemphigus erythematosus. (AU)

Manifestações clínicas graves de pênfigo eritematoso em cão / Severe clinical manifestations pemphigus erythematosus in dog

Descreve-se o diagnóstico e a terapia instituída em um caso de pênfigo eritematoso com grave manifestaçãoclínica, em uma cadela da raça Border Collie. Os sinais clínicos incluíam dermatite eritematosa e ulcerativa nas junções mucocutâneas, além de eritema e erosões extensas nas regiões de axilas, abdômen ventral, pavilhão auricular e regiões interdigitais. No plano nasal e focinho verificou-se ulceração e despigmentação. O exame histopatológico da biópsia cutânea revelou presença de dermatite pustularcom acantólise, associada à dermatite da interface não supurativa e lesões degenerativas indicativas de agressão à membrana basal, compatível com pênfigo eritematoso. O tratamento com altas doses de prednisona associado com azatioprina e enrofloxacina promoveu remissão dos sinais clínicos. Conclui-se que o pênfigo eritematoso pode cursar com manifestações mucocutâneas graves e que a associação de dois imunossupressores pode ser efetiva no tratamento de pênfigo eritematoso grave.

In this work, we described the diagnosis and therapy adopted in a case of pemphigus erythematosus with a severe clinical presentation in a Border Colie bitch. Clinical signs included ulcerative and erythematous dermatitis in the mucocutaneous junctions, in addition to hyperemia and extensive erosions inthe axillary regions, ventral abdomen, auricle and interdigital regions. Ulceration and depigmentationon the nasal planum and nose pad were observed. The histopathological examination of skin biopsy showedthe presence of pustular acantholytic dermatitis associated to the dermatitis of the non-suppurative interface and degenerative lesions indicative of aggression to the basal membrane and consistent with pemphigus erythematosus. The long term treatment with high dosages of prednisone associated with azathioprine and enrofloxacin resulted in remission of clinical signs. It is possible to conclude that pemphigus erythematosus can attend with severe mucocutaneous manifestations and that the association of two immunosuppresors can be effective in the treatment of severe pemphigus erythematosus.