Amphetamine-induced psychosis: Transition to schizophrenia and mortality in a small prospective sample.

BACKGROUND AND OBJECTIVES: We investigated transition from amphetamine-induced psychosis (AIP) to schizophrenia. METHODS: A sample of 28 individuals was identified while hospitalized for AIP. We reviewed their hospital records after six years. RESULTS: During follow-up, seven individuals (25%) died and nine (32%) had moved from the area. Of the remaining 12, four individuals (25%) were diagnosed with schizophrenia. These individuals were, at baseline, characterized by fewer hallucinatory symptoms and more homelessness. CONCLUSION AND SCIENTIFIC SIGNIFICANCE: Hospitalization for AIP was a relatively specific risk factor for schizophrenia and the mortality rate in AIP was high.

Alcohol psychoses and all-cause mortality in Belarus.

BACKGROUND: The burden of alcohol-related problems in central and eastern Europe is the highest in the world. The level of alcohol consumption in Belarus is among the highest in the world, with an annual consumption rate estimated to be 14 litres of pure alcohol per capita. The social, economic and political turmoil that Belarus has experiences in the years following the dissolution of the Soviet Union has been accompanied by a substantial rise in all-cause mortality. Although alcohol seems to be an important contributor to the burden of disease in the former Soviet republics, little systematic research has been undertaken on its impact on all-cause mortality in Belarus. AIMS: The aim of the present study was to address this particular deficit concerning the alcohol-total mortality relationship in Belarus by using aggregate-level data. METHOD: Trends in the all-cause mortality and alcohol psychoses incidence rates (as a proxy for alcohol consumption) from 1970 to 2005 were analyzed employing ARIMA time series analysis in order to asses bivariate relationship between the two time series. RESULTS: The results of time series analysis suggest a close relationship between all-cause mortality and alcohol psychoses rates at the aggregate level. CONCLUSIONS: This study replicates the previous findings that suggested close link between alcohol and mortality. The outcome of present study also supports the hypothesis that alcohol is a crucial factor of mortality crisis in Belarus. Therefore, alcohol control must be a key priority for Belorussian public health policy.

[Descriptive analysis of drug-related deaths over a 5-year period]. / Deskriptive Analyse drogenassoziierter Todesfälle über einen 5-Jahres-Zeitraum.

OBJECTIVE: The purpose of the study was to examine opiate-related deaths in the German town Essen (inhabitants about 600,000) from 1990-1994. Sociodemographic data, psychiatric comorbidity and purity of the used opioids were of focussed interest. METHODS: 189 opiate-related deaths were analysed during the 5-year period. Patient files and police-related documents were used for the retrospective analysis. Purity of opioids was examined in a criminalistic laboratory and correlated with the number of deaths per time interval. RESULTS: The average age to start drug abuse in this cohort of 189 people was about 20, the average time of drug career was about 8.5 years, and the highest number of drug-related deaths was to be found at the age of 29-30. Purity of opioids was correlated statistically significantly (p < 0.05) with the number of deaths per period of time. CONCLUSIONS: After an average start of drug abuse at the age of 20 and a drug career of about a decade the risk of drug-related death seems to be relatively high at the age of about 30 years. Opiate purity seems to be relevant for drug-related death.

Phencyclidine--states of acute intoxication and fatalities.

Phencyclidine is now one of the most frequently used main ingredients of "street drug" preparations. Its effects are highly dose dependent and three varieties of acute intoxication have been seen clinically associated with different dosages and routes of administration. Most persons using phencyclidine smoke it sprinkled on parsley in low doses. The presence of horizontal and vertical nystagmus associated with hypertension in a patient who is agitated or comatose are diagnostic of a phencyclidine intoxicated state. Sensory isolation and intravenous administration of diazepam in the event of seizure activity have proved effective in the treatment of acute intoxicated states. Phencyclidine has pronounced behavioral toxicity and several deaths due to this agent have now been documented. It is unknown whether seizure activity or respiratory depression is the primary cause of death in pharmacological overdoses.