Assuntos
COVID-19 , Preparação para Pandemia , Pandemias , Humanos , COVID-19/epidemiologia , COVID-19/imunologia , COVID-19/prevenção & controle , Previsões , Pandemias/prevenção & controle , SARS-CoV-2 , Estados Unidos/epidemiologia , Preparação para Pandemia/organização & administração , Preparação para Pandemia/normas , Vacinação/normas , Ensaios Clínicos como Assunto/normasRESUMO
The COVID-19 pandemic has urged the need to set up, conduct and analyze high-quality epidemiological studies within a very short time-scale to provide timely evidence on influential factors on the pandemic, e.g. COVID-19 severity and disease course. The comprehensive research infrastructure developed to run the German National Pandemic Cohort Network within the Network University Medicine is now maintained within a generic clinical epidemiology and study platform NUKLEUS. It is operated and subsequently extended to allow efficient joint planning, execution and evaluation of clinical and clinical-epidemiological studies. We aim to provide high-quality biomedical data and biospecimens and make its results widely available to the scientific community by implementing findability, accessibility, interoperability and reusability - i.e. following the FAIR guiding principles. Thus, NUKLEUS might serve as role model for FAIR and fast implementation of clinical epidemiological studies within the setting of University Medical Centers and beyond.