Role of nitric oxide in responses of pial arterial vessels to low-intensity red laser irradiation.

The responses of rat pial vessels to red laser irradiation can be mediated by NO. NO mainly affects major arteries and did not contribute to reactivity of small pial arteries and precortical arterioles.

Effect of laser irradiation on adrenoreactivity of pial arterial vessels in rats.

Experiments on WKY and SHR rats showed that low-intensity laser irradiation reduced the tone of pial arterial vessels thereby potentiating the subsequent constrictor effect of norepinephrine. Irradiation in the red region of the spectrum produced a more pronounced effect in the blue region. The observed effects were less pronounced in SHR rats compared to normotensive WKY rats.

Incidence of central nervous system involvement in chronic lymphocytic leukemia and outcome to treatment.

Leptomeningeal involvement in patients with CLL is relatively rare and the prognosis is usually considered to be poor. The authors reviewed all CLL patients treated in a tertiary referral center to assess the incidence and outcome of leptomeningeal involvement (LI) in CLL. They found an incidence of 1-2% of LI. Most of the patients with LI had a longterm survival, despite failure to clear the cerebrospinal fluid from tumor cells.