RESUMO
No disponible
Assuntos
Feminino , Humanos , Masculino , Dengue Grave/metabolismo , Dengue Grave/patologia , Espanha/epidemiologia , Culicidae/virologia , Febre Amarela/transmissão , Pleurodinia Epidêmica/epidemiologia , Cefaleia/diagnóstico , Dengue Grave/transmissão , Dengue Grave/virologia , Culicidae/classificação , Febre Amarela/virologia , Pleurodinia Epidêmica/complicações , Cefaleia/complicaçõesRESUMO
We describe a case of a 42-year-old man who presented to the emergency department with severe left-sided chest pain and chest tenderness of 1-day duration. The pain was episodic and was aggravated by any chest wall movement. His initial blood tests and ECG were suggestive of acute coronary syndrome (ACS). However, his pattern of pain, lack of response to opiates, raised creatine kinase and signs of pleurisy on chest radiograph raised a suspicion of an alternative diagnosis. The patient showed a dramatic response in pain relief to non-steroidal anti-inflammatory medication. He was suspected to have chest wall myositis with pleural involvement in the form of pleurodynia. His serology test was positive for coxsackie virus antibodies. We will discuss in this case report the pathognomonic features, diagnosis and treatment of a rare infectious condition known as Bornholm disease.
Assuntos
Síndrome Coronariana Aguda/complicações , Infecções por Coxsackievirus/diagnóstico , Miosite/diagnóstico , Pleurodinia Epidêmica/diagnóstico , Parede Torácica , Adulto , Anti-Inflamatórios não Esteroides/uso terapêutico , Dor no Peito/tratamento farmacológico , Dor no Peito/etiologia , Infecções por Coxsackievirus/complicações , Humanos , Masculino , Miosite/tratamento farmacológico , Miosite/virologia , Pleurodinia Epidêmica/complicações , Pleurodinia Epidêmica/virologiaAssuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Hérnia Diafragmática/complicações , Hérnia Diafragmática/diagnóstico , Potássio/análise , Potássio , Prognóstico , Pleurodinia Epidêmica/complicações , Síndrome de Eosinofilia-Mialgia/complicações , Obstrução Intestinal/complicações , Obstrução Intestinal/diagnóstico , Pneumonia/complicações , Frequência CardíacaRESUMO
Coxsackieviruses are responsible for numerable diseases in man. This is also the reason for the high prevalence of endemic infection rates in the population. Our analysis (working hypothesis) will focus on the participation of Coxsackieviruses in chronic decompensated, complex tinnitus. Examination of the Coxsackievirus antibody titers might reveal the extent to which a Coxsackieviruses-triggered disease of the central nervous system participates in the direct sequelae of tinnitus disorders. A spread of Coxsackieviruses to the auditory pathway might lead to an overstimulation of the auditory pathway, comparable to an epileptic lesion. Based on this assumption, treatment with an antiepileptic would make sense. The reasoning behind this working hypothesis is to find a potentially new diagnostic and therapeutic roadmap as a further guide for specialized clinics. The authors are well aware that previous results bear little relevance as they have been based on small case numbers.
Assuntos
Anticonvulsivantes/uso terapêutico , Doenças Auditivas Centrais/diagnóstico , Vias Auditivas , Infecções por Coxsackievirus/diagnóstico , Enterovirus Humano B , Zumbido/tratamento farmacológico , Zumbido/etiologia , Idoso , Doenças Auditivas Centrais/complicações , Doença Crônica , Infecções por Coxsackievirus/complicações , Diagnóstico Diferencial , Humanos , Masculino , Pleurodinia Epidêmica/complicações , Pleurodinia Epidêmica/diagnósticoRESUMO
OBJECTIVE: To document a case of severe, progressive myopathy, myalgias, arthralgias, and weakness possibly caused by amlodipine in a patient with benign essential hypertension. CASE SUMMARY: A 52-year-old white woman with asthma and newly diagnosed hypertension was initiated on zafirlukast therapy for asthma and amlodipine therapy for hypertension. Two months later, the patient reported severe, generalized muscle and joint pain, muscle stiffness, and weakness. The zafirlukast was discontinued without resolution of symptoms. Laboratory tests revealed an elevated C-reactive protein. The amlodipine dosage was increased. Her symptoms persisted and further laboratory tests revealed a positive anti-nuclear antibody screen, and negative single- and double-stranded DNA antibody tests. After another amlodipine dosage increase, the patient experienced a sudden onset of left-sided facial numbness, facial weakness, and a severe headache.The patient was admitted to rule out a possible cerebrovascular event or a metabolic neurologic process. Magnetic resonance imaging showed no abnormalities. The patient discontinued the amlodipine and reported complete resolution of the neurologic symptoms after 4 days. One month later, zafirlukast was reinitiated without a return of symptoms. CONCLUSIONS: Amlodipine was not initially suspected as a cause of these symptoms because these effects are not commonly associated with amlodipine therapy. However, due to the temporal relationship and progression of symptoms with increasing amlodipine dosage, drug-related causes were eventually explored. Review of the medical literature suggests myalgias and arthralgias may be adverse effects common to dihydropyridine calcium-channel antagonists.
Assuntos
Anlodipino/efeitos adversos , Anti-Hipertensivos/efeitos adversos , Doenças Neuromusculares/induzido quimicamente , Anlodipino/uso terapêutico , Anti-Hipertensivos/uso terapêutico , Artralgia/induzido quimicamente , Artralgia/complicações , Feminino , Humanos , Hipertensão/complicações , Hipertensão/tratamento farmacológico , Pessoa de Meia-Idade , Doenças Neuromusculares/complicações , Pleurodinia Epidêmica/induzido quimicamente , Pleurodinia Epidêmica/complicaçõesAssuntos
Artrite/complicações , Infecções por Coxsackievirus/complicações , Enterovirus Humano B/isolamento & purificação , Pleurodinia Epidêmica/complicações , Doença Aguda , Adulto , Artrite/patologia , Infecções por Coxsackievirus/patologia , Humanos , Masculino , Pleurodinia Epidêmica/patologia , Articulação do Punho/patologiaRESUMO
Nine children in the age group of new born to 10 years were seen during the period October 1989 to January 1993 with varying manifestations of Myocarditis. This ranged from cardiogenic shock due to fulminant cardiac failure, recurrent wheezy episodes (mistakenly treated as bronchial asthma) bronchiolitis and rhythm disturbances. Clinical picture was collaborated by radiological evidence of cardiomegaly, ECG changes of low voltage QRS complexes with ST depression, T wave inversion or signs of left ventricular dilatation. SGOT, SGPT, CPK, LDH were elevated significantly in 7 cases. Echocardiographic changes ranged from left ventricular dilatation to global hypokinesia and mild mitral incompetence. Viral studies suggested infection with Coxsackie B1 in 4 cases, B4 in 2, B5 in 2 and Dengue 3 in 1 case. All the children recovered well with routine anti failure measures and treatment of arrhythmias and 2 children needed steroid therapy. At the end of follow up of 6 months to 1 year there has been complete reversal of ECHO changes to normal. Viral Myocarditis can manifest in varied ways in children and if treated adequately may lead to complete recovery.
Assuntos
Infecções por Coxsackievirus/complicações , Dengue/complicações , Enterovirus Humano B , Miocardite/complicações , Pleurodinia Epidêmica/complicações , Arritmias Cardíacas/etiologia , Bronquiolite/etiologia , Broncopneumonia/etiologia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Insuficiência da Valva Mitral/etiologiaAssuntos
Síndrome da Imunodeficiência Adquirida/complicações , Rabdomiólise/etiologia , Sepse/complicações , Infecções Estafilocócicas/complicações , Síndrome da Imunodeficiência Adquirida/tratamento farmacológico , Adulto , Antibacterianos/uso terapêutico , Humanos , Masculino , Pleurodinia Epidêmica/complicações , Pleurodinia Epidêmica/fisiopatologia , Rabdomiólise/fisiopatologia , Sepse/tratamento farmacológico , Sepse/fisiopatologia , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estafilocócicas/fisiopatologia , Zidovudina/uso terapêuticoRESUMO
76 patients with the postviral fatigue syndrome (PVFS) and 30 matched controls were investigated. Virus isolation was attempted from concentrated faecal samples by direct culture and after acid dissociation of virus from antibody. Positive cultures of enteroviruses were obtained from 17 (22%) patients and 2 (7%) controls. An enterovirus-group-specific monoclonal antibody, 5-D8/1, directed against the VP1 polypeptide, was used to detect enteroviral antigen in the circulation, either free or complexed with antibody. VP1 antigen was detected in the serum of 44 (51%) of a further group of 87 PVFS patients. The number of patients positive for VP1 antigen was greater (42/44) when IgM complexes were detectable than when they were not (2/23). 1 year later, the 17 patients of the first group of 76 with positive cultures were again studied. The same virus was again isolated from 5 (29%), 13 (76%) had detectable IgM responses to enteroviruses, and 9 (53%) were positive for VP1 antigen in the serum. These results show that chronic infection with enteroviruses occurs in many PVFS patients and that detection of enterovirus antigen in the serum is a sensitive and satisfactory method for investigating infection in these patients.